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Inhibition of Voltage-Dependent Sodium Channels Suppresses the Functional Magnetic Resonance Imaging Response to Forepaw Somatosensory Activation in the Rodent

Ikuhiro Kida, Fahmeed Hyder, Kevin L. Behar
2001 Journal of Cerebral Blood Flow and Metabolism  
(fMRI) responses during somatosensory activation.  ...  The BOLD fMRI and cerebral blood flow (CBF) experiments were performed at 7 Tesla on ␣-chloralose-anesthetized rats undergoing forepaw stimulation before and for successive times after application of lamotrigine  ...  Acknowledgments: The authors thank P. Brown, S. McIntyre, and T. Nixon for their care and skill in maintaining the spectrometer, and Drs. D. L. Rothman and R. G. Shulman for helpful discussions.  ... 
doi:10.1097/00004647-200105000-00013 pmid:11333369 fatcat:2whzvy6bn5fhrpjurxqvyk6vby

Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models

Zhi-fei Wang, Emily Bame Fessler, De-Maw Chuang
2011 Acta Pharmacologica Sinica  
The mood stabilizers lithium, valproate and lamotrigine are traditionally used to treat bipolar disorder.  ...  We also propose several future research avenues that may extend our understanding of the benefits of lithium, valproate and lamotrigine in improving stroke outcomes.  ...  The authors wish to thank Ioline Henter of the NIMH for her editorial assistance in the preparation of this manuscript.  ... 
doi:10.1038/aps.2011.140 pmid:22056617 pmcid:PMC4010202 fatcat:hf43bg4h4fevnhba6g26top4xa

Is There a Future for mGlu5-Positive Allosteric Modulators in Absence Epilepsy? A Comparison with Ethosuximide [chapter]

Gilles van Luijtelaar, Valerio D'Amore, Ines Santolini, Richard T. Ngomba
2017 mGLU Receptors  
Both Etx and VU0360172 show a good SWD-suppressing effect in the cortex; however, the SWD-suppressing effects of VU0360172 in the thalamus seem to be more pronounced than those of Etx, although it is risky  ...  binding site, group I PAMs potentiate synaptically evoked mGlu1 receptor responses in rat brain slices (Knoflach et al. 2001) , and mGlu1R stimulation enhances excitability in layer V cortical neurons  ... 
doi:10.1007/978-3-319-56170-7_11 fatcat:mv65jqfrkbd3vfvdv6ublbfuye

Spreading Depolarizations

David Y. Chung, Fumiaki Oka, Cenk Ayata
2016 Journal of clinical neurophysiology  
Here, we review the causes and consequences of SDs in injured brain.  ...  Among these mechanisms, spreading depolarizations (SD) are arguably the most elusive and underappreciated in the clinical setting.  ...  The anticonvulsant lamotrigine appeared to shown good efficacy in suppressing SDs after a single dose ( Eikermann-Haerter, Lee et al. 2015 ) .  ... 
doi:10.1097/wnp.0000000000000275 pmid:27258442 pmcid:PMC4894342 fatcat:zco3db4dz5gmdpvcbgg4lx6aaq

Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies

Kirill Smirnov, Tatiana Stroganova, Sophie Molholm, Olga Sysoeva
2021 International Journal of Molecular Sciences  
Electroencephalogram (EEG) has provided useful information to clinicians and scientists, from the very first descriptions of RTT, and yet no reliable neurophysiological biomarkers related to the pathophysiology  ...  in RTT, e.g., shift of mu rhythm frequency and EEG during sleep; (2) closer alignment of approaches between patients with RTT and its animal models to strengthen the translational significance of the  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms22105308 pmid:34069993 pmcid:PMC8157853 fatcat:5gltqhsblze33eg2gjeskaycta

The role of nicotinic acetylcholine receptors in autosomal dominant nocturnal frontal lobe epilepsy

