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Duodenal-Jejunal Bypass Surgery Stimulates the Expressions of Hepatic Sirtuin1 and 3 and Hypothalamic Sirtuin1

Eunyoung Ha, Jong Yeon Kang, Kyung Sik Park, Youn Kyoung Seo, Tae Kyung Ha
2018 Journal of Obesity & Metabolic Syndrome  
Duodenal-Jejunal Bypass Increases Sirtuin1 J Obes Metab Syndr 2018;27:248-253 Ha E, et al. Duodenal-Jejunal Bypass Increases Sirtuin1  ...  DISCUSSION Since its first discovery, sirtuins has been the focus of extensive studies. Studies reveal that sirtuins are involved in the regulation of various metabolic processes in the body.  ... 
doi:10.7570/jomes.2018.27.4.248 pmid:31089570 pmcid:PMC6513307 fatcat:oq24cxokunc4rmhct3nmsfbeyu

All-TransRetinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy

Chul Sik Kim, Jong Suk Park, Chul Woo Ahn, Kyung Rae Kim
2015 Yonsei medical journal  
Our results suggest that ATRA has a potential therapeutic role for diabetic nephropathy.  ...  0.14±0.10 0.14±0.09 0.14±0.11 WBC (10 9 /L) 2.28±1.68 3.28±1.45 3.17±1.48 Platelet (10 9 /L) 725.3±212.1 829.1±231.8 905.1±84.1 LETO, Chul Sik  ...  The inappropriate activation of PKC has been implicated as a putative mediator in the pathogenesis of diabetic nephropathy based on evidence from both in vivo experimental animal diabetic models and in  ... 
doi:10.3349/ymj.2015.56.6.1597 pmid:26446642 pmcid:PMC4630048 fatcat:rxno65mdw5ernbwn5unh2dkdzi

Antioxidant activity is required for the protective effects of cyclophilin A against oxidative stress

2012 Molecular Medicine Reports  
Acknowledgements This study was supported by grants from Kyung Hee University  ...  WT, wild-type; HA, hemagglutinin; Cyp, cyclophilin.  ...  The expression of CypA was determined by western blotting using anti-CypA or anti-HA antibodies.  ... 
doi:10.3892/mmr.2015.3392 pmid:25738284 fatcat:bdrj6mckxramfejcbsmpgoylju

Pancreaticopleural Fistula with Hemothorax

Young-Hoon Sul, Hyoung-Seob Shin, Kyung-Ha Lee, Kwang-Sik Chun, In-Sang Song
2009 Journal of the Korean Surgical Society  
Pancreaticopleural fistula is an uncommon complication of chronic pancreatitis. We report a case of pancreaticopleural fistula that was presented with right-sided hemothorax. A 49-year-old male with a history of chronic alcoholism was presented with a month of dyspnea. A chest radiography showed a right-sided massive pleural effusion with old-blood-colored fluids and amylase levels of 1,020 IU/L. On the chest computerized tomography (CT), there was pleural effusion and a well-defined tract from
more » ... the posterior mediastinum to the pseudocyst in the tail of the pancreas. Even with conservative treatment with closed thoracostomy, octreotide and gabexate mesilate, he developed hemothorax. Abdominal CT revealed an increase of the hemorrhagic pancreatic pseudocyst. Distal pancreatectomy with splenectomy and external drainage of the pancreaticopleural fistula on the posterior mediasternum were performed. The patient had an uneventful course and was discharged on the 27th postoperative day. Management of pancreaticopleural fistula is multimodal included medication, endoscopic stenting and surgery. Surgery in pancreaticopleural fistula might be beneficial in selective cases. (J Korean Surg Soc 2009;76:187-191) 서 론 췌흉강루는 췌관의 파열로 췌장액이 농루나 교통성 가성 낭종을 통하여 흉강에 도달하는 상태로 급, 만성 췌장염 및 췌관 손상 등에서 발생하는 드문 합병증이다.(1) 일반적으 로 췌장염의 과거력이 있는 환자에서 삼출성 흉수의 전형 적인 증상인 호흡곤란, 흉통, 기침이 동반된 경우 췌흉강루 를 의심할 수 있으며,(2) 흉수분석, 역행성 내시경적 담췌관 조영술(ERCP), 전산화 단층촬영, 자기공명 담췌관조영술 (MRCP) 등으로 진단할 수 있다. 췌흉강루는 흉수천자, 금 식, 총비경장적영양, octreotide 등의 보존적 치료를 시도하 지만, 50% 정도는 치료에 반응하지 않고,(1,3) 일부에서는 내시경적 췌관 스텐트 삽입술을 시도할 수 있지만, 모든 경 우에 적용할 수는 없다. 췌흉강루는 급성 췌장염에서 발생하는 흉수와는 달리 많 은 증례에서 대량의 흉수를 동반하고, 혈흉이 동반되는 경 우는 매우 드문 것으로 알려져 있다.(1,3) 저자 등은 보존적 치료에 반응하지 않은, 혈흉을 동반한 췌흉강루 1예의 수술 적 치료를 통한 증상호전을 경험하였기에, 증례를 보고하 며 문헌 고찰을 하고자 한다.
doi:10.4174/jkss.2009.76.3.187 fatcat:xvcxbjuqgve3ji4rj5fwqz2beu

