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Crystal structure of Senecavirus A 3C protease
[article]
2020
bioRxiv
pre-print
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Senecavirus A (SVA), an emerging picornavirus in porcine population, could infect porcines of all age group and cause FMD-like symptoms. Picornaviridae, a group of RNA viruses do harm to both human and stocks; however, most of picornaviruses are lack of effective vaccines and drugs. Picornaviral 3C protease (3Cpro), as an important role in virus maturation, they basically take charge of poly-protein cleavaging, RNA replication, and multiple interventions on host cells. In this study, we
doi:10.1101/2020.02.21.959106
fatcat:pfyitf55qzamnhdojtu45wekvy
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... ully solved the crystal structure of 3Cpro at 1.9 astron resolution. The results showed several differences of the binding groove within picornaviral 3Cpro, and prompted that the accommodate ability of the pocket may associate with the cleavage efficiency. The further research on 3Cpro cleavage efficiency based on structural biology, will prospectively provide an instruction on designing of efficient 3Cpro for universally proteolysis in picornaviral VLP production.
Synthesis of 1,2,6-Trisubstituted Benzimidazoles
2018
Youji huaxue
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[18] 、 Kanhed [19] 和 Zhang [20] 的方法, 以 3-氟-4-硝基苄 腈和苄胺为原料合成 1a 为例, 结果见表 1. 从表 1 可以看出, 加入 K 2 CO 3 后, 反应时间缩短, 反应温度降低, 收率提高. 原因在于 K 2 CO 3 在反应中既 是碱, 催化反应进行, 还可以吸收反应生成的 HF, 促进 反应向正反应方向进行 [20] . ...
doi:10.6023/cjoc201802027
fatcat:wcghrdzlv5caxdicnqmem5joe4
Genetic Electromagnetism-Like Mechanism Based Power System Optimization Research
2017
Chemical Engineering Transactions
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According to the analysis of theory about hydrothermal power system energysaving (Zhang et al., 2013) , in order to bring complementary operation of hydrothermal power system into full play (El-Hana ...
doi:10.3303/cet1762186
doaj:5e2cf4937bf04e7da3d39231d409e10c
fatcat:itb4yqouxvby7kdkl6afb2kdia
Two new taraxerane-type triterpenes from Ledum palustre L
2019
Figshare
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Two new compounds, namely 6α-hydroxy-14-taraxerene-3,16,21-trione and 6α,26-dihydroxy-14-taraxerene-3,16,21-trione were isolated from the Ledum palustre L. Their chemical structures were confirmed after a combined analysis of IR, HR-ESI-TOFMS, 1D-NMR, and 2D-NMR. The compounds were evaluated for cell growth inhibitory activity against two cancer cell lines.
doi:10.6084/m9.figshare.7929737
fatcat:wlr6hbm6vbd6lam5oaw7b5zme4
A peptide derived from apoptin inhibits glioma growth
2017
OncoTarget
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Glioblastoma (GBM) is associated with poor prognosis due to its resistance to surgery, irradiation, and conventional chemotherapy. Thus, efficient therapeutic approaches for the treatment of GBM are urgently needed. HSP70 is an antiapoptotic protein that participates in the inhibition of both mitochondrial and membrane receptor apoptosis pathways and is highly expressed in glioma tissues. Here, we investigated a derivative of apoptin; specifically, a chicken anemia viral protein with selective
doi:10.18632/oncotarget.16094
pmid:28415709
pmcid:PMC5458194
fatcat:yvsczwwjxzfohglfpgxzfcxbva
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... oxicity toward cancer cells that can inhibit hyperactive molecules, including HSP70. Our earlier studies demonstrated that apoptin directly binds to the promoter of HSP70 and inhibits HSP70 transcription, which contributes to HSP70 downregulation. This study provides the first demonstration of the therapeutic potential of an apoptin- derived peptide for the treatment of GBM by identifying the minimal region of the apoptin domain required for interaction with the heat-shock element (HSE). This apoptin-derived peptide (ADP) inhibits glioma cell proliferation and tumor growth as well as exhibits an increased ability to promote apoptosis in GBM cells compared with rapamycin and temozolomide. ADP treatment inhibited xenograft tumor growth and increased the overall health and survival of nude mice implanted with GBM cells. These effects were measured in tumors obtained from cell lines and were observed in both intracranial and subcutaneous xenografts. In conclusion, we provide the first demonstration that ADP has therapeutic potential for the treatment of human GBM. Specifically, this study suggests that ADP is a potent candidate for drug development based on its favorable toxicity and pharmacokinetic profiles as well as its time-and cost-saving benefits.
Edge Anonymity in Social Network Graphs
2009
2009 International Conference on Computational Science and Engineering
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Edges in social network graphs can model sensitive relationships. In this paper, we consider the problem of edges anonymity in graphs. We propose a probabilistic notion of edge anonymity, called graph confidence, which is general enough to capture the privacy breach made by an adversary who is able to pinpoint target persons in a graph partition based on any given set of topological features of vertexes. We then focus on a special type of edge anonymity problem which uses vertex degree to
doi:10.1109/cse.2009.310
dblp:conf/cse/ZhangZ09
fatcat:bgf6ayn6angi7jojdufpu2kovu
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... ion a graph. We analyze edge disclosure in real-world social networks and show that even if graphs are anonymized to prevent vertex disclosure, they still do not guarantee edge anonymity. We present three heuristic algorithms that protect edge anonymity using edge swap or edge deletion. Our experimental results, based on three real-world social networks and several utility measures, show that these algorithms can effectively protect edge anonymity and obtain anonymous graphs of acceptable utility.
