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Lasting consequences of concussion on the aging brain: findings from the Baltimore Longitudinal Study of Aging

Danielle June, Owen A Williams, Chiung-Wei Huang, Yang An, Bennett A. Landman, Christos Davatzikos, Murat Bilgel, Susan M Resnick, Lori L Beason-Held
2020 NeuroImage  
Most neuroimaging studies show effects of concussions in frontal and temporal lobes of the brain, yet the long-term impacts of concussions on the aging brain have not been well studied.  ...  We examined neuroimaging data from 51 participants (mean age at first imaging visit=65.1±11.23) in the Baltimore Longitudinal Study of Aging who reported a concussion in their medical history an average  ...  Acknowledgments This research was supported by the Intramural Research Program of the National Institutes of Health, National Institute on Aging.  ... 
doi:10.1016/j.neuroimage.2020.117182 pmid:32702483 pmcid:PMC7848820 fatcat:wmq2k5vasrdv7gbzix453yleie

Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls

Massimo S. Fiandaca, Mark Mapstone, Amin Mahmoodi, Thomas Gross, Fabio Macciardi, Amrita K. Cheema, Kian Merchant-Borna, Jeffrey Bazarian, Howard J. Federoff, Mark Webber Miller
2018 PLoS ONE  
TBI = traumatic brain injury; mTBI = mild TBI; NC = non-concussed controls; Washington = Washington Hospital Center; Maryland = University of Maryland Shock Trauma Center; Army = NORMAL study; ER = emergency  ...  OPEN ACCESS Citation: Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, et al. (2018) Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls  ...  investigations for use in the External cohort of our study.  ... 
doi:10.1371/journal.pone.0195318 pmid:29677216 pmcid:PMC5909890 fatcat:zvmigikb7zejxbjv57hzat5a3q

The punch-drunk boxer and the battered wife: Gender and brain injury research

Stephen T. Casper, Kelly O'Donnell
2019 Social Science and Medicine  
In boxing, the question of brain injury and its sequelae were analyzed from 1928 on, often on profoundly somatic grounds.  ...  With domestic violence, in contrast, the question of brain injury and its sequelae appear to have been first examined only after 1990.  ...  Acknowledgements Versions of this paper were given to the Department of History at the University of New Hampshire, the American Association for the History of Medicine, and Mississippi State University  ... 
doi:10.1016/j.socscimed.2019.112688 pmid:31830739 fatcat:pmpp3jisc5hhfjgifgeu5gyyme

Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

Diego Iacono, Gloria C. Feltis
2019 Aging  
Numerous studies on aging-related brain diseases show that some genes identified as risk factors for some of the most common neurodegenerative diseases - such as the allele 4 of APOE gene (APOE4) for Alzheimer's  ...  Intriguingly, though, those same genes associated with aging-related brain diseases seem to influence different aspects of the brain functioning much earlier actually, that is, even from the neonatal periods  ...  Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging. Neurobiol Aging. 1996; 17:365-71. 48. Wardell MR, Brennan SO, Janus ED, Fraser R, Carrell RW.  ... 
doi:10.18632/aging.101757 pmid:30677746 pmcid:PMC6366964 fatcat:mlljnahqo5b27lbrzeebqnxstm

Repetitive Model of Mild Traumatic Brain Injury Produces Cortical Abnormalities Detectable by Magnetic Resonance Diffusion Imaging, Histopathology, and Behavior

Fengshan Yu, Dinesh K. Shukla, Regina C. Armstrong, Christina M. Marion, Kryslaine L. Radomski, Reed G. Selwyn, Bernard J. Dardzinski
2017 Journal of Neurotrauma  
To better detect abnormalities from mTBI, we performed longitudinal studies (baseline, 3, 6, and 42 days) using magnetic resonance diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) in  ...  Noninvasive detection of mild traumatic brain injury (mTBI) is important for evaluating acute through chronic effects of head injuries, particularly after repetitive impacts.  ...  Acknowledgments This study was funded by the Department of Defense within the Center for Neuroscience and Regenerative Medicine. We appreciate the assistance of Dr.  ... 
doi:10.1089/neu.2016.4569 pmid:27784203 pmcid:PMC5385606 fatcat:r2z3ykoal5drxkt7eobijlnvby

Movement Path Tortuosity in Free Ambulation: Relationships to Age and Brain Disease

William Diehl Kearns, James Leonard Fozard, Vilis O. Nams
2017 IEEE journal of biomedical and health informatics  
of all ages.  ...  The review elucidates the mathematical assumptions underlying Fractal D, its use in the analysis of movements of free ranging animals, and its application to the study of cognitive impairment and the prediction  ...  Department of Veterans Affairs Normative Aging Study, and the National Institute on Aging's Baltimore Longitudinal Study of Aging, which he directed for 13 years.  ... 
doi:10.1109/jbhi.2016.2517332 pmid:26829811 fatcat:eccbaxwe6zd5pgux3r2ydlh46y

Abstracts Presented at the 2004 Annual Meeting of the Australian Society for the Brain Impairment (ASSBI) and the International Neuropsychological Society (INS), July 7–10, 2004, Brisbane, Australia

2004 Journal of the International Neuropsychological Society  
Behavioural data come from a longitudinal population-based sample of participants in the Australian Longitudinal Study of Ageing (ALSA), based in Adelaide.  ...  In this study we examined driving habits over a 5-year period in the Australian Longitudinal Study of Ageing.  ...  These findings leave open the possibility of cognitive restoration after CEA as a result of recovery from subtle brain damage or due to improved blood supply to the brain.  ... 
doi:10.1017/s1355617704040032 fatcat:vhwnpun3ijaythkza2x4s7es7i

