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Découplage Actif Optique D'Un Capteur Pour L'Irm Endoluminale

Isabelle Saniour, Anne-Laure Perrier, Gwenaël Gaborit, Lionel Duvillaret, Raphaël Sablong, Olivier Beuf
<span title="2016-06-03">2016</span> <i title="Zenodo"> Zenodo </i> &nbsp;
National audience ; Les capteurs endoluminaux utilisés en IRM permettent d'avoir des informations précises dans les maladies gastro-intestinales par l'étude la paroi colique par exemple. En IRM, la phase d'émission du champ magnétique radiofréquence (RF) nécessite un découplage entre les capteurs d'émission et de réception RF pour éviter toute concentration du champ RF pour prévenir son effet sur l'uniformité du signal dans les images RM. Le découplage peut être assuré par l'ajout d'une diode
more &raquo; ... N en parallèle du capteur. Le courant continu provenant de l'IRM, est transmis par un câble coaxial pour activer la diode et changer la fréquence de résonance du capteur. La présence des connexions galvaniques dans un champ RF induit des courants qui causent des échauffements des tissus du patient. Ainsi, l'utilisation clinique d'un tel capteur n'est pas autorisée. Une transmission optique et particulièrement un découplage actif optique apparaît être une solution sécurisante. Cette méthode est basée sur l'utilisation des photodiodes mises en parallèle de la diode PIN pour envoyer un courant continu suffisant pour activer la diode, quand elles sont éclairées. Pendant l'émission du champ RF, le courant de découplage envoyé par l'IRM est converti en un signal optique grâce à un convertisseur électrique-optique. Ce signal est transmis via une fibre optique loin de l'IRM pour être converti en un signal électrique. Ce dernier assure la modulation des lasers dédiés à éclairer les photodiodes. L'expérience a été effectuée dans une IRM 3T pour tester la chaîne de transmission optique de courant de découplage. Les images résultantes en utilisant les deux méthodes de découplage sont similaires en termes d'uniformité du rapport signal-sur-bruit ce qui montre que le découplage optique est faisable dans l'IRM. De plus, la variation locale de la température a été mesurée par un système de fibre optique pour les capteurs avec des circuits de découplage lorsqu'ils sont en réception durant les expériences in vitro. Les résultats montrent un [...]
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5281/zenodo.1288624">doi:10.5281/zenodo.1288624</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6t45vtjwljeibolpgveosjiocy">fatcat:6t45vtjwljeibolpgveosjiocy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220206090911/https://zenodo.org/record/1288624/files/article.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e0/2f/e02f0791063950fc633d8dccaae5ebf9a65b36e5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5281/zenodo.1288624"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> zenodo.org </button> </a>

What Underlies the Observed Hospital Volume-Outcome Relationship?