C-V characteristics of piezotronic metal-insulator-semiconductor transistor
2019
Science Bulletin
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Jiayang Zheng, Yongli Zhou, Yaming Zhang, and Yan Zhang fabricated theoretic frame and analysed the data. ...
Author contributions Jiayang Zheng, Yongli Zhou, and Yaming Zhang contributed equally to this work. Yan Zhang conceived the idea and guided this work. ...
Zhou, Yaming Zhang, Lijie Li, and Yan Zhang wrote this paper. All the authors discussed the results and commented on the manuscript. ...
doi:10.1016/j.scib.2019.11.001
fatcat:mg6kaeviefhq7pz62b7otnmmye
Sildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke in Rats
2002
Stroke
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Zhang et al Sildenafil Use After Stroke
Effects of Sildenafil on Immature Neurons Administration of sildenafil robustly increased number of TuJ1immunoreactive cells in the ipsilateral subventricular ...
doi:10.1161/01.str.0000034399.95249.59
pmid:12411660
fatcat:xow3pxp37jfk7fqakgu24do4rq
Two new species of Apophylia from China (Coleoptera: Chrysomelidae: Galerucinae)
2006
Zenodo
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Bezděk, Jan, Zhang, Lijie (2006): Two new species of Apophylia from China (Coleoptera: Chrysomelidae: Galerucinae). Acta Entomologica Musei Nationalis Pragae 46: 145-150 ...
., / det.Bezděk & Zhang 2006'. ...
doi:10.5281/zenodo.5325365
fatcat:5sak5khldjfe3lwrwgbfinavku
In-Plane Anisotropic Thermal Conductivity of Low-Symmetry PdSe2
2021
Sustainability
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Low-symmetry two-dimensional (2D) materials have exhibited novel anisotropic properties in optics, electronics, and mechanics. Such characteristics have opened up new avenues for fundamental research on nano-electronic devices. In-plane thermal conductivity plays a pivotal role in the electronic performance of devices. This article reports a systematic study of the in-plane anisotropic thermal conductivity of PdSe2 with a pentagonal, low-symmetry structure. An in-plane anisotropic ratio up to
doi:10.3390/su13084155
fatcat:arm5adll7jhftajg4gp4edvcfa
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... 42 was observed by the micro-Raman thermometry method. In the Raman scattering spectrum, we extracted a frequency shift from the mode with the most sensitivity to temperature. The anisotropic thermal conductivity was deduced by analyzing the heat diffusion equations of suspended PdSe2 films. With the increase in thickness, the anisotropy ratio decreased gradually because the thermal conductivity in the x-direction increased faster than in the y-direction. The anisotropic thermal conductivity provides thermal management strategies for the next generation of nano-electronic devices based on PdSe2.
Molecular dynamic simulations on TKX-50/HMX cocrystal
2017
RSC Advances
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TKX-50/HMX cocrystal model was established and calculated using PCFF force field by molecular dynamics simulations.
doi:10.1039/c6ra26146a
fatcat:dxlcqehjqzfbdnlv2kny3zuyby
Piezotronic spin and valley transistors based on monolayer MoS2
2020
Nano Energy
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Piezotronics and piezo-phototronics based on the third generation semiconductors are two novel fields for low power consumption, self-powered technology and internet of things. Strain-induced piezoelectric field plays a key role to modulate not only charge-carrier transport but also quantum transport properties in piezoelectric semiconductors, especially for two-dimensional materials which can withstand large strain. In this paper, we theoretically study piezotronic effect on the modulation of
doi:10.1016/j.nanoen.2020.104678
fatcat:heeeqihtabe6hoiip3rgdulgum
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... pin and valley properties in single-layered MoS 2 . Spin-and valley-dependent conductance, electronic density distribution and polarization ratio are investigated by quantum transport calculation. Because of piezotronic effect, strain-gated spin and valley transistors have excellent quantum state selectivity using by strain. Our work provides not only piezotronic effect on spin and valley quantum states, but also a guidance for designing novel quantum piezotronic devices. 2
Strength Model of Backfill-Rock Irregular Interface Based on Fractal Theory
2021
Frontiers in Materials
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Frontiers in Materials | www.frontiersin.org December 2021 | Volume 8 | Article 792014
Zhang et al.Backfill-Rock Interface Strength Model ...
doi:10.3389/fmats.2021.792014
fatcat:l2vcqlr3mfhhxjjdchz2eonoeq
Piezophototronic effect enhanced luminescence of zinc oxide nanowires
2016
Nano Energy
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Cite this article as: Yan Zhang and Lijie Li, Piezophototronic effect enhanced luminescence of zinc oxide nanowires, Nano Energy, http://dx. ...
doi:10.1016/j.nanoen.2016.02.039
fatcat:dzuc36nmwrh3bjbdewr7x5wocm
Intriguing hybrid nanotubes with tunable structures
2011
Chemical Physics Letters
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Novel hybrid nanomaterials with iron oxide nanoparticles incorporated in nitrogen-doped carbon nanotube have been synthesized with tunable structures by a ready chemical vapor deposition process. These hybrid nanotubes show promising electronic applications.
doi:10.1016/j.cplett.2011.09.077
fatcat:wuoni675ljhbtc66rr2jhukjlq
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