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Thermally on-off switching nylon membrane for controlling drug penetration

Ko-Shao Chen, Yih-Yih Lin, Shan-Yang Lin
1996 Drug Delivery System  
doi:10.2745/dds.11.55 fatcat:5fjdhes6ubcxnaohdmlumjqjse

Clustering with fuzzy supervised algorithm

Fong-Jhu Yih, Yuan-Horng Lin, Jeng-Ming Yih, W.-H. Hsieh
2017 MATEC Web of Conferences  
Furthermore, the FCM-AM algorithms included two algorithms, FCM-M and FCM-CM, proposed by our previous works (Hsiang-Chuan Liu, Jeng-Ming Yih, Shin-Wu Liu, 2007 ).  ... 
doi:10.1051/matecconf/201711901007 fatcat:hqhm7n4eobd6tax4btngnpwcke

Magnetic quantization in multilayer graphenes [article]

Chiun-Yan Lin, Jhao-Ying Wu, Yih-Jon Ou, Yu-Huang Chiu, Ming-Fa Lin
2015 arXiv   pre-print
Essential properties of multilayer graphenes are diversified by the number of layers and the stacking configurations. For an N-layer system, Landau levels are divided into N groups, with each identified by a dominant sublattice associated with the stacking configuration. We focus on the main characteristics of Landau levels, including the degeneracy, wave functions, quantum numbers, onset energies, field-dependent energy spectra, semiconductor-metal transitions, and crossing patterns, which are
more » ... reflected in the magneto-optical spectroscopy, scanning tunneling spectroscopy, and quantum transport experiments. The Landau levels in AA-stacked graphene are responsible for multiple Dirac cones, while in AB-stacked graphene the Dirac properties depend on the number of graphene layers, and in ABC-stacked graphene the low-lying levels are related to surface states. The Landau-level mixing leads to anticrossings patterns in energy spectra, which are seen for intergroup Landau levels in AB-stacked graphene, while in particular, a formation of both intergroup and intragroup anticrossings is observed in ABC-stacked graphene. The aforementioned magneto-electronic properties lead to diverse optical spectra, plasma spectra, and transport properties when the stacking order and the number of layers are varied. The calculations are in agreement with optical and transport experiments, and novel features that have not yet been verified experimentally are presented.
arXiv:1506.06219v1 fatcat:dkpuxjnjjfabrdpnn6iqd53bpu

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Kai-Wun Yeh, Jen-Chih Chen, Mei-In Lin, Yih-Ming Chen, Chu-Yung Lin
2012 Plant Molecular Biology  
Sporamin accounts for about 60% to 80% of total soluble protein in sweet potato tubers, and the predicted protein sequence of sporamin shares significant amino acid sequence identity with some Kunitz-type trypsin inhibitors. We constructed three recombinant plasmids with cDNAs that encode preprosporamin, prosporamin, and sporamin, and these three were expressed in Escherichia coli cells as fusion proteins. All three forms of sporamin expressed in E. coli were shown to have strong inhibitory
more » ... vity to trypsin in vitro, suggesting that post-translational modifications are not essential for trypsin inhibitory activity. Northern blot analysis showed that sporamin transcripts could be systemically induced in leaf tissue of sweet potato by wounding. Therefore, sporamin may have a defense role as a protease inhibitor, in addition to its role as a storage protein.
doi:10.1023/a:1005764702510 fatcat:w3yzcenbx5boji2rndcvxxzarq

Numerical Study on Reduction of Transonic Blade-Vortex Interaction Noise

San-Yih Lin, Yan-Shin Chin, Bae-Yih Hwang
2000 Journal of Aircraft  
JOURNAL OF AIRCRAFT Vol. 37, No. 5, September—October 2000 Numerical Study on Reduction of Transonic Blade-Vortex Interaction Noise San-Yih Lin,* Yan-Shin Chin,’ and Bae-Yih Hwang?  ...  Lin and Chin? have studied numerically the transition of stagnation point, the shock motions, and these two dominant sound waves in detailed.  ... 
doi:10.2514/2.2702 fatcat:vgktk4hmrnagxhg5li5fo626ba

