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Ordered LiNi 0.5 Mn 1.5 O 4 was synthesized through a solid-state reaction. Even though the material has a particle size of 3-5 m, it shows very high rate capability and excellent capacity retention. ... than both ordered and disordered nano-LiNi 0.5 Mn 1.5 O 4 . ... -Capacity vs voltage by PITT in ordered LiNi 0.5 Mn 1.5 O 4 .-Figure 3 shows capacity vs voltage measured by PITT in the as-prepared LiNi 0.5 Mn 1.5 O 4 . ...doi:10.1149/1.3439678 fatcat:37xdv2clhbea3ezunf6vmrwsda
LiNi 0.8 Co 0.15 Al 0.05 O 2 (NCA) secondary particles with high tap density have a great potential for high volumetric energy density lithium (Li)-ion power battery. ... K E Y W O R D S compact structure, grain boundaries, graphene nanosheet, LiNi 0.8 Co 0.15 Al 0.05 O 2 , lithium-ion transport This is an open access article under the terms of the Creative Commons Attribution ... Conventional layered structure LiCoO 2 is not suitable for large-scale applications in EV/PHEV due to its poor safety performance and a relatively small amount of capacity (up to 160 mAh g -1 ). 4 LiNi ...doi:10.1002/sus2.18 fatcat:rs63ntneordplgpies6no5ub2m
S-(-)equol, a natural product of the isoflavone daidzein, has been reported to offer cytoprotective effects with respect to the cardiovascular system, but how this occurs is unclear. Interestingly, S-(-)equol is produced by the human gut, suggesting a role in physiological processes. We report that treatment of human umbilical vein endothelial cells and EA.hy926 cells with S-(-)equol induces ARE-luciferase reporter gene activity that is dose and time dependent. S-(-)equol (10-250 nM) increasesdoi:10.1371/journal.pone.0079075 pmid:24260155 pmcid:PMC3833998 fatcat:sfilsnp7fve2rljysv3lsyk3vq
more »... uclear factor-erythroid 2-related factor 2 (Nrf2) as well as gene products of Nrf2 target genes heme oxygenase-1 (HO-1) and NAD(P)H (nicotinamide-adenine-dinucleotide-phosphate) quinone oxidoreductase 1 (NQO1). Endothelial cells transfected with an HA-Nrf2 expression plasmid had elevated HA-Nrf2, HO-1, and NQO1 in response to S-(-)equol exposure. S-(-)equol treatment affected Nrf2 mRNA only slightly but significantly increased HO-1 and NQO1 mRNA. The pretreatment of cells with specific ER inhibitors or PI3K/Akt (ICI182,780 and LY294002) increased Nrf2, HO-1, and NQO1 protein, impaired nuclear translocation of HA-Nrf2, and decreased ARE-luciferase activity. Identical experiments were conducted with daidzein, which had effects similar to S-(-)equol. In addition, DPN treatment (an ERb agonist) induced the ARE-luciferase reporter gene, promoting Nrf2 nuclear translocation. Cell pretreatment with an ERb antagonist (PHTPP) impaired S-(-)equol-induced Nrf2 activation. Pre-incubation of cells followed by co-treatment with S-(-)equol significantly improved cell survival in response to H 2 O 2 or tBHP and reduced apoptotic and TUNEL-positively-stained cells. Notably, the ability of S-(-)equol to protect against H 2 O 2 -induced cell apoptosis was attenuated in cells transfected with an siRNA against Nrf2. Thus, beneficial effects of S-(-)equol with respect to cytoprotective antioxidant gene activation may represent a novel strategy to prevent and treat cardiovascular diseases.
