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Superior upconversion fluorescence dopants for highly efficient deep-blue electroluminescent devices

Yi-Hsiang Chen, Chih-Chun Lin, Min-Jie Huang, Kevin Hung, Yi-Ching Wu, Wei-Chieh Lin, Ren-Wu Chen-Cheng, Hao-Wu Lin, Chien-Hong Cheng
2016 Chemical Science  
Lin, Dyes Pigments, 2011, 88, 333. 2. Thermal behaviors of styrylpyrene-based materials PCzSP T d = 451 ºC DFASP T d = 410 ºC DPASP T d = TGA profiles of PCzSP, DFASP, and DPASP. Figure S2 .  ... 
doi:10.1039/c6sc00100a pmid:30155047 fatcat:sq63vf4puzbunhdumvhrwrfq3y

Real‐world outcomes of NSCLC patients receiving tissue or circulating tumor DNA‐guided osimertinib treatment

Po‐Lan Su, Szu‐Chun Yang, Yi‐Lin Chen, Yi‐Lin Wu, Chia‐Ying Lin, Wei‐Yuan Chang, Yau‐Lin Tseng, Wu‐Wei Lai, Chung‐Liang Ho, Chien‐Chung Lin, Wu‐Chou Su
2019 Cancer Medicine  
ACKNOWLEDGMENTS We are grateful to Wen-Ping Su, Shang-Yin Wu, Yu-Ming Yeh, and Yi-Ting Yen, for their valuable assistance in recruiting subjects.  ...  AUTHOR CONTRIBUTIONS Po-Lan Su, Szu-Chun Yang and Yi-Lin Chen contributed equally to this work. PLS, SCY, YLW, CLH, and CCL conceived and designed the experiments.  ...  ORCID Chien-Chung Lin SUPPORTING INFORMATION Additional supporting information may be found online in the Supporting Information section at the end of the article  ... 
doi:10.1002/cam4.2485 pmid:31433117 pmcid:PMC6792511 fatcat:u6oubu2wmrekjidx6ovqls4y3a

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Huang-Ju Tu, Yi-Jyun Lin, Min-Wu Chao, Ting-Yi Sung, Yi-Wen Wu, Yi-Ying Chen, Mei-Hsiang Lin, Jing-Ping Liou, Shiow-Lin Pan, Chia-Ron Yang
2018 Clinical Epigenetics  
There are some limitations of standard chemotherapy for acute leukemia. Vincristine and doxorubicin are commonly used for acute leukemia, but they may induce serious side effects such as cardiomyopathy and neurotoxicity. Furthermore, chemotherapy resistance occurs more and more frequently. Therefore, effective treatment strategies are needed. Histone deacetylase 6 inhibition is considered as a potential therapeutic strategy for acute leukemia, since it is observed that HDAC6 is overexpressed in
more » ... acute leukemia and regulates tumor survival. Combination therapy for cancer is used to minimize adverse drug effects, reduce drug dosage, enhance efficacy, and prevent drug resistance. In order to improve efficacy of chemotherapy agents of acute leukemia, this study will investigate the effects of combination MPT0G211, a novel histone deacetylase 6 inhibitor, with doxorubicin or vincristine on human acute leukemia cells.
doi:10.1186/s13148-018-0595-8 pmid:30594243 pmcid:PMC6310984 fatcat:fic4iuwdvzgfvhz6p3bm6oxtxe

Authentication Vector Management for UMTS

Lin-Yi Wu, Yi-Bing Lin
2007 IEEE Transactions on Wireless Communications  
Wu is with MediaTek Inc., No. 1, Dusing Rd. 1, HsinChu Science-Based Industrial Park, HsinChu, Taiwan 300, R.O.C. (e-mail: Y.-B.  ...  Lin is with the Department of Computer Science and Information Engineering, National Chiao Tung University, 1001 Ta Hseuh Rd., Hsinchu 30030, Taiwan (e-mail:  ...  Lin-Yi  ... 
doi:10.1109/twc.2007.060245 fatcat:rxrz7wgfwrcx3ctred7maiunaq

