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Lasting consequences of concussion on the aging brain: findings from the Baltimore Longitudinal Study of Aging
2020
NeuroImage
Most neuroimaging studies show effects of concussions in frontal and temporal lobes of the brain, yet the long-term impacts of concussions on the aging brain have not been well studied. ...
We examined neuroimaging data from 51 participants (mean age at first imaging visit=65.1±11.23) in the Baltimore Longitudinal Study of Aging who reported a concussion in their medical history an average ...
Acknowledgments This research was supported by the Intramural Research Program of the National Institutes of Health, National Institute on Aging. ...
doi:10.1016/j.neuroimage.2020.117182
pmid:32702483
pmcid:PMC7848820
fatcat:wmq2k5vasrdv7gbzix453yleie
Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls
2018
PLoS ONE
TBI = traumatic brain injury; mTBI = mild TBI; NC = non-concussed controls; Washington = Washington Hospital Center; Maryland = University of Maryland Shock Trauma Center; Army = NORMAL study; ER = emergency ...
OPEN ACCESS Citation: Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, et al. (2018) Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls ...
investigations for use in the External cohort of our study. ...
doi:10.1371/journal.pone.0195318
pmid:29677216
pmcid:PMC5909890
fatcat:zvmigikb7zejxbjv57hzat5a3q
The punch-drunk boxer and the battered wife: Gender and brain injury research
2019
Social Science and Medicine
In boxing, the question of brain injury and its sequelae were analyzed from 1928 on, often on profoundly somatic grounds. ...
With domestic violence, in contrast, the question of brain injury and its sequelae appear to have been first examined only after 1990. ...
Acknowledgements Versions of this paper were given to the Department of History at the University of New Hampshire, the American Association for the History of Medicine, and Mississippi State University ...
doi:10.1016/j.socscimed.2019.112688
pmid:31830739
fatcat:pmpp3jisc5hhfjgifgeu5gyyme
Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan
2019
Aging
Numerous studies on aging-related brain diseases show that some genes identified as risk factors for some of the most common neurodegenerative diseases - such as the allele 4 of APOE gene (APOE4) for Alzheimer's ...
Intriguingly, though, those same genes associated with aging-related brain diseases seem to influence different aspects of the brain functioning much earlier actually, that is, even from the neonatal periods ...
Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging. Neurobiol Aging. 1996; 17:365-71. 48. Wardell MR, Brennan SO, Janus ED, Fraser R, Carrell RW. ...
doi:10.18632/aging.101757
pmid:30677746
pmcid:PMC6366964
fatcat:mlljnahqo5b27lbrzeebqnxstm
Repetitive Model of Mild Traumatic Brain Injury Produces Cortical Abnormalities Detectable by Magnetic Resonance Diffusion Imaging, Histopathology, and Behavior
2017
Journal of Neurotrauma
To better detect abnormalities from mTBI, we performed longitudinal studies (baseline, 3, 6, and 42 days) using magnetic resonance diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) in ...
Noninvasive detection of mild traumatic brain injury (mTBI) is important for evaluating acute through chronic effects of head injuries, particularly after repetitive impacts. ...
Acknowledgments This study was funded by the Department of Defense within the Center for Neuroscience and Regenerative Medicine. We appreciate the assistance of Dr. ...
doi:10.1089/neu.2016.4569
pmid:27784203
pmcid:PMC5385606
fatcat:r2z3ykoal5drxkt7eobijlnvby
Movement Path Tortuosity in Free Ambulation: Relationships to Age and Brain Disease
2017
IEEE journal of biomedical and health informatics
of all ages. ...
The review elucidates the mathematical assumptions underlying Fractal D, its use in the analysis of movements of free ranging animals, and its application to the study of cognitive impairment and the prediction ...
Department of Veterans Affairs Normative Aging Study, and the National Institute on Aging's Baltimore Longitudinal Study of Aging, which he directed for 13 years. ...
doi:10.1109/jbhi.2016.2517332
pmid:26829811
fatcat:eccbaxwe6zd5pgux3r2ydlh46y
Abstracts Presented at the 2004 Annual Meeting of the Australian Society for the Brain Impairment (ASSBI) and the International Neuropsychological Society (INS), July 7–10, 2004, Brisbane, Australia
2004
Journal of the International Neuropsychological Society
Behavioural data come from a longitudinal population-based sample of participants in the Australian Longitudinal Study of Ageing (ALSA), based in Adelaide. ...
In this study we examined driving habits over a 5-year period in the Australian Longitudinal Study of Ageing. ...
These findings leave open the possibility of cognitive restoration after CEA as a result of recovery from subtle brain damage or due to improved blood supply to the brain. ...
doi:10.1017/s1355617704040032
fatcat:vhwnpun3ijaythkza2x4s7es7i
Neuropsychiatric Symptoms in Dementia Patients With and Without a History of Traumatic Brain Injury
2010
The Journal of Neuropsychiatry and Clinical Neurosciences
Background: Levodopa, when combined with a decarboxylase inhibitor, delivers dopamine directly to the brain and has no net effect on brain blood vessels. For neuroimaging studies of P3. ...
