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FindYourHelp: an expert finder module on Virtual Learning Environments

Marcos Lapa Santos, Laís Nascimento Salvador, Daniela Soares Cruzes
2012 Informática na educação: teoria & prática  
Um estudo de viabilidade da solução foi desenvolvido e evidenciou a aplicabilidade da ferramenta em relação a seus objetivos iniciais.  ...  Este artigo discute a criação de um módulo adicional para o ambiente Moodle, que permita a identificação automática de especialistas que contribuam em seus fóruns de discussão.  ...  The tool was developed in PHP and as PHP has no native support for parallel processing threads of execution (multithreading) and so we could not improve the execution time of the tool by using parallel  ... 
doi:10.22456/1982-1654.14156 fatcat:md5uqacyzfetpc67i77vrb7whm

Isotope stratigraphy of the Lapa Formation, São Francisco Basin, Brazil: Implications for Late Neoproterozoic glacial events in South America

Karem Azmy, Alan J. Kaufman, Aroldo Misi, Tolentino Flávio de Oliveira
2006 Precambrian Research  
Four boreholes, spanning different depositional settings, were sampled at highresolution and investigated for their petrographic and chemical criteria to evaluate their degree of preservation.  ...  The Lapa Formation is a thick carbonate sequence (∼900 m) that constitutes the upper part of the Vazante Group on the São Francisco craton, Brazil.  ...  Veizer, and an anonymous reviewer for their constructive reviews and Votorantim Metais (Vazante, Minas Gerais, Brazil) for providing field assistance.  ... 
doi:10.1016/j.precamres.2006.07.001 fatcat:zwjiyh3sejghjb24yxikwgbbl4

11C-Methionine-PET: A novel and sensitive tool for monitoring of early response to treatment in multiple myeloma

Katharina Lückerath, Constantin Lapa, Christa Albert, Ken Herrmann, Gerhard Jörg, Samuel Samnick, Herrmann Einsele, Stefan Knop, Andreas K. Buck
2015 OncoTarget  
However, new treatment modalities and novel drugs have been introduced and thus additional tools for therapy monitoring are increasingly needed.  ...  Therefore, we evaluated the radiotracers 11 C-Methionine (paraprotein-biosynthesis) and 18 F-FDG (glucose-utilization) for monitoring response to anti-myeloma-therapy and outcome prediction.  ...  In addition, PET/CT was recently reported to be a very useful tool for monitoring of anti-myeloma therapy (12) .  ... 
doi:10.18632/oncotarget.3053 pmid:25762625 pmcid:PMC4480763 fatcat:qobvmo27hrhpxhq66ywljynvjy

Stability of ground state degeneracy to long-range interactions [article]

Matthew F. Lapa, Michael Levin
2021 arXiv   pre-print
For these models we prove (1) the stability of the gap, and (2) that the residual splitting of the low-energy states below the gap is exponentially small in the system size.  ...  We show that some gapped quantum many-body systems have a ground state degeneracy that is stable to long-range (e.g., power-law) perturbations, in the sense that any ground state energy splitting induced  ...  0) a better trial state than the ferromagnetic state | ⇑ for large enough system size L.  ... 
arXiv:2107.11396v2 fatcat:67yis4hjz5bmdj5npwjjoghluy

Inosine as a Tool to Understand and Treat Central Nervous System Disorders: A Neglected Actor?

Francisney Pinto Nascimento, Sérgio José Macedo-Júnior, Fernanda Rocha Lapa-Costa, Fernando Cezar-dos-Santos, Adair R. S. Santos
2021 Frontiers in Neuroscience  
and pathological processes in the central nervous system (CNS).  ...  Also, inosine was identified as a natural trigger of adenosine receptors.  ...  In parallel, identifying the mechanisms involved in the inosine effects in epilepsy is critical and can be performed using genetic, pharmacological, and in vitro approaches.  ... 
doi:10.3389/fnins.2021.703783 pmid:34504414 pmcid:PMC8421806 fatcat:ieusk2ku6jadnclsue4g67abva