On Continual Model Refinement in Out-of-Distribution Data Streams [article]

Bill Yuchen Lin, Sida Wang, Xi Victoria Lin, Robin Jia, Lin Xiao, Xiang Ren, Wen-tau Yih
2022 arXiv   pre-print
Real-world natural language processing (NLP) models need to be continually updated to fix the prediction errors in out-of-distribution (OOD) data streams while overcoming catastrophic forgetting. However, existing continual learning (CL) problem setups cannot cover such a realistic and complex scenario. In response to this, we propose a new CL problem formulation dubbed continual model refinement (CMR). Compared to prior CL settings, CMR is more practical and introduces unique challenges
more » ... ry-agnostic and non-stationary distribution shift, diverse mixtures of multiple OOD data clusters, error-centric streams, etc.). We extend several existing CL approaches to the CMR setting and evaluate them extensively. For benchmarking and analysis, we propose a general sampling algorithm to obtain dynamic OOD data streams with controllable non-stationarity, as well as a suite of metrics measuring various aspects of online performance. Our experiments and detailed analysis reveal the promise and challenges of the CMR problem, supporting that studying CMR in dynamic OOD streams can benefit the longevity of deployed NLP models in production.
arXiv:2205.02014v1 fatcat:2gpdcjmkkbbjhfkxhp6rczoene

Involvement of hypothalamic PI3K-STAT3 signalling in regulating appetite suppression mediated by amphetamine

Shu-Chen Chu, Pei-Ni Chen, Yih-Shou Hsieh, Ching-Han Yu, Meng-Hsuan Lin, Yan-Han Lin, Dong-Yih Kuo
2014 British Journal of Pharmacology  
BACKGROUND AND PURPOSE Appetite suppression induced by amphetamine has been attributed to its inhibition of neuropeptide Y (NPY) neurons and activation of pro-opiomelanocortin (POMC) neurons in the hypothalamus. This study examined whether STAT3 was involved in these actions of amphetamine. EXPERIMENTAL APPROACH Rats were given amphetamine daily for 4 days. Changes in the expression of NPY, POMC, melanocortin MC3 receptors, PI3K and STAT3 in the hypothalamus were assessed by RT-PCR and Western
more » ... lotting. Antisense oligonucleotides to STAT3 were also used. KEY RESULTS Expression of NPY decreased with a maximum effect day 2 of amphetamine treatment. Expression of POMC, MC3 receptors, PI3K and STAT3 increased with a maximum response on day 2. Moreover, phosphorylation of STAT3 and its DNA binding activity increased and was expressed in a similar pattern. Infusion (i.c.v.) of STAT3 antisense at 60 min before amphetamine treatment, partly blocked amphetamine-induced anorexia and modulated expression of NPY, POMC, MC3 receptors and PI3K, indicating the involvement of STAT3 in amphetamine-treated rats. CONCLUSIONS AND IMPLICATIONS Hypothalamic PI3K-STAT3 signalling participated in the regulation of NPY-and POMC-mediated appetite suppression. These findings may contribute to a better understanding of anorectic drugs.
doi:10.1111/bph.12667 pmid:24597972 pmcid:PMC4080976 fatcat:ypaj5lbgefey5gzrtiaiitigue

Reversible Watermarking For H.264/Avc Videos

Yih-Chuan Lin, Jung-Hong Li
2011 Zenodo  
However, there had two methods [8] - [9] which had Yih-Chuan Lin is with the National Formosa University, Yunlin, 63201 Taiwan (phone: +886-5-631-5576; fax: 886-5-633-0456; e-mail: lyc@ nfu.edu.tw).  ...  (a) akiyo; (b) foreman Yih-Chuan Lin and Jung-HongLi Reversible Watermarking for H.264/AVC Videos International Scholarly and Scientific Research & Innovation 5(6) 2011 scholar.waset.org/1307-6892/1983  ... 
doi:10.5281/zenodo.1056216 fatcat:4qjx3hw6ffhrjpyw7fmnno4xka

