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Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal–septal memory circuit in a mouse model of Down syndrome

Elaine L. Bearer, Xiaowei Zhang, Russell E. Jacobs
2007 NeuroImage  
We trace these connections in living mice by Mn 2+ enhanced 3D MRI and compare normal with a trisomic mouse model of DS, Ts65Dn.  ...  Connections from hippocampus to septal nuclei have been implicated in memory loss and the cognitive impairment in Down syndrome (DS).  ...  The project was in part funded by NINDS NS046810, NIGMS GM47368 (E.L.B.), NCRR U24 RR021760 entitled Mouse BIRN and NIDA R01DA018184 (R.E.J.).  ... 
doi:10.1016/j.neuroimage.2007.05.010 pmid:17566763 pmcid:PMC2074885 fatcat:q37sacfpfrcjjmsmvkur25nuu4

Alterations of functional circuitry in aging brain and the impact of mutated APP expression

Elaine L. Bearer, Brett C. Manifold-Wheeler, Christopher S. Medina, Aaron G. Gonzales, Frances L. Chaves, Russell E. Jacobs
2018 Neurobiology of Aging  
; Manganese-enhanced magnetic resonance imaging (MEMRI); cholinergic neurons; septal nuclei Bearer et al.  ...  Here we perform manganese-enhanced magnetic resonance imaging (MEMRI) to study transport from hippocampus to forebrain in four cohorts of living mice: young and old wild-type and transgenic mice expressing  ...  computational approaches for analysis of mouse brain MRI, Angela Wandinger-Ness (Director of the UNM Cancer Center Biological Imaging Facility), and the Beckman Biological Imaging Center.  ... 
doi:10.1016/j.neurobiolaging.2018.06.018 pmid:30055413 pmcid:PMC6159914 fatcat:rkj5jkpwjne7zp3m5do5zcarca

Decoupling the Effects of the Amyloid Precursor Protein from Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain [chapter]

Christopher S Medina, Taylor W Uselman, Daniel R Barto, Frances Cháves, Russell E Jacobs, Elaine L Bearer
2020 Prime Archives in Neuroscience  
altered, as detected by time-lapse manganese-enhanced magnetic resonance imaging (MEMRI) of the brain in living mice.  ...  To determine the relative contribution of expression of APP SwInd versus plaque on transport dynamics, we developed a Tet-off system to decouple expression of APP SwInd from plaque, and then studied hippocampal  ...  We use manganese-enhanced magnetic resonance imaging (MEMRI) to study axonal transport in the living brain [7] [8] [9] [10] [11] [12] [13] [14] .  ... 
doi:10.37247/pans.1.2020.3 fatcat:y2o4s2xlwrbibirmyhyftqbpua

Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain

Christopher S. Medina, Taylor W. Uselman, Daniel R. Barto, Frances Cháves, Russell E. Jacobs, Elaine L. Bearer
2019 Frontiers in Cellular Neuroscience  
, as detected by time-lapse manganese-enhanced magnetic resonance imaging (MEMRI) of the brain in living mice.  ...  To determine the relative contribution of expression of APPSwInd versus plaque on transport dynamics, we developed a Tet-off system to decouple expression of APPSwInd from plaque, and then studied hippocampal  ...  Bronner, and the Division of Biology and Biological Engineering at Caltech for sponsoring EB as a Visiting Associate.  ... 
doi:10.3389/fncel.2019.00501 pmid:31849608 pmcid:PMC6901799 fatcat:i34i3ffevjg77ncrpp3pek5qs4

Neuropsychiatric Disturbances in Alzheimer's Disease: What Have We Learned from Neuropathological Studies?

Debby Van Dam, Yannick Vermeiren, Alain D. Dekker, Petrus J.W. Naudé, Peter P. De Deyn
2016 Current Alzheimer Research  
Neuropsychiatric symptoms (NPS) are an integral part of the dementia syndrome and were therefore recently included in the core diagnostic criteria of dementia.  ...  of NPS-relevant brain regions and circuits in correlation with specific NPS assessments.  ...  ACKNOWLEDGEMENTS The work of all included authors was supported by the All authors have contributed substantially to the design and writing of the review, as well as inclusion and interpretation of included  ... 
doi:10.2174/1567205013666160502123607 pmid:27137218 pmcid:PMC5070416 fatcat:a2wfea4wrbhexphe6u7bfhvb5m

Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning

György Buzsáki
2015 Hippocampus  
The spike content of SPW-Rs is temporally and spatially coordinated by a consortium of interneurons to replay fragments of waking neuronal sequences in a compressed format.  ...  SPW-Rs assist in transferring this compressed hippocampal representation to distributed circuits to support memory consolidation; selective disruption of SPW-Rs interferes with memory.  ...  Acknowledgments The author thanks John Lisman for reading and providing constructive feedback on the entire manuscript, Jan Born,  ... 
doi:10.1002/hipo.22488 pmid:26135716 pmcid:PMC4648295 fatcat:kmeessu4pbc27lungr5ynewbf4

30th Annual Computational Neuroscience Meeting: CNS*2021–Meeting Abstracts

2021 Journal of Computational Neuroscience  
Currently, most functional models of neural activity are based on firing rates, while the most relevant signals for inter-neuron communication are spikes.  ...  One of the goals of neuroscience is to understand the computational principles that describe the formation of behaviorally relevant signals in the brain, as well as how these computations are realized  ...  O14 On the role of arkypallidal and prototypical neurons for neural synchronization in the basal ganglia Acknowledgements This work was supported by NIH-NIBIB (R01-EB027584).  ... 
doi:10.1007/s10827-021-00801-9 pmid:34931275 pmcid:PMC8687879 fatcat:evpmmfpaivgpxdqpive5xdgmwu

