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Terrestrial Arthropods as a Public Health Issue in South–Eastern Romania

Cristina Preda, Ruben Iosif, Rodica Tudoran, Liliana Ana Tuţă
2016 Travaux du Muséum National d'Histoire Naturelle "Grigore Antipa  
Little is known about the prevalence and severity of allergic reactions caused by terrestrial arthropods in Romania although bites and stings of arthropods represent a widely recognized public health issue. We conducted a retrospective study in Constanța, the largest city at the Romanian Black Sea coast, and documented 207 cases during 2013–2014, representing 0.5% of the total number of records at the Emergency Department of the County Clinical Emergency Hospital. Young men and women presented
more » ... hemselves more often to the hospital to report this type of injuries and most arthropods causing allergic reactions were not identified. Our study brings novel information on the prevalence of injuries inflicted by terrestrial arthropods on the human adult population at the Romanian Black Sea coast, it highlights existing knowledge gaps and provides information on which to base future guidelines.
doi:10.1515/travmu-2016-0005 fatcat:y26jsz6d6rfxje6bfbgutudmam

The Effects of Interferon and Ribavirin in Chronic Hepatite C

Liliana Coldea, Florin Grosu, Alina Liliana Pintea, Sebastian Ioan Cernusca Mitariu, Nicolae Grigore, Raluca Monica Comaneanu, Corina Roman Filip
2017 Revista de chimie (Bucuresti)  
The chronic hepatitis C is a frequently problem in worldwide, the number of infected individuals is high and go on, getting a public health problem [1]. In Romania there are nearly 1 million persons infected with hepatitis C virus, the scope of spreading is related with specific risk factors. An important number of infection with hepatitis C virus present simultaneous extrahepatic manifestations proved to be alone manifestation tracing; its important for diagnosis and treatment. We analyzed the
more » ... effects of interferon and ribavirin in chronic hepatitis C in General C.F. Hospital Sibiu, between 2008 � 2012. The association between infection with hepatitis C virus and extrahepatic manifestations is important to be recognized for adequate diagnosis tests. By comparing the results of therapy in patients with hepatic and extrahepatic manifestations, the study found that 30 patients (58.83 %) with liver manifestations had an incomplete response versus 10 patients (26.32 %) with extrahepatic manifestations; 11 patients (21.54 %) with hepatic manifestations had a complete response versus 3 patients (7.89 %) with extrahepatic manifestations; and 10 patients (19.63 %) with hepatic manifestations did not respond to treatment versus 25 patients (65.79 %) with extrahepatic manifestations. Analyzing the results of antiviral therapy in patients with hepatic manifestations and those with extrahepatic manifestations, antiviral treatment appears to be more advantageous in cases with only hepatic manifestations.
doi:10.37358/rc.17.9.5844 fatcat:7dt2yn6eqjbe3lxkcgmtwmtspq

Melanoma with regression and in-transit metastasis

Alina Florentina Letcă, Loredana Ungureanu, Lavinia Elena Grigore, Liliana Rogojan, Rodica Cosgarea
2016 Clujul Medical  
Introduction. Melanoma is an aggressive tumor with an increasing incidence worldwide. In-transit metastases represent a unique pattern of dissemination. Case report. We report the case of a 42-year-old woman who presented with two lesions on the left latero-cervical region: a pigmented macule with irregular borders and colors and a firm, dome-shaped 5 mm nodule with an erythematous base and a black crust on top, at the periphery of the first lesion. The clinical picture supported the diagnosis
more » ... f melanoma with in-transit metastasis, but the histopathology examination raised, initially, the problem of two primary melanomas: a superficial spreading melanoma and a minimal deviation melanoma. Conclusions. Our case highlights the necessity of clinical and histopathological correlations in every case and the necessity of a good collaboration between the dermatologist and the pathologist.
doi:10.15386/cjmed-525 fatcat:5qmo3j5ahvcubnhx2qntrsuy4y

The Therapeutic Relevance of Vitamin E

Lucretia Anghel, Liliana Baroiu, Adrian Beznea, Gabi Toporcamelia Ana Grigore
2019 Revista de chimie (Bucuresti)  
Maintaining cellular homeostasis in the context of its normal metabolic function is achieved by establishing the balance between its own antioxidant capacity and the level of harmful compounds resulting from the mitochondrial activity and the immune system. One of the antioxidants involved in this process is vitamin E with its most active form -alpha-tocopherol, which exerts its functions through vitamin C. The main functions of this antioxidant are: regulation of platelet aggregation, cellular
more » ... signaling, antioxidation. The therapeutic relevance of vitamin E has increased due to the incrimination of oxidative stress as a link in the pathophysiology of many chronic diseases. Respectively, the role most targeted is that of antioxidant.
doi:10.37358/rc.19.10.7630 fatcat:t73lbotx3jckpp4fiz7nzyreqm


