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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Joel Ramirez, Christopher J.M. Scott, Alicia A. McNeely, Courtney Berezuk, Fuqiang Gao, Gregory M. Szilagyi, Sandra E. Black
2014 Journal of Visualized Experiments  
Finally, the Lesion-Seg component involves manual checking of the automatic lesion segmentation of subcortical hyperintensities (SH) for false positive errors.  ...  Obtaining in vivo human brain tissue volumetrics from MRI is often complicated by various technical and biological issues.  ...  Alzheimer Association (US), the Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (HSFCPSR), and the LC Campbell Foundation.  ... 
doi:10.3791/50887 pmid:24797507 pmcid:PMC4168739 fatcat:3pj6k5pu3rh7ncjtoxtxm4yzha

Cortical thickness estimation in individuals with cerebral small vessel disease, focal atrophy, and chronic stroke lesions [article]

Miracle Ozzoude, Joel Ramirez, Pradeep Reddy Raamana, Melissa F Holmes, Kirstin Walker, Christopher J M Scott, Maged Goubran, Donna Kwan, Maria C. Tartaglia, Derek Beaton, Stephen C Strother, Sean Symons (+4 others)
2020 bioRxiv   pre-print
Corrected procedures reduced 'Fail' ratings from 11% to 0% for the cortical ribbon and 62% to 8% for tissue segmentation.  ...  Results: Corrected procedures increased 'Acceptable' QC ratings from 18% to 76% for the cortical ribbon and from 38% to 92% for tissue segmentation.  ...  Acknowledgements: We would like to thank the ONDRI participants for the time, consent, and participation in our study. Thank you to the L.C.  ... 
doi:10.1101/2020.08.04.236760 fatcat:2arbqx5a5vampgxoywzgw2vfcq

Cortical Thickness Estimation in Individuals With Cerebral Small Vessel Disease, Focal Atrophy, and Chronic Stroke Lesions

Miracle Ozzoude, Joel Ramirez, Pradeep Reddy Raamana, Melissa F. Holmes, Kirstin Walker, Christopher J. M. Scott, Fuqiang Gao, Maged Goubran, Donna Kwan, Maria C. Tartaglia, Derek Beaton, Gustavo Saposnik (+8 others)
2020 Frontiers in Neuroscience  
"Acceptable" QC ratings from 18 to 76% for the cortical ribbon and from 38 to 92% for tissue segmentation.  ...  Corrected procedures reduced "Fail" ratings from 11 to 0% for the cortical ribbon and 62 to 8% for tissue segmentation.  ...  ACKNOWLEDGMENTS We would like to thank the ONDRI participants for the time, consent, and participation in our study. Thank you to the L.C.  ... 
doi:10.3389/fnins.2020.598868 pmid:33381009 pmcid:PMC7768006 fatcat:djodsrji45fb5bodcz7nnbhsse

Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

François De Guio, Eric Jouvent, Geert Jan Biessels, Sandra E Black, Carol Brayne, Christopher Chen, Charlotte Cordonnier, Frank-Eric De Leeuw, Martin Dichgans, Fergus Doubal, Marco Duering, Carole Dufouil (+29 others)
2016 Journal of Cerebral Blood Flow and Metabolism  
The aim is to summarise, for each marker, what is currently known about: 1) its reproducibility in studies with a scan-rescan procedure either in single or multi centre settings; 2) the acquisition-related  ...  Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to bereliablyused as outcome measures in future clinical trials.  ...  Supplementary material for this paper can be found at http://jcbfm.sagepub.com/content/by/supplemental-data  ... 
doi:10.1177/0271678x16647396 pmid:27170700 pmcid:PMC4976752 fatcat:62yvvbsgorgnbnlgv6v3w3j3bu

CIVET-Macaque: an automated pipeline for MRI-based cortical surface generation and cortical thickness in macaques [article]

Claude Lepage, Konrad Wagstyl, Benjamin Jung, Jakob Seidlitz, Caleb Sponheim, Leslie Ungerleider, Xindi Wang, Alan C. Evans, Adam Messinger
2020 biorxiv/medrxiv   pre-print
Results have been obtained using CIVET-macaque to process the anatomical scans of the 31 macaques used to generate the NMT and another 95 macaques from the PRIME-DE initiative.  ...  The MNI CIVET pipeline for automated extraction of cortical surfaces and evaluation of cortical thickness from in-vivo human MRI has been extended for processing macaque brains.  ...  Acknowledgments This research was supported (in part) by the Intramural Research Program of the NIMH and includes the relevant Annual Report number in the following format (ZICMH002899).  ... 
doi:10.1101/2020.08.04.237149 fatcat:crvw5eciqnc2bi4g2ba56luvbm