Mechanisms of immunogenic cell death and immune checkpoint blockade therapy

Richard A. Lin, Jessica K. Lin, Shiaw‐Yih Lin
2021 Kaohsiung Journal of Medical Sciences  
ORCID Shiaw-Yih Lin https://orcid.org/0000-0002-3838-0358 and the secretion of proinflammatory cytokines such as TNF and type I IFNs 45 alert the cellular microenvironment.  ... 
doi:10.1002/kjm2.12375 pmid:33636043 fatcat:eik4ohzhqfftlo4dyvhgbnzwum

Detection of hepatitis B virus-host junction sequences in urine of infected patients [article]

Selena Y Lin, Yih-Ping Su, Evan R Trauger, Ben P Song, Emilie G.C. Thompson, Malcolm C Hoffman, Ting-Tsung Chang, Yih-Jyh Lin, Yu-Lan Kao, Yixiao Cui, Hie-Won Hann, Grace Park (+2 others)
2021 medRxiv   pre-print
& Aims: Integrated hepatitis B virus (HBV) DNA, found in >85% of HBV-associated hepatocellular carcinomas (HBV-HCC), can play a significant role in HBV-related liver disease progression. HBV-host junction sequences (HBV-JS's), created through integration events, have been used to determine HBV-HCC clonality. Here, we investigate the feasibility of analyzing HBV integration in a noninvasive urine liquid biopsy. Approach & Results: Utilizing an HBV-targeted NGS assay, we first identified HBV-JS's
more » ... in 8 HBV-HCC tissues and designed short-amplicon junction-specific PCR assays to detect HBV-JSs in matched urine. We detected and validated tissue-derived junctions in 5 of 8 matched urine samples. Next, we screened 32 urine samples collected from 25 HBV-infected patients (5 with hepatitis, 10 with cirrhosis, 4 with HCC, and 6 post-HCC). Encouragingly, all 32 urine samples contained HBV-JS's detectable by HBV-targeted NGS. Of the 712 total HBV-JS's detected in urine, 351 were in gene-coding regions, 11 of which, including TERT, had previously been reported as recurrent integration sites in HCC tissue and were found in urine of cirrhosis or HCC patients only. The integration breakpoints of HBV DNA detected in urine were found predominantly (~70%) at a previously identified integration hotspot, HBV DR1-2. Conclusions: HBV viral-host junction DNA can be detected in urine of HBV-infected patients. This study is the first study to demonstrate the potential for a noninvasive urine liquid biopsy of integrated HBV DNA to monitor HBV-infected patients for HBV-associated liver diseases and the efficacy of antiviral therapy.
doi:10.1101/2021.04.28.21254562 fatcat:ano7sehnavhnrfudm47lo3sloq

Identification of Grown-In Defects in CZ Silicon after Cu Decoration

Kun-Lin Lin, Yi-Ling Jian, Che-Yu Lin, Chien-Cheng Lin, Yih-Rong Luo, Chien-Chia Tseng
2017 Microscopy Research  
Bulk Czochralski silicon crystals were decorated with Cu and characterized by transmission electron microscopy (TEM) with energy-dispersive spectroscopy (EDS), atomic force microscopy (AFM), optical microscopy (OM), scanning electron microscopy (SEM), and photoluminescence spectroscopy (PL). The vacancy-type core, oxidation-induced stacking faults (OISF) ring, nearly defect-free ring, and self-interstitial-type rich outer ring were delineated in the Si crystal wafer. At the surface of the Si
more » ... stal, vertical-horizontal line (V-H line) defects and windmill defects (W-defects) were formed instead of OISF. The families of growth planes and directions were expressed as {011} and <110> for the V-H line and {010} and <010> for W-defects, respectively. In addition to V-H line defects and W-defects, pits or voids and Si oxide with dissolved Cu were found in the Si crystal wafer.
doi:10.4236/mr.2017.52002 fatcat:lacgftrco5ayxjhgvo6k7br6my

Characteristics of YBa2Cu3O7 Thin Films Deposited on Substrates Buffered by Various TiO2 Layers

