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Chirality based sensor for bisphenol A detection

Zhou Xu, Liguang Xu, Yingyue Zhu, Wei Ma, Hua Kuang, Libing Wang, Chuanlai Xu
2012 Chemical Communications  
doi:10.1039/c2cc31327h pmid:22516914 fatcat:ocbkkhbchzaztmtcldfo2e5etq

Dynamic Nanoparticle Assemblies

Libing Wang, Liguang Xu, Hua Kuang, Chuanlai Xu, Nicholas A. Kotov
2012 Accounts of Chemical Research  
Liguang Xu is currently a PhD candidate under the guidance of Prof. Chuanlai Xu. His research is focused on the assembly of nanoparticles.  ...  BIOGRAPHICAL INFORMATION Libing Wang received his PhD degrees from Jiangnan University. He is a full professor with research focused on the analytical aspects of nanoparticle assemblies.  ... 
doi:10.1021/ar200305f pmid:22449243 pmcid:PMC3479329 fatcat:3xcel4nhmnfati3ff3cdqvxz6q

Effect of rapamycin on endometriosis in mice

2016 Experimental and Therapeutic Medicine  
The aims of the present study were to investigate the impact of rapamycin (RAPA) on the endometriosis (EMS) lesions in severe combined immunodeficiency (SCID) mice, and to examine the possible mechanism involved in a novel therapy in EMS. Following the successful establishment of an EMS-SCID mouse model, the mice were randomly assigned into the RAPA, control and saline treatment groups. Subsequent to treatment for 2 weeks, the serum hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial
more » ... rowth factor (VEGF) were detected using ELISA. The levels of HIF-1α and VEGF, as well as the size of EMS lesions, were compared among the three groups. In addition, the HIF-1α, VEGF and CD34 protein expression levels, and the microvessel density (MVD) of the lesions were determined by immunohistochemical analysis. Compared with the control and saline groups, the volume of EMS lesions in the RAPA-treated SCID mice was significantly reduced. Furthermore, the serum level and protein expression of VEGF, and the MVD in the lesions of the RAPA-treated group were significantly reduced when compared with the other two groups. These parameters were comparable in the control and saline groups. In conclusion, RAPA may inhibit the growth of endometriotic lesions, most possibly through the inhibition of the expression of VEGF in lesions, thereby inhibiting angiogenesis.
doi:10.3892/etm.2016.3280 pmid:27347023 pmcid:PMC4907216 fatcat:dh6opxe64rgt7jvtunhjfgvkum

Attomolar DNA detection with chiral nanorod assemblies

Wei Ma, Hua Kuang, Liguang Xu, Li Ding, Chuanlai Xu, Libing Wang, Nicholas A. Kotov
2013 Nature Communications  
Nanoscale plasmonic assemblies display exceptionally strong chiral optical activity. So far, their structural design was primarily driven by challenges related to metamaterials whose practical applications are remote. Here we demonstrate that gold nanorods assembled by the polymerase chain reaction into DNA-bridged chiral systems have promising analytical applications. The chiroplasmonic activity of side-by-side assembled patterns is attributed to a 7-9 degree twist between the nanorod axes.
more » ... s results in a strong polarization rotation that matches theoretical expectations. The amplitude of the bisignate 'wave' in the circular dichroism spectra of side-by-side assemblies demonstrates excellent linearity with the amount of target DNA. The limit of detection for DNA using side-by-side assemblies is as low as 3.7 aM. The chiroplasmonic method may be particularly useful for biological analytes larger than 2-5 nm which are difficult to detect by methods based on plasmon coupling and 'hot spots'. Circular polarization increases for inter-nanorod gaps between 2 and 20 nm when plasmonic coupling rapidly decreases. Reaching the attomolar limit of detection for simple and reliable bioanalysis of oligonucleotides may have a crucial role in DNA biomarker detection for early diagnostics of different diseases, forensics and environmental monitoring.
doi:10.1038/ncomms3689 pmid:24162144 pmcid:PMC3826651 fatcat:zwnxh4ygqfacrkzdjwke2besmm

Carbon Nanotubes in Biomedicine and Biosensing [chapter]

Yingyue Zhu, Libing Wang, Chuanlai Xu
2011 Carbon Nanotubes - Growth and Applications  
Wang and Chuanlai Xu (2011) .  ...  (Shim, Chen, Doty, Xu, & Kotov, 2008) .  ... 
doi:10.5772/16558 fatcat:bdgsxi2r4rczfod7uujj7hfjyu

Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics (Theranostics)

Wei Chen, Naifeng Xu, Liguang Xu, Libing Wang, Zuokun Li, Wei Ma, Yingyue Zhu, Chuanlai Xu, Nicholas A. Kotov
2010 Macromolecular rapid communications  
doi:10.1002/marc.200900793 pmid:21590896 fatcat:t7wobu6nqrccro7wbedatuawiy

Sensitive Detection of Silver Ions Based on Chiroplasmonic Assemblies of Nanoparticles

Zhou Xu, Liguang Xu, Luis M. Liz-Marzán, Wei Ma, Nicholas A. Kotov, Libing Wang, Hua Kuang, Chuanlai Xu
2013 Advanced Optical Materials  
Xu and L. Xu contributed equally to this work.  ...  Kotov , Libing Wang , Hua Kuang ,* and Chuanlai Xu * Figure 1 . 1 Schematic representation of the detection of Ag + ions based on Cyt-Ag-Cyt recognition between 10 nm and 25 nm Au NPs, each modifi ed  ...  For the heterodimer assembled by 26 bp DOI: 10.1002/adom.201300148 Sensitive Detection of Silver Ions Based on Chiroplasmonic Assemblies of Nanoparticles Zhou Xu , Liguang Xu , Luis M.  ... 
doi:10.1002/adom.201300148 fatcat:ns4sl4i3ljdhfhrxlfaebo26gy

Overview of Analytical Techniques for Herbicides in Foods [chapter]

Hua Kuang, Libing Wang, Chuanlai Xu
2011 Herbicides, Theory and Applications  
How to reference In order to correctly reference this scholarly work, feel free to copy and paste the following: Hua Kuang, Libing Wang and Chuanlai Xu (2011) .  ... 
doi:10.5772/13355 fatcat:wupaskfmhjbijdval2ez4eeely

A one-step homogeneous plasmonic circular dichroism detection of aqueous mercury ions using nucleic acid functionalized gold nanorods

Yingyue Zhu, Liguang Xu, Wei Ma, Zhou Xu, Hua Kuang, Libing Wang, Chuanlai Xu
2012 Chemical Communications  
Materials 2 Cetyltrimethylammonium bromide (CTAB, 99%) and sodium borohydride, L-ascorbic acid,
doi:10.1039/c2cc36559f pmid:23125979 fatcat:2v7ta2ppwvdzvpzrnjbsfydbku

Development of an Enzyme-Linked Immunosorbent Assay for Dibutyl Phthalate in Liquor

Hua Kuang, Liqiang Liu, Liguang Xu, Wei Ma, Lingling Guo, Libing Wang, Chuanlai Xu
2013 Sensors  
A monoclonal antibody specifically recognizing dibutyl phthalate (DBP) was prepared based on a hapten (di-n-butyl-4-aminophthalate). After optimizing various parameters such as concentrations of antibody, coating antigen and composition of the assay buffer, an inhibition curve was plotted with the 50% inhibition concentration value (IC 50 ) 33.6 ± 2.5 ng/mL. A low level of cross-reactivity (<5%) was found for other phthalate esters. Recovery tests were conducted using liquor simulant (a mixture
more » ... of water and ethanol) at two fortification levels (100 ng/mL and 300 ng/mL). The recovery rates ranged from 84.7% to 94.5% with a coefficient of variation between 7.1% and 12.8%. Nine liquor samples of different alcoholic strengths were detected using the proposed measure and confirmatory analysis was performed using liquid chromatography-mass spectroscopy (LC-MS). The detection results showed good consistency between the two measures and all the data above indicated that the proposed ELISA could be applied in DBP screening.
doi:10.3390/s130708331 pmid:23807690 pmcid:PMC3758596 fatcat:dogwjvzprbewzgidr56njs4244

