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Large-scale virtual screening for discovering leads in the postgenomic era

B. Waszkowycz, T. D. J. Perkins, R. A. Sykes, J. Li
2001 IBM Systems Journal  
Virtual screening, or in silico screening, is a new approach attracting increasing levels of interest in the pharmaceutical industry as a productive and cost-effective technology in the search for novel  ...  feasibility of performing very largescale virtual screening as a route to identifying novel drug leads.  ...  Acknowledgments For assistance with the modeling, programming, and administrative tasks involved in the DockCrunch project, we acknowledge the contributions of Carol Baxter, Chris Murray, Paul Greaney,  ... 
doi:10.1147/sj.402.0360 fatcat:dcnfx36lqffcro2lxcprhl4e5y

Chemical genomics as an emerging paradigm for postgenomic drug discovery

F Raymond Salemme
2003 Pharmacogenomics (London)  
Chemical genomics approaches are evolving to overcome key problems limiting the efficiency of drug discovery in the postgenomic era.  ...  Many of these stem from the low success rates in finding drugs for novel genomics targets whose biochemical properties and therapeutic relevance is poorly understood.  ...  An emerging paradigm for drug discovery in the postgenomic era Well known examples include proteases [1, [13] [14] [15] [16] 29] , kinases [1, 19, 31] , and nuclear hormone receptors [1, 51, 52] . 3D  ... 
doi:10.1517/phgs.4.3.257.22692 pmid:12718717 fatcat:n757db6vdne7hlob2g45i3mau4

Novel Computing Technologies for Bioinformatics and Cheminformatics

Chuan Yi Tang, Che-Lun Hung, Ching-Hsien Hsu, Huiru Zheng, Chun-Yuan Lin
2014 BioMed Research International  
Acknowledgments The guest editors would like to express sincere gratitude to numerous reviewers for their professional effort, insight, and hard work put into commenting on the selected articles which  ...  reflect the essence of this special issue.  ...  in the postgenome era.  ... 
doi:10.1155/2014/392150 pmid:25610863 pmcid:PMC4291190 fatcat:46kwkovqkbfexosjew4r2il5kq

Drosophila RNAi screening in a postgenomic world

C. Bakal
2011 Briefings in Functional Genomics  
The contribution of the fruit fly to science and medicine continues in the postgenomic era as cell-based Drosophila RNAi screens are a cost-effective and scalable enabling technology that can be used to  ...  Drosophila melanogaster has a long history as a model organism with several unique features that make it an ideal research tool for the study of the relationship between genotype and phenotype.  ...  INTRODUCTION In the postgenomic era, the mapping, sequencing and cloning of genes, once considered major hurdles in genetics research, have become trivial processes.  ... 
doi:10.1093/bfgp/elr015 pmid:21752787 pmcid:PMC3144739 fatcat:5rtudjmg6rhrvdtns4evhklnim

Information visualization techniques in bioinformatics during the postgenomic era

Ying Tao, Yang Liu, Carol Friedman, Yves A. Lussier
2004 Drug Discovery Today BIOSILICO  
In the postgenomic era, information visualization tools are indispensable for biomedical research.  ...  Information visualization techniques, which take advantage of the bandwidth of human vision, are powerful tools for organizing and analyzing a large amount of data.  ...  Acknowledgments The authors thank Spotfire Company and Human-Computer Interaction Laboratory at University of Maryland for providing software to produce the figures in this paper.  ... 
doi:10.1016/s1741-8364(04)02423-0 pmid:20976032 pmcid:PMC2957900 fatcat:t55dnvyiszejjaqahu2674ejsq

A Postgenomic Perspective on Molecular Cytogenetics

Henry H. Heng, Steven D. Horne, Sophia Chaudhry, Sarah M. Regan, Guo Liu, Batoul Y. Abdallah, Christine J. Ye
2018 Current Genomics  
The postgenomic era is featured by massive data collection and analyses from various large scale-omics studies.  ...  Following a brief summary of the contributions of molecular cytogenetics/cytogenomics in the pre-and post-genomic eras, new challenges for postgenomic research are discussed.  ...  This work was supported by the WSU Office of the Vice President for Research Bridge Funding Grant to H. H. Heng.  ... 
doi:10.2174/1389202918666170717145716 pmid:29606910 pmcid:PMC5850511 fatcat:lwojec3zara6be4zfqouphusc4

New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics

Si-Yuan Pan, Shu-Feng Zhou, Si-Hua Gao, Zhi-Ling Yu, Shuo-Feng Zhang, Min-Ke Tang, Jian-Ning Sun, Dik-Lung Ma, Yi-Fan Han, Wang-Fun Fong, Kam-Ming Ko
2013 Evidence-Based Complementary and Alternative Medicine  
The prospect of drug discovery from herbal medicines in the postgenomic era was made with the provision of future directions in this area of drug development.  ...  While the endeavor for drug discovery from herbal medicines is "experience driven," the search for a therapeutically useful synthetic drug, like "looking for a needle in a haystack," is a daunting task  ...  Acknowledgments This paper was supported by the National Natural Science Foundation of China (Grant no. 31071989) and the Outstanding Teaching Team of Chinese Herbal Pharmacology in Beijing City (Grant  ... 
doi:10.1155/2013/627375 pmid:23634172 pmcid:PMC3619623 fatcat:tyfbfwqc4ngrhhl5v63qvuhfbi