Carp Liliana, Friptuleac Grigore
2020 Zenodo  
Objectives. Ensuring the population with quality drinking water and in appropriate quantities, is one of the priority tasks of the state, aimed at improving health indicators and welfare of the population of the Republic of Moldova. The aim of the study was the assessment of quantitative and qualitative features of drinking water supply in the Republic of Moldova. Materials and methods. In order to achieve the objectives of the current study, there were used hygienic, sanitary-chemical and
more » ... stical investigation methods. There were evaluated the results of laboratory investigations, performed during the audit monitoring of the quality of drinking water, used for drinking purposes, by the population of the Republic of Moldova, for the period 2015-2019. Results and discussions. Currently, the population of the Republic of Moldova is supplied with water, for drinking purposes, from underground and surface sources. The share of water non-conformity in urban aqueducts, fed from surface and underground sources, is, respectively, on average, 8.6% and 40.1% (for microbiological parameters, corresponding to 6.3% and 5.6%). In aqueducts, in rural localities, fed mainly from underground sources, the average share of water non-compliance with chemical parameters is 52.0% (microbiological – 21.0%). The population that does not have access to centralized sources of drinking water, use water from mine wells, which, in 77.2 percent of cases, does not correspond according to chemical parameters and, in 47.6 percent of cases, according to microbiological parameters. Recently, there has been an improvement in the quality of water in children's and medical institutions. Conclusions. In order to provide the population with safe, quality water, well-coordinated multisector interventions and a political will of national decision-makers are needed.
doi:10.5281/zenodo.4173979 fatcat:6e3fkskcnzeflnb3q4uoo4jzzi

Biological Features of Tumors Results of Experimental Studies

Ana Camelia Grigore, Camelia Busila, Ioana Bianca Chesaru, Alina Calin, Liliana Lacramioara Pavel
2017 Revista de chimie (Bucuresti)  
Tumor anaplasia can be of varying degrees, being especially marked in fast-growing malignant tumors. Blastomatose tissue is characterized by morphological, chemical, physico-chemical and energetic anaplasia. Structural changes of the tissue specific to blastomatose growth often provide the opportunity to differentiate this tissue from a normal or any other growing tissue. Out of various factors that may influence the external environment of tumors, we should mention food, profession, living and
more » ... working conditions. Tumors and especially malignant tumors are accompanied by changes in the entire body. These are not just a consequence of the blastomatose growth but also play a role in its subsequent development. Experimental tumors are one of the methods of studying the issue of blastomatose growth. The tumor transplantation method is widespread and extensively applied in laboratory practice. It uses standard strains of tumors (rats, mice, etc.). The simplicity of the tumor transplantation method, which consists of the inoculation under the skin of animals of tumor fragments using a trocar or of the injection of a tumor emulsion under aseptic conditions, enables researchers to maintain the purity of the strain for a long time. Various views have been formulated at different times on the origin of tumor growth in accordance with the level of knowledge on this issue.
doi:10.37358/rc.17.3.5508 fatcat:wz5qnxt47vbgrnsjer4zhyhzbq

The Challenge of Lipid Management in Patients with Diabetes or Other Endocrine Disorders

Alberico L Catapano, Liliana Grigore, Angela Pirillo
2010 European Endocrinology  
Diabetes increases the risk of developing cardiovascular disease (CVD), and several guidelines suggest that subjects with diabetes are at high risk of developing CVD. The increased risk can be attributed, at least in part, to associated risk factors, including hypertension and dyslipidaemia. The role of statins in primary and secondary prevention of CVD is well established, and the positive effect has been clearly demonstrated also in patients with type 2 diabetes. A number of studies have
more » ... ated the effect of statin therapy on incident CVD and shown that statin therapy produces a great reduction in cardiovascular risk, but a recent meta-analysis revealed a slight increase in the risk of developing diabetes. Such risk is, however, low, especially when compared with the reduction in cardiovascular events and should not interfere with the choice of treating diabetic patients with a cholesterol-lowering therapy.
doi:10.17925/ee.2011.07.02.92 fatcat:rm6362epz5acfpvbdidtejxye4

