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Periconceptional Folic Acid Supplementation and Newborn Birth Weights

Jing Lin, Cheng Wang, Sisi Li, Jie Zhang, Lei Jin, Mingkun Tong, Wenying Meng, Aiguo Ren, Lei Chen, Lei Jin
2022 Frontiers in Pediatrics  
BackgroundThe relationship between maternal folic acid supplementation and the birth weights of offspring remains inconclusive.AimTo examine the associations between maternal supplementation with folic acid only (FAO) or multiple micronutrients containing folic acid (MMFA) and newborn birth weights, as well as the risk of small for gestational week age (SGA) and large for gestational week age (LGA) newborns.MethodsData on 31,107 births from 2015 to 2018 were extracted from the population-based
more » ... renatal health care system in a district of Beijing. Generalized linear and logistic regression models were used to evaluate the association between maternal periconceptional folic acid supplementation and birth weights or with risk of small for gestational week age (SGA) and large for gestational week age (LGA).ResultsCompared with newborns whose mothers did not use any folic acid supplements, the newborns with maternal periconceptional folic acid supplementation had similar median birth weight but had a lower risk of SGA [adjusted odds ratio (aOR) = 0.81 (95% CI: 0.68–0.97)], however newborns born to mothers who took multiple micronutrients with folic acid (MMFA) with high compliance had a 25.59 g (95% CI: 6.49–44.69) higher median birth weight. Periconceptional women took folic acid only (FAO) (aOR = 0.83; 95%CI: 0.67–1.01) or MMFA (aOR = 0.74; 95%CI: 0.60–0.91) with high compliance decreased the risk of SGA, but has no impact on the risk of LGA.ConclusionPericonceptional FAO supplementation has no impact on the median birth weight of offspring and the risk of LGA. Compared with FAO, MMFA supplementation may increase the average birth weight, and a high compliance of supplementation with FAO or MMFA may reduce the risk of SGA, with MMFA having ad stronger effect than FAO.
doi:10.3389/fped.2022.844404 pmid:35573945 pmcid:PMC9096220 fatcat:kk2xwofotjdxzosqxsjtjb4dz4

Two-path interference for enantiomer-selective state transfer of chiral molecules [article]

Jin-Lei Wu, Yan Wang, Jin-Xuan Han, Cong Wang, Shi-Lei Su, Yan Xia, Yongyuan Jiang, Jie Song
2020 arXiv   pre-print
With a microwave-regime cyclic three-state configuration, an enantiomer-selective state transfer (ESST) is carried out through the two-path interference between a direct one-photon coupling and an effective two-photon coupling. The π-phase difference in the one-photon process between two enantiomers makes the interference constructive for one enantiomer but destructive for the other. Therefore only one enantiomer is excited into a higher rotational state while the other remains in the ground
more » ... te. The scheme is of flexibility in the pulse waveforms and the time order of two paths. We simulate the scheme in a sample of cyclohexylmethanol (C_7H_14O) molecules. Simulative results show the robust and high-fidelity ESST can be obtained when experimental concerns are considered. Finally, we propose to employ the finished ESST in implementing enantio-separation and determining enantiomeric excess.
arXiv:2003.10334v1 fatcat:zswgitdxbvddlavmfgvroguwbi

MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm

Lei Wang, Jianming Zheng, Chang Sun, Li Wang, Gang Jin, Lei Xin, Zhendong Jin, Dong Wang, Zhaoshen Li
2017 OncoTarget  
Copyright: Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA
more » ... RNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. When comparing the miRNA expression between IPMN patient samples and controls, we found that miR-210, miR-223, miR-221, miR-155 and miR-187 were differentially expressed in normal pancreas and IPMNs. We further studied the miRNA expression profiles in different pancreatic diseases and identified miRNA features that are associated with Chronic pancreatitis (CP), IPMN, and Pancreatic ductal adenocarcinoma (PDAC). Therefore, these miRNAs might serve as new risk biomarkers of IPMN and could be useful for future targeted therapies.
doi:10.18632/oncotarget.17679 pmid:28938594 pmcid:PMC5601690 fatcat:pyen5bwkszg23piyvsw42cnk5i