39th Annual European Brain and Behaviour Society Abstracts

2007 Neural Plasticity  
The EUROPEAN BRAIN AND BEHAVIOUR SOCIETY has held its 39th Annual General Meeting in Trieste, in the campus next to the Miramare castle and its park, co-hosted by SISSA, the International School for Advanced  ...  Alessandro Treves (SISSA) was the head and inspiration of the Local Organizing committee, supported by P. Battaglini, L. Chelazzi, M. Diamond and G. Vallortigara.  ...  A recent series of studies has shown that a test of object-in-place paired-associate learning (PAL), as part of the Cambridge neurological test battery (CaNTaB), is very effective at predicting whether  ... 
doi:10.1155/2007/23250 fatcat:7xnzbdkh5bgqxfe5vemcbmoie4

Panel Session Co-Morbid Pain and Addiction: Novel Treatments

2006 Neuropsychopharmacology  
preclinical memory models may be useful for predicting the ability of selected agents to enhance cognition, and receptor-based studies might predict whether or not a compound may diminish suicidality.  ...  Brain-derived nerve growth factor (BDNF) is critical for neuronal survival and differentiation; it also plays pivotal roles in the maintenance and remodeling of neuronal functioning in the adult brain.  ...  The Time Course of Antipsychotics Versus Placebo: On Overall Efficacy, Positive, Negative and Cognitive Symptoms John M. Davis*  ... 
doi:10.1038/sj.npp.1301265 fatcat:6odqjmshuncm5muxk5g5knprui

EMG-based Simultaneous and Proportional Estimation of Wrist Kinematics and its Application in Intuitive Myoelectric Control for Unilateral transradial Amputees

Farina Dario
2011 Frontiers in Computational Neuroscience  
Although patterns of intra-and inter-layer synaptic connectivity have been identified in PFC, the laminar organization of sensory, motor and memory-related activity within this network remains unknown.  ...  Supported by the German BMBF FKZ 0315522B. [W 52] Reliable and adaptive numerical methods for realistic neurons Dan A.  ...  Also functional magnetic resonance imaging (fMRI) has revealed a critical role of the AMTL in accessing semantic information.  ... 
doi:10.3389/conf.fncom.2011.53.00081 fatcat:nkq5wesfpbcjnikbxqh3v3gtqi

1st Annual Meeting: The Canadian Association for Neuroscience / Association canadienne de neuroscience

2007 Canadian Journal of Neurological Sciences  
To further investigate the role of non-neuronal cells in the disease onset and progression, we developed mouse model for live imaging of astrogliosis in ALS.  ...  All patients had mesial temporal sclerosis on magnetic resonance imaging. Dual pathology was identified in 12 patients (70.5%).  ... 
doi:10.1017/s0317167100017066 fatcat:aupmr4ntyjd6xes4gp5epa2epm

Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior

F. T. Crews, R. P. Vetreno, M. A. Broadwater, D. L. Robinson
2016 Pharmacological Reviews  
Authorship Contributions Wrote or contributed to the writing of the manuscript: Crews, Vetreno, Broadwater, Robinson.  ...  In a study of 885 individuals between 3 and 20 years of age, magnetic resonance imaging brain scans accurately distinguished biologic age, primarily by using diffusivity indices of white matter maturation  ...  Magnetic resonance imaging studies find lower GABA in frontal cortex in 18to 24-year-old binge drinkers compared with light drinkers, and binge drinkers with blackouts additionally had lower levels of  ... 
doi:10.1124/pr.115.012138 pmid:27677720 pmcid:PMC5050442 fatcat:zyuje5pex5b2lnfyspmlg2g7ye

Abstracts of the Fourth Brainstorming Research Assembly for Young Neuroscientists (BraYn), Italy, 20–22 October 2021

Giovanni Ferrara
2022 Neurology International  
On behalf of the BraYn Association, we are pleased to present the Abstracts of the Fourth Brainstorming Research Assembly for Young Neuroscientists, which was held from 20–22 October 2021.  ...  We congratulate all the presenters on their research work and contribution.  ...  Employing functional magnetic resonance imaging (fMRI) data acquired in resting state (rs), previous studies applied static functional connectivity (FC) analysis and showed a link between the increase  ... 
doi:10.3390/neurolint14010010 pmid:35076571 pmcid:PMC8788553 fatcat:k4hlduj3pzhndlllu5zdbozsby

Control of Sleep and Wakefulness

Ritchie E. Brown, Radhika Basheer, James T. McKenna, Robert E. Strecker, Robert W. McCarley
2012 Physiological Reviews  
Sleep results from the inhibition of wake-promoting systems by homeostatic sleep factors such as adenosine and nitric oxide and GABAergic neurons in the preoptic area of the hypothalamus, resulting in  ...  homeostatic control, process S) as proposed in the two-process model of Borbely (122).  ...  ACKNOWLEDGMENTS We thank the two anonymous reviewers for their time and helpful critiques which helped to improve the manuscript.  ... 
doi:10.1152/physrev.00032.2011 pmid:22811426 pmcid:PMC3621793 fatcat:hojtfpikovgi3kqayidhbahgsy

Abstracts for the 24th Annual Meeting of the American Society for Neural Therapy and Repair

2017 Cell Transplantation  
In a relay race, team members take turns participating in a portion of a race. Success depends on each person performing to the best of his or her abilities.  ...  I close by outlining a set of recommendations for limiting the burdens of failure in neurological drug development, maximizing prospects of success, and capitalizing on failed drug development trajectories  ...  Magnetic resonance imaging (MRI) can be used as a minimally invasive tool to guide the cell transplantation.  ... 
doi:10.3727/096368917x695146 pmid:28494821 pmcid:PMC5657807 fatcat:wpxmgozq2fgyxp6vvb7bk6i5au
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