Impact of Pre-Analytical Variables on Cancer Targeted Gene Sequencing Efficiency

Luiz H. Araujo, Cynthia Timmers, Konstantin Shilo, Weiqiang Zhao, Jianying Zhang, Lianbo Yu, Thanemozhi G. Natarajan, Clinton J. Miller, Ayse Selen Yilmaz, Tom Liu, Joseph Amann, José Roberto Lapa e Silva (+3 others)
2015 PLoS ONE  
Herein, we evaluated the effect of pre-sequencing parameters to guide proper sample selection for targeted gene sequencing.  ...  Data from 113 FFPE lung tumor specimens were collected, and targeted gene sequencing was performed.  ...  Variant calling was performed using the Genome Analysis Tool Kit (GATK) Unified Genotyper.  ... 
doi:10.1371/journal.pone.0143092 pmid:26605948 pmcid:PMC4659597 fatcat:7yzaf65htbfjvo4xqpv25bphfa

Recent Paradigm Shifts in Molecular Cardiac Imaging – Establishing Precision Cardiology through Novel 18F-labeled PET Radiotracers

Rudolf A. Werner, Xinyu Chen, Steven P. Rowe, Constantin Lapa, Mehrbod S. Javadi, Takahiro Higuchi
2019 Trends in cardiovascular medicine  
Due to physical and chemical key properties, these imaging agents allow for more flexibility of imaging protocols and a better employment in the clinic.  ...  more thorough evaluation, mainly due to superior characteristics associated with the latter imaging modality.  ...  Their long half-life of 110 min allow for a.) the use of dispatch systems (for delivery from central cyclotron facilities), b.) the injection of a lower amount of radioactivtiy (due to a higher positron  ... 
doi:10.1016/j.tcm.2019.02.007 pmid:30824163 fatcat:3fraundkeneard5m2swgrdic2y

Cyclotron resonant scattering feature simulations

F.-W. Schwarm, R. Ballhausen, S. Falkner, G. Schönherr, K. Pottschmidt, M. T. Wolff, P. A. Becker, F. Fürst, D. M. Marcu-Cheatham, P. B. Hemphill, E. Sokolova-Lapa, T. Dauser (+3 others)
2017 Astronomy and Astrophysics  
to gain information about the underlying physics in these systems.  ...  We develop a new simulation code to generate synthetic cyclotron lines for complex scenarios, allowing for unprecedented physical interpretation of the observed data.  ...  We thank the International Space Science Institute in Bern for inspiring team meetings. The fruitful discussions within the MAGNET collaboration also had a very positive impact on this work.  ... 
doi:10.1051/0004-6361/201630250 fatcat:gkavolbtdvdajet62w2ibpwipe

Deconstructing Local Adaptation Plans for Action (LAPAs) Analysis of Nepal and Pakistan LAPA initiatives Deconstructing Local Adaptation Plans for Action (LAPAs) Analysis of Nepal and Pakistan LAPA initiatives

Abrar Chaudhury, Chase Sova, Tahir Rasheed, Thomas Thornton, Prajwal Baral, Anam Zeb, Abrar Chaudhury, Chase Sova, Tahir Rasheed, Thomas Thornton, Prajwal Baral, Anam Zeb
While each frame is a powerful tool of analysis in its own right, this paper focuses on the structural frame for comparing the two country LAPAs.  ...  (prioritization of adaptation options), LAPA implementation and annual assessment Tool kit for LAPA development 15 participatory tools deployed Assessment of risks, design of strategy and methods and  ... 

Thyroglobulin fluctuations in patients with iodine-refractory differentiated thyroid carcinoma on lenvatinib treatment – initial experience

R. A. Werner, K. Lückerath, J. S. Schmid, T. Higuchi, M. C. Kreissl, I. Grelle, C. Reiners, A. K. Buck, C. Lapa
2016 Scientific Reports  
Tumor restaging was performed every 2-3 months including contrastenhanced computed tomography (CT, RECIST 1.1). Serum Tg was measured and compared to imaging findings.  ...  Initiation of lenvatinib in iodine-refractory DTC patients is associated with a significant reduction in serum Tg levels as a marker of treatment response.  ...  Additionally, we express our gratitude to Johanna Vogt for her assistance in data analysis.  ... 
doi:10.1038/srep28081 pmid:27306607 pmcid:PMC4910099 fatcat:kvvnil4f2zdrbduwzkzgtg3qpm

Fitting strategies of accretion column models and application to the broadband spectrum of Cen X-3 [article]

