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Permeability is an import character of soil, especially in excavation and tunnelling. Hollow cylindrical apparatus (HCA) is often used to determine soil anisotropy, particularly soil strength and stiffness under different directions of major principal stress, so complex stress paths can be simulated and the corresponding soil properties can be examined. It can also be used to determine the permeability coefficient if a special mode is added, therefore the seepage test can be expected. Owing todoi:10.1051/e3sconf/20199202012 fatcat:plni4biopfdzrj2xjcoqugb7qm
more »... o seepage test has been conducted by HCA before, the complete procedure of HCA seepage tests after static and dynamic loading are respectively studied. And the seepage stability stage is discussed since only data in this stage are valid and reliable for permeability calculation. The results show that:1) when the difference in average permeability coefficient within unit time (3600 seconds) less than 2% in 24h, it is reliable to take the average permeability coefficient in this period as the ultimate permeability in static seepage test; 2) for dynamic test, if the average permeability in 3600 seconds varies with 5% in 24h, the average permeability coefficient in this period can be taken as the ultimate value. Research in this paper provides a solid foundation for HCA seepage test under complex stress paths.
In the past, researchers have developed a number of popular taint-analysis approaches, particularly in the context of Android applications. Numerous studies have shown that automated code analyses are adopted by developers only if they yield a good "signal to noise ratio", i.e., high precision. Many previous studies have reported analysis precision quantitatively, but this gives little insight into what can and should be done to increase precision further. To guide future research on increasingdoi:10.1109/ase.2019.00020 dblp:conf/kbse/LuoBS19 fatcat:d2vokxxy7zgmpayrxbcvqepw6y
more »... precision, we present a comprehensive study that evaluates static Android taint-analysis results on a qualitative level. To unravel the exact nature of taint flows, we have designed COVA, an analysis tool to compute partial path constraints that inform about the circumstances under which taint flows may actually occur in practice. We have conducted a qualitative study on the taint flows reported by FlowDroid in 1,022 real-world Android applications. Our results reveal several key findings: Many taint flows occur only under specific conditions, e.g., environment settings, user interaction, I/O. Taint analyses should consider the application context to discern such situations. COVA shows that few taint flows are guarded by multiple different kinds of conditions simultaneously, so tools that seek to confirm true positives dynamically can concentrate on one kind at a time, e.g., only simulating user interactions. Lastly, many false positives arise due to a too liberal source/sink configuration. Taint analyses must be more carefully configured, and their configuration could benefit from better tool assistance.
Acute lymphoblastic leukemia (ALL) is a common malignant hematologic disease that is characterized by large numbers of dedifferentiated lymphoid cells. Statistical data of ALL's incidence and mortality are fundamental for policymakers to allocate resources optimally. In this study, we reported the incidence, death, and disability-adjusted life year (DALY) of ALL in the globe from 1990 to 2017. Our analysis showed that the incidence case of ALL increased by 30.81%, while the age-standardizeddoi:10.18632/aging.103982 pmid:33203796 pmcid:PMC7746341 fatcat:gk2hefj4tre4fiz5nmloc5pa5m
more »... dence rate (ASIR) maintained stable. Subgroup analysis by social-demographic index (SDI) showed that ALL's ASIR was significantly decreased in high SDI countries, but were moderately increased in high-middle SDI countries. The change trends of age-standardized death rate and DALY rate were similar to ASIR trends. Subgroup analysis by age groups showed that children and the elderly were more likely to suffer ALL. Risk factor analysis demonstrated that smoking was the most significant contributor to ALL's death and DALY in the globe. Besides, the high body-mass index is playing an increasingly important role in ALL-caused mortality. Multiple methods to counteract potential risk factors should be adopted, such as controlling body-mass index in all regions and avoiding occupational exposure to carcinogens in low SDI countries.
