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Treatment of cornual pregnancy in a patient with adenomyosis by high-intensity focused ultrasound (HIFU) ablation

Lixia Yu, Linying Xu, Xiaoyan Xu
2017 Medicine  
Rationale: Cornual ectopic pregnancy in adenomyosis patients is a rare clinical condition, which may require careful approach for accurate diagnosis and treatment. Patient concerns: A 38-year-old woman presented with amenorrhea for 8 weeks and serum HCG levels of 1455 mmol/L. The B ultrasound showed an endometrial thickness of 1.7 cm, and the presence of a cystic structure (16 6 mm) at the right uterine horn. Color Doppler flow imaging (CDFI) accurately detected and confirmed the position of
more » ... cystic structure with its clear boundaries. Diagnoses: Cornual ectopic pregnancy in adenomyosis. Interventions: The diagnosis was confirmed and treated by HIFU ablation. Total ablation was performed for 738 seconds without any bleeding. Outcomes: Serum HCG levels decreased to < 0.1 mmol/L after 60 days post operation, and follow-up for 11 months showed a regular menstrual cycle without dysmenorrhea. Gestational sac was not obvious at postoperative 90 days by MRI. The adenomyosis associated lesion with blood perfusion became smaller at postoperative 90 days. Lessons: In this case, we successfully performed HIFU ablation and treated the cornual ectopic pregnancy in an adenomyosis patient for the first time, without any adverse complications. Abbreviations: CDFI = color Doppler flow imaging, EMI = endometrial-myometrium interface, G2P1L1A1 = gestation twice and one birth, i.e. one live delivery and one abortion after an unplanned pregnancy, HIFU = high-intensity focused ultrasound, JZ = junction zone, LMP = last menstruation period.
doi:10.1097/md.0000000000008874 pmid:29310371 pmcid:PMC5728772 fatcat:km3gsphifnc53pky4tyb3mvxsu

Tris(trimethylsilyl) borate as an electrolyte additive for high-voltage lithium-ion batteries using LiNi 1/3 Mn 1/3 Co 1/3 O 2 cathode

Chunfeng Yan, Ying Xu, Jianrong Xia, Cuiran Gong, Kerong Chen
2016 Journal of Energy Chemistry  
Xu). time [7] [8] [9] . And there will be more gas generated in the cells at higher temperature, bringing about security problems.  ...  All rights reserved. 16] , LiNi 0.5 Co 0.2 Mn 0.3 O 2 (4.4 V) [15] , LiNi 0.5 Mn 1.5 O 4 (4.9 V) [17] and lay- ered lithium-rich oxide cathode Li[Li 0.2 Mn 0.54 Ni 0.13 Co 0.13 ]O 2 (4.8 V) [18] .  ... 
doi:10.1016/j.jechem.2016.04.010 fatcat:amtthci4efgxdd5b2utnhbwwh4

IVOA HiPS Implementation in the Framework of WorldWide Telescope [article]

Yunfei Xu, Chenzhou Cui, Dongwei Fan, Shanshan Li, Changhua Li, Jun Han, Linying Mi, Boliang He, Hanxi Yang, Yihan Tao, Sisi Yang, Lan He
2020 arXiv   pre-print
The WorldWide Telescope(WWT) is a scientific visualization platform which can browse deep space images, star catalogs, and planetary remote sensing data from different observation facilities in a three-dimensional virtual scene. First launched and then open-sourced by Microsoft Research, the WWT is now managed by the American Astronomical Society (AAS). Hierarchical Progressive Survey (HiPS) is an astronomical data release scheme proposed by Centre de Donn\'ees astronomiques de Strasbourg (CDS)
more » ... and has been accepted as a recommendation by International Virtual Observatory Alliance (IVOA). The HiPS solution has been adopted widely by many astronomical institutions for data release. Since WWT selected Hierarchical Triangular Mesh (HTM) as the standard for data visualization in the early stage of development, data released by HiPS cannot be visualized in WWT, which significantly limits the application of WWT. This paper introduces the implementation method for HiPS dataset visualization in WWT, and introduces HiPS data projection, mesh rendering, and data index implementation in WWT. Taking Chang'E-2 lunar probe data as an example, this paper introduces how to convert planetary remote sensing data into a HiPS dataset and integrate it into WWT. This paper also compares the efficiency and memory consumption of WWT loading its native data and HiPS data, and illustrates the application of HiPS in scientific data visualization and science education in WWT.
arXiv:2003.02029v1 fatcat:4vf62hpogje4jdbrdvrxarrvwm