Marius Huguet, Xavier Joutard, Isabelle Ray-Coquard, Lionel Perrier
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tol7woxlqjeg5bmzadeg6qrg3e" style="color: black;">Social Science Research Network</a> </i> &nbsp;
Studies of the hospital volume-outcome relationship have highlighted that a greater volume activity improves patient outcomes. While this finding has been known for years in health services research, most studies to date have failed to delve into what underlies this relationship. This study aimed to shed light on the basis of the hospital volume effect by comparing treatment modalities for epithelial ovarian carcinoma patients. Hospital volume activity was instrumented by the distance from
more &raquo; ... nts' homes to their hospital, the population density, and the median net income of patient municipalities. We found that higher volume hospitals appear to more often make the right decisions in regard to how to treat patients, which contributes to the positive impact of hospital volume activities on patient outcomes. Based on our parameter estimates, we found that the rate of complete tumor resection would increase by 10% with centralized care, and by 6% if treatment decisions were coordinated by high volume centers compared to the ongoing organization of care. In both scenarios, the use of neoadjuvant chemotherapy would increase by 10%. As volume alone is an imperfect correlate of quality, policy makers need to know what volume is a proxy for in order to devise volume-based policies. SUMMARY Studies of the hospital volume-outcome relationship have highlighted that a greater volume activity improves patient outcomes. While this finding has been known for years in health services research, most studies to date have failed to delve into what underlies this relationship. This study aimed to shed light on the basis of the hospital volume effect by comparing treatment modalities for epithelial ovarian carcinoma patients. Hospital volume activity was instrumented by the distance from patients' homes to their hospital, the population density, and the median net income of patient municipalities. We found that higher volume hospitals appear to more often make the right decisions in regard to how to treat patients, which contributes to the positive impact of hospital volume activities on patient outcomes. Based on our parameter estimates, we found that the rate of complete tumor resection would increase by 10% with centralized care, and by 6% if treatment decisions were coordinated by high volume centers compared to the ongoing organization of care. In both scenarios, the use of neoadjuvant chemotherapy would increase by 10%. As volume alone is an imperfect correlate of quality, policy makers need to know what volume is a proxy for in order to devise volume-based policies.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2139/ssrn.3186407">doi:10.2139/ssrn.3186407</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/62f6tbezufc7fekhbdt4owzjty">fatcat:62f6tbezufc7fekhbdt4owzjty</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719123436/https://halshs.archives-ouvertes.fr/halshs-01801598/file/1809.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8b/52/8b521e95ffe01fdff21e49db14bebf10c6c33285.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2139/ssrn.3186407"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ssrn.com </button> </a>

Direct Optical Measurement Of The Rf Electrical Field For Mri

Isabelle Saniour, Anne-Laure Perrier, Gwenaël Gaborit, Jean Dahdah, Lionel Duvillaret, Olivier Beuf
<span title="2016-05-07">2016</span> <i title="Zenodo"> Zenodo </i> &nbsp;
In magnetic resonance imaging (MRI), the real time measurement of electrical field E associated with the radiofrequency (RF) magnetic field B1 is important to quantify the energy absorbed by the tissues and to assess possible safety hazards due to local heating phenomenon. E-field could effectively increase the temperature in the tissues nearby by inducing RF currentsin any implant or metallic cables used for signal transmission and placed inside the transmit body-coil1, 2. For the measurement
more &raquo; ... f the intensities and the distribution of E-field, the adequate probe should be non-magnetic and non-perturbative regarding the E-field and must have a large working frequency range depending on B0. The commonly used probes have either a metallic structure or a large dimension which limits their bandwidth3, 4 and may disturb the electromagnetic field with bias measurements. Others optical probes do not measure directly the Efield 5. In the following, the E-field measurement experiment using a sub-cm electro-optical (EO) probe in a preclinical 4.7-T MR system is presented.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5281/zenodo.1289159">doi:10.5281/zenodo.1289159</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gd4yx3g3k5g4pclgqctcvjfrdi">fatcat:gd4yx3g3k5g4pclgqctcvjfrdi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220121225705/https://zenodo.org/record/1289159/files/article.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ad/41/ad419ca66a013fb12f7c4409d183bd91019adb10.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5281/zenodo.1289159"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> zenodo.org </button> </a>

What underlies the observed hospital volume-outcome relationship?