Philipp Thalhammer, Matthias Bissinger, Ralf Ballhausen, Katja Pottschmidt, Michael T. Wolff, Jakob Stierhof, Ekaterina Sokolova-Lapa, Felix Fürst, Christian Malacaria, Amy Gottlieb, Diana M. Marcu-Cheatham, Peter A. Becker (+1 others)
2021 arXiv   pre-print
We demonstrate this approach as well a study of possible parameter degeneracies with a comprehensive Markov-chain Monte Carlo analysis of the complete parameter space for a combined NuSTAR and Swift/XRT  ...  While the behavior of these models is well understood and they allow for a comparison of different sources and studying source behavior, the extent to which the underlying physics can be derived from the  ...  This research also has made use of a collection of ISIS functions (ISISscripts) provided by ECAP/Remeis observatory and MIT (  ... 
arXiv:2109.14565v1 fatcat:sqtyxob3mvf5bako2jg3ufxgbm

A Novel CXCL10-Based GPI-Anchored Fusion Protein as Adjuvant in NK-Based Tumor Therapy

Niklas Muenchmeier, Sophia Boecker, Lorenz Bankel, Laura Hinz, Nicole Rieth, Constantin Lapa, Anna N. Mendler, Elfriede Noessner, Ralph Mocikat, Peter J. Nelson, Paul Proost
2013 PLoS ONE  
Methodology/Principal Findings: A fusion protein comprising a CXCL10 chemokine head (CXCL10-mucin-GPI) was used for proof of concept for this approach and expressed constitutively in Chinese Hamster Ovary  ...  Cellular therapy is a promising therapeutic strategy for malignant diseases. The efficacy of this therapy can be limited by poor infiltration of the tumor by immune effector cells.  ...  Mack for providing the MP71 and pEF vectors, respectively, as well as Frank Lehmann for providing the murine T cells. Author Contributions  ... 
doi:10.1371/journal.pone.0072749 pmid:24023642 pmcid:PMC3758322 fatcat:khks6dr5hbhujogwv4n4od6poa

Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications

Agata Łapa, Mark Cresswell, Ian Campbell, Phil Jackson, Wolfgang H. Goldmann, Rainer Detsch, Andrew Parsons, Ifty Ahmed, Aldo R. Boccaccini
2019 Journal of materials chemistry. B  
Soluble Ga/Ce-doped phosphate glass fibres exhibiting controlled release of ions were developed and characterised for wound healing applications.  ...  Moreover, solid state NMR analysis would be a powerful tool to evaluate the character of the bonding in PGF.  ...  A glass fibre mesh was also subsequently developed as a degradable dressing for wound healing applications and properties such as degradation and water uptake were also evaluated.  ... 
doi:10.1039/c9tb00820a pmid:31624824 fatcat:mjefenpw6rcefflh3yuvkyic2a

Prevalence and characteristics of new-onset pain in COVID-19 survivors, a controlled study

Felipe Henriques Carvalho Soares, Gabriel Taricani Kubota, Ana Mércia Fernandes, Bruno Hojo, Catarina Couras, Bárbara Venturoti Costa, Jorge Dornellys da Silva Lapa, Luíza Mansur Braga, Matheus Merula de Almeida, Pedro Henrique Martins da Cunha, Vítor Hugo Honorato Pereira, Adriano Donizeth Silva de Morais (+3 others)
2021 European Journal of Pain  
No statistically significant differences were found for mean new-onset pain intensity and interference with daily activities between both groups.  ...  COVID-19 was associated with a significantly higher prevalence of de novo CP, chronic daily headache, and new-onset pain in general, which was associated with persistent anosmia.  ...  All interviews were performed by a line phone or by a video-call in some instances. No financial compensation was provided for study participation.  ... 
doi:10.1002/ejp.1755 pmid:33619793 pmcid:PMC8013219 fatcat:ylrmdvjb45f4hnlzu772umhmkq

The Mycobacterium tuberculosis Complex-Restricted Gene cfp32 Encodes an Expressed Protein That Is Detectable in Tuberculosis Patients and Is Positively Correlated with Pulmonary Interleukin-10

R. C. Huard, S. Chitale, M. Leung, L. C. O. Lazzarini, H. Zhu, E. Shashkina, S. Laal, M. B. Conde, A. L. Kritski, J. T. Belisle, B. N. Kreiswirth, J. R. Lapa e Silva (+1 others)
2003 Infection and Immunity  
Overall, CFP32 is an attractive target for drug and vaccine design as well as new diagnostic strategies. Downloaded from FIG. 8.  ...  active TB case patients, along with the sera of 11 healthy household contacts (seven PPD skin test negative and four PPD skin test positive), were used in an ELISA to identify human humoral specificity for  ...  Johnson for suggestions, support, and encouragement.  ... 
doi:10.1128/iai.71.12.6871-6883.2003 pmid:14638775 pmcid:PMC308900 fatcat:g3sehgnezbaejjprwgyfougr54
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