Po-Iem Lin, Chia-Wen Liu, Chich-Chang Hsieh, Kaung-Hsiung Wu, Jenh-Yih Juang, Tseng-Ming Uen, Jiunn-Yuan Lin, Yih-Shung Gou
2001 Japanese Journal of Applied Physics  
Titanium nitride (TiN) and superconducting YBa 2 Cu 3 O 7 (YBCO) thin films have been deposited sequentially on SrTiO 3 (STO)(100) substrates by in situ pulsed laser ablation. The TiN films were originally intended to serve as the lower contact electrode of the c-axis YBCO thin films. It was found that, although high-quality YBCO films could be obtained with the YBCO/TiN/STO(100) bilayer structure, the TiN(100) layer was oxidized which changed the structure into YBCO/TiO 2 /STO(100) during YBCO
more » ... deposition. Comparative studies of depositing YBCO films directly onto a dc-sputtered TiO 2 /STO(100) template conventionally used in the selective epitaxial growth (SEG) process have, however, resulted in formation of a nonsuperconducting YBCO top layer. The characteristics of the resultant TiO 2 layers obtained using various processes were analyzed to delineate the apparent discrepancies.
doi:10.1143/jjap.40.l377 fatcat:ig7i26jz6bgz5efhtgjuaxirge

Undergraduates' Speaking Anxiety in English as Second Language (ESL) Classrooms

Kimberley Lau Yih Long, Yeo Jiin Yih, Sandra Sim Phek Lin
2020 International Journal of Service Management and Sustainability  
Many students exhibit fear of speaking in English in the English as Second Language (ESL) classrooms. Additionally, there are limited studies in this area of concern among the undergraduates in Sarawak. Hence, this study aimed to identify the students" anxiety level towards speaking English based on four components, namely communication apprehension, test anxiety, fear of negative evaluation, and comfort in using English in the classrooms. This study also examined whether there is any
more » ... t difference in the level of anxiety in terms of gender. A total of 592 undergraduates from two public institutions of higher learning in Sarawakwere involved in this study. A Public Speaking Class Anxiety Scale (PSCAS) by Yaikhong and Usaha (2012) was adopted in this study to measure anxiety in the ESL speaking classes. The results gathered through the questionnaires were analysed using SPSS package to determine the students" speaking anxiety levels and the significant difference in the level of anxiety in speaking English in terms of gender. The findings revealed that undergraduates experienced an average level of speaking anxiety. T-test analysis of the findings in the study also portrayed that generally the female undergraduates experienced higher speaking anxiety as compared to the male undergraduates in all the four factors of ESL speaking anxiety. Among the four factors of speaking anxiety, only the factor of 'comfort in using English' in the classrooms showed a statistically significant difference between male and female undergraduates. Findings of this study would be significant as knowing the level of anxiety among the undergraduates in ESL classrooms will provide the basis for educators to plan better strategies or techniques to help students in overcoming their English speaking anxiety and to improve their oral English proficiency. It will also help students to be aware of their own speaking anxiety level so that they can seek for measures to overcome their speaking anxiety.
doi:10.24191/ijsms.v4i1.8180 fatcat:ungrajcmrfb2tjvqpblqftafdy

Phase transformation, reaction kinetics and microwave characteristics of Bi2O3–ZnO–Nb2O5 ceramics

San-Yuan Chen, Shinn-Yih Lee, Yih-Jaw Lin
2003 Journal of the European Ceramic Society  
Oxide powders of Bi 2 O 3 , ZnO and Nb 2
doi:10.1016/s0955-2219(02)00199-1 fatcat:fiacfmmeergw3opn5rlp23idte

On the origin of photogenerated terahertz radiation from current-biased superconducting YBa2Cu3O7−δ thin films

Po-Iem Lin, Chih-Wei Luo, Hsin-Shan Liu, Shyh-Feng Chen, Kaung-Hsiung Wu, Jenh-Yih Juang, Tseng-Ming Uen, Yih-Shung Gou, Jiunn-Yuan Lin
2004 Journal of Applied Physics  
doi:10.1063/1.1738537 fatcat:2kfohvfgbzfrje64zbii5jknkm
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