Antibodies against Helicobacter pylori heat shock protein 60 aggravate HSP60-mediated proinflammatory responses

Kuang-Wen Liao, Chen-Si Lin, Wen-Liang Chen, Chu-Ting Yang, Ching-Min Lin, Wei-Tung Hsu, Yi-Yin Lin, Yi-Han Chiu, Kuo-Chin Huang, Hsin-Yi Wu, Ming-Shiang Wu, Chang-Jer Wu (+2 others)
2011 Cytokine  
Anti-Helicobacter pylori heat shock protein 60 (HpHSP60) antibodies are usually found in H. pyloriinfected patients and are known to be associated with the progression of gastric diseases. However, the effects of these antibodies on the functions of HpHSP60 have not been identified. This study aims to investigate the effects of the interaction between anti-HSP60 antibodies and HpHSP60 on inflammatory responses. Anti-HpHSP60 polyclonal sera and monoclonal antibodies (mAbs) were produced to
more » ... te their effects on HpHSP60-induced IL-8 and TNF-a activity. The results indicated that anti-HpHSP60 polyclonal sera collected from patients infected with H. pylori or from rabbit and mice immunized with HpHSP60 could significantly enhance HpHSP60-mediated IL-8 and TNF-a secretion from monocytic THP-1 cells. Similar effects were also found with anti-HpHSP60 mAbs. Further analysis revealed that this phenomenon was only carried out by anti-HpHSP60 antibody but not by other non-specific mAbs. Moreover, the non-specific mAbs decreased the synergism of HpHSP60 and anti-HpHSP60 mAbs in proinflammatory cytokine induction. Herein, we have examined the role of anti-HpHSP60 antibody in host immune responses for the first time. This study demonstrated that H. pylori HSP60/mAbs could modulate helicobacterial pathogenesis by increasing IL-8 and TNF-a production. The pathogen-specific antibodies may execute potential immune functions rather than recognize or neutralize microbes.
doi:10.1016/j.cyto.2011.04.011 pmid:21565524 fatcat:eadcq77ns5h7tfbuyjywgh4lgq

Author Response

Chang-Yi Yen, Kwan-Hwa Lin, Ming-Hsia Hu, Ruey-Meei Wu, Tung-Wu Lu, Chia-Hwa Lin
2011 Physical Therapy  
Author Response Chang-Yi Yen, Kwan-Hwa Lin, Ming-Hsia Hu, Ruey-Meei Wu, Tung-Wu Lu, Chia-Hwa Lin The commentary by Deutsch et al 1 focuses on the strengths and weaknesses of virtual reality (VR)augmented  ...  strategy, such as traffic auditory distraction and traffic light recognition, would be considered in future design of VR balance training with dual tasks. 7, 8 DOI: 10.2522/ 16 Yen C-Y, Lin  ... 
doi:10.2522/ fatcat:xztez6npbrhtrlxzlaionh77ke

The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study

Ping-Hsun Wu, Yi-Ting Lin, Yi-Hsin Yang, Yu-Chih Lin, Yi-Ching Lin
2015 Scientific Reports  
The risk of active tuberculosis (TB) in patients with dermatomyositis (DM) is poorly understood. The cohort study aimed to investigate the association between DM and the risk of active TB disease. We conducted a population based study on 4,958 patients with newly diagnosed DM and 19,832 matched controls according to age, sex, and index date between 1998 and 2008. The hazard ratios (HRs) and cumulative incidences of active TB disease between DM patients and controls were analyzed. During the
more » ... y period, a total of 85 (1.7%) DM patients developed active TB disease, which was significantly higher than that of non-DM patients (0.64%). The incidence rate of active TB disease was higher among DM patients than controls (incidence rate ratio 2.95; 95% confidence interval [CI], 2.24 to 3.88). The Cox regression model demonstrated significantly higher active TB disease rate among DM patients compared with controls (adjusted HR, 2.64; 95% CI, 1.97 to 3.54; p < 0.001) after adjusting for age, sex, and underlying medical disorders. The most significant risk factors for developing active TB included male sex, diabetes mellitus comorbidity, and use of corticosteroids and azathioprine in DM patients. In conclusion, DM patients are at a greater risk for active TB disease. Dermatomyositis (DM) is systemic autoimmune rheumatic disease characterized by chronic inflammation of the skeletal muscles, which is frequently accompanied by characteristic skin rashes. In DM patients, ten-year survival rates are reported to be widely variable, ranging from 53-91% 1-3 , and infection is considered one of the leading causes of mortality 1,2,4 . Several factors, such as immunosuppressive medication use and DM-induced immune system dysfunction, may increase infection susceptibility in DM patients 1,4,5 .
doi:10.1038/srep16303 pmid:26573418 pmcid:PMC4647179 fatcat:vihjpelymzh67pdngotkubersy

