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Laboratory replication of scientific discovery processes

Y Qin
1990 Cognitive Science  
The experiment demonstrates the feasibility of examining some of the processes of scientific discovery by recreating, in the laboratory, discovery situations of substontiol historical relevance.  ...  We believe that this result can be generalized to cover most, perhaps all, of the processes of scientific discovery.  ...  Use one or two of the pairs of observations to conjecture a formula and test it by other pairs.  ... 
doi:10.1016/0364-0213(90)90005-h fatcat:xzlv5y6thvawjbzjyrbh6wvz3i

Laboratory Replication of Scientific Discovery Processes

Yulin Qin, Herbert A. Simon
1990 Cognitive Science  
The experiment demonstrates the feasibility of examining some of the processes of scientific discovery by recreating, in the laboratory, discovery situations of substontiol historical relevance.  ...  We believe that this result can be generalized to cover most, perhaps all, of the processes of scientific discovery.  ...  Use one or two of the pairs of observations to conjecture a formula and test it by other pairs.  ... 
doi:10.1207/s15516709cog1402_4 fatcat:t7aqxxtzxjalpjbcbub4yhtnnu

Communicating about the discovery of extraterrestrial life: Different searches, different issues

Margaret S. Race
2008 Acta Astronautica  
Moreover, the meaning and implications of a 'discovery' in each of the categories are different, as are the policy, legal and societal ramifications.  ...  Each search-type occurs in different locations, uses different scientific instruments and methods, and seeks different types of evidence and data.  ...  If for example, a Miller-Urey type of experiment or a laboratory impact simulation show evidence for initiation of a replicating process based on organic life forms, it would allow direct comparison with  ... 
doi:10.1016/j.actaastro.2006.12.020 fatcat:ekcd4kabkna43gpca3qlkmk6hi

Is most published research really false? [article]

Jeffrey T Leek, Leah R Jager
2016 bioRxiv   pre-print
Here we describe the range of definitions of false discoveries in the scientific literature. We summarize the philosophical, statistical, and experimental evidence for each type of false discovery.  ...  We discuss common underpinning problems with the scientific and data analytic practices and point to tools and behaviors that can be implemented to reduce the problems with published scientific results  ...  Acknowledgements Parts of the text of this review have appeared in the blog posts: "A summary of the evidence that most published research is false" and "Why the three biggest positive contributions to  ... 
doi:10.1101/050575 fatcat:gxqxysf4xvbhbdnfyb5enbs6uq

The Division of Replication Labor

Felipe Romero
2020 Philosophy of Science  
In theory, confirmation, which includes replication among other practices, is an essential step in the scientific process (but see Leonelli 2018; Feest 2019) .  ...  In particular, the combination of replication work and statistical inference offers one straightforward instantiation of this self-corrective process: as the number of replications of an experiment increases  ... 
doi:10.1086/710625 fatcat:7xmkzslyinhpnaohs75dwyzfrq

Metascience could rescue the 'replication crisis'

Jonathan W. Schooler
2014 Nature  
By pre-registering all aspects of new scientific studies and then repeatedly trying to replicate them, the project allows careful scrutiny of all parts of the research process, from inception to replication  ...  In fact, psychological science has long been at the forefront of refining and improving the scientific process.  ... 
doi:10.1038/515009a pmid:25373639 fatcat:h4h7gkkebnazvjzs7vcvlwzowu

Crisis or self-correction: Rethinking media narratives about the well-being of science

Kathleen Hall Jamieson
2018 Proceedings of the National Academy of Sciences of the United States of America  
Sackler Colloquium of the National Academy of Sciences, "Reproducibility of Research: Issues and Proposed Remedies," held March 8-10, 2017, at the National Academy of Sciences in Washington, DC.  ...  The complete program and video recordings of most presentations are available on the NAS website at www.nasonline. org/Reproducibility.  ...  This article was completed during a Shorenstein fellowship at Harvard University's Kennedy School of Government.  ... 
doi:10.1073/pnas.1708276114 pmid:29531076 pmcid:PMC5856501 fatcat:3tiuk653hfhwxg2gho4sdbvvwa

Find the Needle in the Haystack, Then Find It Again: Replication and Validation in the 'Omics Era