Marius Huguet, Xavier Joutard, Isabelle Ray-Coquard, Lionel Perrier
<span title="2022-01-14">2022</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3nwt2t3wqff4rigjayo4xqjvdm" style="color: black;">BMC Health Services Research</a> </i> &nbsp;
Background Studies of the hospital volume-outcome relationship have highlighted that a greater volume activity improves patient outcomes. While this finding has been known for years, most studies to date have failed to delve into what underlies this relationship. Objective This study aimed to shed light on the basis of the hospital volume effect on patient outcomes by comparing treatment modalities for epithelial ovarian carcinoma patients. Data An exhaustive dataset of 355 patients in
more &raquo; ... e treatment for Epithelial Ovarian Carcinoma (EOC) in 2012 in three regions of France was used. These regions account for 15% of the metropolitan French population. Methods In the presence of endogeneity induced by a reverse causality between hospital volume and patient outcomes, we used an instrumental variable approach. Hospital volume of activity was instrumented by the distance from patients' homes to their hospital, the population density, and the median net income of patient municipalities. Results Based on our parameter estimates, we found that the rate of complete tumor resection would increase by 15.5 percentage points with centralized care, and by 8.3 percentage points if treatment decisions were coordinated by high-volume centers compared to decentralized care. Conclusion As volume alone is an imperfect correlate of quality, policy-makers need to know what volume is a proxy for in order to devise volume-based policies.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12913-021-07449-2">doi:10.1186/s12913-021-07449-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35031047">pmid:35031047</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8760746/">pmcid:PMC8760746</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wmstbxahrzfxvabi26wrx7rlwq">fatcat:wmstbxahrzfxvabi26wrx7rlwq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220209130919/https://bmchealthservres.biomedcentral.com/track/pdf/10.1186/s12913-021-07449-2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6b/42/6b42147a6964a2b4794d952aa9a63a43168634b1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12913-021-07449-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760746" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Economic burden of seasonal influenza B in France during winter 2010-2011

Maria Laura Silva, Lionel Perrier, Hans-Martin Späth, Isidore Grog, Anne Mosnier, Nathalie Havet, Jean Marie Cohen
<span title="2014-01-20">2014</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/aqnbwmukundndoqlyssp4bs4yi" style="color: black;">BMC Public Health</a> </i> &nbsp;
on behalf of the IBGP team Abstract Background: In France, 2-15% of the population is affected annually by influenza, which causes significant socioeconomic disruption. Nevertheless, despite its importance for policy makers, few published studies have evaluated the impact of influenza B. Therefore, we assessed the costs associated with influenza B during 2010-2011 in France. Methods: Cases of lab-confirmed influenza B were analyzed as part of the Influenza B in General Practice Study. Cost
more &raquo; ... lations were based on micro-costing methods according to the French Health Insurance (FHI) perspective (in Euros, 2011). Costs were compared between age groups using the Kruskal-Wallis test, and when significant, by multiple comparisons based on rank. Moreover, uncertainties were assessed using one-way sensitivity and probabilistic analyses. Overall economic burden was estimated by multiplying cost per patient, flu attack rate, and the French population. Results: A total of 201 patients were included in the study. We found that the mean cost associated with Influenza B was 72€ (SD: 205) per patient: 70€ (SD: 262) for younger children, 50€ (SD: 195) for older children, 126€ (SD: 180) for adults, and 42€ (SD: 18) for elderly. Thus, we observed significantly different costs between the distinct age groups (p<0.0001). Finally, the economic burden of influenza B for the FHI was estimated to be 145 million Euros (95% CI: 88-201). Conclusions: Our findings highlight the important impact of influenza B and encourage further investigation on policy regarding vaccination strategies in France.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1471-2458-14-56">doi:10.1186/1471-2458-14-56</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24443900">pmid:24443900</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3909302/">pmcid:PMC3909302</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/w4cf6q6ehzbqbmzohr7inaz66e">fatcat:w4cf6q6ehzbqbmzohr7inaz66e</a> </span>
<a target="_blank" rel="noopener" href="https://archive.org/download/pubmed-PMC3909302/PMC3909302-1471-2458-14-56.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> File Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b4/d0/b4d009f0a4423f0d17ce63025b831644c50f5e73.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1471-2458-14-56"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909302" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A literature review to identify factors that determine policies for influenza vaccination