Bruise-like cutaneous lesions as the early presentation of blastic plasmacytoid dendritic cell neoplasm

Yi-Hsuan Chou, Ruey-Yi Lin, Meng-Sui Lee, Hsiao-Ping Wu, Che-Pin Lin, Chen-Yi Wu
2014 Zhōnghuá Pífūkē Yīxué Zázhì  
blastic natural-killer cell lymphoma blastic plasmacytoid dendritic cell neoplasm CD4þCD56þ hematodermic neoplasm a b s t r a c t Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare and highly aggressive hematopoietic malignancy associated with a poor prognosis. It has been recognized to originate from precursors of plasmacytoid dendritic cells and has recently been established as a distinct entity. The most frequent clinical presentations are prominent skin lesions, followed by
more » ... peripheral blood, bone marrow, and other organ involvement. Treatment outcomes are often disappointing due to a high relapse rate after chemotherapy and risk of leukemic dissemination. Herein, we report a case of BPDCN in a 41-year-old man who presented with cutaneous and nasopharyngeal lesions, and achieved a complete response after systemic chemotherapy. Dermatologists should be aware of BPDCN and its clinical presentations, as early diagnosis with appropriate treatment is crucial to improve its prognosis.
doi:10.1016/j.dsi.2013.07.002 fatcat:ii54yrubabcehhfsflhl7wxqqq

TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma

Jau-Chen Lin, Yi-Ying Wu, Jing-Yi Wu, Tzu-Chieh Lin, Chen-Tu Wu, Yih-Leong Chang, Yuh-Shan Jou, Tse-Ming Hong, Pan-Chyr Yang
2012 EMBO Molecular Medicine  
Epigenetic inactivation of TROP2 promotes lung tumours These authors contributed equally to this work. 472 ß 2012 EMBO Molecular Medicine EMBO Mol Med 4, 472-485 Research Article Jau-Chen Lin  ...  et al. EMBO Mol Med 4, 472-485 ß 2012 EMBO Molecular Medicine ß 2012 EMBO Molecular Medicine EMBO Mol Med 4, 472-485 Research Article Jau-Chen Lin et al.  ...  We found Research Article Jau-Chen Lin et al. knockdown by either lenti-shTROP2A or lenti-shTROP2C enhanced cell proliferation. C.  ... 
doi:10.1002/emmm.201200222 pmid:22419550 pmcid:PMC3443948 fatcat:pigcdu24ajh2jb6e7mvk3ljsg4

Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells

Jung-Lin Wu, Hsin-Yi Wu, Dong-Yan Tsai, Ming-Feng Chiang, Yi-Ju Chen, Shijay Gao, Chun-Cheng Lin, Chun-Hung Lin, Kay-Hooi Khoo, Yu-Ju Chen, Kuo-I. Lin
2016 Nature Communications  
Acknowledgements We thank Cheng-Tsung Lu and Tzong-Yi Lee for the support of bioinformatics analysis.  ... 
doi:10.1038/ncomms12526 pmid:27555448 pmcid:PMC4999498 fatcat:jzc222cbxnaw3ibia4jpkudc5y

