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Interference Between the PHA-4 and PEB-1 Transcription Factors in Formation of the Caenorhabditis elegans Pharynx

John M Kalb, Laura Beaster-Jones, Anthony P Fernandez, Peter G Okkema, Barbara Goszczynski, James D McGhee
2002 Journal of Molecular Biology  
cell-specific transcription, one must first identify a target gene, and an excellent candidate is myo-2, a gene that produces a myosin specific for pharyngeal muscle. 13 By analyzing the myo-2 promoter, Okkema  ... 
doi:10.1016/s0022-2836(02)00555-7 pmid:12095247 fatcat:tjciuvsbhvhntmr2yeybiq3qva

An early pharyngeal muscle enhancer from the Caenorhabditis elegans ceh-22 gene is targeted by the Forkhead factor PHA-4

Tomas Vilimas, Alin Abraham, Peter G Okkema
2004 Developmental Biology  
Okkema, unpublished) .  ...  We are also grateful to Matthew Schau, Tony Fernandez, and Laura Beaster-Jones for comments on this manuscript, and to the colleagues in the LMB for advice during this work.  ... 
doi:10.1016/j.ydbio.2003.10.015 pmid:14738885 fatcat:lrsnahwdkfeifd72fsh45dppgy

Volumes 187, 188, 189 January–December 2011

2011 Genetics  
Odom, Duncan O'Donnell, Janis Ohkura, Hiroyuki Ohler, Uwe Ohya, Yoshikazu Okkema, Peter Oliver, Brian Olson, Jørn Olson, Maynard Orive, Maria E. Orr, H.  ...  Lee, Laura Lee, Siu (Sylvia) Lehmann, Laurent Lei, Elissa Leitch, Andrew Leman, Scotland Lenormand, Thomas Leon-Novelo, Luis Lew, Daniel L'Hernault, Steven W.  ... 
doi:10.1093/genetics/189.4.1527 fatcat:gcwa3vfcxbcltkdfvlpzde2rwm

G3 Reviewer Index 2018

2018 G3: Genes, Genomes, Genetics  
Noguchi, Eishi Nozaki, Hisayoshi O'Connor, Michael Oakey, Helena Obbard, Darren Ogden, Rob Ohkura, Hiroyuki Okagaki, Ron Okkema  ...  Bruno, Vincent Buckley, Thomas Budak, Hikmet Budar, Francoise Burgio, Gaetan Burkard, Christine Burmeister, Louise Burrack, Laura  ... 
doi:10.1534/g3.117.200837 doaj:ed26e6038b8f4cd9b4829d1a42eb60ac fatcat:i7jy2m5ej5fffpwxow5gxgqsrm

C. elegans peb-1 mutants exhibit pleiotropic defects in molting, feeding, and morphology

Anthony P. Fernandez, Jack Gibbons, Peter G. Okkema
2004 Developmental Biology  
We are also grateful to Laura Beaster-Jones, Dawn Franks, and two anonymous reviewers for comments on the manuscript, and to Betsy Goodwin and colleagues in the LMB for advice and encouragement.  ...  PEB-1 activity requires an intact DNA-binding domain (Beaster-Jones and Okkema, 2004) , and this deletion removes sequences encoding most of this domain.  ...  Individual animals were genotyped by single worm duplex PCR as described previously (Beaster-Jones and Okkema, 2004) . peb-1(cu9) was out-crossed four times to wild type.  ... 
doi:10.1016/j.ydbio.2004.08.040 pmid:15581870 fatcat:gqwyiwdwi5aqnkslwlwozs4bgy

Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegans

S Strome, P Martin, E Schierenberg, J Paulsen
1995 Development  
anti-myosin antibody; Jim Priess, Tim Schedl and Joel Rothman for advice on laser ablations; Heidi Browning for a refresher course on using the confocal microscope; Cindi Madej for help with figures; and Laura  ...  The transgenic strain PD56 containing the unc-54::lacZ construct (Okkema et al., 1993) was a gift from Andy Fire.  ...  the region. (2) Transformation rescue experiments have delimited the mes-1-containing region to 17 kb, and the bn74 allele is a 20-25 kb deletion that lacks the entire 17 kb of rescuing genomic DNA (Laura  ... 
pmid:7555722 fatcat:gxvwv6tp6nfftkteomn4mwzqxe