Microendoscopic discectomy (MED) is an established procedure used to treat lumbar central spinal stenosis (LCSS) and lateral recess stenosis (LRS). The Interlaminar Endoscopic Surgical System iLESSYS® Delta approach has been developed from the traditional interlaminar endoscopic technique for the treatment of LCSS and LRS. In the present study, MED was used as a reference to evaluate this newly developed approach. A total of 82 and 52 patients with radicular leg pain and/or neurogenicdoi:10.3892/etm.2020.9382 pmid:33178350 pmcid:PMC7651884 fatcat:lx5i7ra57rd7zogfdzlpp5byau
more »... on symptoms were treated by spinal canal decompression using the MED or iLESSYS® Delta approach, respectively. The clinical outcomes of the patients were analyzed using the Modified MacNab's criteria, visual analogue scale (VAS) leg pain score, VAS back pain score and the Oswestry Disability Index (ODI) score. Finally, the effectiveness of the decompression was evaluated on a cross-sectional area of the dural sac (CSAD) at the disc level. The incision length in the iLESSYS® Delta group was significantly decreased compared with the MED group (P<0.05); however, the duration of the operation in the iLESSYS® Delta group was significantly longer compared with the MED group (P<0.05). The VAS score of the back and ODI score in the iLESSYS® Delta group were significantly decreased compared with the MED group at the 1-week follow-up (P<0.0125). The postoperative CSAD was also significantly increased in both groups compared with before the operation (P<0.05); however, there were no significant differences in the postoperative CSAD between the two groups. The good-to-excellent rates of the MED and iLESSYS® Delta approach were 89.0 and 90.4%, respectively, whereas the complication rates of the MED and iLESSYS® Delta system were 3.66 and 3.85% in the two groups, respectively. In conclusion, the iLESSYS® Delta approach was identified to be comparable with the MED approach for treating LCSS and LRS, demonstrating both precise and limited decompression. In addition, the iLESSYS® Delta approach may reduce the short-term back pain and promote faster recovery compared with the MED.
AbstractHigh myopia is a leading cause of blindness worldwide. Myopia progression may lead to pathological changes of lens and affect the outcome of lens surgery, but the underlying mechanism remains unclear. Here, we find an increased lens size in highly myopic eyes associated with up-regulation of β/γ-crystallin expressions. Similar findings are replicated in two independent mouse models of high myopia. Mechanistic studies show that the transcription factor MAF plays an essential role indoi:10.1038/s41467-021-22041-2 pmid:33833231 fatcat:46f6nbkoqjemtiurfr7zt3cizm
more »... gulating β/γ-crystallins in high myopia, by direct activation of the crystallin gene promoters and by activation of TGF-β1-Smad signaling. Our results establish lens morphological and molecular changes as a characteristic feature of high myopia, and point to the dysregulation of the MAF-TGF-β1-crystallin axis as an underlying mechanism, providing an insight for therapeutic interventions.
doi:10.3389/fpls.2017.01284 pmid:28769973 pmcid:PMC5515872 fatcat:xtebzzrgtncgvdapvw75y3636q
The coronavirus disease-19 (COVID-19) is a resource-intensive global pandemic. It is important for healthcare systems to identify high risk COVID-19 positive patients who need timely health care. This study was conducted to predict hospitalization of older adults who have tested positive for COVID-19. We screened all patients with COVID test records from 11 Mass General Brigham (MGB) hospitals to identify the study population. A total of 1,495 patients with age 65 and above from the outpatientdoi:10.1093/jamia/ocac083 pmid:35595237 fatcat:vccca6t3yjd2fd54jxr6vo6h2e
more »... etting were included in the final cohort, among which 459 patients were hospitalized. We conducted a clinician-guided, three-stage feature selection and phenotyping process using iterative combinations of literature review, clinician expert opinion and EHR data exploration. A list of 44 features, including temporal features, were generated from this process and used for model training. Four machine learning prediction models were developed, including regularized logistic regression, support vector machine, random forest, and neural network. All four models achieved AUC greater than 0.80. Random forest achieved the best predictive performance (AUC = 0.83). Albumin, an index for nutritional status, was found to have the strongest association with hospitalization among COVID positive older adults. In this study, we developed four machine learning models for predicting general hospitalization among COVID positive older adults. We identified important clinical factors associated with hospitalization and observed temporal patterns in our study cohort. Our modeling pipeline and algorithm could potentially be used to facilitate more accurate and efficient decision support for triaging COVID positive patients.
