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The Pseudophosphatase MK-STYX Induces Neurite-Like Outgrowths in PC12 Cells

Brittany M. Flowers, Lauren E. Rusnak, Kristen E. Wong, Dallas A. Banks, Michelle R. Munyikwa, Alexander G. McFarland, Shantá D. Hinton, Wenhui Hu
2014 PLoS ONE  
Taken together our data suggest that MK-STYX may be OPEN ACCESS Citation: Flowers BM, Rusnak LE, Wong KE, Banks DA, Munyikwa MR, et al. (2014) The Pseudophosphatase MK-STYX Induces Neurite-Like Outgrowths  ... 
doi:10.1371/journal.pone.0114535 pmid:25479605 pmcid:PMC4257672 fatcat:5nsp6avpbjd6fbuauncxddsqh4

The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies

Zenggang Li, Andrei A. Ivanov, Rina Su, Valentina Gonzalez-Pecchi, Qi Qi, Songlin Liu, Philip Webber, Elizabeth McMillan, Lauren Rusnak, Cau Pham, Xiaoqian Chen, Xiulei Mo (+12 others)
2017 Nature Communications  
In this manuscript, Zenggang and colleagues have developed protein-protein interaction networks in lung cancer cells to identify many new interactions. They have also reported new regulatory mechanisms for the genes such as MYC, STK11 and CDK4 in lung canc er. This manuscript also aims to associate tumor suppressors to drug targets and also explores therapeutic options. The presented dataset of protein-protein interactions in lung cancer cells would be useful for detailed mechanistic
more » ... ng of lung ca ncer related genes. The high-throughput approach followed in the manuscript to identify PPI networks is impressive, but the conclusions drawn are not well supported from the reported experiments and need more evidence to strengthen them. In addition, man y key methodological details are lacking, which make the manuscript hard to follow at many places in its current form. Some additional analyses would also improve the significance of this study. Specific comments that need to be addressed are listed below: Major comments: 1. The high-throughput identification of PPI networks have historically had a high false positive rate. How false positive connections were identified and filtered out from the FRET experiments is not clear. The authors could consider a set of random pairs of genes, which are known to be non-binders as a "negative control" in their FRET experiments? Figure 2A shows very high connectivity of the genes altered in lung cancer, which doesn't seem plausible. It is not clear how each bait protein is interacting with almost every other protein considered in this study (Table S2) . Is it because of the bias in the scoring scheme? Why FOC values were not normalized for signals of any two non-binders? In particular the choice of negative control is crucial for HT experiments such as these as they can be biased by promiscuity in interactors, and low off-rate of FRET signal. In addition, as a control the authors should show that FRET signal is independent of the single Venus or GST signal. 2. Authors have performed three independent experiments in triplicates for both fusions for 83 lung cancer genes in pairwise manner. However, they haven't discussed the reproducibility of interactions in different replicates. What is the specificity of the identified interactions? How correlated are signals when the Venus-GST pairs are swapped (so called A-B, B-A correlation)? These variables will help in identifying the high confidence interactors from such a huge datasets. 3. It is not clear if the overlap of the identified PPI dataset with other available datasets is significant. An enrichment analysis using known interactions can show the significance of the overlap. A sufficiently detailed venn diagram representation of overlap with all the known datasets (eg. STRING, Bioplex) can better explain how many known interactions were
doi:10.1038/ncomms14356 pmid:28205554 pmcid:PMC5316855 fatcat:654xnndk7jhzdnvmxm3eqdfe7m

Page 80 of American Chiropractic Association. The ACA Journal of Chiropractic Vol. 33, Issue 10 [page]

1996 American Chiropractic Association. The ACA Journal of Chiropractic  
Rusnak, Alain Philippe Salas, David A. Sandefur, Windie Christine Sims-McKay, John Travis Smiley, Jeannine Gale Mehlberg- Smith, TTiomas Patrick Smith, III, Sean Karl Stevens, Cherie D.  ...  Baker, Eugene Everett Bledsoe, Kent Richard Bohac, Michael George Carbone, Ralph Steven Cardin, Curtis Erikson Cook, Lauren Rachel Davis, Rhonda S. Felheim, Scott M. Ferguson, Steven Finck, Kassie R.  ... 