Neuropsychiatric Symptoms in Dementia Patients With and Without a History of Traumatic Brain Injury

V. Rao, P. Rosenberg, Q. S. Miles, D. Patadia, K. Treiber, M. Bertrand, M. Norton, M. Steinberg, J. Tschanz, C. Lyketsos
2010 The Journal of Neuropsychiatry and Clinical Neurosciences  
Background: Levodopa, when combined with a decarboxylase inhibitor, delivers dopamine directly to the brain and has no net effect on brain blood vessels. For neuroimaging studies of P3.  ...  Locally, they may provide elevated levels of 5HT and DA, and are associated with afferents from the BLA.  ...  Method: 58 adolescents with mildmoderate and severe traumatic brain injury (ages 12-17) were matched on variables of age, gender and race with 58 controls from the standardized sample of the CVLT-C (N ‫  ... 
doi:10.1176/appi.neuropsych.22.2.166 pmid:20463110 pmcid:PMC2928219 fatcat:cz6z2lqjwnbqlmq2uhcsiwrq6m

Mental disorders as "brain diseases" and Jaspers' legacy

Mario Maj
2013 World Psychiatry  
Acknowledgements The author would like to thank Drs. R.C. Bowen and L. Balbuena for editorial assistance.  ...  Acknowledgement This publication has been partially supported by an unrestricted educational grant from H. Lundbeck A/S, which is hereby gratefully acknowledged. Acknowledgements  ...  Longitudinal studies have been advocated during the last decade, as a plethora of cross-sectional data was emerging.  ... 
doi:10.1002/wps.20000 pmid:23471786 pmcid:PMC3619168 fatcat:zfyuuy5hrbgfdacxhepmrdiimq

Biochemical Assessment of Precuneus and Posterior Cingulate Gyrus in the Context of Brain Aging and Alzheimer's Disease

Chera L. Maarouf, Tyler A. Kokjohn, Douglas G. Walker, Charisse M. Whiteside, Walter M. Kalback, Alexis Whetzel, Lucia I. Sue, Geidy Serrano, Sandra A. Jacobson, Marwan N. Sabbagh, Eric M. Reiman, Thomas G. Beach (+2 others)
2014 PLoS ONE  
conditions from aging-associated changes.  ...  Our experiments revealed that the bioindicators of emerging brain pathology remained steady or decreased with advancing age. One exception was S100B, which significantly increased with age.  ...  Human tissue for the young adult group was obtained from the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland, Baltimore, MD.  ... 
doi:10.1371/journal.pone.0105784 pmid:25166759 pmcid:PMC4148328 fatcat:cx5gudk5mnh3blc437zkoyzmfu

Final Program Forty Second Annual Meeting International Neuropsychological Society February 12–15, 2014 Seattle, Washington, USA

2014 Journal of the International Neuropsychological Society  
While n-of-1 designs will be touched on, most of the workshop content will focus on group studies.  ...  effectiveness studies, and the goals of each phase  ...  on the first and last day of a 20 week program.  ... 
doi:10.1017/s1355617714000381 pmid:24666775 fatcat:6bwv7b2wjjez3beb3z5bryms6i


L. W. Freeman, T. W. Wright
1953 Annals of Surgery  
Like any collec- tion of blood in a vital area, it must find channels of drainage or it will produce dam- age.  ...  In the early twentieth cen- tury, Ramon y Cajal** was presenting his findings on neural regeneration.  ... 
doi:10.1097/00000658-195304000-00001 pmid:13031478 pmcid:PMC1802525 fatcat:kzyuqawb4zblzc4qbyfewdz5hq

Abstracts Presented at the Thirty-First Annual International Neuropsychological Society Conference, February 5–8, 2003 Honolulu, Hawaii

2003 Journal of the International Neuropsychological Society  
Seventy-three Baltimore Longitudinal Study of Aging participants (44 men and 29 women) were tested twice approximately 7.9 years apart (Time 2 age range 5 29-89 years).  ...  We examined the effect of ApoE status on comprehensive neuropsychological results from 161 healthy adults (M age 5 59 years) from the NIMH longitudinal study of risk for Alzheimer's disease at baseline  ...  This study is part of TRAILS (TRacking Adolescents' Individual Lives Survey): a longitudinal study of the psychosocial development from prepuberty into young adulthood.  ... 
doi:10.1017/s1355617703920017 fatcat:hzhzynda5ndgbmkvyjqxmc6tum

Final Program, Abstracts Presented at the Thirty–Fifth Annual International Neuropsychological Society Conference, February 7–10, Portland, Oregon, USA

2007 Journal of the International Neuropsychological Society  
Despite this, there were no differences on any of the depression measures.  ...  The role of disease variables, age, and depression proneness in predicting depression in MS patients.  ...  E-mail: dschret@jhmi Objective: To compare the findings from our cross-sectional and longitudinal studies on the effects of age on confrontation naming (60-item BNT) in normal older adults.  ... 
doi:10.1017/s1355617707079969 fatcat:hyqc3ut5ybg3rnk6shatuylham

Art. II.—An Examination of the Causes, Diagnosis, and Operative Treatment of Compression of the Brain, as met with in Army Practice

1873 American Journal of the Medical Sciences  
The last case was one of coma withont paralysis consequent npon a complicated fracture of the frontal bone. The trephine was applied, the dura mater opened, and a spoonful of matter evacuated.  ...  A man, for example, is struck on the head by a ball or a fragment of shell, and the phenomena of concussion of the brain ensue.  ... 
doi:10.1097/00000441-187307000-00002 fatcat:vyjhzcf22fbjtnlstpgoicp67q
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