ACE2 pathway regulates thermogenesis and energy metabolism

Xi Cao, Tingting Shi, Chuanhai Zhang, Wanzhu Jin, Lini Song, Yichen Zhang, Jingyi Liu, Fangyuan Yang, Charles N Rotimi, Aimin Xu, Jinkui Yang
2022 eLife  
Identification of key regulators of energy homeostasis holds important therapeutic promise for metabolic disorders, such as obesity and diabetes. ACE2 cleaves angiotensin II (Ang II) to generate Ang-(1-7) which acts mainly through the Mas1 receptor. Here, we identify ACE2 pathway as a critical regulator in the maintenance of thermogenesis and energy expenditure. We found that ACE2 is highly expressed in brown adipose tissue (BAT) and that cold stimulation increases ACE2 and Ang-(1-7) levels in
more » ... AT and serum. Ace2 knockout mice (Ace2-/y) and Mas1 knockout mice (Mas1-/-) displayed impaired thermogenesis. Mice transplanted with brown adipose tissue from Mas1-/- display metabolic abnormalities consistent with those seen in the Ace2 and Mas1 knockout mice. In contrast, impaired thermogenesis of Leprdb/db obese diabetic mice and high-fat diet-induced obese mice were ameliorated by overexpression of Ace2 or continuous infusion of Ang-(1-7). Activation of ACE2 pathway was associated with improvement of metabolic parameters, including blood glucose, lipids and energy expenditure in multiple animal models. Consistently, ACE2 pathway remarkably enhanced the browning of white adipose tissue. Mechanistically, we showed that ACE2 pathway activated Akt/FoxO1 and PKA pathway, leading to induction of UCP1 and activation of mitochondrial function. Our data propose that adaptive thermogenesis requires regulation of ACE2 pathway and highlight novel potential therapeutic targets for the treatment of metabolic disorders.
doi:10.7554/elife.72266 pmid:35014608 pmcid:PMC8776250 fatcat:gyx25vbx3bcjxk7xielxy55pxe

High-Throughput Identification of Antibacterials Against Pseudomonas aeruginosa

Shijia Li, Pengfei She, Linying Zhou, Xianghai Zeng, Lanlan Xu, Yaqian Liu, Lihua Chen, Yong Wu
2020 Frontiers in Microbiology  
Copyright © 2020 Li, She, Zhou, Zeng, Xu, Liu, Chen and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fmicb.2020.591426 pmid:33362739 pmcid:PMC7755642 fatcat:u3532lgafjgl3gwdx2iqihj464

Role of Peripheral Inflammatory Markers in Postoperative Cognitive Dysfunction (POCD): A Meta-Analysis

Linying Peng, Liwei Xu, Wen Ouyang, Kenji Hashimoto
2013 PLoS ONE  
Postoperative cognitive dysfunction (POCD) is common following cardiac and non-cardiac surgery, but the pathogenic mechanisms remain unknown. Many studies suggest that an inflammatory response is a key contributor to POCD. The current meta-analysis shows that the levels of peripheral inflammatory markers are associated with POCD. Methods: An online search was performed to identify peer-reviewed studies without language restriction that measured peripheral inflammatory markers of patients with
more » ... d without POCD, using PubMed, ScienceDirect, SinoMed and the National Knowledge Infrastructure database. Extracted data were analyzed with STATA (version 12).The standardized mean difference (SMD) and the 95% confidence interval (95%CI) were calculated for each outcome using a random effect model. Tests of heterogeneity assessment of bias, and meta-regression were performed in the meta-analysis. Results : A total of 13 studies that measured the concentrations of peripheral inflammatory markers were included. The current meta-analysis found significantly higher concentrations of S-100β(SMD[95%CI]) (1.377 [0.423, 2.331], pvalue < 0.001, N [POCD/non-POCD] =178/391, 7 studies), and interleukin(IL)-6 (SMD[95%CI]) (1.614 [0.603,2.624], p-value < 0.001, N[POCD/non-POCD] = 91/99, 5 studies) , but not of neuron specific enolase, interleukin-1β, or tumor necrosis factor-α , in POCD compared with patients without POCD. In meta-regression analyses, a significant positive association was found between the SMD and the preoperative interleukin-6 peripheral blood concentration in patients with POCD (Coef.= 0.0587, p-value=0.038, 5 studies). Conclusions: This study shows that POCD is indeed correlated with the concentrations of peripheral inflammatory markers, particularly interleukin-6 and S-100β.
doi:10.1371/journal.pone.0079624 pmid:24236147 pmcid:PMC3827367 fatcat:wsuermfo5jclfcvtfot2rm34zm