Author Contributions The first two authors (Linghui Luo and Felix Pauck) contributed equally to this research and share the first authorship. ... Decompilation is widely used in reverse engineering and validation of software analysis results for closed-source applications (Luo et al. 2019a; Benz et al. 2020) . ... Multiple studies indicate that the scores achieved only hold for micro benchmarks apps and cannot be achieved when analyzing real-world apps (Qiu et al. 2018; Pauck et al. 2018; Luo et al. 2019a ). ...doi:10.1007/s10664-021-10013-5 fatcat:lacwyfdxwjbrpdsayg6qbnunra
Background Lung adenocarcinoma (LUAD) is a common pulmonary malignant disease with a poor prognosis. There were limited studies investigating the influences of the tumor immune microenvironment on LUAD patients' survival and response to immune checkpoint inhibitors (ICIs). Methods Based on TCGA-LUAD dataset, we constructed a prognostic immune signature and validated its predictive capability in the internal as well as total datasets. Then, we explored the differences of tumor-infiltratingdoi:10.1007/s00262-020-02817-z pmid:33386920 fatcat:yifl5f2tgfeevlkwann6qhza5m
more »... cytes, tumor mutation burden, and patients' response to ICI treatment between the high-risk score group and low-risk score group. Results This immune signature consisted of 17 immune-related genes, which was an independent prognostic factor for LUAD patients. In the low-risk score group, patients had better overall survival. Although the differences were non-significant, patients with low-risk scores had more tumor-infiltrating follicular helper T cells and fewer macrophages (M0), which were closely related to clinical outcomes. Additionally, the total TMB was markedly decreased in the low-risk score group. Using immunophenoscore as a surrogate of ICI response, we found that patients with low-risk scores had significantly higher immunophenoscore. Conclusion The 17-immune-related genes signature may have prognostic and predictive relevance with ICI therapy but needs prospective validation.
Luo, J. Dolby, and E. ... Luo, J. Dolby, and E. Bodden 21:13 specified in LSP, the editors send the project root path (rootURI) to the server in the first request initialize. ...doi:10.4230/lipics.ecoop.2019.21 dblp:conf/ecoop/LuoDB19 fatcat:pcb2qr2z6fhuvgy5a72hvmy2f4
As a portable standard, two-dimensional optical calibration plate is playing an increasingly important role in precision industry measurement. Therefore, it is of great scientific significance and obvious socioeconomic benefits to carry out the research of comparator. This paper was based on rich experience with the institute in the field of the geometric measurement technology for a long time, the measurement uncertainty of the optical calibration plate was studied, and the measurementdoi:10.1051/e3sconf/202123304044 fatcat:o2e6jz3k7va7nk2scndduw6mfq
more »... nty of the instrument has been researched. The measurement uncertainty of the error of the calibration plate's setting and marking value was U= (0.14+ 0.015L) m k=2 L: mm.
Journal of Fungi
The liquid fermentation of Antrodia cinnamomea is a promising alternative source for fungus production compared to the wildly grown fruiting body. Elicitation is a strong tool to enhance the productivity in microbial cells to obtain more compounds of interest. In this study, in order to improve the fungus growth and its terpenoids production, various vegetable oils were added in the fermentation broth of A. cinnamomea. It was found that corn oil from a group of vegetable oils exhibited the bestdoi:10.3390/jof7110926 pmid:34829215 pmcid:PMC8622282 fatcat:otnejendvzfovktvazoxzhgbpy
more »... effect on the biomass and triterpenoid content. After optimization, the initial addition of 1% (v/v) corn oil plus the inoculation of 10% (v/v) mycelia led to a maximum triterpenoid yield (532.3 mg L−1), which was increased as much as fourfold compared to the blank control. Differential transcriptome analysis demonstrated that corn oil significantly enriched several metabolic pathways including glycolysis/gluconeogenesis, propanoate metabolism and transmembrane hydrophobins. The enriched pathways interacted with deferentially expressed genes (DEGs) induced by corn oil treatment. Our research provides a potential strategy for the large production of triterpenoids by the improved fermentation of A. cinnamomea.