Wei Perng, Stella Aslibekyan
2020 Metabolites  
Given the foundational role of reproducibility in scientific inference, replication and validation of 'omics findings are cornerstones of this effort.  ...  Advancements in high-throughput technologies have made it feasible to study thousands of biological pathways simultaneously for a holistic assessment of health and disease risk via 'omics platforms.  ...  Replication • Original (discovery) and confirmatory (replication) populations should be similar in terms of sex, age, and race/ethnic distributions. • Use of identical laboratory procedures, data processing  ... 
doi:10.3390/metabo10070286 pmid:32664690 fatcat:f6a35xhth5e3nhkga6w7asln5i

Studies of scientific discovery: Complementary approaches and convergent findings

David Klahr, Herbert A. Simon
1999 Psychological bulletin  
, direct observation of ongoing scientific laboratories, and computational modeling of scientific discovery processes-by viewing them through the lens of the theory of human problem solving.  ...  Finally, they provide several examples of convergent principles of the process of scientific discovery.  ...  In studying scientific discovery, laboratory experiments need not be limited to replicating the processes scientists have used to discover hypotheses to fit data, or to test hypotheses.  ... 
doi:10.1037//0033-2909.125.5.524 fatcat:i6flsidd35b4lmlltsg5gecopi

Studies of scientific discovery: Complementary approaches and convergent findings

David Klahr, Herbert A. Simon
1999 Psychological bulletin  
, direct observation of ongoing scientific laboratories, and computational modeling of scientific discovery processes-by viewing them through the lens of the theory of human problem solving.  ...  Finally, they provide several examples of convergent principles of the process of scientific discovery.  ...  In studying scientific discovery, laboratory experiments need not be limited to replicating the processes scientists have used to discover hypotheses to fit data, or to test hypotheses.  ... 
doi:10.1037/0033-2909.125.5.524 fatcat:os2l2ih52jazho4652pe2nm2bm

Arthur Kornberg. 3 March 1918 -- 26 October 2007

I. R. Lehman
2012 Biographical Memoirs of Fellows of the Royal Society  
and Cori laboratories, namely that every biochemical process, no matter how complex, should be amenable to the power of biochemistry.  ...  process.  ... 
doi:10.1098/rsbm.2012.0032 fatcat:dqu4gzcqdrddtf2mlltn22c3ui

Distributed Drug Discovery, Part 1: Linking Academia and Combinatorial Chemistry to Find Drug Leads for Developing World Diseases

William L. Scott, Martin J. O'Donnell
2009 Journal of combinatorial chemistry  
can economically accelerate the identification of leads in the early stages of the drug discovery process.  ...  We believe an analogous process can be developed and employed at the synthesis stage of drug-lead discovery. The distributed  ...  We gratefully acknowledge Frank Jasper for the photograph of the Bill-Board equipment. We acknowledge the National Institutes of Health (R01 GM028193), The  ... 
doi:10.1021/cc800183m pmid:19105724 pmcid:PMC2651689 fatcat:wq3ncaiibbanvoz74xzasdnnqe

Is Most Published Research Really False?

Jeffrey T. Leek, Leah R. Jager
2017 Annual Review of Statistics and Its Application  
Here we describe the range of definitions of false discoveries in the scientific literature. We summarize the philosophical, statistical, and experimental evidence for each type of false discovery.  ...  We discuss common underpinning problems with the scientific and data analytic practices and point to tools and behaviors that can be implemented to reduce the problems with published scientific results  ...  The added complexity of the scientific process also contributes to the difficulties in verifying the results from scientific publications.  ... 
doi:10.1146/annurev-statistics-060116-054104 fatcat:azvv7qo4ijg53dcjsplogip3d4

Time to do something about reproducibility

Sean J Morrison
2014 eLife  
Individual scientists, scientific communities and scientific journals can do more to assess the publication of irreproducible results, to promote good science, and to increase the efficiency with which  ...  the scientific community self-corrects.  ...  But to be responsible stewards of the public's investment in this work we have to maximize the pace of discovery and the efficiency with which discoveries get translated to the benefit of patients.  ... 
doi:10.7554/elife.03981 pmid:25493617 pmcid:PMC4260475 fatcat:xywhkwazzzge7bfi5k3h4v4lgi

An incentive-based approach for improving data reproducibility

Michael Rosenblatt
2016 Science Translational Medicine  
Independent commercial laboratories might arise for the express purpose of replicating data.  ...  Like all scientific endeavor, key early experiments on a disease or biological process build the foundation for further investigation.  ... 
doi:10.1126/scitranslmed.aaf5003 pmid:27122610 fatcat:pgwlsq3kdjd45nsec7kt3wejja
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