Page 3504 of Mathematical Reviews Vol. , Issue 93f [page]

1993 Mathematical Reviews  
Rose, Lauren L. .......... RNIN. besueiscsssncvees eben cae vane 65074 Rosen, Michael I. ............... See * 11002 Rosenberg, I. G. .......... III, NS...  ...  Rusnak, J. Russo, E. RO FONGE GS, 506. 600 <ctcccccs Rustamov, Kh. P. Ruszczynski, Andrzej Ny 5 ene ee ema, eT 47015 PT Ne oc cinacesecevsccssvenere 03006 Rybicki, Slawomir Ryckkov, S.  ... 

Page 846 of Psychological Abstracts Vol. 88, Issue 2 [page]

2001 Psychological Abstracts  
J., 3148 Rush, Stephen, 4505 Rusnak, Milan, 4591 Russ, Frederick A., 6065 Russell, B.  ...  ., 4976 Ratcliffe, Laurene, 3579 Ratinckx, Elie, 3964 Ratsepp, Marju, 5138 Rau, Devaki, 4366 Rauch, Jodee, 6001 Raudenbush, Stephen L., 4364 Raudenbush, Stephen W., 3235 Ravaglia, Giovanni, 5049 Ravindran  ... 

Safety and Tolerability of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Asian Patients with Pretreated Recurrent or Refractory Gastric Cancer

Yoon-Koo Kang, Yung-Jue Bang, Shunsuke Kondo, Hyun Cheol Chung, Kei Muro, Isabelle Dussault, Christoph Helwig, Motonobu Osada, Toshihiko Doi
2020 Clinical Cancer Research  
Medical writing support was provided by Lauren Rusnak, data (provided animals, acquired and managed patients, provided facilities, etc.): 349 Y.-K. Kang, Y.-J. Bang, S. Kondo, H.C. Chung, K. Muro, T.  ...  Tumor histology was initially captured using the Japanese or World Health Organization 134 classification systems and later mapped to the Lauren classification system (Supplementary 128 133 135  ... 
doi:10.1158/1078-0432.ccr-19-3806 pmid:32299818 fatcat:tnqrekboivhadm2al4pp6jrlm4

Safety and Tolerability of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Asian Patients with Pretreated Recurrent or Refractory Gastric Cancer

Yoon-Koo Kang, Yung-Jue Bang, Shunsuke Kondo, Hyun Cheol Chung, Kei Muro, Isabelle Dussault, Christoph Helwig, Motonobu Osada, Toshihiko Doi
2020 Clinical Cancer Research  
Medical writing support was provided by Lauren Rusnak, PhD, of ClinicalThinking, Inc, and funded by Merck KGaA and GlaxoSmithKline in accordance with Good Publication Practice (GPP3) guidelines (http:/  ...  Tumor histology was initially captured using the Japanese or World Health Organization classification systems and later mapped to the Lauren classification system (Supplementary Table S1 ; refs. [30]  ...  with heavily pretreated advanced GC/GEJC (61% received ≥3 prior lines of Histology was initially captured using the Japanese or World Health Organization classification systems and later mapped to the Lauren  ... 
doi:10.1158/1078-0432.ccr-19-3806 fatcat:qytibseqgfakrmwl6e67bi633y

Page 971 of Psychological Abstracts Vol. 84, Issue Author Index [page]

Psychological Abstracts  
British Journal of Psychotherapy, 1996(Fal), Vol 13(1), 37-52. 30624 Russell, Connie L.; Bard, Kim A. & Adamson, Lauren B. Social referencing by young chimpanzees (Pan troglodytes).  ...  American Journal of Geriatric Psychiatry, 1996(Sum), Vol 4(3), 208-217. 19165 Rusnak, Kristin— See Carlson, John G. 1737 Russ, Mark J.; Clark, W. Crawford; Cross, Lisa W.; Kemper- man, Ingrid et al.  ... 

OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc

A A Ivanov, V Gonzalez-Pecchi, L F Khuri, Q Niu, Y Wang, Y Xu, Y Bai, X Mo, E V Prochownik, M A Johns, Y Du, F R Khuri (+1 others)
2017 Oncogene  
We thank Lauren Rusnak for editing the manuscript.  ... 
doi:10.1038/onc.2017.180 pmid:28628118 pmcid:PMC5648601 fatcat:yuydmfcgazgz7kddauiyozozpu

Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGFβ and PD-L1, in Patients with Esophageal Squamous Cell Carcinoma: Results from a Phase 1 Cohort in Asia

Chia-Chi Lin, Toshihiko Doi, Kei Muro, Ming-Mo Hou, Taito Esaki, Hiroki Hara, Hyun Cheol Chung, Christoph Helwig, Isabelle Dussault, Motonobu Osada, Shunsuke Kondo
2021 Targeted oncology  
Medical writing support was provided by Lauren Rusnak, PhD, of ClinicalThinking Inc., Hamilton, NJ, USA, which was also funded by Merck KGaA and GlaxoSmithKline in accordance with Good Publication Practice  ... 
doi:10.1007/s11523-021-00810-9 pmid:33840050 pmcid:PMC8266718 fatcat:bz4aqgkdlbbvbi24i7vst3utm4

Zooming through development: Using video chat to support family connections

Gabrielle A. Strouse, Elisabeth McClure, Lauren J. Myers, Jennifer M. Zosh, Georgene L. Troseth, Olivia Blanchfield, Ellen Roche, Subul Malik, Rachel Barr
2021 Human Behavior and Emerging Technologies  
Additionally, video chat may offer opportunities for young children to explore and experiment with how screen media relate to their in-person world (Myers et al., 2017; Rusnak & Barr, 2020; Strouse et  ...  young children to eventually build a nascent concept of screen-based digital technology: how events on a screen relate to (but are not the same as) events in the real world (Myers, Keyser, & Cors, 2019; Rusnak  ... 
doi:10.1002/hbe2.268 fatcat:64qqt7zrjngxxkojxo4csb3cge

The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK

N. Ronkina, A. Kotlyarov, O. Dittrich-Breiholz, M. Kracht, E. Hitti, K. Milarski, R. Askew, S. Marusic, L.-L. Lin, M. Gaestel, J.-B. Telliez
2006 Molecular and Cellular Biology  
Genotyping and mouse colony maintenance were done by Tatiana Iakovleva, Gretchen Ireland, Lauren Rusnak, and Brenda Lager.  ... 
doi:10.1128/mcb.01456-06 pmid:17030606 pmcid:PMC1800641 fatcat:noqyhcmd2vgzjbetxcwkuyqcpa

Validation of novelMycobacterium tuberculosisisoniazid resistance mutations not detectable by common molecular tests [article]

Justin L. Kandler, A Mercante, Tracy Dalton, Matthew N. Ezewudo, Lauren Cowan, Scott P. Burns, Beverly Metchock, Peter Cegielski, James E Posey
2018 bioRxiv   pre-print
Wengenack NL, Uhl JR, St Amand AL, Tomlinson AJ, Benson LM, Naylor S, Kline BC, Cockerill FR, 557 3rd, Rusnak F. 1997.  ... 
doi:10.1101/322750 fatcat:xuy6iixvazeofnegaosqzto4ri

Identification of a Water-Coordinating HER2 Inhibitor by Virtual Screening Using Similarity-Based Scoring

Jiaye Guo, Stephen Collins, W. Todd Miller, Robert C. Rizzo
2018 Biochemistry  
., Rusnak, D. W., Owens, G., Alligood, K. J., and Spector, N.  ...  Derived from MD Simulations of Candidate Compounds Predicted to Coordinate the Bridging Water HIVPR ■ ACKNOWLEDGMENTS ACKNOWLEDGMENTS The authors thank Dwight McGee, Yuchen Zhou, Courtney Singleton, Lauren  ... 
doi:10.1021/acs.biochem.8b00524 pmid:29975516 pmcid:PMC6110523 fatcat:oy6o4tlfd5ao5ceqcoevpez624

University of San Diego Yearbooks

Alcala '
1982 unpublished
Second row L to R: Mi- chele Raya, Maria Rusnak, Chiarme Paras, Rosemary Boatright (Secre tary), Sharon Cook, Monique Van- Son (Treasurer), Terri Melvin.  ...  Front row L to R: Lauren Ledbetter, Bonnie Kieta, Pablo Mendoza, Roxanne Short, Cindy Beezley, Michele Raya.  ... 
fatcat:25v4k7t5g5esxbjk3u3pkse3jq
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