Symmetric illumination in Fourier ptychography

Zhang Lei-Lei, Tang Li-Jin, Zhang Mu-Yang, Liang Yan-Mei
2017 Wuli xuebao  
Fourier ptychography (FP) is a newly developed imaging technology, which can reconstruct high-resolution (HR) wide-field image from a series of low-resolution (LR) images. The limitation of FP is its long acquisition and reconstruction time due to the numerous LR images that are needed and the low illumination intensity of light-emitting diodes (LEDs) which lead to long exposure time of imaging sensors. Many researches have been done to speed up FP. The available speeding-up methods with single
more » ... LED illumination are still constrained by low illumination intensity of LED. Although multi-illumination methods can improve illumination intensity, they are time-consuming during spectrum decomposition. In this paper, we demonstrate a new efficient method, termed symmetric Fourier ptychography (SFP). For thin samples irrespective of phases, two center-symmetric illuminations generate the same intensity distribution, so that two center-symmetric LEDs used in FP can be lit up simultaneously and the illumination intensity is doubled. Spectra have central conjugate symmetry in Fourier domain so that only half of spectra need recovering, then, the processing time can be reduced by about 50%. Simulations are conducted with the 'Cameraman' image as input amplitude. The LR images are generated based on the FP simulation process and then the LR images generated by LEDs from two center-symmetrical positions are summed. Furthermore, HR images are recovered by using FP reconstruction algorithms. It is found that root-mean-square-error of SFP is almost the same as that of traditional FP, which indicates that the SFP can achieve the same performance as that of traditional FP. Then, central conjugate symmetry is adopted in Fourier domain, where only half of spectra are recovered and the other half of spectra are obtained from conjugate symmetry. It proves that HR images can be recovered based on central conjugate symmetry in Fourier domain and 50% of processing time is saved. For imaging experiments of USAF target and biological samples, two LEDs of central symmetry are lit up simultaneously, and 113 LR images are gathered in contrast with 225 ones of traditional FP. It is also found that SFP can achieve the same resolution as that of the traditional FP. In the meantime, SFP can reduce about 50% LR images and save about 70% acquisition time without increasing the complexity of FP system and algorithms. In addition, SFP can be combined with other methods to further speed up the speed of FP, and its feasibility is proven by the experimental results of combination with adaptive Fourier ptychography. All results in this paper indicate that the proposed method has the potential to improve the application of FP in real-time imaging.
doi:10.7498/aps.66.224201 fatcat:77wzuyr65vdl3eai53nddqx5ry

The mouse Balbiani body maintains primordial follicle quiescence via RNA storage [article]

Lei Lei, Kanako Ikami, Haley Abbott, Shiying Jin
2020 bioRxiv   pre-print
In mammalian females, the transition between quiescent primordial follicles and follicular development is critical for maintaining ovarian function and reproductive longevity. In primary oocytes of mouse quiescent primordial follicles, Golgi complexes are organized into a spherical structure, the Balbiani body. Here, we show that the structure of the B-body is maintained by microtubules and actin. The B-body stores mRNA-capping enzyme and 597 mRNAs associated with mRNA-decapping enzyme 1A.
more » ... ins encoded by these mRNAs function in enzyme binding, cellular component organization and packing of telomere ends. Pharmacological disassembly of the B-body triggers translation of stored mRNAs and activates primordial follicles in culture and in vivo mouse model. Thus, primordial follicle quiescence is maintained by the B-body, and translationally inactive B-body-stored mRNAs may be regulated by 5-prime capping.
doi:10.1101/2020.01.17.911040 fatcat:ujnbwyf2azdpvodx5bai6hmocy

Bacteria slingshot more on soft surfaces

Rongrong Zhang, Lei Ni, Zhenyu Jin, Jiahong Li, Fan Jin
2014 Nature Communications  
Moreover, Jin et al. 14 have shown that bacteria can differently deploy their TFP to alternatively generate pull actions and slingshots in the crawling motility, where the velocities of slingshots are  ... 
doi:10.1038/ncomms6541 pmid:25412641 pmcid:PMC4263163 fatcat:6bqiibl6endc7ktkbmh5y6rxmq

Noise-resistant phase gates with amplitude modulation [article]