Authors' Contributions Fan Bai and Hui Luo contributed equally to this work. Fan Bai and Hui Luo put forward the idea of this study and designed the method of this systematic review. ... Fan Bai, Liying Wang, Linghui Zhu, and Yuanyuan Guan searched the articles, conducted data collection and extraction, and analyzed the data. ...doi:10.1155/2021/6390530 pmid:34394389 pmcid:PMC8357480 fatcat:hetybtfh3be2rdv26r77hiywyq
A one-pot synthesis, initiated by a copper salt with (NH4)2CO3 as the nitrogen source, forms divergent aryl imidazole derivatives from ketones via C–H activation, α-amination and oxidative C–C bond cleavage and condensation cascade reaction.doi:10.1039/d0ra01408g pmid:35492973 pmcid:PMC9051655 fatcat:yqyi4nmj2rcn3pkmmeh5vjnelu
Pre-operative non-invasive differentiation of benign and malignant thyroid nodules is difficult for doctors. This study aims to determine whether amide proton transfer (APT) imaging and zonally oblique multi-slice (ZOOM) diffusion-weighted imaging (DWI) can provide increased accuracy in differentiating benign and malignant thyroid nodules. Methods: This retrospective study was approved by the institutional review board and included 60 thyroid nodules in 50 patients. All of the nodules weredoi:10.3389/fendo.2018.00747 fatcat:cjvyivkexbdvtb6tlwk7kb3w3y
more »... ified as malignant (n = 21) or benign (n = 39) based on pathology. It was meaningful to analyze the APT and apparent diffusion coefficient (ADC) values of the two groups by independent t-test to identify the benign and malignant thyroid nodules. The relationship between APT and ZOOM DWI was explored through Pearson correlation analysis. The diagnostic efficacy of APT and ZOOM DWI in determining if thyroid nodules were benign or malignant was compared using receiver operating characteristic (ROC) curve analysis. Results: The mean APTw value of the benign nodules was 2.99 ± 0.79, while that of the malignant nodules was 2.14 ± 0.73. Additionally, there was a significant difference in the APTw values of the two groups (P < 0.05). The mean ADC value of the benign nodules was 1.84 ± 0.41, and was significantly different from that of the malignant nodules, which was 1.21 ± 0.19 (P < 0.05). Scatter point and Pearson test showed a moderate positive correlation between the APT and ADC values (P < 0.05). The ROC curve showed that the area under the curve (AUC) value of ZOOM DWI (AUC = 0.937) was greater than that of APT (AUC = 0.783) (P = 0.028). Conclusion: APT and ZOOM DWI imaging improved the accuracy of distinguishing between benign and malignant thyroid nodules. ZOOM DWI is superior to APTw imaging (Z = 2.198, P < 0.05).
Weichao Teng, Yachao Kang, Wenjuan Hou, Wenji Luo. Supervision: Yachao Kang, Linghui Wang. Visualization: Wenji Luo, Boyu Zhang. Writing -original draft: Weichao Teng. ... Author Contributions Data curation: Yachao Kang, Linghui Wang. Formal analysis: Houzhen Hu. ...doi:10.1371/journal.pone.0190900 pmid:29324770 pmcid:PMC5764327 fatcat:grzqaqs57ngb7ev3rdnttjidsa
Authors ̕ contributions Linghui Xia conceived the study, Ran Zhang, Xiaoxiao Wang and Mei Hong conducted most of the experiments, and wrote the paper; Ting Luo, Miaomiao Zhao and Haorui Shen carried out ... GRANT SUPPORT This work was supported by National Natural Sciences Foundation of P.R.China (no. 81370668, for Linghui Xia) and Collaborative Innovation Center of Hematology of P.R.China. ...doi:10.18632/oncotarget.15579 pmid:28423578 pmcid:PMC5410310 fatcat:zfmu4nsy5ram3ay2lnmupct7gy
We present a user study with developers at Amazon Web Services on their expectations of IDE support for cloud-based static analyses. The paper was originally presented at ESEC/FSE 2021. Many companies are providing Static Application Security Testing (SAST) tools as a service. These tools fit well into CI/CD, because CI/CD allows time for deep static analyses on large code bases and prevents vulnerabilities in the early stages of the development lifecycle. In CI/CD, the SAST tools usually rundoi:10.18420/se2022-ws-019 fatcat:qcdgbpjlw5go3mhmeyokwsbw7m
more »... the cloud and provide findings via a web interface. Recent studies show that developers prefer seeing the findings of these tools directly in their IDEs. Most tools with IDE integration run lightweight static analyses and can give feedback at coding time, but SAST tools take longer to run and usually are not able to do so. Can developers interact directly with a cloud-based SAST tool that is typically used in CI/CD through their IDE? We conducted a user study to explore how such IDE support should be designed. Through this study we identified the key design elements expected by developers and investigated whether an IDE solution fits better into developers' workflow in comparison to a web-based solution.
Due to the lack of established real-world benchmark suites for static taint analyses of Android applications, evaluations of these analyses are often restricted and hard to compare. Even in evaluations that do use real-world applications, details about the ground truth in those apps are rarely documented, which makes it difficult to compare and reproduce the results. Our recent study fills this gap. It first defines a set of sensible construction criteria for such a benchmark suite. It furtherdoi:10.18420/se2022-ws-020 fatcat:673wontyajfuhiibdfl6pfih4e
more »... roposes the TaintBench benchmark suite designed to fulfil these construction criteria. Along with the suite, this paper introduces the TaintBench framework, which allows tool-assisted benchmark suite construction, evaluation and inspection. Our experiments using TaintBench reveal new insights of popular Android taint analysis tools.
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