Targeting ferroptosis in breast cancer

Zhaoqing Li, Lini Chen, Cong Chen, Yulu Zhou, Dengdi Hu, Jingjing Yang, Yongxia Chen, Wenying Zhuo, Misha Mao, Xun Zhang, Ling Xu, Linbo Wang (+1 others)
2020 Biomarker Research  
Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to previous studies. We also compare ferroptosis to common regulated cell death patterns and discuss the
more » ... ivity to ferroptosis in different subtypes of breast cancer. We propose that viewing ferroptosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.
doi:10.1186/s40364-020-00230-3 pmid:33292585 fatcat:dan6mdkmljcrbfgqgkdh762pfi

Repurposing Candesartan Cilexetil as Antibacterial Agent for MRSA Infection

Lanlan Xu, Pengfei She, Lihua Chen, Shijia Li, Linying Zhou, Zubair Hussain, Yaqian Liu, Yong Wu
2021 Frontiers in Microbiology  
Staphylococcus aureus is an important pathogen causing hospital-acquired infections. Methicillin-resistant S. aureus (MRSA), biofilms, and persisters are highly tolerant to traditional antibiotics and make it difficult to treat. Therefore, new antimicrobial agents are urgently needed to treat hard-to-eradicate diseases caused by this bacterium. In this study, candesartan cilexetil (CC), an angiotensin hypertension drug, had strong antimicrobial activity against S. aureus with minimal inhibitory
more » ... concentrations (MICs) and minimal bactericidal concentrations (MBCs) of 8–16 μg/ml and 16–32 μg/ml. CC exhibited limited cytotoxicity and low potential to induce drug resistance. In addition, it showed a synergistic antibacterial effect when combined with gentamicin and tobramycin. The effective concentrations to inhibit MRSA biofilm formation were 16–64 μg/ml, and intractable persisters were killed at 4–8 × MIC. Through the analysis of its mechanism of action, it was evident that the membrane permeability was disrupted as well as the cell structure was damaged. Furthermore, we demonstrated that CC had antibacterial effects in vivo in MRSA-infected murine skin abscess models. In conclusion, these results imply that CC might be a potential antibacterial agent for the treatment of S. aureus-associated infections.
doi:10.3389/fmicb.2021.688772 pmid:34589063 pmcid:PMC8473943 fatcat:uvoy46wjkjg7nhvtkyyj4zobxu

NiCo nanoalloy encapsulated in graphene layers for improving hydrogen storage properties of LiAlH4

Chengli Jiao, Lixian Sun, Fen Xu, Shu-Sheng Liu, Jian Zhang, Xia Jiang, Lini Yang
2016 Scientific Reports  
NiCo nanoalloy (4-6 nm) encapsulated in grapheme layers (NiCo@G) has been prepared by thermolysis of a 3D bimetallic complex CoCo[Ni(EDTA)] 2 ·4H 2 O and successfully employed as a catalyst to improve the dehydrogenation performances of LiAlH 4 by solid ball-milling. NiCo@G presents a superior catalytic effect on the dehydrogenation of LiAlH 4 . For LiAlH 4 doped with 1 wt% NiCo@G (LiAlH 4 -1 wt% NiCo@G), the onset dehydrogenation temperature of LiAlH 4 is as low as 43 °C, which is 109 °C lower
more » ... than that of pristine LiAlH 4 . 7.3 wt% of hydrogen can be released from LiAlH 4 -1 wt% NiCo@G at 150 °C within 60 min. The activation energies of LiAlH 4 dehydrogenation are extremely reduced by 1 wt% NiCo@G doping.
doi:10.1038/srep27429 pmid:27270633 pmcid:PMC4895212 fatcat:b3a2wukburh3ljyeff7epslnpy

Application of Lane-Emden differential equation numerical method in fair value analysis of financial accounting