Cervical ectopic thymoma

I.-Lin Hsu, Ming-Ho Wu, Wu-Wei Lai, Mu-Yen Lin, Jia-Ming Chang, Yi-Ting Yen, Yau-Lin Tseng
2007 Journal of Thoracic and Cardiovascular Surgery  
Reduction of regional RV function can occur around the ventriculotomy site after TOF repair. So that postoperative RV function will be preserved, ventriculotomy should be minimal and performed only if necessary. 2. Sheehan FH, Bolson EL, Dodge HT, Mathey DG, Schofer J, Woo HW. Advantages and applications of the centerline method for characterizing regional ventricular function. Circulation. 1986; 74:293-305. 3. Alexiou C, Chen Q, Galogavrou M, Gnanapragasam J, Salmon AP, Keeton BR, et al.
more » ... of tetralogy of Fallot in infancy with a transventricular or a transatrial approach. Eur J Cardiothorac Surg. 2002;22:174-83. 4. d'Udekem Y, Ovaert C, Grandjean F, Gerin V, Cailteux M, Shango-Lody P, et al. Tetralogy of Fallot: transannular and right ventricular patching equally affect late functional status.
doi:10.1016/j.jtcvs.2007.01.037 pmid:17532980 fatcat:dvfv35d4q5g4zi7p5dte32jtpu

Sequential Loading ofSaccharomyces cerevisiaeKu and Cdc13p to Telomeres

Tzung-Ju Wu, Yi-Hsuan Chiang, Yi-Chien Lin, Chang-Ru Tsai, Tai-Yuan Yu, Ming-Ta Sung, Yan-Hwa Wu Lee, Jing-Jer Lin
2009 Journal of Biological Chemistry  
Ku is a heterodimeric protein involved in nonhomologous end-joining of the DNA double-stranded break repair pathway. It binds to the double-stranded DNA ends and then activates a series of repair enzymes that join the broken DNA. In addition to its function in DNA repair, the yeast Saccharomyces cerevisiae Ku (Yku) is also a component of telomere protein-DNA complexes that affect telomere function. The yeast telomeres are composed of duplex C 1-3 (A/T)G 1-3 telomeric DNA repeats plus
more » ... nded TG 1-3 telomeric DNA tails. Here we show that Yku is capable of binding to a tailed-duplex DNA formed by telomeric DNA that mimics the structure of telomeres. Addition of Cdc13p, a single-stranded telomeric DNA-binding protein, to the Yku-DNA complex enables the formation of a ternary complex with Cdc13p binding to the single-stranded tail of the DNA substrate. Because pre-loading of Cdc13p to the single-stranded telomeric tail inhibits the binding of Yku, the results suggested that loading of Yku and Cdc13p to telomeres is sequential. Through generating a double-stranded break near telomeric DNA sequences, we found that Ku protein appears to bind to the de novo synthesized telomeres earlier than that of Cdc13p in vivo. Thus, our results indicated that Yku interacts directly with telomeres and that sequential loading of Yku followed by Cdc13p to telomeres is required for both proteins to form a ternary complex on telomeres. Our results also offer a mechanism that the binding of Cdc13p to telomeres might prevent Yku from initiating DNA double-stranded break repair pathway on telomeres.
doi:10.1074/jbc.m809131200 pmid:19276071 pmcid:PMC2676010 fatcat:ntcvhlqtrvembpa4b2iwdqiuay