Neuroimaging of structural pathology and connectomics in traumatic brain injury: Toward personalized outcome prediction

Andrei Irimia, Bo Wang, Stephen R. Aylward, Marcel W. Prastawa, Danielle F. Pace, Guido Gerig, David A. Hovda, Ron Kikinis, Paul M. Vespa, John D. Van Horn
2012 NeuroImage: Clinical  
This is particularly the case when such methods are appropriately combined with volumetric/morphometric analysis of brain structures and with the exploration of TBI-related changes in brain network properties  ...  and network analysis to identify outcome biomarkers, and (3) the application of multivariate statistics to predict outcome using neuroimaging metrics.  ...  Morphometric methods frequently make use of MRI volume segmentations to fit a mesh of points to the surface of the brain and then parcellate its structures into regions using a population atlas as a structural  ... 
doi:10.1016/j.nicl.2012.08.002 pmid:24179732 pmcid:PMC3757727 fatcat:2yxon4yu6rfrlfpton5qc4k5si

Pathomechanisms of HIV-Associated Cerebral Small Vessel Disease: A Comprehensive Clinical and Neuroimaging Protocol and Analysis Pipeline

Kyle D Murray, Meera V Singh, Yuchuan Zhuang, Md Nasir Uddin, Xing Qiu, Miriam T Weber, Madalina E Tivarus, Henry Z Wang, Bogachan Sahin, Jianhui Zhong, Sanjay B Maggirwar, Giovanni Schifitto
2020 Frontiers in Neurology  
MRI imaging follows the recommended clinical small vessel imaging standards and adds several advanced sequences to obtain quantitative assessments of brain tissues including white matter microstructure  ...  Rationale: We provide an in-depth description of a comprehensive clinical, immunological, and neuroimaging study that includes a full image processing pipeline.  ...  ACKNOWLEDGMENTS We would like to acknowledge the contributions of additional team members to the efforts of this study, including study coordination, statistical support, image processing assistance, and  ... 
doi:10.3389/fneur.2020.595463 pmid:33384655 pmcid:PMC7769815 fatcat:mdxpzurd7zazbbq77x5zbhadxu

Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression

Hyun Kook Lim, Won Sang Jung, Kook Jin Ahn, Wang Youn Won, Changtae Hahn, Seung Yup Lee, InSeong Kim, Chang Uk Lee
2011 Neuropsychopharmacology  
The aim of this study was to investigate the differences in both cortical thickness and subcortical volumes between drug-naive LOD patients and healthy controls and explore the relationship between LOD  ...  This study was the first study to explore the relationships between the cortical thickness/subcortical volumes and cognitive impairments of drug-naive patients with LOD.  ...  ACKNOWLEDGEMENTS This work was supported by a grant from the Next-Generation BioGreen 21 Program (No. PJ007186), Rural Development Administration, Republic of Korea.  ... 
doi:10.1038/npp.2011.264 pmid:22048467 pmcid:PMC3260976 fatcat:s6q5ormlkzgidekprhcvlb7fke

Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland

Rozanna Meijboom, Stewart J. Wiseman, Elizabeth N. York, Mark E. Bastin, Maria del C. Valdés Hernández, Michael J. Thrippleton, Daisy Mollison, Nicole White, Agniete Kampaite, Koy Ng Kee Kwong, David Rodriguez Gonzalez, Dominic Job (+5 others)
2022 Wellcome Open Research  
Conclusions: FutureMS aims to reduce uncertainty around disease course and allow for targeted treatment in RRMS by exploring the role of conventional and advanced MRI measures as biomarkers of disease  ...  Neuroimaging is a central component of the study and provides two main primary endpoints for disease activity and neurodegeneration.  ...  Acknowledgements We would like to thank Dr Pascal Sati for his help with implementing the SWI sequence in the FutureMS protocol.  ... 
doi:10.12688/wellcomeopenres.17731.1 fatcat:no5yazwd2zbsjppd5laeqvgdg4

Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland [article]

Rozanna Meijboom, Stewart J Wiseman, Elizabeth N York, Mark E Bastin, Maria del Carmen Valdes Hernandez, Michael J Thrippleton, Daisy Mollison, Nicole White, Agniete Kampaite, Koy Chong Ng Kee Kwong, David Rodriguez Gonzalez, Dominic Job (+5 others)
2021 medRxiv   pre-print
FutureMS aims to reduce uncertainty around disease course and allow for targeted treatment in RRMS by exploring the role of conventional and advanced MRI measures as biomarkers of disease severity and  ...  Neuroimaging is a central component of the study and provides two main primary endpoints for disease activity and neurodegeneration.  ...  ACKNOWLEDGEMENTS With thanks to FutureMS, hosted by Precision Medicine Scotland Innovation Centre (PMS-IC) and funded by a grant from the Scottish Funding Council to PMS-IC and Biogen Idec Ltd Insurance  ... 
doi:10.1101/2021.03.10.21253264 fatcat:kudc6s4imzcydpmybwjtadreqi