Surgical Technique for Distal Femur Varization Osteotomy

Yi Rak Seo, Kyung Wook Nha, Sung Sik Ha
2018 The Journal of the Korean Orthopaedic Association  
The MPTA of the tibia between the tibial high pelvic line and the tibial epicondylar axis normally has an average angle of 87° and the medial lateral tibial angle between the ankle line and the tibia is  ... 
doi:10.4055/jkoa.2018.53.4.301 fatcat:3rbxxlh5yzat3ptunor5i5kkzi

TisN0M1 Sigmoid Colon Cancer: A Case Report

Kyung Ha Lee, Jin Su Kim, Kwang Sik Cheon, In Sang Song, Dae Young Kang, Ji Yeon Kim
2014 Annals of Coloproctology  
Distant metastasis of a colon carcinoma in situ has not yet been reported. We experienced a case of a sigmoid colon carcinoma in situ with common hepatic lymph node metastasis.  ...  Distant metastasis has been thought to be impossible in a Tis tumor.  ...  However, distant metastasis of a colon carcinoma in situ has not yet been reported. Herein, we report a case of a patient with a pTisN0M1 tumor.  ... 
doi:10.3393/ac.2014.30.3.141 pmid:24999466 pmcid:PMC4079813 fatcat:4byiv4e6ojczvb5bp3qzi5nd7e

Electroacupuncture preconditioning reduces cerebral ischemic injury via BDNF and SDF-1α in mice

Ji Hyun Kim, Kyung Ha Choi, Young Jung Jang, Ha Neui Kim, Sun Sik Bae, Byung Tae Choi, Hwa Kyoung Shin
2013 BMC Complementary and Alternative Medicine  
Clinically, acupuncture has shown significant therapeutic benefits for stroke patients [1, 2, 24, 25] .  ...  EA pretreatment has recently been shown to induce ischemic tolerance in a fashion mimicking the ischemia pretreatment [10, 11] .  ... 
doi:10.1186/1472-6882-13-22 pmid:23356671 pmcid:PMC3562247 fatcat:7vstkqj5ebgavew6ohkgssncgy

Involvement of phospholipase D in oxidative stress-induced necrosis of vascular smooth muscle cells

Eun-Young Shin, Do Sik Min, Ji-Cheol Shin, Kyung-Sun Shin, Min-Soo Hyun, Kwon-Soo Ha, Hun-Sik Kim, Hee-Yul Ahn, Eung-Gook Kim
2001 FEBS Letters  
Phospholipase D (PLD) has been associated with necrosis. However, it is not clear whether PLD plays a causative role in this cellular process.  ...  It has been reported that pervanadate induces apoptosis in HeLa cells and lymphoid cell lines [4, 5] .  ...  In addition, we, for the ¢rst time, demonstrate that the activation of PLD has a causal relation with VSMC necrosis.  ... 
doi:10.1016/s0014-5793(01)03059-9 pmid:11718730 fatcat:nlw2lpfgf5gs3dxfh3tcfwbarm

Comparative analysis of radiofrequency ablation and surgical resection for colorectal liver metastases

Kyung Ho Kim, Yong Sik Yoon, Chang Sik Yu, Tae Won Kim, Hye Jin Kim, Pyo Nyun Kim, Hyun Kwon Ha, Jin Cheon Kim
2011 Journal of the Korean Surgical Society  
Although RFA has been investigated as an alternative to surgery in and combination therapy groups.  ...  Kyung Ho Kim, et al. Factors associated with OS and DFS Univariate and multivariate analysis using Cox proportional hazard analysis revealed several factors associated with OS after  ... 
doi:10.4174/jkss.2011.81.1.25 pmid:22066097 pmcid:PMC3204557 fatcat:ukgokwj7bzgljj67qeaf2dm6e4

Laccase Fermentation of Clove Extract Increases Content of Dehydrodieugenol, Which Has Neuroprotective Activity against Glutamate Toxicity in HT22 Cells

