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Little is known about the prevalence and severity of allergic reactions caused by terrestrial arthropods in Romania although bites and stings of arthropods represent a widely recognized public health issue. We conducted a retrospective study in Constanța, the largest city at the Romanian Black Sea coast, and documented 207 cases during 2013–2014, representing 0.5% of the total number of records at the Emergency Department of the County Clinical Emergency Hospital. Young men and women presenteddoi:10.1515/travmu-2016-0005 fatcat:y26jsz6d6rfxje6bfbgutudmam
more »... hemselves more often to the hospital to report this type of injuries and most arthropods causing allergic reactions were not identified. Our study brings novel information on the prevalence of injuries inflicted by terrestrial arthropods on the human adult population at the Romanian Black Sea coast, it highlights existing knowledge gaps and provides information on which to base future guidelines.
The chronic hepatitis C is a frequently problem in worldwide, the number of infected individuals is high and go on, getting a public health problem . In Romania there are nearly 1 million persons infected with hepatitis C virus, the scope of spreading is related with specific risk factors. An important number of infection with hepatitis C virus present simultaneous extrahepatic manifestations proved to be alone manifestation tracing; its important for diagnosis and treatment. We analyzed thedoi:10.37358/rc.17.9.5844 fatcat:7dt2yn6eqjbe3lxkcgmtwmtspq
more »... effects of interferon and ribavirin in chronic hepatitis C in General C.F. Hospital Sibiu, between 2008 � 2012. The association between infection with hepatitis C virus and extrahepatic manifestations is important to be recognized for adequate diagnosis tests. By comparing the results of therapy in patients with hepatic and extrahepatic manifestations, the study found that 30 patients (58.83 %) with liver manifestations had an incomplete response versus 10 patients (26.32 %) with extrahepatic manifestations; 11 patients (21.54 %) with hepatic manifestations had a complete response versus 3 patients (7.89 %) with extrahepatic manifestations; and 10 patients (19.63 %) with hepatic manifestations did not respond to treatment versus 25 patients (65.79 %) with extrahepatic manifestations. Analyzing the results of antiviral therapy in patients with hepatic manifestations and those with extrahepatic manifestations, antiviral treatment appears to be more advantageous in cases with only hepatic manifestations.
Introduction. Melanoma is an aggressive tumor with an increasing incidence worldwide. In-transit metastases represent a unique pattern of dissemination. Case report. We report the case of a 42-year-old woman who presented with two lesions on the left latero-cervical region: a pigmented macule with irregular borders and colors and a firm, dome-shaped 5 mm nodule with an erythematous base and a black crust on top, at the periphery of the first lesion. The clinical picture supported the diagnosisdoi:10.15386/cjmed-525 fatcat:5qmo3j5ahvcubnhx2qntrsuy4y
more »... f melanoma with in-transit metastasis, but the histopathology examination raised, initially, the problem of two primary melanomas: a superficial spreading melanoma and a minimal deviation melanoma. Conclusions. Our case highlights the necessity of clinical and histopathological correlations in every case and the necessity of a good collaboration between the dermatologist and the pathologist.
Maintaining cellular homeostasis in the context of its normal metabolic function is achieved by establishing the balance between its own antioxidant capacity and the level of harmful compounds resulting from the mitochondrial activity and the immune system. One of the antioxidants involved in this process is vitamin E with its most active form -alpha-tocopherol, which exerts its functions through vitamin C. The main functions of this antioxidant are: regulation of platelet aggregation, cellulardoi:10.37358/rc.19.10.7630 fatcat:t73lbotx3jckpp4fiz7nzyreqm
more »... signaling, antioxidation. The therapeutic relevance of vitamin E has increased due to the incrimination of oxidative stress as a link in the pathophysiology of many chronic diseases. Respectively, the role most targeted is that of antioxidant.