Int J Clin Exp Med
Objective: To compare the therapeutic efficacy of heparin cap and clave connector in tube sealing of PICC in elderly patients with tumor. Methods: One hundred and sixty cases of elderly patients with PICC placement were selected and randomly divided into control group and experimental group with 80 cases respectively. The catheters in control group were sealed with heparin cap while the catheters in experimental group were sealed with clave connector. The tube-plugging rate, phlebitis, catheterfatcat:pucp3wtw55h7bcx3ylvabdljri
more »... indwelling time, infection rate and so on were respectively compared between these two groups. Results: Compared with the control group, the application of clave connec-tor significantly reduced the rate of tube-plugging (P=0.0035), phlebitis (P=0.0027) and infection (P=0.0041), and prolonged catheter indwelling time (P<0.01). Conclusion: The efficacy of clave connector in tube sealing was significantly better than heparin cap for patients with PICC placement. And clave connector, with simple, safe and convenient operational procedure, was worthy of promotion in clinical application.
TG/DTA studies were performed on the gel-precursor and suggest the formation of the layered LiNi 0.5 Mn 0.5 O 2 at low temperatures. ... The layered LiNi 0.5 Mn 0.5 O 2 powders synthesized by this novel route have several advantages as compared to its conventional synthesis techniques. ... Our results of CV of LiNi 0.5 Mn 0.5 O 2 are in agree-289 ment with Lu et al  and Kang et al. . ...doi:10.1016/j.electacta.2003.09.034 fatcat:pqdltkyyrncmfkkizwqs4h5pmq
Trehalose-6-phosphate phosphatases genes (TPPs) are involved in the development and stress response of plants by regulating the biosynthesis of trehalose, though little is currently known about TPPs in common wheat (Triticum aestivum L.). In this study, we performed a genome-wide identification of the TPP gene family in common wheat, and identified a total of 31 TaTPP genes. These were subdivided into six subfamilies based on the phylogenetic relationships and the conservation of protein in sixdoi:10.1186/s12870-022-03504-0 pmid:35296251 pmcid:PMC8925099 fatcat:azx6v5ksm5fjhkni7ijdv7vefe
more »... monocot and eudicot plants. The majority of TPP genes were represented by 2-3 wheat homoalleles (named TaTPPX_ZA, TaTPPX_ZB, or TaTPPX_ZD), where Z is the location on the wheat chromosome of the gene number (X). We also analyzed the chromosomal location, exon-intron structure, orthologous genes, and protein motifs of the TaTPPs. The RNA-seq data was used to perform an expression analysis, which found 26 TaTPP genes to be differentially expressed based on spatial and temporal characteristics, indicating they have varied functions in the growth and development of wheat. Additionally, we assessed how the promoter regulatory elements were organized and used qRT-PCR in the leaves to observe how they were expressed following ABA, salt, low tempreture, and drought stress treatments. All of these genes exhibited differential expression against one or more stress treatments. Furthermore, ectopic expression of TaTPP11 in Arabidopsis exhibited a phenotype that delayed plant development but did not affect seed morphology. TaTPPs could serve important roles in the development and stress response in wheat. These results provide a basis for subsequent research into the function of TaTPPs.