Han-Saem Lee, Eun-Ju Yang, Taeho Lee, Kyung-Sik Song
2018 Journal of Microbiology and Biotechnology  
However, the protective effect of 2 on HT22 cells against high concentrations of glutamate has not been reported, to the best of our knowledge.  ...  It has been reported that glutamate toxicity leads to the depletion of glutathione in cells, resulting in the inhibition of cystine uptake through the glutamate/ cystine antiporter [17] .  ... 
doi:10.4014/jmb.1709.09052 pmid:29169218 fatcat:j2qfzau2njbwxpy6o3qwe2eoti

Removal of electrocardiogram distortion in portable high-power medical device

Hyung-Sik Kim, Sung-Jun Park, Tae Kyung Ha, Jeong-Han Yi, K. Abou-El-Hossein
2016 MATEC Web of Conferences  
The design has been examined in both transient and steady state of the operating conditions.  ...  At this point, to increase the success rate of defibrillation, the voltage of the capacitor has to reach its target voltage in a short time.  ...  This amplifier has a 1010 Ωof input impedance, 50 μV offset voltage, 0.5 μV/ drift, 120 dB of common-mode rejection ratio, and excellent noise characteristics.  ... 
doi:10.1051/matecconf/20165410003 fatcat:gacsvs7i45ayhnehldqfowwiai

Isolated Duodenal Injury following Blunt Abdominal Trauma

Young Hoon Sul, Kwang Sik Cheon, Chang Eun Jang, Kyung Ha Lee, Sang Il Lee, In Sang Song
2015 Journal of Trauma and Injury  
The isolated duodenal injury following blunt abdominal trauma is extremely rare. Because, duodenal injury is usually presented with other intra-abdominal organs injuries such as hepatic injury, pancreatic injury due to the anatomical position. So, We report a case of isolated duodenal injury following blunt abdominal trauma, and the discuss about the related article. [ J Trauma Inj 2015; 28: 47-50 ]
doi:10.20408/jti.2015.28.1.47 fatcat:uueuirahkvefzoty3tkpw74mz4

Aralia cordata Protects Against Amyloid β Protein (25–35)–Induced Neurotoxicity in Cultured Neurons and Has Antidementia Activities in Mice

Soon Ock Cho, Ju Yeon Ban, Joo Youn Kim, Ha Yeon Jeong, Ik Soo Lee, Kyung-Sik Song, KiHwan Bae, Yeon Hee Seong
2009 Journal of Pharmacological Sciences  
Oleanolic acid has also been reported to have inhibitory activity against COX-1 and COX-2 (21) .  ...  The root of Aralia cordata Thunb. has been used as a traditional Chinese medicine for rheumatism, lumbago, and lameness (17) .  ... 
doi:10.1254/jphs.08271fp pmid:19763045 fatcat:cuh5utvkazcwtozm2mzjuue2vm

Mutagenesis of two N-terminal Thr and five Ser residues in HslV, the proteolytic component of the ATP-dependent HslVU protease

Soon Ji Yoo, Yoon Kyung Shim, Ihn Sik Seong, Jae Hong Seol, Man-Sik Kang, Chin Ha Chung
1997 FEBS Letters  
HslVU in E. coli is a new type of ATP-dependent protease consisting of two heat shock proteins: the HslU ATPase and the HslV peptidase that has two repeated Thr residues at its N terminus, like certain  ...  Like the 20S proteasomes, HslV has two conserved Thr residues at its N terminus [4, 8] .  ...  Furthermore, lactacystin has been shown to partially inhibit the peptidase activity of the HslVU protease [5, 6] .  ... 
doi:10.1016/s0014-5793(97)00742-4 pmid:9257689 fatcat:aswvbfqulvgdjb3rli5r62xjdq

Extracts of Korean Natural Herb Alleviate Pathophysiology of Nonalcoholic Fatty Liver

Jeong-Won Kim, Kyung-Soo Chang, Yun-Tae Kim, Kyung-Yae Hyun, Joon-Sun Lee, Mi-Ha Joo, Hwa-Sik Choi, Seok-Cheol Choi
2015 International Journal of Bio-Science and Bio-Technology  
This study was designed to examine effects of Korean Acer tegmentosum Maximowocz extract, which has traditionally been used for the treatment of liver damages in fat dietinduced obese rats. 40 male SD  ...  Also, obesity group has relatively much fat mass in lower abdomen with compared with control and ATM groups.  ...  RDW has been reported to be a risk marker of morbidity and mortality for cardiovascular diseases in various study populations (Wang et al., 2011; Osadnik et al., 2013) .  ... 
doi:10.14257/ijbsbt.2015.7.5.32 fatcat:x5ntbg5lkzbljiw75ztmjmjw4i
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