Maria Laura Silva, Lionel Perrier, Jean Marie Cohen, William John Paget, Anne Mosnier, Hans Martin Späth
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/u6xsvhwp5fhl7bd62uarvfdsqy" style="color: black;">Health Policy</a> </i> &nbsp;
., Perrier, L., Cohen, J.M., Paget, W.J., Mosnier, A., Späth, H.M. A literature review to identify factors that determine policies for influenza vaccination.  ...  ., Perrier, L., Cohen, J.M., Paget, W.J., Mosnier, A., Späth, H.M. A literature review to identify factors that determine policies for influenza vaccination.  ...  ., Perrier, L., Cohen, J.M., Paget, W.J., Mosnier, A., Späth, H.M. A literature review to identify factors that determine policies for influenza vaccination.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.healthpol.2015.04.006">doi:10.1016/j.healthpol.2015.04.006</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25936267">pmid:25936267</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7qyhidsk5jenrhek4chuiuwidu">fatcat:7qyhidsk5jenrhek4chuiuwidu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190506170324/http://postprint.nivel.nl/PPpp5782.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a9/bd/a9bd588d38d0e8ada2e1a998528c4e26de8f5861.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.healthpol.2015.04.006"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Influenza vaccination policy-making processes in France and The Netherlands: Framework and determinants

Maria Laura Silva, Lionel Perrier, John W. Paget, Anne Mosnier, Valérie Buthion, Jean Marie Cohen, Hans Martin Späth
<span title="">2016</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/u6xsvhwp5fhl7bd62uarvfdsqy" style="color: black;">Health Policy</a> </i> &nbsp;
., Perrier, L., Paget, W.J., Mosnier, A., Buthion, V., Cohen, J.M., Späth, H.M. Influenza vaccination policy-making processes in France and The Netherlands: framework and determinants.  ...  ., Perrier, L., Paget, W.J., Mosnier, A., Buthion, V., Cohen, J.M., Späth, H.M. Influenza vaccination policy-making processes in France and The Netherlands: framework and determinants.  ...  ., Perrier, L., Paget, W.J., Mosnier, A., Buthion, V., Cohen, J.M., Späth, H.M. Influenza  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.healthpol.2016.01.005">doi:10.1016/j.healthpol.2016.01.005</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26806677">pmid:26806677</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4c7d7y3iqzg33mjdlznek5ejqq">fatcat:4c7d7y3iqzg33mjdlznek5ejqq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190507050403/http://postprint.nivel.nl/PPpp6151.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/28/40/2840c7ddd3f939df62f051efaddcb35a3f96e700.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.healthpol.2016.01.005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Unbiased Electro-Optic Waveguide as a Sensitive Nuclear Magnetic Resonance Sensor

Reina Ayde, Gwenalel Gaborit, Jean Dahdah, Lionel Duvillaret, Nadege Courjal, Clement Guyot, Raphael Sablong, Anne-Laure Perrier, Olivier Beuf
<span title="">2014</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wqvvi4ohyzhnpnfzrltgohq4mi" style="color: black;">IEEE Photonics Technology Letters</a> </i> &nbsp;
Perrier, and O.  ...  Beuf are with CREATIS, Université de Lyon, Villeurbanne 69100, France (e-mail: reina.ayde@creatis.insa-lyon.fr; raphael.sablong@univ-lyon1.fr; anne-laure. perrier@creatis.insa-lyon.fr; anne-laure.perrier  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/lpt.2014.2321099">doi:10.1109/lpt.2014.2321099</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nhq3txxacvdp3mxxzkntx47api">fatcat:nhq3txxacvdp3mxxzkntx47api</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190428183632/http://hal.univ-smb.fr/hal-01814491/file/2014_IEEE%20PTL_NMR_EO_optique%20integre.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1f/a4/1fa407aadbc374619238d81ab86847d4b73abf92.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/lpt.2014.2321099"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Literature Review of the Decision-Making Determinants Related to the Influenza Vaccination Policy