The result show that the diameter of LiNi ⅓ Co ⅓ Mn ⅓ O 2 fibers was in the range of 100 -300nm. ... The initial charge-discharge curves LiNi ⅓ Co ⅓ Mn ⅓ O 2 nanowires in the range of 3.0 -4.5V at 0.5C are shown in Fig 3. ...doi:10.1007/s10832-012-9762-z fatcat:smzkmlzkq5b3topkpsxocg3fwy
Neurologie pro praxi
PEGylovaný interferon beta-1a - nový interferon v léčbě roztroušené sklerózy
PEGylovaný interferon beta-1a - nový interferon v léčbě roztroušené sklerózy
PEGylovaný interferon beta-1a nyní rozšiřuje portfolio léků DMD (disease modifying drugs) 1. linie, které jsou používány pro léčbu klinicky izolovaného syndromu nebo relaps remitentní RS. ... Tato látka, jejíž mnohé výhody ocení nejen kliničtí neurologové, ale zejména pacienti s RS, si jistě najde své místo mezi dosud užívanými DMD léky první linie. ... Pegylace Tento proces zahrnuje připojení řetězce molekuly polyetylenglykolu (PEG) k biologické molekule, např. proteinu (Kang et al., 2009 ). ...doi:10.36290/neu.2017.094 fatcat:pvjw2sqzmrc35azumtecaixx2q
Pemerintah saat ini sedang gencar melakukan penyederhanaan perizinan usaha di semua lini pemerintahan untuk merespon rendahnya nilai investasi baik dari dalam maupun luar negeri. ... Sayang nya hanya ada satu apoteker yang kebetulan istri Kang Trisno sendiri. Untuk meminta bantuan Pemda Semarang masalah kebutuhan Apoteker tidak lah mudah. ... Hal ini tidak lepas dari peran Kang Trisno berserta para anggota Pokdarwis yang selalu membuka diri untuk berkembang dengan tiak jera-jearnya menerima berbagai masukan berupa pelatihan kepariwisataan. ...doi:10.26877/e-dimas.v11i2.4611 fatcat:6arwtc3qgfci3ohxvgspfs7tvm
Journal of the Korean Electrochemical Society
층상계 산화물 양극의 4.6V 고전압 특성 향상에서의 Sulfone 첨가제의 역할
층상계 산화물 양극의 4.6V 고전압 특성 향상에서의 Sulfone 첨가제의 역할
LiCoO 2 , LiNiO 2 , LiMnO 2 각 각의 단점과 장점을 2-6) 보완한 삼성분계 LiNi 1-x-y Co x Mn y O 2 양극활물질이 최근 고에너지 이차전지로의 적용을 위해 주목 받아 왔는데, 그 중 LiNi 0.5 Co 0.2 Mn 0.3 O 2 양극활물질은 비교적 안정한 구조특성을 가지며 4.3 V vs. ... 초 록 층상구조 삼성분계 LiNi 1-x-y Co x Mn y O 2 양극활물질을 4.3 V 이상 고전압으로 충전시키면 용량 증 가를 기대할 수 있으나 기존 전해액의 산화안정성이 낮아 고전압 성능 구현에 제한이 있다. ... 본 연구에서는 Dimethyl sulfone (CH 3 SO 2 CH 3 , DMS) 등 선형 설폰계 화합물을 고전압 첨가제로 사 용하여 4.6 V 충전전압 조건하에서 LiNi 0.5 Co 0.2 Mn 0.3 O 2 양극의 사이클 성능을 향상시키고 양극 표면 에 형성된 표면층 조성과 안정성이 충방전 사이클 특 성에 미치는 영향과 역할에 대해 보고하고자 한다.LiNi ...doi:10.5229/jkes.2016.19.1.1 fatcat:ulrf7qpkxrb55et5cd3aphofki
Menurut Kang UU, pemilik 2 Kopi Dewa, faktor self branding dari Kang Restu sangat membantu dalam penjualan produk roast bean karena Kang Restu telah lebih dahulu dikenal sebagai Q Grader. organisasi memiliki ... Kopi Dewa ditetapkan sebagai objek penelitian oleh peneliti karena Kopi Dewa telah merintis usaha perkopian dari berbagai lini usaha. ...doi:10.31104/jsab.v3i1.92 fatcat:o66yuzex6zbmbmoeztapp3s6se
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