30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries

Rishi Singhal, Christian Ludwig, Gavin Rudge, Georgios V. Gkoutos, Abd Tahrani, Kamal Mahawar, Michał Pędziwiatr, Piotr Major, Piotr Zarzycki, Athanasios Pantelis, Dimitris P. Lapatsanis, Georgios Stravodimos (+422 others)
2021 Obesity Surgery  
Background There are data on the safety of cancer surgery and the efficacy of preventive strategies on the prevention of postoperative symptomatic COVID-19 in these patients. But there is little such data for any elective surgery. The main objectives of this study were to examine the safety of bariatric surgery (BS) during the coronavirus disease 2019 (COVID-19) pandemic and to determine the efficacy of perioperative COVID-19 protective strategies on postoperative symptomatic COVID-19 rates.
more » ... hods We conducted an international cohort study to determine all-cause and COVID-19-specific 30-day morbidity and mortality of BS performed between 01/05/2020 and 31/10/2020. Results Four hundred ninety-nine surgeons from 185 centres in 42 countries provided data on 7704 patients. Elective primary BS (n = 7084) was associated with a 30-day morbidity of 6.76% (n = 479) and a 30-day mortality of 0.14% (n = 10). Emergency BS, revisional BS, insulin-treated type 2 diabetes, and untreated obstructive sleep apnoea were associated with increased complications on multivariable analysis. Forty-three patients developed symptomatic COVID-19 postoperatively, with a higher risk in non-whites. Preoperative self-isolation, preoperative testing for SARS-CoV-2, and surgery in institutions not concurrently treating COVID-19 patients did not reduce the incidence of postoperative COVID-19. Postoperative symptomatic COVID-19 was more likely if the surgery was performed during a COVID-19 peak in that country. Conclusions BS can be performed safely during the COVID-19 pandemic with appropriate perioperative protocols. There was no relationship between preoperative testing for COVID-19 and self-isolation with symptomatic postoperative COVID-19. The risk of postoperative COVID-19 risk was greater in non-whites or if BS was performed during a local peak.
doi:10.1007/s11695-021-05493-9 pmid:34328624 pmcid:PMC8323543 fatcat:a3xyuljq7nchvjtg2t6hvkg7he

Conservation of the C.elegans tra-2 3'UTR translational control

E. Jan
1997 EMBO Journal  
We would like to thank Amy Bejsovec and Pete Okkema for critical reading of the manuscript, and Laura Graves, Karen Hofstra, Jim Kramer and Cindy Motzny for valuable discussions.  ...  In addition, tra-1 may feed back positively on to tra-2 to amplify commitment to female development (Okkema and Kimble, 1991) . (B) Sex determination in the germ line.  ...  predicted to encode a large transmembrane protein, called TRA-2A, which is thought to function by inhibiting downstream male determinants and by coordinating neighboring cells to adopt the same fate (Okkema  ... 
doi:10.1093/emboj/16.20.6301 pmid:9321409 pmcid:PMC1326314 fatcat:ryylhrtxqvfwfjukba2opp2wxm

The C. elegans adult male germline: Stem cells and sexual dimorphism

Dyan E. Morgan, Sarah L. Crittenden, Judith Kimble
2010 Developmental Biology  
Acknowledgments We thank Peggy Kroll-Connor and Beth Thompson for isolating fog-1(q785), Kimble lab members for helpful discussions, and Anne Helsley-Marchbanks and Laura Vanderploeg for help in preparing  ...  To ask if the X:A ratio controls the distal gonad, we examined XX tra-2(q276) mutant males, which are morphologically indistinguishable from XO wild-type males (Okkema and Kimble, 1991) .  ...  We used the wild-type strain, N2, and the following mutants: LG I: fog-1 (q785) (this work); LG II: tra-2(q276) (Okkema and Kimble, 1991) ; LG III: tra-1(e1488) (Hodgkin, 1987) , tra-1(e1732) (Hodgkin  ... 
doi:10.1016/j.ydbio.2010.07.022 pmid:20659446 pmcid:PMC2945412 fatcat:ykiswxus3ravdpimefkjtrylnm