Gut microbial characteristics of adult patients with allergy rhinitis

Libing Zhu, Feng Xu, Wenrong Wan, Bin Yu, Lin Tang, Yiming Yang, Yanling Du, Zhangran Chen, Hongzhu Xu
2020 Microbial Cell Factories  
Although recent studies have indicated that intestinal microbiota dweller are involved in the pathogenesis of allergy rhinitis (AR), the influence of gut microbiota on AR adult has not been fully elucidated yet. Hence, we carried out this study to uncover the distinctive bacterial taxa that differentiate allergy rhinitis patients from healthy individuals. Feces samples from thirty three AR patients and thirty one healthy individuals were analyzed by 16S rRNA gene sequencing. Results showed that
more » ... the bacterial diversity in AR group was significantly higher than that of the non-AR group. Bacterial communities between AR and non-AR group were significantly differentiated as revealed by Principal coordinates analysis (PCoA) and the variation within non-AR were higher than that of the counterpart. Firmicutes, Fusobacteria, Actinobacteria, Cyanobacteria and Chloroflexi were the significantly differed phyla taxa and the top significantly distinguished bacterial genus included Prevotella_9, Phascolarctobacterium, Roseburia, Megamonas, Alistipes, Lachnoclostridium and Fusobacterium. The higher network complexity in AR group were dominated by taxa belonging to Firmicutes. The predicted function, alpha linolenic acid metabolism and bacterial invasion of epithelial cells pathway were higher in non-AR group while gonadotropin-releasing hormone (GnRH) signaling pathway, Fc γ-R mediated phagocytosis and endocytosis were higher in AR patients. Although the bacterial diversity between moderate and severe AR patients showed no significant difference, the significant correlation between featured genus and total nasal symptom score or rhinoconjunctivitis quality of life questionnaire, such as Butyricicoccus and Eisenbergiella, revealed the potential to intervene the AR status by means of gut microbiota. In conclusion, patients with allergy rhinitis had distinguished gut microbiota characteritics in comparison with healthy controls. The results suggest that gut microbiota might play crucial roles in influencing the course and different symptoms of AR. Trial registration ChiCTR, ChiCTR1900028613. Registered 29 December 2019, .
doi:10.1186/s12934-020-01430-0 pmid:32873292 fatcat:keaai75xvbdvvbtksxhxanlwve

Fluorescent strip sensor for rapid determination of toxins

Libing Wang, Wei Chen, Wenwei Ma, Liqinag Liu, Wei Ma, Yuan Zhao, Yingyue Zhu, Liguang Xu, Hua Kuang, Chuanlai Xu
2011 Chemical Communications  
doi:10.1039/c0cc04032k pmid:21116526 fatcat:ht265zrs4ne73nejqwoplxu63y

Correction to: Gut microbial characteristics of adult patients with allergy rhinitis

Libing Zhu, Feng Xu, Wenrong Wan, Bin Yu, Lin Tang, Yiming Yang, Yanling Du, Zhangran Chen, Hongzhi Xu
2020 Microbial Cell Factories  
The author name Hongzhi Xu had been (incorrectly) spelled as 'Hongzhu Xu' .  ...  to: Microb Cell Fact (2020) 19:171 https :// 4-020-01430 -0 Following publication of the original article [1], the authors identified two errors: one in the author name of Hongzhi Xu  ... 
doi:10.1186/s12934-020-01441-x pmid:33032584 fatcat:mqh2s5aaa5e2tizm5qzq2tc6hm