Differentiating between visual hallucination-free dementia with Lewy bodies and corticobasal syndrome on the basis of neuropsychology and perfusion single-photon emission computed tomography

Michael R Misch, Sara Mitchell, Philip L Francis, Kayla Sherborn, Katayoun Meradje, Alicia A McNeely, Kie Honjo, Jiali Zhao, Christopher JM Scott, Curtis B Caldwell, Lisa Ehrlich, Prathiba Shammi (+5 others)
2014 Alzheimer's Research & Therapy  
Behavioural, perfusion, and cortical volume and thickness measures were compared between the groups to identify features that serve to differentiate them.  ...  Perfusion data were available for forty-two controls.  ...  Julian Li for creating Figure 1 , and Courtney Berezuk for her help in processing the MRI data. This grant was supported by a Parkinson Society Canada New Investigator Award to MM and a CIHR  ... 
doi:10.1186/s13195-014-0071-4 pmid:25484929 pmcid:PMC4256921 fatcat:l7o3ztswkvc6zgwryymzel3iui

Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes

Katherine J. Bangen, Madeleine L. Werhane, Alexandra J. Weigand, Emily C. Edmonds, Lisa Delano-Wood, Kelsey R. Thomas, Daniel A. Nation, Nicole D. Evangelista, Alexandra L. Clark, Thomas T. Liu, Mark W. Bondi
2018 Frontiers in Aging Neuroscience  
ASL CBF, Type 2 Diabetes, and Cognition pathology (medial temporal lobe and inferior parietal regions).  ...  Results also suggest that CBF measured with ASL MRI may reflect an early and important marker of risk of cognitive impairment in T2DM and related conditions.  ...  500358 to EE, and AARF-17-528918 to KT), and NIH (K24 AG026431 to MB; R01 AG049810 to MB, EE, and LD-W).  ... 
doi:10.3389/fnagi.2018.00270 pmid:30250430 pmcid:PMC6139361 fatcat:p2vtqsxsxnfszjo6brbbvw73u4

Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis [article]

Einar August Høgestøl, Gro Owren Nygaard, Petter Espeseth Emhjellen, Tobias Kaufmann, Mona Kristiansen Beyer, Piotr Sowa, Ole Andreas Andreassen, Elisabeth Gulowsen Celius, Nils Inge Landrø, Lars Tjelta Westlye, Hanne Flinstad Harbo
2019 biorxiv/medrxiv   pre-print
A machine-learning model using Freesurfer-processed T1-weighted brain MRI data from 3208 healthy controls, was applied to develop a prediction model for brain age.  ...  We aimed to identify if estimated brain age from MRI could serve as an imaging marker for early cognitive symptoms in a longitudinal MS study.  ...  We acknowledge the collaboration with members of the Multiple Sclerosis Research Group at the University of Oslo and Oslo University hospital, especially Professor Elisabeth G. Celius.  ... 
doi:10.1101/651521 fatcat:h46va3z6r5cwdicg4daues7odm

Multi-modal neuroimaging of dual-task walking: Structural MRI and fNIRS analysis reveals prefrontal grey matter volume moderation of brain activation in older adults

Mark E. Wagshul, Melanie Lucas, Kenny Ye, Meltem Izzetoglu, Roee Holtzer
2019 NeuroImage  
Dual-task walking, such as walking while performing a cognitive task, is a necessary skill for everyday functioning, and has been shown to activate prefrontal lobe areas in healthy older people.  ...  Regional analysis identified bilateral superior and rostral middle gyri as the primary areas driving these results.  ...  Future studies will explore similar associations throughout other cortical and subcortical regions.  ... 
doi:10.1016/j.neuroimage.2019.01.045 pmid:30710680 pmcid:PMC6422701 fatcat:ihdq3vt2gfcypfue5bqwjlc5pm

Scientific paper sessions

2009 Neuroradiology  
Of the 28 tumors, 21 were located in the region of the 4th ventricle; 7 were found ;5/28 were MBEN; 6/28 were a desmoplastic/ nodular variant; and one was a large cell MB.  ...  MATERIALS AND METHODS MR examinations and clinical and pathology reports from 4 institutions, for a total of 28 patients with histologically proven diagnosis of MB, were retrospectively analyzed.  ...  Quantitative volumetric analysis was performed on the 3D-MPRAGE images using SPM5; it consisted of brain normalization, segmentation, gray matter parcellation according to the AAL template (116regions)  ... 
doi:10.1007/s00234-009-0561-4 fatcat:o5kffdrey5e7pp6rpqpvepbowy
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