Linying Xu, Marwan Aouad
2021 Applied Mathematics and Nonlinear Sciences  
In order to study the fair value analysis of financial accounting, the Euler wavelet method is proposed to solve the numerical solutions of a class of Lane-Emden type differential equations with Dirichlet, Neumann and Neumann-Robin boundary conditions. The results show that the fractional integral formula of Euler wavelet function under the Riemann-Liouville fractional order definition and the L∞ and L2 errors of Haar wavelet are derived by the analytic form of Euler polynomial. By fixing M=4
more » ... d increasing the resolution scale k of Euler wavelet, a stable convergence solution can be obtained. The Lane-Emden equation with boundary conditions is transformed into algebraic equations by Euler wavelet collocation method, and the numerical results are compared with the results and exact solutions of other methods. The application advantages of fair value can be exerted through financial accounting to promote the transformation and upgrading of enterprises and realise the stable economic growth.
doi:10.2478/amns.2021.1.00094 fatcat:n6r365beozhnfjke44sps57zoy

Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients

Dan Zhu, Hui Chen, Xiguang Yang, Weisong Chen, Linying Wang, Jilin Xu, Long Yu
2014 Diagnostic Pathology  
MicroRNA-224 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression and clinical significance in non-small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to explore the effects of miR-224 in NSCLC tumorigenesis and development. Methods: Using real-time quantitative RT-PCR, we detected miR-224 expression in NSCLC cell lines and primary tumor tissues. The association of miR-224 expression with
more » ... ogical factors and prognosis was also statistically analyzed. MTT, flow cytometric, Transwell invasion and migration assays, and scratch migration assay were used to test the proliferation, apoptosis, invasion, and migration of NSCLC cells after miR-224 mimics transfection. Results: MiR-224 expression levels were significantly down-regulated in NSCLC compared to the corresponding noncancerous lung tissues (P <0.001). In addition, decreased miR-224 expression was significantly associated with lymph node metastasis (P = 0.002), advanced TNM stage (P <0.001), and shorter overall survival (P <0.001). Multivariate regression analysis corroborated that down-regulation of miR-224 was an independent unfavourable prognostic factor for patients with NSCLC. Furthermore, transfection of miR-224 mimics in NSCLC A549 cells was able to reduce cell proliferation, invasion, and migration, and promote cell apoptosis. Conclusions: These findings indicate that miR-224 may act not only as a novel diagnostic and prognostic marker, but also as a potential target for miR-based therapy of NSCLC. Virtual Slides: The virtual slide(s) for this article can be found here: 13000_2014_198
doi:10.1186/s13000-014-0198-4 pmid:25410592 pmcid:PMC4245734 fatcat:h4byfh6psrfxznceksoekityo4

Multifunctional Gelatin-Nanoparticle-Modified Chip for Enhanced Capture and Non-Destructive Release of Circulating Tumor Cells

Linying Xu, Tiantian Ma, Kelin Zhang, Qilin Zhang, Mingxia Yu, Xingzhong Zhao
2022 Micromachines  
Circulating tumor cells (CTCs) in cancer patients' peripheral blood have been demonstrated to be a significant biomarker for metastasis detection, disease prognosis, and therapy response. Due to their extremely low concentrations, efficient enrichment and non-destructive release are needed. Herein, an FTO chip modified with multifunctional gelatin nanoparticles (GNPs) was designed for the specific capture and non-destructive release of CTCs. These nanoparticles share a similar dimension with
more » ... microvilli and pseudopodium of the cellular surface; thus, they can enhance adhesion to CTCs, and then GNPs can be degraded by the enzyme matrix metalloproteinase (MMP-9), gently releasing the captured cells. In addition, the transparency of the chip makes it possible for fluorescence immunoassay identification in situ under a microscope. Our chip attained a high capture efficiency of 89.27%, a release efficiency of 91.98%, and an excellent cellular viability of 96.91% when the concentration of MMP-9 was 0.2 mg/mL. Moreover, we successfully identified CTCs from cancer patients' blood samples. This simple-to-operate, low-cost chip exhibits great potential for clinical application.
doi:10.3390/mi13030395 pmid:35334686 pmcid:PMC8955365 fatcat:gsm5p53mlrcp3ptyl6o2zq6rpa

Targeting PIN 1 exerts potent antitumor activity in pancreatic ductal carcinoma via inhibiting tumor metastasis