Chiral plasmonics of self-assembled nanorod dimers

Wei Ma, Hua Kuang, Libing Wang, Liguang Xu, Wei-Shun Chang, Huanan Zhang, Maozhong Sun, Yinyue Zhu, Yuan Zhao, Liqiang Liu, Chuanlai Xu, Stephan Link (+1 others)
2013 Scientific Reports  
Chiral nanoscale photonic systems typically follow either tetrahedral or helical geometries that require four or more different constituent nanoparticles. Smaller number of particles and different chiral geometries taking advantage of the self-organization capabilities of nanomaterials will advance understanding of chiral plasmonic effects, facilitate development of their theory, and stimulate practical applications of chiroplasmonics. Here we show that gold nanorods self-assemble into
more » ... ide orientated pairs and "ladders" in which chiral properties originate from the small dihedral angle between them. Spontaneous twisting of one nanorod versus the other one breaks the centrosymmetric nature of the parallel assemblies. Two possible enantiomeric conformations with positive and negative dihedral angles were obtained with different assembly triggers. The chiral nature of the angled nanorod pairs was confirmed by 4p full space simulations and the first example of single-particle CD spectroscopy. Self-assembled nanorod pairs and "ladders" enable the development of chiral metamaterials, (bio)sensors, and new catalytic processes. A ssemblies of gold nanoparticles (NPs) 1-4 and nanorods (NRs) 5,6 attract scientists by the diversity of optical plasmonic effects. Research in this area is concentrated around spectroscopy of different plasmon modes 7 , appearance of hot spots, enhancement of different optical effects by plasmonic fields 8 , plasmon-to-heat conversion, and a variety of applications related to these effects 9 . Compared to the large progress in these areas, we are only beginning to understand a variety of chiral effects related to nanoscale plasmonic materials 10-17 . Chirality of individual NPs can arise from electronic "imprints" of molecules on their surface 16, 17 . Different chirooptical effects for plasmonic materials could be unusually strong 7, 8, 11, 14, 22 and enable several new photonics technologies 11,7,23 . The fundamental studies and technology of chiral photonics depends on finding new preparative methods for chiral plasmonic enantiomers. So far, it was primarily achieved using chiral stabilizers 17 and chiral scaffolds forcing asymmetry in the geometrical positioning of NPs, while in other cases equal amounts of dextrorotatory (1) or levorotatory (2) enantiomers were formed 20 . NP/NR superstructures are typically designed to be tetrahedral 10,21 or helical 3,18-20 in geometry, which de facto replicates the cases of well-known chiral organic and biological molecules. Such geometries typically require more than four constituent NPs to construct chiral three-dimensional systems as well as complex biomolecules, and multistep synthesis process. It would certainly be important to simplify methods of their preparation and to find different chiral geometries with smaller number of constituents. In this paper, we demonstrate that strongly chiral nanoscale systems can be made from as few as two gold NRs. They form side-by-side oriented NR pairs as well as multi-NR "ladders". Chiral properties originate from the small dihedral angle between two adjacent NRs which breaks centrosymetric nature of two parallel identical cylinders. Importantly, the synthesis proceeds via self-assembly route, which is characteristic for many nanoscale colloids and represents their intrinsic similarity to biomacromolecules 24 , and can be accomplished with different assembly triggers leading to both (1) and (2) enantiomers. The chiroplasmonic properties of NR pairs in dispersions match the CD spectra obtained for single NR pairs. Results Gold NRs were prepared by a standard seeded growth method 25 . Their assembly was triggered by the hybridization of DNA oligomers in the standard PCR process (Fig. 1A , see SI), as well as by simple addition of sodium SUBJECT AREAS: MOLECULAR SELF-ASSEMBLY NANOPARTICLES SELF-ASSEMBLY BIOMIMETICS
doi:10.1038/srep01934 pmid:23752317 pmcid:PMC3678134 fatcat:r545rxbdangbhdbpkno6ghzejy

Glutathione S-Transferase M1 Gene Polymorphism and Laryngeal Cancer Risk: A Meta-Analysis

Xin-Jiang Ying, Pin Dong, Bin Shen, Cheng-Zhi Xu, Hong-Ming Xu, Shu-Wei Zhao, Libing Song
2012 PLoS ONE  
and Objectives: Studies investigating the association between glutathione S-transferase M1 (GSTM1) gene polymorphism and laryngeal cancer risk have reported conflicting results. The aim of the present study was to conduct a meta-analysis assessing the possible associations of GSTM1 gene polymorphism with laryngeal cancer risk. Methods: The relevant studies were identified through a search of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure until May 2011 and
more » ... ected on the basis of the established inclusion criteria for publications, then a meta-analysis was performed to quantitatively summarize association of GSTM1 polymorphism with laryngeal cancer susceptibility. Results: Seventeen studies were included in the present meta-analysis (2,180 cases and 2,868 controls). The combined results based on all studies showed that GSTM1 null genotype was associated with increased laryngeal cancer risk (OR = 1.17, 95% CI = 1.04,1.31). When stratifying for race, GSTM1 null genotype exhibited increased laryngeal cancer risk in Caucasians (OR = 1.15, 95% CI = 1.01,1.31), while no significant association was detected in Asians (OR = 1.25, 95% CI = 0.80,1.96). In the subgroup analysis based on source of controls, significant associations were observed in the population-based studies (OR = 1.15, 95% CI = 1.01,1.31) yet not in the hospital-based studies (OR = 1.25, 95% CI = 0.93,1.67). Furthermore, in the subgroup analysis based on sample size, significant associations were also found in studies with at least 50 cases and 50 controls (OR = 1.15, 95% CI = 1.02,1.30) but not in studies with fewer than 50 cases or 50 controls (OR = 1.46, 95% CI = 0.87,2.46). Conclusions: This meta-analysis supported that the GSTM1 gene polymorphism was associated with laryngeal cancer, particularly in Caucasians, and these associations varied in different subgroup, which indicated that population-based study with larger sample size was more appropriate in design of future study.
doi:10.1371/journal.pone.0042826 pmid:22900055 pmcid:PMC3416752 fatcat:mq6krhnklrhjbfcbvq7eo2zg4i
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