Chemical Senses Taste Sensation and Chemical Composition

Cerasela Dorina Sincar, Camelia Ana Grigore, Silvia Martu, Liliana Lacramioara Pavel, Alina Calin, Alina Plesea Condratovici, Bianca Ioana Chesaru
2017 Materiale plastice  
Taste and smell are chemical senses, which means that the receptors (chemoreceptors) of these senses respond to chemical stimuli. In order for a substance to produce a taste sensation, it should be ingested in a solution or subsequently dissolved in saliva; a solid substance put in the mouth perfectly dry is tasteless. Therefore, taste receptors or taste buds occur only on wet surfaces, more precisely in the oral cavity in land vertebrates; however, in aquatic animals, these receptors are
more » ... red all over the body. There are functionally different types of receptors for each of the primary tastes and the distribution of each type is not even on the surface of the tongue mucosa. The sweet and sour sensitive buds are located mainly on the tip of the tongue, those sensitive to acids are located on the sides of the tongue and those stimulated by the bitter taste are located towards the back of the tongue and in the epiglottis area. Taste may be generated by substances which touch the taste buds through the blood; thus, histamine injected intravenously causes a metallic taste, glucin a sweet taste, whereas jaundice may trigger a bitter taste due to the big concentration of gallbladder constituents in the blood.
doi:10.37358/mp.17.1.4810 fatcat:oiqqzfkuabgxpjghs447ppkq5m

Combination therapy in cholesterol reduction: focus on ezetimibe and statins

Liliana Grigore, Giuseppe Danilo Norata, Alberico L Catapano
2008 Vascular Health and Risk Management  
Although widely used in lipid lowering therapy, HMG CoA reductase inhibitors (even when administered at high doses) are frequently insufficient to achieve guideline-recommended LDL-C goals for many patients with hypercholesterolemia in everyday clinical practice. Many patients do not achieve LDL-C goal on the initial dose of statin and the majority of these patients does not reach their goal after 6 months. As a consequence, a wide therapeutic gap exists between target LDL-C levels and those
more » ... ically achieved in clinical practice. A recent and more effective therapeutic hypocholesterolemic strategy is to treat the two main sources of cholesterol simultaneously (production of cholesterol, mainly in the liver, and absorption of cholesterol in the intestine) with a complementary mechanism of action, by co-administering ezetimibe, a novel agent inhibiting cholesterol absorption, with a statin, which inhibits cholesterol production in the liver. Ezetimibe can be effectively and safely co-administered with any dose of any statin and, compared with the single inhibition of cholesterol production, afforded by statins alone, provides consistently greater reductions in LDL-C through dual inhibition of both cholesterol production and absorption. We summarize the pivotal role of both the liver and intestine in the overall balance of cholesterol in the body and describe the clinical impact and relevance of using ezetimibe either alone or co-administered with statins in controlling elevated levels of plasma LDL cholesterol.
pmid:18561502 pmcid:PMC2496970 fatcat:4tigs6xgsrebxjl4zahgx5f6ie

Rare Romanian Ethnographic Textiles—Reverse Engineering of Fabrics for Fashion Trends

ElSayed A. Elnashar, Liliana Indrie, Dorina Camelia Ilieş, Zlatin Zlatev, Grigore Vasile Herman, Cristina Secan, Jan A. Wendt
2022 Sustainability  
(1) Investigating, collecting data with specific character, as well as registering and investigating data concerning ornaments and colors, patterns as expressive possibilities of designs of Romanian folk textile are important activities to do. The first goal of the research undertaken was to collect, preserve, and protect knowledge about old patterns and weaving techniques in selected regions of Romania, and the second to use old patterns for the modern needs of folk handicraft weaving and the
more » ... lothing industry. (2) In the undertaken research, material was obtained from antique textiles, clothes, and paintings on canvas, from selected objects in the Maramureș region and Bihor region. The selection was made by the ReliefF method. The specimens of specification throw weight by the geometry method was used to characterize the types of weaving techniques. Principal component analysis methods were used to reduce the amount of data of the vector of textural features. (3) The research on selected Romanian textiles allowed for the construction of a model of texture features that describes them. The results include the specimens' measurements, analysis of fabric structures, yarn specification, and the reconstruction of the fabrics. Based on the obtained results, a simulation of fashion trends was performed. (4) The analysis of individual components increased the knowledge of weaving techniques in the studied regions and may be an inspiration for contemporary design in local and regional handicrafts as well as in the clothing industry.
doi:10.3390/su14116859 fatcat:xycnqsctajbunfxcfhyxa4hvqu