Objectives. Ensuring the population with quality drinking water and in appropriate quantities, is one of the priority tasks of the state, aimed at improving health indicators and welfare of the population of the Republic of Moldova. The aim of the study was the assessment of quantitative and qualitative features of drinking water supply in the Republic of Moldova. Materials and methods. In order to achieve the objectives of the current study, there were used hygienic, sanitary-chemical anddoi:10.5281/zenodo.4173979 fatcat:6e3fkskcnzeflnb3q4uoo4jzzi
more »... stical investigation methods. There were evaluated the results of laboratory investigations, performed during the audit monitoring of the quality of drinking water, used for drinking purposes, by the population of the Republic of Moldova, for the period 2015-2019. Results and discussions. Currently, the population of the Republic of Moldova is supplied with water, for drinking purposes, from underground and surface sources. The share of water non-conformity in urban aqueducts, fed from surface and underground sources, is, respectively, on average, 8.6% and 40.1% (for microbiological parameters, corresponding to 6.3% and 5.6%). In aqueducts, in rural localities, fed mainly from underground sources, the average share of water non-compliance with chemical parameters is 52.0% (microbiological – 21.0%). The population that does not have access to centralized sources of drinking water, use water from mine wells, which, in 77.2 percent of cases, does not correspond according to chemical parameters and, in 47.6 percent of cases, according to microbiological parameters. Recently, there has been an improvement in the quality of water in children's and medical institutions. Conclusions. In order to provide the population with safe, quality water, well-coordinated multisector interventions and a political will of national decision-makers are needed.
Tumor anaplasia can be of varying degrees, being especially marked in fast-growing malignant tumors. Blastomatose tissue is characterized by morphological, chemical, physico-chemical and energetic anaplasia. Structural changes of the tissue specific to blastomatose growth often provide the opportunity to differentiate this tissue from a normal or any other growing tissue. Out of various factors that may influence the external environment of tumors, we should mention food, profession, living anddoi:10.37358/rc.17.3.5508 fatcat:wz5qnxt47vbgrnsjer4zhyhzbq
more »... working conditions. Tumors and especially malignant tumors are accompanied by changes in the entire body. These are not just a consequence of the blastomatose growth but also play a role in its subsequent development. Experimental tumors are one of the methods of studying the issue of blastomatose growth. The tumor transplantation method is widespread and extensively applied in laboratory practice. It uses standard strains of tumors (rats, mice, etc.). The simplicity of the tumor transplantation method, which consists of the inoculation under the skin of animals of tumor fragments using a trocar or of the injection of a tumor emulsion under aseptic conditions, enables researchers to maintain the purity of the strain for a long time. Various views have been formulated at different times on the origin of tumor growth in accordance with the level of knowledge on this issue.
Diabetes increases the risk of developing cardiovascular disease (CVD), and several guidelines suggest that subjects with diabetes are at high risk of developing CVD. The increased risk can be attributed, at least in part, to associated risk factors, including hypertension and dyslipidaemia. The role of statins in primary and secondary prevention of CVD is well established, and the positive effect has been clearly demonstrated also in patients with type 2 diabetes. A number of studies havedoi:10.17925/ee.2011.07.02.92 fatcat:rm6362epz5acfpvbdidtejxye4
more »... ated the effect of statin therapy on incident CVD and shown that statin therapy produces a great reduction in cardiovascular risk, but a recent meta-analysis revealed a slight increase in the risk of developing diabetes. Such risk is, however, low, especially when compared with the reduction in cardiovascular events and should not interfere with the choice of treating diabetic patients with a cholesterol-lowering therapy.