Andrea Becchetti, Patrizia Aracri, Simone Meneghini, Simone Brusco, Alida Amadeo
2015 Frontiers in Physiology  
Overall, the uncertainties about both the etiology and the pathogenesis of ADNFLE point to the current gaps in our knowledge the regulation of neuronal networks in the cerebral cortex.  ...  Functional evidence points to alterations in prefrontal GABA release, and the synaptic unbalance probably arises during the cortical circuit maturation.  ...  In mouse, for instance, the response of layer VI pyramidal neurons to nicotine in the medial PFC is more sensitive than the one observed in primary somatosensory and motor cortices (Tian et al., 2014  ... 
doi:10.3389/fphys.2015.00022 pmid:25717303 pmcid:PMC4324070 fatcat:2jszrrkdzrfvhhp5nbquykmspu

Mechanisms and Pharmacology of Neuropathic Pain in Multiple Sclerosis [chapter]

T. Iannitti, B. J. Kerr, B. K. Taylor
2014 Current topics in behavioral neurosciences  
Future behavioral studies in EAE models are essential towards a new pharmacotherapy of multiple sclerosis pain.  ...  An even smaller, but emerging, number of translational studies are using rodent models of experimental autoimmune encephalomyelitis (EAE), which exhibit pain-like behaviors resembling those of MS patients  ...  Somatosensory Evoked Potentials (SEPs) in response to stimulation of median or posterior tibial nerves may also be delayed in MS patients, and can indicate lesions or dysfunction of the dorsal column tract  ... 
doi:10.1007/7854_2014_288 pmid:24590824 pmcid:PMC4464806 fatcat:4tph4hdoinah5mgl73qtg4iasq

The Effect of Anti-seizure Medications on the Propagation of Epileptic Activity: A Review

Mohamed Khateb, Noam Bosak, Moshe Herskovitz
2021 Frontiers in Neurology  
The clinical importance of seizure propagation stems mainly from the fact that the epileptic manifestations cannot be attributed solely to the activity in the seizure focus itself, but rather to the propagation  ...  Motivated by the extensive impact of this phenomenon, we sought to review the literature regarding the propagation of epileptic activity and specifically the effect of commonly used ASMs on it.  ...  It was shown to increase the threshold for paroxysmal activity in response to electrical stimulation in a dose-dependent manner.  ... 
doi:10.3389/fneur.2021.674182 pmid:34122318 pmcid:PMC8191738 fatcat:fo4r3cgmmfbdzcdsmgilpx4k5u

Group I mGluR-Mediated Activation of Martinotti Cells Inhibits Local Cortical Circuitry in Human Cortex

Tim Kroon, Julia Dawitz, Ioannis Kramvis, Jasper Anink, Joshua Obermayer, Matthijs B. Verhoog, René Wilbers, Natalia A. Goriounova, Sander Idema, Johannes C. Baayen, Eleonora Aronica, Huibert D. Mansvelder (+1 others)
2019 Frontiers in Cellular Neuroscience  
Some other interneurons, including fast-spiking interneurons, are depolarized but do not fire action potentials in response to group I mGluR activation.  ...  and inhibition in the human cortical network.  ...  ACKNOWLEDGMENTS We thank Anton Pieneman and Christiaan de Kock for their assistance in biocytin stainings, and Hans Lodder, Tim Heistek, and Jaap Timmerman for their excellent technical assistance.  ... 
doi:10.3389/fncel.2019.00315 pmid:31354435 pmcid:PMC6637283 fatcat:2sr2isipbrbszm2wnmeep4u2yy

Functional and Pharmacological MRI in Understanding Brain Function at a Systems Level [chapter]

Angelo Bifone, Alessandro Gozzi
2011 Current topics in behavioral neurosciences  
Functional magnetic resonance imaging (fMRI) methods have been extensively applied to study the human brain and its functional organization in healthy and disease states.  ...  This chapter describes the methodological aspects of fMRI and phMRI in preclinical species, and some of the key findings, with a special emphasis on the translational potential of these methods in neuropharmacological  ...  modulation of the phMRI 312 response to PCP, with complete suppression of the relative cerebral blood volume 313 (rCBV) response in the thalamus (Gozzi et al. 2008b ).  ... 
doi:10.1007/7854_2010_103 pmid:21225416 fatcat:3cddqqdnkzdubharizfi57e5vu

