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Disability Evaluation

Kyeong-Seok Lee
2008 Journal of Korean Medical Association  
Lee KS Table 1 .  ... 
doi:10.5124/jkma.2008.51.7.664 fatcat:h7uh62qq7fhdvofpxadkocmbrq

Virus Incidence of Sweet Potato in Korea from 2011 to 2014

Jaedeok Kim, Jung wook Yang, Hae-Ryun Kwak, Mi-Kyeong Kim, Jang-Kyun Seo, Mi-Nam Chung, Hyeong-un Lee, Kyeong-Bo Lee, Sang Sik Nam, Chang-Seok Kim, Gwan-Seok Lee, Jeong-Soo Kim (+2 others)
2017 The Plant Pathology Journal  
doi:10.5423/ppj.oa.08.2016.0167 pmid:29018310 pmcid:PMC5624489 fatcat:m67udhmce5f3jbvh3heoj6qiuu

Identification of Novel Biomarker for Early Detection of Diabetic Nephropathy

Kyeong-Seok Kim, Jin-Sol Lee, Jae-Hyeon Park, Eun-Young Lee, Jong-Seok Moon, Sang-Kyu Lee, Jong-Sil Lee, Jung-Hwan Kim, Hyung-Sik Kim
2021 Biomedicines  
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus. After development of DN, patients will progress to end-stage renal disease, which is associated with high morbidity and mortality. Here, we developed early-stage diagnostic biomarkers to detect DN as a strategy for DN intervention. For the DN model, Zucker diabetic fatty rats were used for DN phenotyping. The results revealed that DN rats showed significantly increased blood glucose, blood urea nitrogen
more » ... , and serum creatinine levels, accompanied by severe kidney injury, fibrosis and microstructural changes. In addition, DN rats showed significantly increased urinary excretion of kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Transcriptome analysis revealed that new DN biomarkers, such as complementary component 4b (C4b), complementary factor D (CFD), C-X-C motif chemokine receptor 6 (CXCR6), and leukemia inhibitory factor (LIF) were identified. Furthermore, they were found in the urine of patients with DN. Since these biomarkers were detected in the urine and kidney of DN rats and urine of diabetic patients, the selected markers could be used as early diagnosis biomarkers for chronic diabetic nephropathy.
doi:10.3390/biomedicines9050457 pmid:33922243 fatcat:nrvbh7ufcjfifekmzepgcaxf4e

Silicon nanodisk array design for effective light trapping in ultrathin c-Si

Inho Kim, Doo Seok Jeong, Wook Seong Lee, Won Mok Kim, Taek-Sung Lee, Doh-Kwon Lee, Jong-Han Song, Joon-Kon Kim, Kyeong-Seok Lee
2014 Optics Express  
The use of ultrathin c-Si (crystalline silicon) wafers thinner than 20 μm for solar cells is a very promising approach to realize dramatic reduction in cell cost. However, the ultrathin c-Si requires highly effective light trapping to compensate optical absorption reduction. Conventional texturing in micron scale is hardly applicable to the ultrathin c-Si wafers; thus, nano scale texturing is demanded. In general, nanotexturing is inevitably accompanied by surface area enlargements, which must
more » ... e minimized in order to suppress surface recombination of minority carriers. In this study, we demonstrate using optical simulations that periodic c-Si nanodisk arrays of short heights less than 200 nm and optimal periods are very useful in terms of light trapping in the ultrathin c-Si wafers while low surface area enlargements are maintained. Double side texturing with the nanodisk arrays leads to over 90% of the Lambertian absorption limit while the surface area enlargement is kept below 1.5.
doi:10.1364/oe.22.0a1431 pmid:25607300 fatcat:m2sim6yu6jcivnip46rhyxkgvq

History of Chronic Subdural Hematoma

Kyeong-Seok Lee
2015 Korean Journal of Neurotrauma  
Am J Phys Anthropol 152:484-494, 2013 31) Lee KS. Natural history of chronic subdural haematoma. Brain Inj 18:351-358, 2004 32) Lee KS.  ...  J Korean Med Sci 15:560-568, 2000 34) Lee KS, Bae WK, Park YT, Yun IG. The pathogenesis and fate of traumatic subdural hygroma. Br J Neurosurg 8:551-558, 1994 35) Lee KS, Doh JW, Bae HG, Yun IG.  ... 
doi:10.13004/kjnt.2015.11.2.27 pmid:27169062 pmcid:PMC4847516 fatcat:2runydxrvzbebfoqtgq4sjukt4