Taste and smell are chemical senses, which means that the receptors (chemoreceptors) of these senses respond to chemical stimuli. In order for a substance to produce a taste sensation, it should be ingested in a solution or subsequently dissolved in saliva; a solid substance put in the mouth perfectly dry is tasteless. Therefore, taste receptors or taste buds occur only on wet surfaces, more precisely in the oral cavity in land vertebrates; however, in aquatic animals, these receptors aredoi:10.37358/mp.17.1.4810 fatcat:oiqqzfkuabgxpjghs447ppkq5m
more »... red all over the body. There are functionally different types of receptors for each of the primary tastes and the distribution of each type is not even on the surface of the tongue mucosa. The sweet and sour sensitive buds are located mainly on the tip of the tongue, those sensitive to acids are located on the sides of the tongue and those stimulated by the bitter taste are located towards the back of the tongue and in the epiglottis area. Taste may be generated by substances which touch the taste buds through the blood; thus, histamine injected intravenously causes a metallic taste, glucin a sweet taste, whereas jaundice may trigger a bitter taste due to the big concentration of gallbladder constituents in the blood.
Although widely used in lipid lowering therapy, HMG CoA reductase inhibitors (even when administered at high doses) are frequently insufficient to achieve guideline-recommended LDL-C goals for many patients with hypercholesterolemia in everyday clinical practice. Many patients do not achieve LDL-C goal on the initial dose of statin and the majority of these patients does not reach their goal after 6 months. As a consequence, a wide therapeutic gap exists between target LDL-C levels and thosepmid:18561502 pmcid:PMC2496970 fatcat:4tigs6xgsrebxjl4zahgx5f6ie
more »... ically achieved in clinical practice. A recent and more effective therapeutic hypocholesterolemic strategy is to treat the two main sources of cholesterol simultaneously (production of cholesterol, mainly in the liver, and absorption of cholesterol in the intestine) with a complementary mechanism of action, by co-administering ezetimibe, a novel agent inhibiting cholesterol absorption, with a statin, which inhibits cholesterol production in the liver. Ezetimibe can be effectively and safely co-administered with any dose of any statin and, compared with the single inhibition of cholesterol production, afforded by statins alone, provides consistently greater reductions in LDL-C through dual inhibition of both cholesterol production and absorption. We summarize the pivotal role of both the liver and intestine in the overall balance of cholesterol in the body and describe the clinical impact and relevance of using ezetimibe either alone or co-administered with statins in controlling elevated levels of plasma LDL cholesterol.
(1) Investigating, collecting data with specific character, as well as registering and investigating data concerning ornaments and colors, patterns as expressive possibilities of designs of Romanian folk textile are important activities to do. The first goal of the research undertaken was to collect, preserve, and protect knowledge about old patterns and weaving techniques in selected regions of Romania, and the second to use old patterns for the modern needs of folk handicraft weaving and thedoi:10.3390/su14116859 fatcat:xycnqsctajbunfxcfhyxa4hvqu
more »... lothing industry. (2) In the undertaken research, material was obtained from antique textiles, clothes, and paintings on canvas, from selected objects in the Maramureș region and Bihor region. The selection was made by the ReliefF method. The specimens of specification throw weight by the geometry method was used to characterize the types of weaving techniques. Principal component analysis methods were used to reduce the amount of data of the vector of textural features. (3) The research on selected Romanian textiles allowed for the construction of a model of texture features that describes them. The results include the specimens' measurements, analysis of fabric structures, yarn specification, and the reconstruction of the fabrics. Based on the obtained results, a simulation of fashion trends was performed. (4) The analysis of individual components increased the knowledge of weaving techniques in the studied regions and may be an inspiration for contemporary design in local and regional handicrafts as well as in the clothing industry.