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

Chieh-Ju C Tang, Shin-Yi Lin, Wen-Bin Hsu, Yi-Nan Lin, Chien-Ting Wu, Yu-Chih Lin, Ching-Wen Chang, Kuo-Sheng Wu, Tang K Tang
2011 EMBO Journal  
Centriole duplication involves the growth of a procentriole next to the parental centriole. Mutations in STIL and CPAP/CENPJ cause primary microcephaly (MCPH). Here, we show that human STIL has an asymmetric localization to the daughter centriole and is required for procentriole formation. STIL levels oscillate during the cell cycle. Interestingly, STIL interacts directly with CPAP and forms a complex with hSAS6. A natural mutation of CPAP (E1235V) that causes MCPH in humans leads to
more » ... ly lower binding to STIL. Overexpression of STIL induced the formation of multiple procentrioles around the parental centriole. STIL depletion inhibited normal centriole duplication, Plk4-induced centriole amplification, and CPAP-induced centriole elongation, and resulted in a failure to localize hSAS6 and CPAP to the base of the nascent procentriole. Furthermore, hSAS6 depletion hindered STIL targeting to the procentriole, implying that STIL and hSAS6 are mutually dependent for their centriolar localization. Together, our results indicate that the two MCPH-associated proteins STIL and CPAP interact with each other and are required for procentriole formation, implying a central role of centriole biogenesis in MCPH.
doi:10.1038/emboj.2011.378 pmid:22020124 pmcid:PMC3243611 fatcat:455yvqtn5zb5lac4r3lie7pypy

Generation of Functional Cardiomyocytes from Human Gastric Fibroblast-Derived Induced Pluripotent Stem Cells

Chih-Hsien Wu, Hsuan-Hwai Lin, Yi-Ying Wu, Yi-Lin Chiu, Li-Yen Huang, Cheng-Chung Cheng, Chung-Chi Yang, Tsung-Neng Tsai
2021 Biomedicines  
Coronary artery diseases are major problems of the world. Coronary artery disease patients frequently suffer from peptic ulcers when they receive aspirin treatment. For diagnostic and therapeutic purposes, the implementation of panendoscopy (PES) with biopsy is necessary. Some biopsy samples are wasted after the assay is completed. In the present study, we established a protocol for human gastric fibroblast isolation and induced pluripotent stem cell (iPSC) generation from gastric fibroblasts
more » ... a PES with biopsy. We showed that these iPSCs can be differentiated into functional cardiomyocytes in vitro. To our knowledge, this is the first study to generate iPSCs from gastric fibroblasts in vitro.
doi:10.3390/biomedicines9111565 pmid:34829794 pmcid:PMC8615619 fatcat:ozmjxa6txbgwbpdbdun7iz63v4

Positive Effects of Preventive Nutrition Supplement on Anticancer Radiotherapy in Lung Cancer Bearing Mice

Yu-Ming Liu, Tsung-Han Wu, Yi-Han Chiu, Hang Wang, Tsung-Lin Li, Simon Hsia, Yi-Lin Chan, Chang-Jer Wu
2020 Cancers  
(1) Background: Radiotherapy (RT) is one of the major treatments for non-small cell lung cancer, but RT-associated toxicities usually impede its anticancer effect. Nutrient supplementation has been applied for cancer prevention or a complementary measure to anticancer therapy. Here, we explored the influence of total nutrition supplementation before and after cancer occurrence on the anticancer benefit and side effects of RT. (2) Methods: C57BL/6JNarl mice were inoculated with Lewis lung
more » ... ma cells and then treated with radiotherapy. TNuF, a total nutrition formula, was prescribed by oral gavage. In the preventive groups, TNuF supplementation started from seven days before tumor inoculation. In the complementary groups, TNuF supplementation began after tumor inoculation. (3) Results: TNuF successfully enhanced the anticancer effect of RT against primary tumor and lung metastasis. Additionally, the complementary supplement improved the high serum TNF-α level and the wasting of sartorius muscle in mice receiving RT. In histologic and molecular analysis, TNuF was observed to modulate EGFR, apoptosis, and VEGF and PD-1/PD-L1 pathways. Furthermore, the anticancer benefit of the preventive supplement was comparable to that of the complementary administration. (4) Conclusions: Our results demonstrated that the prescription of the TNuF total nutrition formula before and after cancer diagnosis attains similar benefits in testing subjects with typical anticancer RT. TNuF is also a potential sensitizer to anti-PD-1 immune therapy.
doi:10.3390/cancers12092445 pmid:32872195 fatcat:lii3npdg4velndmhxpigrj3s2u
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