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Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide

Nan Mei, Lei Guo, Jo Tseng, Stacey L. Dial, Wayne Liao, Mugimane G. Manjanatha
2008 Environmental and Molecular Mutagenesis  
In this study, groups of male mice were administered 500 mg/L AA in drinking water for 3 weeks, and gene expression changes were evaluated in the livers of AA-treated mice within 24 hr of the last treatment  ...  When a two-fold cutoff value and a P-value less than 0.05 were selected, 696 genes (233 up-regulated and 463 down-regulated) were identified as differentially expressed genes in AA-treated mice when compared  ...  In this study, we isolated total RNA from the livers of six control and 4 AA-treated mice, which were treated without or with 500 mg/L in drinking water for 3 weeks and sacrificed within 24 hr of the last  ... 
doi:10.1002/em.20429 pmid:18800343 pmcid:PMC5739318 fatcat:qyug4qayordvphfahjioqdn3z4

Effect of Acrylamide on Liver Proteins Expression in Mice

Ahlam S. Al-Azkawi, Saif N. Al-Bahry, Ibrahim Y. Mahmoud, Michael J. Barry
2013 Journal of Food Research  
However, analysis by 2-D gel of liver proteins from mice treated with 0.5 µg acrylamide/kg for 9 weeks showed variations in protein expression.  ...  The liver protein pattern from sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE) treated mice with acrylamide in drinking water for 9 weeks did not show variations from the control.  ...  After one week of acclimation mice were treated as follow: group 1 served as a control, received drinking water only, group 2 was treated with 0.5 μg/kg body weight of acrylamide in drinking water according  ... 
doi:10.5539/jfr.v2n5p132 fatcat:i7ujpd7fsjb2bowrhelc3mpyme

Evaluation of cII gene mutation in the brains of Big Blue mice exposed to acrylamide and glycidamide in drinking water

Hai-fang Li, Sharon D. Shelton, Todd A. Townsend, Nan Mei, Mugimane G. Manjanatha
2016 Journal of Toxicological Sciences  
Big Blue mice with 0, 1.4 mM, and 7.0 mM AA or GA in drinking water for up to 4 weeks.  ...  AA is tumorigenic in rodents, and a large number of studies indicate that AA is genotoxic in multiple organs of mice and rats.  ...  Tao Chen and Xiaoqing Guo for their critical review of this manuscript. The information in this manuscript is not a formal dissemination of information by the U.S.  ... 
doi:10.2131/jts.41.719 pmid:27853100 pmcid:PMC8720368 fatcat:sk7tmelzpbec3m74ffeyb335se

A review of mechanisms of acrylamide carcinogenicity

A. Besaratinia, G. P. Pfeifer
2006 Carcinogenesis  
Both genotoxic and non-genotoxic modes of action of acrylamide are discussed with special emphasis on DNA adducttargeted mutagenesis.  ...  The fact that acrylamide, a proven rodent carcinogen, is present in significant quantities (up to several mg/kg of foodstuff) in a wide range of commonly consumed human foods is alarming.  ...  Acknowledgements Work of the authors is supported by National Institutes of Health grant CA84469. Conflict of Interest Statement: None declared.  ... 
doi:10.1093/carcin/bgm006 pmid:17234719 fatcat:gvib3i62grhyri4hksaugu5uvm

Alcohol Facilitates CD1d Loading, Subsequent Activation of NKT Cells, and Reduces the Incidence of Diabetes in NOD Mice

Karsten Buschard, Axel Kornerup Hansen, Karen Jensen, Dicky J. Lindenbergh-Kortleve, Lilian F. de Ruiter, Thomas C. Krohn, Majbritt R. Hufeldt, Finn K. Vogensen, Bent Aasted, Thomas Osterbye, Bart O. Roep, Colin de Haar (+2 others)
2011 PLoS ONE  
NOD mice were found to tolerate 5% ethanol in their drinking water without signs of impairment in liver function. Giving this treatment, the diabetes incidence declined significantly.  ...  Increased concentrations of IFN-c were detected in 24-hour blood samples of alcohol treated mice.  ...  Squares represent mice treated with 5% ethanol in the drinking water and dots represent mice receiving pure drinking water.  ... 
doi:10.1371/journal.pone.0017931 pmid:21483778 pmcid:PMC3069977 fatcat:ny2p7eqfnbex5o6o2pidnti7ym

Expression of Mouse Acute-Phase (SAA1.1) and Constitutive (SAA4) Serum Amyloid A Isotypes : Influence on Lipoprotein Profiles