Lionel Perrier, Maria Laura Dias Alves e Silva, Jean-Marie Cohen, Anne Mosnier, John W. Paget, Hans-Martin Späth
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tol7woxlqjeg5bmzadeg6qrg3e" style="color: black;">Social Science Research Network</a> </i> &nbsp;
Seasonal influenza concerns the worldwide population every year, whilst pandemic influenza is an unpredictable threat. Due to an important socioeconomic impact, mitigation measures must be specified. Governments elaborate vaccination policy based on scientific evidence. However, this process is, in general, not transparent. Objectives: To study the decision-making process related to the influenza vaccination policy, identifying the actors involved, the decisions made and describing the
more &raquo; ... on used by type and level of importance. Methods: Six major databases were searched in seven languages, without time limit, using keywords related to influenza vaccination, decision-making and health policy. Titles and abstracts were screened according to three established criteria. Selected articles were analysed and compared against a checklist for context, stakeholders and evidence. Results: 111 articles were retrieved since the 1990s, most of them (40%) were conducted in the USA. The decision-making process mainly concerned vaccination strategies (53%) and pandemic preparedness (28%). Stakeholders were identified at an institutional, production and consumer level. Evidence used by policy-makers was similar (e.g. logistics of vaccines), but the factors influencing were different (e.g. social conditions). Conclusion: Considering the imminent risk of socio-economic disruption and media pressure, the pandemic threat needs to be integrated into an analysis of decision making processes regarding seasonal influenza vaccination.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2139/ssrn.2246749">doi:10.2139/ssrn.2246749</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4s2xtbj5undipc3hwhfniy34re">fatcat:4s2xtbj5undipc3hwhfniy34re</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170922071036/https://halshs.archives-ouvertes.fr/halshs-00808536/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e5/6c/e56c93be3090f509419a9447d584bc7a653ff26c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2139/ssrn.2246749"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ssrn.com </button> </a>

Functional relevance of Computational Fluid Dynamics in the field of nasal obstruction: a literature review

Thomas Radulesco, Lionel Meister, Gilles Bouchet, Jérôme Giordano, Patrick Dessi, Pierre Perrier, Justin Michel
<span title="2019-06-24">2019</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jinp2c6665akvnoaj4awstpt5a" style="color: black;">Clinical Otolaryngology</a> </i> &nbsp;
Nasal airway obstruction (nasal obstruction) is a common symptom affecting the quality of life of patients. It can be estimated by patient perception or physical measurements. Computational fluid dynamics (CFD) can be used to analyse nasal ventilation modalities. There is a lack of comparative studies investigating the correlations between CFD variables and patient perception or physical measurements.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/coa.13396">doi:10.1111/coa.13396</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31233660">pmid:31233660</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cmajvdlu2fbrpooda227rkulme">fatcat:cmajvdlu2fbrpooda227rkulme</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210715030915/https://hal.archives-ouvertes.fr/hal-03198716/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/09/2f/092fa183656bfaa551a04874c48d43ac12bbf4d9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/coa.13396"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Competitive direct vs. indirect photochromism dynamics of constrained inverse dithienylethene molecules

Aude Lietard, Giovanni Piani, Lionel Poisson, Benoît Soep, Jean-Michel Mestdagh, Stéphane Aloïse, Aurélie Perrier, Denis Jacquemin, Michinori Takeshita
<span title="">2014</span> <i title="Royal Society of Chemistry (RSC)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/knc3mgis4rdntku3ubqh4roxhu" style="color: black;">Physical Chemistry, Chemical Physics - PCCP</a> </i> &nbsp;
Relaxation observed through several parallel pathways from the first excited state to the ground-state in inverse dithienylethene molecules.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1039/c4cp02310b">doi:10.1039/c4cp02310b</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25219416">pmid:25219416</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/m4yoklp5gzelxkeqw3m66yyhvm">fatcat:m4yoklp5gzelxkeqw3m66yyhvm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190222003427/http://pdfs.semanticscholar.org/364c/a35ed90361f8387cf732f650dfad9cf1340a.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/36/4c/364ca35ed90361f8387cf732f650dfad9cf1340a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1039/c4cp02310b"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