Yan Wang, Jin-Lei Wu, Jin-Xuan Han, Yong-Yuan Jiang, Yan Xia, Jie Song
2020 arXiv   pre-print
We propose a simple scheme for implementing fast arbitrary phase gates and employ pulse modulation to improve the gate robustness against different sources of noise. Parametric driving of a cavity is introduced to induce Rabi interactions between the cavity and qutrits, and then a two-qubit arbitrary phase gate is constructed by designing proper logical states. On this basis, we implement amplitude-shaped gates to obtain enhanced resilience to control errors in gate time and frequency detuning.
more » ... By virtue of specifically designed logical states, the scheme displays intrinsic resistance to the energy relaxations of qutrits. Furthermore, we show that the gate robustness against cavity decay can be enhanced significantly with amplitude modulation.
arXiv:2008.05670v1 fatcat:cvh2aa64ibcbhlzckmjh2f3zzi

Zero-dimensional isomorphic dynamical models [article]

Tomasz Downarowicz, Lei Jin, Wolfgang Lusky, Yixiao Qiao
2018 arXiv   pre-print
By an assignment we mean a mapping from a Choquet simplex K to probability measure-preserving systems, obeying some natural restrictions. We prove that if Φ is an aperiodic assignment on a Choquet simplex K such that the set of extreme points exK is a countable union _n E_n, where each set E_n is compact, zero-dimensional, and the restriction of Φ to the Bauer simplex K_n spanned by E_n can be 'embedded' in some topological dynamical system, then Φ can be 'realized' in a zero-dimensional system.
arXiv:1811.02206v1 fatcat:cyzo2fpcjnao5andiykngjdyza

Challenge-Aware RGBT Tracking [article]

Chenglong Li, Lei Liu, Andong Lu, Qing Ji, Jin Tang
2020 arXiv   pre-print
RGB and thermal source data suffer from both shared and specific challenges, and how to explore and exploit them plays a critical role to represent the target appearance in RGBT tracking. In this paper, we propose a novel challenge-aware neural network to handle the modality-shared challenges (e.g., fast motion, scale variation and occlusion) and the modality-specific ones (e.g., illumination variation and thermal crossover) for RGBT tracking. In particular, we design several parameter-shared
more » ... anches in each layer to model the target appearance under the modality-shared challenges, and several parameterindependent branches under the modality-specific ones. Based on the observation that the modality-specific cues of different modalities usually contains the complementary advantages, we propose a guidance module to transfer discriminative features from one modality to another one, which could enhance the discriminative ability of some weak modality. Moreover, all branches are aggregated together in an adaptive manner and parallel embedded in the backbone network to efficiently form more discriminative target representations. These challenge-aware branches are able to model the target appearance under certain challenges so that the target representations can be learnt by a few parameters even in the situation of insufficient training data. From the experimental results we will show that our method operates at a real-time speed while performing well against the state-of-the-art methods on three benchmark datasets.
arXiv:2007.13143v1 fatcat:ll6o3omzwbccncsagfe5snrrse

Research Progress in Trajectory Prediction for Near Space Hypersonic Vehicle

Shao Lei, Lei Humin, Zhao Jin
2021 Hangkong bingqi  
Trajectory prediction for near space hypersonic vehicle is of great significance to the guidance and intercept. The common prediction methods for near space hypersonic vehicle are analyzed from the cooperation and non-cooperation point. Firstly, for the cooperation vehicle, the analytic method and numerical method are summed up and analyzed combined with the process of aircraft prediction-correction guidance. Then, predictions based on motion model probability density and game antagonism are
more » ... lyzed for the non-cooperation vehicle. Finally, the possible research directions for trajectory prediction is analyzed.
doi:10.12132/issn.1673-5048.2020.0138 doaj:e331b8dcd54e43d3b0dd5cf9b1a33299 fatcat:iaz2chdidza7riblj6ke5f3wsi

Optogenetics reprogramming of planktonic cells for biofilm formation [article]

Fan Jin, Aiguo Xia, Shuai Yang, Yajia Huang, Zhenyu Jin, Lei Ni, Lu Pu, Guang Yang
2017 bioRxiv   pre-print
Single-cell behaviors play essential roles during early-stage biofilms formation. In this study, we evaluated whether biofilm formation could be guided by precisely manipulating single cells behaviors. Thus, we established an illumination method to precisely manipulate the type IV pili (TFP) mediated motility and microcolony formation of Pseudomonas aeruginosa by using a combination of a high-throughput bacterial tracking algorithm, optogenetic manipulation and adaptive microscopy. We termed
more » ... s method as Adaptive Tracking Illumination (ATI). We reported that ATI enables the precise manipulation of TFP mediated motility and microcolony formation during biofilm formation by manipulating bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) levels in single cells. Moreover, we showed that the spatial organization of single cells in mature biofilms can be controlled using ATI. Thus, the established method (i.e., ATI) can markedly promote ongoing studies of biofilms.
doi:10.1101/229229 fatcat:2rpu6k7hgvcunpusci2cg2g7wq