Neurochemical and Behavioral Features in Genetic Absence Epilepsy and in Acutely Induced Absence Seizures

A. S. Bazyan, G. van Luijtelaar
2013 ISRN Neurology  
The absence epilepsy typical electroencephalographic pattern of sharp spikes and slow waves (SWDs) is considered to be due to an interaction of an initiation site in the cortex and a resonant circuit in  ...  The role of thalamic HCN in SWD occurrence is less clear.  ...  Acknowledgment The authors want to acknowledge the value of discussions with Dr. Maarten Kole and the contribution of MSc Nicole Tillmanns.  ... 
doi:10.1155/2013/875834 pmid:23738145 pmcid:PMC3664506 fatcat:lozxxnacdfbnbfjhkk6ack4o5y

Glutamate Receptor Antagonists as Fast-Acting Therapeutic Alternatives for the Treatment of Depression: Ketamine and Other Compounds

Mark J. Niciu, Ioline D. Henter, David A. Luckenbaugh, Carlos A. Zarate, Dennis S. Charney
2014 Annual Review of Pharmacology and Toxicology  
These effects are in direct contrast to the more modest effects seen after weeks of treatment with classic monoaminergic antidepressants.  ...  The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has rapid and potent antidepressant effects in treatment-resistant major depressive disorder and bipolar depression.  ...  Because ketamine increases glutamate in the rodent PFC, acute and/or chronic changes in glutamate have been hypothesized to contribute to ketamine's antidepressant response.  ... 
doi:10.1146/annurev-pharmtox-011613-135950 pmid:24392693 pmcid:PMC4089991 fatcat:kd7st4ociffbbahcjfyesqve2i

Basic and clinical aspects of gastrointestinal pain

Charles H. Knowles, Qasim Aziz
2009 Pain  
The anatomical and molecular basis of gastrointestinal nociception, conditions associated with chronic unexplained visceral pain, and developments in treatment are presented in this review.  ...  A complex arrangement of nerves and ancillary cells contributes to the sensorimotor apparatus required to subserve such essential functions that are with the exception of the extreme upper and lower ends  ...  Abhishek Sharma who were both PhD students of Professor Aziz are acknowledged for contributions to the text in the sections on GI pain modulation: beyond the nociceptor.  ... 
doi:10.1016/j.pain.2008.12.011 pmid:19155134 fatcat:k32sbd2zybbhzdsn3bicpehuba

Alterations of cortical and hippocampal EEG activity in MeCP2-deficient mice

Jennifer Anne D'Cruz, Chiping Wu, Tariq Zahid, Youssef El-Hayek, Liang Zhang, James H. Eubanks
2010 Neurobiology of Disease  
To address this issue, in vivo recordings of the hippocampus and somatosensory cortex of MeCP2-deficient mice were taken during exploration, immobility, and sleep.  ...  Collectively, these findings indicate that a deficiency of MeCP2 in mice leads to only subtle alterations in brain wave activity, contrasting the severely abnormal EEG observed in Rett girls.  ...  Increased BDNF levels lead to cortical hyperexcitability and epileptiform activities while suppression of BDNF was found to retard the development of seizures in rodents (Xu et al, 2004) .  ... 
doi:10.1016/j.nbd.2009.12.018 pmid:20045053 fatcat:36oppx73h5c6zajttwcdylkm6u

A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia

Meng di Hou, Viviana Santoro, Andrea Biondi, Sukhi S. Shergill, Isabella Premoli
2021 Journal of Psychiatry & Neuroscience  
Transcranial magnetic stimulation can be combined with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) to evaluate the excitatory and inhibitory functions of the cerebral cortex in a standardized  ...  The aim of this review was to provide a comprehensive overview of TMS-EMG and TMS-EEG research in schizophrenia, focused on excitation or inhibition, connectivity, motor cortical plasticity and the effect  ...  simultaneous electroenceph- lation to explore the neurophysiological mechanisms in- alography (EEG) to obtain a more detailed profile response of volved in schizophrenia.  ... 
doi:10.1503/jpn.210006 pmid:34933940 pmcid:PMC8695525 fatcat:pjmjs6vt7fatznlqxbznq6hkey
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