Locally, they may provide elevated levels of 5HT and DA, and are associated with afferents from the BLA. ...
Method: 58 adolescents with mildmoderate and severe traumatic brain injury (ages 12-17) were matched on variables of age, gender and race with 58 controls from the standardized sample of the CVLT-C (N ...
doi:10.1176/appi.neuropsych.22.2.166
pmid:20463110
pmcid:PMC2928219
fatcat:cz6z2lqjwnbqlmq2uhcsiwrq6m
Mental disorders as "brain diseases" and Jaspers' legacy
2013
World Psychiatry
Acknowledgements The author would like to thank Drs. R.C. Bowen and L. Balbuena for editorial assistance. ...
Acknowledgement This publication has been partially supported by an unrestricted educational grant from H. Lundbeck A/S, which is hereby gratefully acknowledged.
Acknowledgements ...
Longitudinal studies have been advocated during the last decade, as a plethora of cross-sectional data was emerging. ...
doi:10.1002/wps.20000
pmid:23471786
pmcid:PMC3619168
fatcat:zfyuuy5hrbgfdacxhepmrdiimq
Biochemical Assessment of Precuneus and Posterior Cingulate Gyrus in the Context of Brain Aging and Alzheimer's Disease
2014
PLoS ONE
conditions from aging-associated changes. ...
Our experiments revealed that the bioindicators of emerging brain pathology remained steady or decreased with advancing age. One exception was S100B, which significantly increased with age. ...
Human tissue for the young adult group was obtained from the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland, Baltimore, MD. ...
doi:10.1371/journal.pone.0105784
pmid:25166759
pmcid:PMC4148328
fatcat:cx5gudk5mnh3blc437zkoyzmfu
Final Program Forty Second Annual Meeting International Neuropsychological Society February 12–15, 2014 Seattle, Washington, USA
2014
Journal of the International Neuropsychological Society
While n-of-1 designs will be touched on, most of the workshop content will focus on group studies. ...
effectiveness studies, and the goals of each phase ...
on the first and last day of a 20 week program. ...
doi:10.1017/s1355617714000381
pmid:24666775
fatcat:6bwv7b2wjjez3beb3z5bryms6i
EXPERIMENTAL OBSERVATIONS OF CONCUSSION AND CONTUSION OF THE SPINAL CORD
1953
Annals of Surgery
Like any collec- tion of blood in a vital area, it must find channels of drainage or it will produce dam- age. ...
In the early twentieth cen- tury, Ramon y Cajal** was presenting his findings on neural regeneration. ...
doi:10.1097/00000658-195304000-00001
pmid:13031478
pmcid:PMC1802525
fatcat:kzyuqawb4zblzc4qbyfewdz5hq
Abstracts Presented at the Thirty-First Annual International Neuropsychological Society Conference, February 5–8, 2003 Honolulu, Hawaii
2003
Journal of the International Neuropsychological Society
Seventy-three Baltimore Longitudinal Study of Aging participants (44 men and 29 women) were tested twice approximately 7.9 years apart (Time 2 age range 5 29-89 years). ...
We examined the effect of ApoE status on comprehensive neuropsychological results from 161 healthy adults (M age 5 59 years) from the NIMH longitudinal study of risk for Alzheimer's disease at baseline ...
This study is part of TRAILS (TRacking Adolescents' Individual Lives Survey): a longitudinal study of the psychosocial development from prepuberty into young adulthood. ...
doi:10.1017/s1355617703920017
fatcat:hzhzynda5ndgbmkvyjqxmc6tum
Final Program, Abstracts Presented at the Thirty–Fifth Annual International Neuropsychological Society Conference, February 7–10, Portland, Oregon, USA
2007
Journal of the International Neuropsychological Society
Despite this, there were no differences on any of the depression measures. ...
The role of disease variables, age, and depression proneness in predicting depression in MS patients. ...
E-mail: dschret@jhmi Objective: To compare the findings from our cross-sectional and longitudinal studies on the effects of age on confrontation naming (60-item BNT) in normal older adults. ...
doi:10.1017/s1355617707079969
fatcat:hyqc3ut5ybg3rnk6shatuylham
Art. II.—An Examination of the Causes, Diagnosis, and Operative Treatment of Compression of the Brain, as met with in Army Practice
1873
American Journal of the Medical Sciences
The last case was one of coma withont paralysis consequent npon a complicated fracture of the frontal bone. The trephine was applied, the dura mater opened, and a spoonful of matter evacuated. ...
A man, for example, is struck on the head by a ball or a fragment of shell, and the phenomena of concussion of the brain ensue. ...
doi:10.1097/00000441-187307000-00002
fatcat:vyjhzcf22fbjtnlstpgoicp67q
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