Repeat Vertebroplasty for the Subsequent Refracture of Procedured Vertebra

Sang Sik Choi, Won Seok Hur, Jae Jin Lee, Seok Kyeong Oh, Mi Kyoung Lee
2013 The Korean Journal of Pain  
Vertebroplasty (VP) can effectively treat pain and immobility caused by vertebral compression fracture. Because of complications such as extravasation of bone cement (polymethylmethacrylate, PMMA) and adjacent vertebral fractures, some practitioners prefer to inject a small volume of PMMA. In that case, however, insufficient augmentation or a subsequent refracture of the treated vertebrae can occur. A 65-year-old woman visited our clinic complaining of unrelieved severe low back and bilateral
more » ... ank pain even after she had undergone VP on the 1 st and 4 th (L1 and L4) lumbar vertebrae a month earlier. Radiologic findings showed the refracture of L1. We successfully performed the repeat VP by filling the vertebra with a sufficient volume of PMMA, and no complications occurred. The patient's pain and immobility resolved completely three days after the procedure and she remained symptom-free a month later. In conclusion, VP with small volume cement impaction may fail to relieve fracture-induced symptoms, and the refracture of an augmented vertebral body may occur. In this case, repeat VP can effectively resolve both the persistent symptoms and problems of new onset resulting from refracture of the augmented vertebral body due to insufficient volume of bone cement. (Korean J Pain 2013; 26: 94-97)
doi:10.3344/kjp.2013.26.1.94 pmid:23342217 pmcid:PMC3546220 fatcat:lkcmgh5g4ngbriniz2gyiu3wzi

Cerebral Aneurysms in Judicial Precedents

Kyeong-Seok Lee, Jae-Jun Shim, Jae-Hyun Shim, Jae-Sang Oh, Seok-Mann Yoon
2018 Journal of Korean Neurosurgical Society  
Objective : From November 30, 2016, the Korean Government carried the revised Medical Dispute Mediation and Arbitration Act into effect. Mediation will start automatically without agreements of the defendant, when the outcome of the patient was death, coma more than a month or severe disability. Cerebral aneurysm has a definite risk of bad outcome, especially in the worst condition. Any surgical intervention to this lesion has its own high risk of complications. Recently, Seoul central district
more » ... court decided 50% responsibility of the doctors who made a rupture of the aneurysm during coiling (2015Ga-Dan5243104). We reviewed judicial precedents related to cerebral aneurysms in lawsuit using a web search. Methods : We searched judicial precedents at a web search of the Supreme Court, using the key words, "cerebral aneurysm". Results : There were 15 precedents, six from the Supreme Court, seven from the High Court, and two from district courts. Seven precedents were related to the causation analysis, such as work-relationship. Five precedents were malpractice suits related bad results or complications. Remaining three precedents were related to the insurance payment. In five malpractice precedents, two precedents of the Supreme Court reversed former two precedents of the High Court. Conclusion : Judicial precedents on the cerebral aneurysm included not only malpractice suits, but also causation analysis or insurance payment. Attention to these subjects is needed. We also need education of the independent medical examination. To avoid medical disputes, shared decision making seems to be useful, especially in cases of high risk condition or procedures.
doi:10.3340/jkns.2017.0404.012 pmid:29631385 pmcid:PMC6046580 fatcat:peq5ig4si5d7dpi4iocz6kdiu4

Everolimus improves neuropsychiatric symptoms in a patient with tuberous sclerosis carrying a novel TSC2 mutation

Su-Kyeong Hwang, Jae-Hyung Lee, Jung-eun Yang, Chae-Seok Lim, Jin-A Lee, Yong-Seok Lee, Kyungmin Lee, Bong-Kiun Kaang
2016 Molecular Brain  
Tuberous sclerosis complex (TSC) is a neurocutaneous disorder characterized by multiple symptoms including neuropsychological deficits such as seizures, intellectual disability, and autism. TSC is inherited in an autosomal dominant pattern and is caused by mutations in either the TSC1 or TSC2 genes, which enhance activation of the mammalian target of rapamycin (mTOR) signaling pathway. Recent studies have suggested that mTOR inhibitors such as rapamycin can reverse TSC-associated deficits in
more » ... ent models of TSC. In addition, clinical trials are ongoing to test the efficacy of mTOR inhibitors toward the psychiatric symptoms associated with TSC. Here, we report a case study of a Korean patient with TSC, who exhibited multiple symptoms including frequent seizures, intellectual disability, language delays, and social problems. We performed whole exome sequencing and identified a novel small deletion mutation in TSC2. Expressing the novel deletion mutant in HEK293T cells significantly increased mTOR pathway activation. Furthermore, everolimus treatment showed not only reduction in SEGA size, but dramatically improved behavioral deficits including autism related behaviors in the patient. In summary, we identified a novel small deletion mutation in TSC2 associated with severe TSC in a Korean family that enhances the activation of mTOR signaling in vitro. Everolimus treatment improved behavioral deficits in the patient.
doi:10.1186/s13041-016-0222-6 pmid:27216612 pmcid:PMC4878062 fatcat:ye2cnohjybd7lbqxinviupl5km