Antimicrobial and anticancer drug resistance represent two of the main global challenges for the public health, requiring immediate practical solutions. In line with this, we need a better understanding of the origins of drug resistance in prokaryotic and eukaryotic cells and the evolutionary processes leading to the occurrence of adaptive phenotypes in response to the selective pressure of therapeutic agents. The purpose of this paper is to present some of the analogies between thedoi:10.3389/fmicb.2022.960693 pmid:36003940 pmcid:PMC9393787 fatcat:73tstxa24rgcvihehuzo5ubcwi
more »... l and anticancer drug resistance. Antimicrobial and anticancer drugs share common targets and mechanisms of action as well as similar mechanisms of resistance (e.g., increased drug efflux, drug inactivation, target alteration, persister cells' selection, protection of bacterial communities/malignant tissue by an extracellular matrix, etc.). Both individual and collective stress responses triggered by the chemotherapeutic agent involving complex intercellular communication processes, as well as with the surrounding microenvironment, will be considered. The common themes in antimicrobial and anticancer drug resistance recommend the utility of bacterial experimental models for unraveling the mechanisms that facilitate the evolution and adaptation of malignant cells to antineoplastic drugs.
Chitosan is a natural polymer, which presents, according to studies made up to present, low toxicity and goodbiocompatibility. Recent studies are focused not only on its antimicrobial effects on textiles, because this polysaccharideleads to improvements such as: shrink resistance, dye uptake etc. Two Romanian traditional shirts were non-invasively tested by applying Chitosan and by investigating the SEM images,before and after applying the chitosan. The paper underlines the surfacedoi:10.35530/it.072.03.1812 fatcat:6p353gt64fdc7gun7kazb7t34u
more »... of tested textiles using chitosan.The odd agents on the fibres surfaces were removed and the limitation of the number of microorganisms was observed
Introduction. Rhinosinusitis is the infection and inflammation of at least one of the 4 paranasal sinuses (frontal, maxillary, ethmoid and sphenoid). Their correct diagnosis is generally determined by examining the patient clinically and by rhinosinusal endoscopic examination. There are also cases that show complications or continued evolution despite the correct treatment, and then we will use some imaging investigations to find out more about affection(radiography of anterior sinuses of thedoi:10.14748/orl.v14i3.6761 fatcat:o6auvopyl5dntj2to4gp6za7wm
more »... ce, sinus computerized tomography, sinus magnetic resonance imaging). In particular, acute rhinosinusitis should be carefully managed to avoid complications such as the local ones: orbital cellulitis, orbital abscess, osteomyelitis, cavernous sinus thrombosis; and intracranial complications: meningitis, epidural abscess, subdural abscess, cerebral abscess. Materials and methods. There will be presented all orbital complications according to the cases treated in the ENT Clinic of the Coltea Clinical Hospital. Conclusions. Diagnosis of rhinosinusitis is largely clinical and endoscopic. When complications of the condition arise, these should be investigated imagistically to determine their exact extent and to institute the correct treatment as soon as possible. The complications of rhinosinusitis are medical and surgical life-threatening emergencies, which is why in order to diagnose and correct and quickly institute therapy requires a multidisciplinary approach.
DOI: 10.35530/IT.071.06.1756 EVA BOU-BELDA ZHARAS BERDENOV LILIANA INDRIE GRIGORE HERMAN DORINA CAMELIA ILIEȘ TUDOR CACIORA NICOLAIE HODOR The aim of our study is to test the feasibility of ...doi:10.35530/it.071.06.1756 fatcat:ldxz6exifzbjrk6u4ivxwoy6xm
Stress urinary incontinence in women is a condition widely encountered in the entire world with a prevalence between 12.8% and 46.0%. Stress urinary incontinence is a public health problem causing a significant decrease in quality of life, involving social, physical, psychological, occupational and sexual suffering of patients. The minimal invasive treatment of the stress urinary incontinence (SUI) consists in fixing a suburethral polypropylene mesh (SPM) in retropubic (TVT) or transobturatordoi:10.37358/mp.17.4.4915 fatcat:tsdxaa2gnbbejjgqolv5bhva6i
more »... OT) space, in order to regain the pelvic support of the urethra, with the consecutive augmentation of the pressure of urethral closing during effort. The objective of this paper is to present the advantage of SPM in the SUI treatment in the eleven years� experience of Department of Urology Sibiu.
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