Reaction Theory and Advanced CDCC [article]

A.M. Moro, J. Casal, Jin Lei, M. Gómez-Ramos
2019 arXiv   pre-print
The Continuum-Discretized Coupled-Channels (CDCC) has been successfully employed to describe elastic and breakup of nuclear reactions induced by weakly bound projectiles. In this contribution, we review some other, less widespread applications of the CDCC wavefunction, some of them in combination with other reaction formalisms, which are being currently employed in the analysis of reactions involving three or more fragments in the initial or final state.
arXiv:1910.00307v1 fatcat:fwvm5nvlmvdztam7jp5vnjbpey

Outage Analysis of Aerial Semi-Grant-Free NOMA Systems [article]

Hongjiang Lei, Chen Zhu, Ki-Hong Park, Imran Shafique Ansari, Weijia Lei, Hong Tang, Kyeong Jin Kim
2022 arXiv   pre-print
In this paper, we analyze the outage performance of unmanned aerial vehicles (UAVs)-enabled downlink non-orthogonal multiple access (NOMA) communication systems with the semi-grant-free (SGF) transmission scheme. A UAV provides coverage services for a grant-based (GB) user and one user is allowed to utilize the same channel resource opportunistically. The hybrid successive interference cancellation scheme is implemented in the downlink NOMA scenarios for the first time. The analytical
more » ... s for the exact and asymptotic outage probability (OP) of the grant-free (GF) user are derived. The results demonstrate that no-zero diversity order can be achieved only under stringent conditions on users' quality of service requirements. Subsequently, we propose an efficient dynamic power allocation (DPA) scheme to relax such data rate constraints to address this issue. The analytical expressions for the exact and asymptotic OP of the GF user with the DPA scheme are derived. Finally, Monte Carlo simulation results are presented to validate the correctness of the derived analytical expressions and demonstrate the effects of the UAV's location and altitude on the OP of the GF user.
arXiv:2205.06063v1 fatcat:wwhzngbabrgwpldcd3ppr2wnpy

Flexibility of nucleic acids: from DNA to RNA [article]

Lei Bao, Xi Zhang, Lei Jin, Zhi-Jie Tan
2015 arXiv   pre-print
The structural flexibility of nucleic acids plays a key role in many fundamental life processes, such as gene replication and expression, DNA-protein recognition, and gene regulation. To obtain a thorough understanding of nucleic acid flexibility, extensive studies have been performed using various experimental methods and theoretical models. In this review, we will introduce the progress that has been made in understanding the flexibility of nucleic acids including DNAs and RNAs, and will
more » ... size the experimental findings and the effects of salt, temperature, and sequence. Finally, we will discuss the major unanswered questions in understanding the flexibility of nucleic acids.
arXiv:1509.06450v2 fatcat:5snrf6sovnemrny2gixtptdoyy

A single-source molten salt synthesis of uniform octahedral Na2Ti3O7 particels composed of nanorods [article]

Huan Xie, Jin Chen, Bingyu Lei, Lei Zhou
2018 arXiv   pre-print
Na2Ti3O7, as one of the most potential anode electrode materials, is expected to play an important role in various fields. In this work, we synthesized uniform hollow octahedral Na2Ti3O7 particles through directly sintering a kind of precursors obtained by (NH4)2TiF6 and NH4OH in the presence of sodium-containing cationic polyacrylamide. XRD, SEM, TEM were used to characterize precursors and Na2Ti3O7 particles. In addition, the synthesis conditions and the formation mechanism were discussed in
more » ... etail. This single-source molten salt method is flexible, efficient and controllable. Moreover, the strategy of this method makes it possible for us to synthesize other sodium titanate materials.
arXiv:1803.02951v1 fatcat:rmrolemjkfefziyw5jjvjm3xiu
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