Linying Chen, Xiao Xu, Xinxin Wen, Shenmin Xu, Long Wang, Wenxian Lu, Mingting Jiang, Jing Huang, Dayun Yang, Jichuang Wang, Min Zheng, Xiao Zhen Zhou (+2 others)
2019 Cancer Science  
The human prolyl isomerase PIN1, best known for its association with carcinogenesis, has recently been indicated in the disease of pancreatic ductal adenocarcinoma (PDAC). However, the functions of PIN1 and the feasibility of targeting PIN1 in PDAC remain elusive. For this purpose, we examined the expression of PIN1 in cancer, related paracarcinoma and metastatic cancer tissues by immunohistochemistry and analyzed the associations with the pathogenesis of PDAC in 173 patients. The functional
more » ... es of PIN1 in PDAC were explored in vitro and in vivo using both genetic and chemical PIN1 inhibition. We showed that PIN1 was upregulated in pancreatic cancer and metastatic tissues. High PIN1 expression is significantly association with poor clinicopathological features and shorter overall survival and disease-free survival. Further stratified analysis showed that PIN1 phenotypes refined prognostication in PDAC. Inhibition of PIN1 expression with RNA interference or with all trans retinoic acid decreased not only the growth but also the migration and invasion of PDAC cells through regulating the key molecules of multiple cancer-driving pathways, simultaneously resulting in cell cycle arrest and mesenchymal-epithelial transition in vitro. Furthermore, genetic and chemical PIN1 ablation showed dramatic inhibition of the tumorigenesis and metastatic spread and then reduced the tumor burden in vivo. We provided further evidence for the use of PIN1 as a promising therapeutic target in PDAC. Genetic and chemical PIN1 ablation exerted potent antitumor effects through blocking multiple cancer-driving pathways in PDAC. More potent and specific PIN1 targeted inhibitors could be exploited to treat this aggressive cancer.
doi:10.1111/cas.14085 pmid:31148345 pmcid:PMC6676117 fatcat:sn752v7vmbawvphhrflhs2n344

Effects of specific egg yolk immunoglobulin on pan-drug-resistant Acinetobacter baumannii

Huaying Shi, Jie Zhu, Boyang Zou, Lei Shi, Linying Du, Yayi Long, Huaxin Wang, Hong Xu, Yuhong Zhen, Lidan Sun
2017 Biomedicine and Pharmacotherapy  
With the growing emergence of pan-drug-resistant Acinetobacter baumannii (PDR-Ab) strains in clinical, new strategies for the treatment of PDR-Ab infections are urgently needed. Egg yolk immunoglobulin (IgY) as a convenient and inexpensive antibody has been widely applied to the therapy of infectious diseases. The aim of this study was to produce IgY specific to PDR-Ab and investigate its antibacterial effects in vitro and in vivo. IgYs specific to two PDR-Ab strains were produced by immunizing
more » ... hens with formaldehyde inactivated PDR-Ab cells and isolated from yolks with a purity of 90% by water dilution, salt precipitations and ultrafiltration. IgYs showed high titers when subjected to an ELISA and inhibited the growth of PDR-Ab in a dose-dependent manner in liquid medium. Scanning electron microscopy assay showed structural modification and aggregation of PDR-Ab treated with specific IgYs. Freshly cultured PDR-Ab cells were nasally inhaled in BALB/c mice to induce acute pneumonia. The infected mice were intraperitoneally injected with specific IgYs using cefoperazone/sulbactam and dexamethasone as positive controls. The IgYs specific to PDR-Ab lowered the mortality of mice with PDR-Ab-induced acute pneumonia, decreased the level of TNF-α and IL-1β in serum and reduced inflammation in lung tissue. Specific IgY has the potential to be used as a new therapeutic approach for the treatment of A. baumannii-induced infections.
doi:10.1016/j.biopha.2017.09.112 pmid:28962078 pmcid:PMC7126593 fatcat:g5lt6atjpbcerfpyqxdd46ijya

Facile preparation of nanocrystal-assembled hierarchical mordenite zeolites with remarkable catalytic performance

Yangyang Yuan, Linying Wang, Hongchao Liu, Peng Tian, Miao Yang, Shutao Xu, Zhongmin Liu
2015 Chinese Journal of Catalysis  
., 2015, 36: 1910-1919 doi: 10.1016/S1872-2067(15)60519-6 Facile preparation of nanocrystal-assembled hierarchical mordenite zeolites with remarkable catalytic performance Yangyang Yuan, Linying Wang,  ...  Hongchao Liu, Peng Tian *, Miao Yang, Shutao Xu, Zhongmin Liu * Dalian Institute of Chemical Physics, Chinese Academy of Sciences; University of Chinese Academy of Sciences NaAlO 2 SiO 2 NaOH H 2 O  ... 
doi:10.1016/s1872-2067(15)60960-3 fatcat:p3fkr4e4h5ebdpaho6odrw6svi
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