A cost-consequence analysis of hepatitis B screening in an immigrant population

Alessandra Buja, Diego Martines, Salvatore Lobello, Angela Vinelli, Giorgia Bardelle, Stefania Lopatriello, Franca De Lazzari, Lionel Perrier, Vincenzo Baldo
<span title="">2015</span> <i title="Istituto Superiore di Sanita"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/75z2mh4daba63psknstdprzib4" style="color: black;">Annali dell&#39;Istituto Superiore di Sanità</a> </i> &nbsp;
Screening for HBV among groups at risk, such as migrant populations, has proved to be a cost-effective strategy. With a view to advising local policy-makers, the cost-consequences of HBV screening was assessed using a modeling approach. This cost-consequence analysis of an HBV screening strategy was conducted in a cohort of adult migrants in the province of Padua, northern Italy. The population targeted for screening consisted of 65 405 migrants, among whom the weighted rate for the prevalence
more &raquo; ... f HBV was 0.04972, with 3251 people infected. Over a period of 5 years, the screening strategy prevented 565 cases/year of chronic hepatitis, 141 of compensated cirrhosis, 9 of decompensated cirrhosis, 14 hepatocellular carcinomas and 12 deaths. The above data revealed that the incremental cost of the screening strategy compared to no screening strategy was € 7 974 959 over the five year period. The cost per life saved amounted to € 676 709. The present study provides useful information to policy-makers at local and regional levels.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4415/ann_15_04_13">doi:10.4415/ann_15_04_13</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26783220">pmid:26783220</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7qc2bvmeo5b77arklkrnqwgnkm">fatcat:7qc2bvmeo5b77arklkrnqwgnkm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200216172624/http://old.iss.it/binary/publ/cont/ANN_15_04_13.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e6/84/e684c4d7751c7198036f5e155726538df335fed5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4415/ann_15_04_13"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Atypical Evolution of Secondary Hemolytic Uremic Syndrome Defined as Paraneoplastic Syndrome under Eculizumab and Palbociclib Therapies

Quentin Perrier, Johan Noble, Steven Grangé, Pierrick Bedouch, Rachel Tetaz, Lionel Rostaing
<span title="2021-04-12">2021</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2odm6uidlnbv7amr43nrz5rzku" style="color: black;">Case Reports in Oncology</a> </i> &nbsp;
Perrier contributed to acquisition of data and writing of the manuscript. J. Noble, S. Grangé, P. Bedouch, R. Tetaz, and L. Rostaing provided supervision and mentorship.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000514982">doi:10.1159/000514982</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33976652">pmid:33976652</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8077600/">pmcid:PMC8077600</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ipt62pxqfbcelkgfetalntyesy">fatcat:ipt62pxqfbcelkgfetalntyesy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210427134149/https://www.karger.com/Article/Pdf/514982" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4a/bd/4abd56fd48aa408a7619a28bb3631512a33f837d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000514982"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077600" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Interpretable Machine Learning Model for Locoregional Relapse Prediction in Oropharyngeal Cancers