New Paradigms in Drug Design and Discovery

Nouri Neamati, Joseph Barchi,Jr.
2002 Current Topics in Medicinal Chemistry  
The new millennium has ushered in an era of science that will revolutionize a great majority of our daily activities.  ...  The primary reason for this increase is the changes we have made in the last 2-3 decades both in how we live our lives as well as how we treat our maladies when they arise.  ...  to be analyzed and managed on a very large scale and in an extremely short time.  ... 
doi:10.2174/1568026023394227 pmid:11944817 fatcat:naskbpapmrcgxihg5zhvcbwhui

New Paradigms in Drug Design and Discovery

Joseph J. Barchi Jr., Nouri Neamati
2004 Frontiers in Medicinal Chemistry - Online  
The new millennium has ushered in an era of science that will revolutionize a great majority of our daily activities.  ...  The primary reason for this increase is the changes we have made in the last 2-3 decades both in how we live our lives as well as how we treat our maladies when they arise.  ...  to be analyzed and managed on a very large scale and in an extremely short time.  ... 
doi:10.2174/1567204043396398 fatcat:2avlru3txrclvmsdy63ujbub2a

Insect omics research coming of age1This review is part of a virtual symposium on recent advances in understanding a variety of complex regulatory processes in insect physiology and endocrinology, including development, metabolism, cold hardiness, food intake and digestion, and diuresis, through the use of omics technologies in the postgenomic era

Bart Boerjan, Dries Cardoen, Rik Verdonck, Jelle Caers, Liliane Schoofs
2012 Canadian Journal of Zoology  
diuresis, through the use of omics technologies in the postgenomic era. 440  ...  Omics experiments are an elegant way to deliver candidate genes, the function of which can be further explored by genetic tools for functional inactivation or overexpression of the genes of interest.  ...  This work was supported by the research Fund of KU Leuven (GOA) and by the Fund for Scientific Research Flanders (FWO, G.0628.11).  ... 
doi:10.1139/z2012-010 fatcat:zgmhbcmz7ra5hahcvh5wlm6zue

Proteomics in Vaccinology and Immunobiology: An Informatics Perspective of the Immunone

Irini A. Doytchinova, Paul Taylor
2003 Journal of Biomedicine and Biotechnology  
The postgenomic era, as manifest, inter alia, by proteomics, offers unparalleled opportunities for the efficient discovery of safe, efficacious, and novel subunit vaccines targeting a tranche of modern  ...  Informatics techniques, working to address issues of both data management and through prediction to shortcut the experimental process, can be of enormous benefit in leveraging the proteomic revolution.  ...  and phosphorylation), and the large-scale identification of protein-protein interactions.  ... 
doi:10.1155/s1110724303209232 pmid:14688414 pmcid:PMC521502 fatcat:yosbr6vxinhqfn6mywqmbkamea

African trypanosomes in the 21st century: what is their future in science and in health?

George A.M. Cross
2001 International Journal of Parasitology  
The African trypanosomes remain well recognised for their role as an interesting model eukaryote for basic science, but are loosing ground in their ability to contribute to understanding common cellular  ...  What can be done to keep trypanosome biology relevant and vigorous in the 21 st century?  ...  My research is supported by the National Institutes of Health (principally by grant number AI 21729) and, in the form of individual postdoctoral fellowships, by diverse agencies.  ... 
doi:10.1016/s0020-7519(01)00141-2 pmid:11334926 fatcat:5grs6iqdozevhkehgrj7iefyby

Bacterial Genomics and Pathogen Evolution

David M. Raskin, Rekha Seshadri, Stefan U. Pukatzki, John J. Mekalanos
2006 Cell  
ACKNOWLEDGMENTS We thank Su Chiang for editing the manuscript. D.M.R. is an Ellison Medical Foundation Fellow of the Life Sciences Research Foundation.  ...  Virulence Gene Discovery in the Pre-and Postgenomic Eras How has microbial genomics changed the way virulence genes are discovered?  ...  mechanisms in the post-genomic era.  ... 
doi:10.1016/j.cell.2006.02.002 pmid:16497582 fatcat:moyzrh24hjhu5nw4cy55ua2vvi

Mosaic retroposon insertion patterns in placental mammals

G. Churakov, J. O. Kriegs, R. Baertsch, A. Zemann, J. Brosius, J. Schmitz
2009 Genome Research  
By contrast, in the mammalian genomes where they were highly active, the insertion of retroelements and their comparative insertion patterns constitute a neutral, virtually homoplasy-free archive of evolutionary  ...  mammals and for the futile search for a clear root dichotomy.  ...  Acknowledgments We thank Marsha Bundman for editorial assistance and Ronald Blakey for providing the two terrestrial globes in Figure 4 .  ... 
doi:10.1101/gr.090647.108 pmid:19261842 pmcid:PMC2675975 fatcat:6mvimu77bravzivxc6njuzal4i

Metabolomics and its Value in Today?s Era

Kadambini Tripathy, Tushar Nanda
2011 Journal of computer science and systems biology  
The report also highlights the use of metabolomics in maximizing and sustaining revenues post-marketing and in the development of clinical diagnostics.  ...  Metabolomics is the newly emerging field of 'omics' research.Its Comprehensive and simultaneous systematic determination of metabolite levels in the metabolome and their changes over time.This review outlines  ...  Acknowledgement The Author is thankful to her family members for their support and Mrs. Sudharani for her valuable comments while preparation of the article.  ... 
doi:10.4172/jcsb.s13-001 fatcat:iciku6pmebghrich4q7unjui5a
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