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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
2014
Journal of Visualized Experiments
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Finally, the Lesion-Seg component involves manual checking of the automatic lesion segmentation of subcortical hyperintensities (SH) for false positive errors. ...
Obtaining in vivo human brain tissue volumetrics from MRI is often complicated by various technical and biological issues. ...
Alzheimer Association (US), the Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (HSFCPSR), and the LC Campbell Foundation. ...
doi:10.3791/50887
pmid:24797507
pmcid:PMC4168739
fatcat:3pj6k5pu3rh7ncjtoxtxm4yzha
Cortical thickness estimation in individuals with cerebral small vessel disease, focal atrophy, and chronic stroke lesions
[article]
2020
bioRxiv
pre-print
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Corrected procedures reduced 'Fail' ratings from 11% to 0% for the cortical ribbon and 62% to 8% for tissue segmentation. ...
Results: Corrected procedures increased 'Acceptable' QC ratings from 18% to 76% for the cortical ribbon and from 38% to 92% for tissue segmentation. ...
Acknowledgements: We would like to thank the ONDRI participants for the time, consent, and participation in our study. Thank you to the L.C. ...
doi:10.1101/2020.08.04.236760
fatcat:2arbqx5a5vampgxoywzgw2vfcq
Cortical Thickness Estimation in Individuals With Cerebral Small Vessel Disease, Focal Atrophy, and Chronic Stroke Lesions
2020
Frontiers in Neuroscience
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"Acceptable" QC ratings from 18 to 76% for the cortical ribbon and from 38 to 92% for tissue segmentation. ...
Corrected procedures reduced "Fail" ratings from 11 to 0% for the cortical ribbon and 62 to 8% for tissue segmentation. ...
ACKNOWLEDGMENTS We would like to thank the ONDRI participants for the time, consent, and participation in our study. Thank you to the L.C. ...
doi:10.3389/fnins.2020.598868
pmid:33381009
pmcid:PMC7768006
fatcat:djodsrji45fb5bodcz7nnbhsse
Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease
2016
Journal of Cerebral Blood Flow and Metabolism
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The aim is to summarise, for each marker, what is currently known about: 1) its reproducibility in studies with a scan-rescan procedure either in single or multi centre settings; 2) the acquisition-related ...
Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to bereliablyused as outcome measures in future clinical trials. ...
Supplementary material for this paper can be found at http://jcbfm.sagepub.com/content/by/supplemental-data ...
doi:10.1177/0271678x16647396
pmid:27170700
pmcid:PMC4976752
fatcat:62yvvbsgorgnbnlgv6v3w3j3bu
CIVET-Macaque: an automated pipeline for MRI-based cortical surface generation and cortical thickness in macaques
[article]
2020
biorxiv/medrxiv
pre-print
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Results have been obtained using CIVET-macaque to process the anatomical scans of the 31 macaques used to generate the NMT and another 95 macaques from the PRIME-DE initiative. ...
The MNI CIVET pipeline for automated extraction of cortical surfaces and evaluation of cortical thickness from in-vivo human MRI has been extended for processing macaque brains. ...
Acknowledgments This research was supported (in part) by the Intramural Research Program of the NIMH and includes the relevant Annual Report number in the following format (ZICMH002899). ...
doi:10.1101/2020.08.04.237149
fatcat:crvw5eciqnc2bi4g2ba56luvbm
Neuroimaging of structural pathology and connectomics in traumatic brain injury: Toward personalized outcome prediction
2012
NeuroImage: Clinical
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This is particularly the case when such methods are appropriately combined with volumetric/morphometric analysis of brain structures and with the exploration of TBI-related changes in brain network properties ...
and network analysis to identify outcome biomarkers, and (3) the application of multivariate statistics to predict outcome using neuroimaging metrics. ...
Morphometric methods frequently make use of MRI volume segmentations to fit a mesh of points to the surface of the brain and then parcellate its structures into regions using a population atlas as a structural ...
doi:10.1016/j.nicl.2012.08.002
pmid:24179732
pmcid:PMC3757727
fatcat:2yxon4yu6rfrlfpton5qc4k5si
Pathomechanisms of HIV-Associated Cerebral Small Vessel Disease: A Comprehensive Clinical and Neuroimaging Protocol and Analysis Pipeline
2020
Frontiers in Neurology
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MRI imaging follows the recommended clinical small vessel imaging standards and adds several advanced sequences to obtain quantitative assessments of brain tissues including white matter microstructure ...
Rationale: We provide an in-depth description of a comprehensive clinical, immunological, and neuroimaging study that includes a full image processing pipeline. ...
ACKNOWLEDGMENTS We would like to acknowledge the contributions of additional team members to the efforts of this study, including study coordination, statistical support, image processing assistance, and ...
doi:10.3389/fneur.2020.595463
pmid:33384655
pmcid:PMC7769815
fatcat:mdxpzurd7zazbbq77x5zbhadxu
Regional Cortical Thickness and Subcortical Volume Changes Are Associated with Cognitive Impairments in the Drug-Naive Patients with Late-Onset Depression
2011
Neuropsychopharmacology
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The aim of this study was to investigate the differences in both cortical thickness and subcortical volumes between drug-naive LOD patients and healthy controls and explore the relationship between LOD ...