Paul Giraud, Philippe Giraud, Eliot Nicolas, Pierre Boisselier, Marc Alfonsi, Michel Rives, Etienne Bardet, Valentin Calugaru, Georges Noel, Enrique Chajon, Pascal Pommier, Magali Morelle (+4 others)
<span title="2020-12-28">2020</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2zwku6u6nfdcri773tpisi6ldi" style="color: black;">Cancers</a> </i> &nbsp;
There is no evidence to support surgery or radiotherapy as the best treatment for resectable oropharyngeal cancers with a negative HPV status. Predictive algorithms may help to decide which strategy to choose, but they will only be accepted by caregivers and European authorities if they are interpretable. As a proof of concept, we developed a predictive and interpretable algorithm to predict locoregional relapse at 18 months for oropharyngeal cancers as a first step towards that goal. Methods:
more &raquo; ... he model was based on clinical and Pyradiomics features extracted from the dosimetric CT scan. Intraclass correlation was used to filter out features dependant on delineation. Correlated redundant features were also removed. An XGBoost model was cross-validated and optimised on the HN1 cohort (79 patients), and performances were assessed on the ART ORL cohort (45 patients). The Shapley Values were used to provide an overall and local explanation of the model. Results: On the ART ORL cohort, the model trained on HN1 yielded a precision—or predictive positive value—of 0.92, a recall of 0.42, an area under the curve of the receiver operating characteristic of 0.68 and an accuracy of 0.64. The most contributory features were shape Voxel Volume, grey level size zone matrix Small Area Emphasis (glszmSAE), gldm Dependence Non Uniformity Normalized (gldmDNUN), Sex and Age. Conclusions: We developed an interpretable and generalizable model that could yield a good precision—positive predictive value—for relapse at 18 months on a different test cohort.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers13010057">doi:10.3390/cancers13010057</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33379188">pmid:33379188</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3rihqgztqrdfdnl5worfbpcyne">fatcat:3rihqgztqrdfdnl5worfbpcyne</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210715003927/https://hal.sorbonne-universite.fr/hal-03146371/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/10/b6/10b6a89e3c02dc6860c408903d4ed95c90ed0d81.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers13010057"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Effect of adenosine on short-term synaptic plasticity in mouse piriform cortex in vitro: adenosine acts as a high-pass filter

Simon P. Perrier, Marie Gleizes, Caroline Fonta, Lionel G. Nowak
<span title="">2019</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6ayevhxi35euzde2yfzij52rii" style="color: black;">Physiological Reports</a> </i> &nbsp;
We examined the effect of adenosine and of adenosine A1 receptor blockage on short-term synaptic plasticity in slices of adult mouse anterior piriform cortex maintained in vitro in an in vivo-like ACSF. Extracellular recording of postsynaptic responses was performed in layer 1a while repeated electrical stimulation (5-pulse-trains, frequency between 3.125 and 100 Hz) was applied to the lateral olfactory tract. Our stimulation protocol was aimed at covering the frequency range of oscillatory
more &raquo; ... vities observed in the olfactory bulb in vivo. In control condition, postsynaptic response amplitude showed a large enhancement for stimulation frequencies in the beta and gamma frequency range. A phenomenological model of short-term synaptic plasticity fitted to the data suggests that this frequency-dependent enhancement can be explained by the interplay between a short-term facilitation mechanism and two short-term depression mechanisms, with fast and slow recovery time constants. In the presence of adenosine, response amplitude evoked by low-frequency stimulation decreased in a dose-dependent manner (IC50 = 70 μmol/L). Yet short-term plasticity became more dominated by facilitation and less influenced by depression. Both changes compensated for the initial decrease in response amplitude in a way that depended on stimulation frequency: compensation was strongest at high frequency, up to restoring response amplitudes to values similar to those measured in control condition. The model suggested that the main effects of adenosine were to decrease neurotransmitter release probability and to attenuate short-term depression mechanisms. Overall, these results suggest that adenosine does not merely inhibit neuronal activity but acts in a more subtle, frequency-dependent manner.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.14814/phy2.13992">doi:10.14814/phy2.13992</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30740934">pmid:30740934</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6369103/">pmcid:PMC6369103</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3zyjl7kzzbhk3k6pwjievyvzo4">fatcat:3zyjl7kzzbhk3k6pwjievyvzo4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210429074445/https://hal.archives-ouvertes.fr/hal-02362906/file/Perrier_SP_2019_e13992.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/31/48/3148b55a71c58458080de26d10744c78620b07c3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.14814/phy2.13992"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369103" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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