Common themes in antimicrobial and anticancer drug resistance

Mariana Carmen Chifiriuc, Roxana Filip, Marian Constantin, Gratiela Gradisteanu Pircalabioru, Coralia Bleotu, Liliana Burlibasa, Elena Ionica, Nicolae Corcionivoschi, Grigore Mihaescu
2022 Frontiers in Microbiology  
Antimicrobial and anticancer drug resistance represent two of the main global challenges for the public health, requiring immediate practical solutions. In line with this, we need a better understanding of the origins of drug resistance in prokaryotic and eukaryotic cells and the evolutionary processes leading to the occurrence of adaptive phenotypes in response to the selective pressure of therapeutic agents. The purpose of this paper is to present some of the analogies between the
more » ... l and anticancer drug resistance. Antimicrobial and anticancer drugs share common targets and mechanisms of action as well as similar mechanisms of resistance (e.g., increased drug efflux, drug inactivation, target alteration, persister cells' selection, protection of bacterial communities/malignant tissue by an extracellular matrix, etc.). Both individual and collective stress responses triggered by the chemotherapeutic agent involving complex intercellular communication processes, as well as with the surrounding microenvironment, will be considered. The common themes in antimicrobial and anticancer drug resistance recommend the utility of bacterial experimental models for unraveling the mechanisms that facilitate the evolution and adaptation of malignant cells to antineoplastic drugs.
doi:10.3389/fmicb.2022.960693 pmid:36003940 pmcid:PMC9393787 fatcat:73tstxa24rgcvihehuzo5ubcwi

Heritage ethnographic objects – antimicrobial effects of chitosan treatment

2021 Industria Textila  
Chitosan is a natural polymer, which presents, according to studies made up to present, low toxicity and goodbiocompatibility. Recent studies are focused not only on its antimicrobial effects on textiles, because this polysaccharideleads to improvements such as: shrink resistance, dye uptake etc. Two Romanian traditional shirts were non-invasively tested by applying Chitosan and by investigating the SEM images,before and after applying the chitosan. The paper underlines the surface
more » ... of tested textiles using chitosan.The odd agents on the fibres surfaces were removed and the limitation of the number of microorganisms was observed
doi:10.35530/it.072.03.1812 fatcat:6p353gt64fdc7gun7kazb7t34u

Orbital complications of acute rhinosinusitis

Gloria Munteanu, Serban Bertesteanu, Denisa Mitran, Mihnea Condeescu-Cojocarita, Bogdan Popescu, Paula Pascu, Catrinel Antonie, Liliana Nitu, Radu Popescu, Anca Cirstea, Elena Arjoca, Alexandru Nicolaescu (+1 others)
2018 International Bulletin of Otorhinolaryngology  
Introduction. Rhinosinusitis is the infection and inflammation of at least one of the 4 paranasal sinuses (frontal, maxillary, ethmoid and sphenoid). Their correct diagnosis is generally determined by examining the patient clinically and by rhinosinusal endoscopic examination. There are also cases that show complications or continued evolution despite the correct treatment, and then we will use some imaging investigations to find out more about affection(radiography of anterior sinuses of the
more » ... ce, sinus computerized tomography, sinus magnetic resonance imaging). In particular, acute rhinosinusitis should be carefully managed to avoid complications such as the local ones: orbital cellulitis, orbital abscess, osteomyelitis, cavernous sinus thrombosis; and intracranial complications: meningitis, epidural abscess, subdural abscess, cerebral abscess. Materials and methods. There will be presented all orbital complications according to the cases treated in the ENT Clinic of the Coltea Clinical Hospital. Conclusions. Diagnosis of rhinosinusitis is largely clinical and endoscopic. When complications of the condition arise, these should be investigated imagistically to determine their exact extent and to institute the correct treatment as soon as possible. The complications of rhinosinusitis are medical and surgical life-threatening emergencies, which is why in order to diagnose and correct and quickly institute therapy requires a multidisciplinary approach.
doi:10.14748/orl.v14i3.6761 fatcat:o6auvopyl5dntj2to4gp6za7wm

Chitosan – a non-invasive approach for the preservation of historical textiles

2020 Industria Textila  
doi:10.35530/it.071.06.1756 fatcat:ldxz6exifzbjrk6u4ivxwoy6xm

Polypropylene Mesh in Minimally Invasive Treatment of Female Stress Urinary Incontinence

Nicolae Grigore, Valentin Pirvut, Ionela Mihai, Adrian Hasegan, Elisabeta Antonescu, Liliana Coldea, Sebastian Ioan Cernusca Mitariu
2017 Materiale plastice  
Stress urinary incontinence in women is a condition widely encountered in the entire world with a prevalence between 12.8% and 46.0%. Stress urinary incontinence is a public health problem causing a significant decrease in quality of life, involving social, physical, psychological, occupational and sexual suffering of patients. The minimal invasive treatment of the stress urinary incontinence (SUI) consists in fixing a suburethral polypropylene mesh (SPM) in retropubic (TVT) or transobturator
more » ... OT) space, in order to regain the pelvic support of the urethra, with the consecutive augmentation of the pressure of urethral closing during effort. The objective of this paper is to present the advantage of SPM in the SUI treatment in the eleven years� experience of Department of Urology Sibiu.
doi:10.37358/mp.17.4.4915 fatcat:tsdxaa2gnbbejjgqolv5bhva6i
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