M. S. Kindy, M. C. de Beer, J. Yu, F. C. de Beer
2000 Arteriosclerosis, Thrombosis and Vascular Biology  
SAA association with the HDL particles at this concentration did not significantly alter the apoA-I or HDL cholesterol levels or change the lipoprotein profiles in the transgenic mice compared with wild-type  ...  Injection of adenovirus expressing the mouse SAA1.1 protein resulted in high-level expression (72Ϯ8 mg/dL) but did not alter apoA-I levels.  ...  Acknowledgments This work was supported by National Institutes of Health grants NS-32221 and AG-12981 (M.S.K.) and AG-10886 (F.C.d.D.) and the Sanders-Brown Center on Aging.  ... 
doi:10.1161/01.atv.20.6.1543 pmid:10845870 fatcat:7hqqelkvofh6xfk3mretu6b24i

STAT5b-deficient Mice Are Growth Hormone Pulse-resistant

Helen W. Davey, Soo-Hee Park, David R. Grattan, Michael J. McLachlan, David J. Waxman
1999 Journal of Biological Chemistry  
feminization of the pituitary GH secretory profile leading to the observed feminization of body growth and liver gene expression.  ...  growth hormone (GH) pulse-dependent responses in mice with a targeted disruption of the STAT5b gene.  ...  Negishi for provision of CYP2D9 antibody, Ric Broadhurst for assistance with anesthesia and surgery, Glenda Smith and Bobby Smith for assisting with care of the mice, and Harold Henderson for statistical  ... 
doi:10.1074/jbc.274.50.35331 pmid:10585399 fatcat:6ygizlqqlbfd3oiy4b7njp73h4

Dietary Acrylamide and the Risks of Developing Cancer: Facts to Ponder

Jaya Kumar, Srijit Das, Seong Lin Teoh
2018 Frontiers in Nutrition  
Acrylamide (AA) is a water soluble white crystalline solid commonly used in industries. It was listed as an industrial chemical with potential carcinogenic properties.  ...  In the present review, we discuss the formation of AA in food products, its consumption, and possible link to the development of any cancers.  ...  AA/kg bw/day was given in drinking water for 5, 15, or 31 days Expression profiling by next-generation sequencing of RNA, bioinformatics to identify differentially expressed genes and gene ontology pathway  ... 
doi:10.3389/fnut.2018.00014 pmid:29541638 pmcid:PMC5835509 fatcat:2jqp3sveefcltp3mjreshrkl5m

Gene expression analysis in the lung of the rasH2 transgenic mouse at week 4 prior to induction of malignant tumor formation by urethane and N-methylolacrylamide

Satoshi Tsuji, Yusuke Kuwahara, Hironori Takagi, Masayuki Sugiura, Yutaka Nakanishi, Masaki Wakamatsu, Katsuki Tsuritani, Yasushi Sato
2015 Journal of Toxicological Sciences  
The gene expressions of epireguline, aurora kinase B, and cyclin B1 increased in the UR-treated Tg mice.  ...  In the present study, we examined the comprehensive gene expressions in the lungs of Tg and non-Tg mice prior to the induction of malignant tumors.  ...  Kawai et al. (2008) showed enhanced mRNA expressions of the ras/MAPK pathway and cell cycle genes in the livers of the rasH2 Tg mice treated with FF for 7 weeks after DEN initiation.  ... 
doi:10.2131/jts.40.685 pmid:26558449 fatcat:j3prwcrrejerfptmhwofbbgwj4

Proteomic Analysis of Gastrocnemius Muscle in Rats with Streptozotocin-Induced Diabetes and Chronically Exposed to Fluoride

Aline Lima Leite, Janete Gualiume Vaz Madureira Lobo, Heloísa Aparecida Barbosa da Silva Pereira, Mileni Silva Fernandes, Tatiani Martini, Fernanda Zucki, Dóris Hissako Sumida, Alfredo Rigalli, Marília Afonso Rabelo Buzalaf, Stephen E. Alway
2014 PLoS ONE  
This study determined the profile of protein expression in the gastrocnemius muscle of rats with streptozotocin-induced diabetes that were chronically exposed to F.  ...  Analysis of subnetworks revealed that, in all comparisons, proteins with fold changes interacted with GLUT4.  ...  A previous study reported the absence of L-lactate dehydrogenase A chain in the liver of rats (ND) treated with F [28] . Decreased expression of this enzyme leads to increased aerobic glycolysis.  ... 
doi:10.1371/journal.pone.0106646 pmid:25180703 pmcid:PMC4152332 fatcat:mkba47h3jjh77k4m2z7ubav5wu

Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice

Jianmin Tian, Haiyan Huang, Barbara Hoffman, Dan A. Liebermann, Giovanna M. Ledda-Columbano, Amedeo Columbano, Joseph Locker
2011 Journal of Clinical Investigation  
Moreover, early transcriptional stimulation of CAR target genes was weaker in Gadd45b -/mice than in wild-type animals, and more genes were downregulated.  ...  In the liver, Gadd45b (encoding Gadd45β) is the gene most strongly induced early during both compensatory regeneration and drug-induced hyperplasia.  ...  Acknowledgments We are grateful to Aldo Massimi for assistance with the microarray studies and to Radma Mahmood for immunohistochemistry. The work was supported by NIH grants CA104292 to J.  ... 
doi:10.1172/jci38760 pmid:21965327 pmcid:PMC3204825 fatcat:kkf5gd6chjaldje23jntwbf7qy

Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury

Marc Weidenbusch, Severin Rodler, Shangqing Song, Simone Romoli, Julian A. Marschner, Franziska Kraft, Alexander Holderied, Santosh Kumar, Shrikant R. Mulay, Mohsen Honarpisheh, Satish Kumar Devarapu, Maciej Lech (+1 others)
2017 Bioscience Reports  
For regeneration studies, mice received normal drinking water after 24 h of exposure to CaOx drinking water and kidneys were collected 24 and 48 h later.  ...  drinking water as previously described [52] .  ...  Competing interests The authors declare that there are no competing interests associated with the manuscript.  ... 
doi:10.1042/bsr20170099 pmid:29054964 pmcid:PMC5741834 fatcat:ncigjs6k4behfptrewcji7rwnq

Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation

Marica Cariello, Annalisa Contursi, Raffaella Maria Gadaleta, Elena Piccinin, Stefania De Santis, Marilidia Piglionica, Ada Fiorenza Spaziante, Carlo Sabbà, Gaetano Villani, Antonio Moschetta
2020 Nutrients  
Furthermore, mice treated with Ogliarola, Coratina and Cima di Mola EVO displayed a reduction of rectal bleeding and IL-1β, TGFβ, IL-6 gene expression levels.  ...  For instance, oleic acid displays a protective effect in liver dysfunction and gut inflammation, whereas phenolic compounds protect colon cells against oxidative damage and improve the symptoms of chronic  ...  Acknowledgments: The authors acknowledge the contribution of Oliveti Terra di Bari (Sig. Gennaro Sicolo) to provide EVO cultivars. Scientific discussions on this topic with Drs.  ... 
doi:10.3390/nu12041084 pmid:32295122 fatcat:2uuiuaoonjhcthwgrgtsyfb6ke

Protein expression analysis of inflammation-related colon carcinogenesis

Takuji Tanaka, Yumiko Yasui
2009 Journal of Carcinogenesis  
Materials and Methods: Male ICR mice were given a single intraperitoneal injection of AOM (10 mg/kg body weight), followed by 2% (w/v) DSS in their drinking water for seven days, starting one week after  ...  Conclusions: There were 21 differentially expressed proteins in the cancerous tissues of the mice that received AOM and DSS.  ...  [49] Trx-overexpressing transgenic mice show a decreased severity of colitis in mice treated with DSS.  ... 
doi:10.4103/1477-3163.51851 pmid:19491504 pmcid:PMC2699605 fatcat:k5cpbs37mvgn7aaqw7dtoi4ko4

Protective Effects of White Button Mushroom (Agaricus bisporus) against Hepatic Steatosis in Ovariectomized Mice as a Model of Postmenopausal Women

Noriko Kanaya, Makoto Kubo, Zheng Liu, Peiguo Chu, Charles Wang, Yate-Ching Yuan, Shiuan Chen, Franky L. Chan
2011 PLoS ONE  
OVX mice were fed a high fat diet supplemented with WBM powder. We found that dietary WBM intake significantly lowered liver weight and hepatic injury markers in OVX mice.  ...  the liver of mushroom-fed mice.  ...  Wendong Huang of Beckman Research Institute of the City of Hope, Department of Gene Regulation and Drug Discovery, for kindly providing Huh7 cells. The authors would also like to thank Dr.  ... 
doi:10.1371/journal.pone.0026654 pmid:22046322 pmcid:PMC3201963 fatcat:vh4pgyflfjep7jph6sqbd3if7u
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