This study was the first study to explore the relationships between the cortical thickness/subcortical volumes and cognitive impairments of drug-naive patients with LOD. ...
ACKNOWLEDGEMENTS This work was supported by a grant from the Next-Generation BioGreen 21 Program (No. PJ007186), Rural Development Administration, Republic of Korea. ...
doi:10.1038/npp.2011.264
pmid:22048467
pmcid:PMC3260976
fatcat:s6q5ormlkzgidekprhcvlb7fke
Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland
2022
Wellcome Open Research
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Conclusions: FutureMS aims to reduce uncertainty around disease course and allow for targeted treatment in RRMS by exploring the role of conventional and advanced MRI measures as biomarkers of disease ...
Neuroimaging is a central component of the study and provides two main primary endpoints for disease activity and neurodegeneration. ...
Acknowledgements We would like to thank Dr Pascal Sati for his help with implementing the SWI sequence in the FutureMS protocol. ...
doi:10.12688/wellcomeopenres.17731.1
fatcat:no5yazwd2zbsjppd5laeqvgdg4
Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland
[article]
2021
medRxiv
pre-print
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FutureMS aims to reduce uncertainty around disease course and allow for targeted treatment in RRMS by exploring the role of conventional and advanced MRI measures as biomarkers of disease severity and ...
Neuroimaging is a central component of the study and provides two main primary endpoints for disease activity and neurodegeneration. ...
ACKNOWLEDGEMENTS With thanks to FutureMS, hosted by Precision Medicine Scotland Innovation Centre (PMS-IC) and funded by a grant from the Scottish Funding Council to PMS-IC and Biogen Idec Ltd Insurance ...
doi:10.1101/2021.03.10.21253264
fatcat:kudc6s4imzcydpmybwjtadreqi
Differentiating between visual hallucination-free dementia with Lewy bodies and corticobasal syndrome on the basis of neuropsychology and perfusion single-photon emission computed tomography
2014
Alzheimer's Research & Therapy
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Behavioural, perfusion, and cortical volume and thickness measures were compared between the groups to identify features that serve to differentiate them. ...
Perfusion data were available for forty-two controls. ...
Julian Li for creating Figure 1 , and Courtney Berezuk for her help in processing the MRI data. This grant was supported by a Parkinson Society Canada New Investigator Award to MM and a CIHR ...
doi:10.1186/s13195-014-0071-4
pmid:25484929
pmcid:PMC4256921
fatcat:l7o3ztswkvc6zgwryymzel3iui
Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes
2018
Frontiers in Aging Neuroscience
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ASL CBF, Type 2 Diabetes, and Cognition pathology (medial temporal lobe and inferior parietal regions). ...
Results also suggest that CBF measured with ASL MRI may reflect an early and important marker of risk of cognitive impairment in T2DM and related conditions. ...
500358 to EE, and AARF-17-528918 to KT), and NIH (K24 AG026431 to MB; R01 AG049810 to MB, EE, and LD-W). ...
doi:10.3389/fnagi.2018.00270
pmid:30250430
pmcid:PMC6139361
fatcat:p2vtqsxsxnfszjo6brbbvw73u4
Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis
[article]
2019
biorxiv/medrxiv
pre-print
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A machine-learning model using Freesurfer-processed T1-weighted brain MRI data from 3208 healthy controls, was applied to develop a prediction model for brain age. ...
We aimed to identify if estimated brain age from MRI could serve as an imaging marker for early cognitive symptoms in a longitudinal MS study. ...
We acknowledge the collaboration with members of the Multiple Sclerosis Research Group at the University of Oslo and Oslo University hospital, especially Professor Elisabeth G. Celius. ...
doi:10.1101/651521
fatcat:h46va3z6r5cwdicg4daues7odm
Multi-modal neuroimaging of dual-task walking: Structural MRI and fNIRS analysis reveals prefrontal grey matter volume moderation of brain activation in older adults
2019
NeuroImage
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Dual-task walking, such as walking while performing a cognitive task, is a necessary skill for everyday functioning, and has been shown to activate prefrontal lobe areas in healthy older people. ...
Regional analysis identified bilateral superior and rostral middle gyri as the primary areas driving these results. ...
Future studies will explore similar associations throughout other cortical and subcortical regions. ...
doi:10.1016/j.neuroimage.2019.01.045
pmid:30710680
pmcid:PMC6422701
fatcat:ihdq3vt2gfcypfue5bqwjlc5pm
Scientific paper sessions
2009
Neuroradiology
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Of the 28 tumors, 21 were located in the region of the 4th ventricle; 7 were found ;5/28 were MBEN; 6/28 were a desmoplastic/ nodular variant; and one was a large cell MB. ...
MATERIALS AND METHODS MR examinations and clinical and pathology reports from 4 institutions, for a total of 28 patients with histologically proven diagnosis of MB, were retrospectively analyzed. ...
Quantitative volumetric analysis was performed on the 3D-MPRAGE images using SPM5; it consisted of brain normalization, segmentation, gray matter parcellation according to the AAL template (116regions) ...
doi:10.1007/s00234-009-0561-4
fatcat:o5kffdrey5e7pp6rpqpvepbowy
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