Selected list of books and journals in allied health

A N Brandon, D R Hill
1996 Bulletin of the Medical Library Association  
HARING, JOEN LANNUCC, AND LIND, LAURA JANSEN. Radio- graphic Interpretation for the Dental Hygienist. Philadelphia, Saunders, 1993. $36.00. *49. HARRIS, NoRMAN 0., AND CHRISTEN, ARDEN G.  ...  OKKEMA, KATHLEEN. Cognition and Perception in the Stroke Patient: A Guide to Functional Outcomes in Occupational Therapy. Gaithersburg, Md., Aspen, 1993. $76.00. 215. PEDRETTI, LORRAINE WILLIAMS, ed.  ... 
pmid:16018053 pmcid:PMC226150 fatcat:mll7pjvi45ayxficyjrimuv57m

gon-4, a Cell Lineage Regulator Required for Gonadogenesis in Caenorhabditis elegans

Lisa Friedman, Sonia Santa Anna-Arriola, Jonathan Hodgkin, Judith Kimble
2000 Developmental Biology  
We are grateful to Sarah Crittenden, Jeff Hardin, Eric Lambie, Laura Mathies, Kevin O'Connell, and Kellee Siegfried, for thoughtful comments on the manuscript, and to all the members of the Kimble lab  ...  ., 1997; Mello and Fire, 1995; Okkema et al., 1993) .  ... 
doi:10.1006/dbio.2000.9944 pmid:11112335 fatcat:yku6lcq52jardg4id4irmzgfoy

Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development

T. Fukushige, T. M. Brodigan, L. A. Schriefer, R. H. Waterston, M. Krause
2006 Genes & Development  
have obtained identical results with independent reporter genes, and we confirmed that HND-1 was transiently present in bodywall muscle lineages (and other lineages) using antibodies kindly provided by Laura  ...  types in C. elegans, namely pharyngeal and bodywall, each utilize distinct MHCs (Miller et al. 1986 ) and distinct transcriptional regulators: the Nkx2.5-related factor CEH-22 for pharyngeal muscle (Okkema  ... 
doi:10.1101/gad.1481706 pmid:17142668 pmcid:PMC1698447 fatcat:zadhre6bk5b3plqdig45ro7nn4

Germline and developmental roles of the nuclear transport factor importin alpha3 in C. elegans

K G Geles, S A Adam
2001 Development  
Eric Jan and Laura Graves, for invaluable expertise and reagents used.  ...  Full-length cDNA sequences for ima-1 and ima-3 were obtained from a mixed-stage λgt11 cDNA library, using yk148a11 and yk8f10, respectively, by hybridization screening of the library provided by Dr Peter Okkema  ... 
pmid:11311162 fatcat:qz4qgwnrvrdapoi4r3jwrdihlq

The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans

Gabriela Huelgas-Morales, Carlos Giovanni Silva-García, Laura S. Salinas, David Greenstein, Rosa E. Navarro
2016 G3: Genes, Genomes, Genetics  
To this end, we used tra-2(q276) mutants, which are XX but develop into fully functional males (Okkema and Kimble 1991) , and fog-2(q71) hermaphrodites, which do not produce sperm and are often referred  ... 
doi:10.1534/g3.115.026815 pmid:26865701 pmcid:PMC4825639 fatcat:ijuhreb4lngxpaydgywigqqvhu

Soma–Germ Cell Interactions inCaenorhabditis elegans:Multiple Events of Hermaphrodite Germline Development Require the Somatic Sheath and Spermathecal Lineages

James McCarter, Bart Bartlett, Thanh Dang, Tim Schedl
1997 Developmental Biology  
Strains, reagents, experimental protocols, and productive suggestions were provided by Laura Wilson Berry, Bob Clif-serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo.  ...  ., 1986) . unc-54 is expressed in the sheath fem genes were reduced, but levels of tra-2 gene product along with myo-3, which encodes myosin A (Okkema et were maintained, the fem gene products might not  ... 
doi:10.1006/dbio.1996.8429 pmid:9013925 fatcat:fzc47xyitrh5leqieovzdkzaje
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