Fabrication of parabolic Si nanostructures by nanosphere lithography and its application for solar cells

See-Eun Cheon, Hyeon-seung Lee, Jihye Choi, Ah Reum Jeong, Taek Sung Lee, Doo Seok Jeong, Kyeong-Seok Lee, Wook-Seong Lee, Won Mok Kim, Heon Lee, Inho Kim
2017 Scientific Reports  
We demonstrated fabrication of a parabola shaped Si nanostructures of various periods by combined approach of nanosphere lithography and a single step CF 4 /O 2 reactive ion etch (RIE) process. Silica nanosphere monolayers in a hexagonal array were well deposited by a solvent controlled spin coating technique based on binary organic solvents. We showed numerically that a parabolic Si nanostructure of an optimal period among various-shaped nanostructures overcoated with a dielectric layer of a
more » ... nm thickness provide the most effective antireflection. As the simulation results as a design guide, we fabricated the parabolic Si nanostructures of a 520 nm period and a 300 nm height exhibiting the lowest weighted reflectance of 2.75%. With incorporation of such parabolic Si nanostructures, a damage removal process for 20 sec and SiN x antireflection coating of a 70 nm thickness, the efficiency of solar cells increased to 17.2% while that of the planar cells without the nanostructures exhibited 16.2%. The efficiency enhancement of the cell with the Si nanostructures was attributed to the improved photocurrents arising from the broad spectral antireflection which was confirmed by the external quantum efficiency (EQE) measurements. Published: xx xx xxxx OPEN 2 Scientific REpORtS | 7: 7336 |
doi:10.1038/s41598-017-07463-7 pmid:28779077 pmcid:PMC5544770 fatcat:xvj4kwbom5csjobaquu6d3vdiq

Clinical Features of Interhemispheric Subdural Hematomas

Jae-Min Ahn, Kyeong-Seok Lee, Jae-Hyun Shim, Jae-Sang Oh, Jai-Joon Shim, Seok-Mann Yoon
2017 Korean Journal of Neurotrauma  
Objective: Interhemispheric subdural hematoma (IHSDH) is uncommon, because of their unusual location. However, it is a distinct lesion with its unique characteristics. We investigated clinical features and outcomes of consecutive 42 patients with IHSDH, retrospectively. Methods: From 2006 to 2015, we treated 105 patients with IHSDH. All patients were diagnosed by computed tomography (CT) or magnetic resonance imaging. We selected 42 patients with thick (3 mm or more) IHSDH. We retrospectively
more » ... viewed the clinical and radiological findings, management and outcomes. Results: The male to female ratio was 2:1. Two thirds of the patients were over 60 years old. Slip or fall was the most common cause of trauma. The level of consciousness on admission was Glasgow Coma Scale (GCS) 13 to 15 in 25 patients. The most common symptom was headache. All IHSDH was hyperdense in CT at the time of diagnosis. IHSDH frequently accompanied convexity subdural hematoma. The outcome was favorable in 27 patients, however, six patients were expired. Twenty-two patients were managed conservatively. Surgery was performed in ten patients to remove the concurrent lesion. The outcome was poor in spontaneous one, patients with low GCS, and patients with conservative treatment. Conclusion: IHSDH is rare especially the isolated one. The outcome was dependent to the severity of injury. Surgery may be helpful to remove the concurrent mass lesion, however, conservative treatment is generally preferred. (Korean J Neurotrauma 2017;13(2):103-107) KEY WORDS: Craniocerebral trauma ㆍGlasgow outcome scale ㆍHematoma, subdural ㆍSymptom assessment. CLINICAL ARTICLE Korean
doi:10.13004/kjnt.2017.13.2.103 pmid:29201842 pmcid:PMC5702743 fatcat:eiwt65btazbkrjxd4ctnx4bph4

Results of Isotope Cisternography in 175 Patients with a Suspected Hydrocephalus

Kyeong-Seok Lee, Sang-Mi Lee, Jae-Joon Shim, Seok-Mann Yoon, Hack-Gun Bae, Jae-Won Doh
2015 Korean Journal of Neurotrauma  
doi:10.13004/kjnt.2015.11.1.11 pmid:27169059 pmcid:PMC4847488 fatcat:lbg5ske7gfamfkseef66siu4qy

Prognostic Value of the C-reactive Protein Levels in the Head Injury

Deok-Gu Lee, Kyeong-Seok Lee, Jai-Joon Shim, Seok-Mann Yoon, Hack Gun Bae
2005 Journal of Korean Neurotraumatology Society  
Objective: C-reactive protein (CRP) is an acute-phase protein, whose the blood levels increase rapidly in response to infection, trauma, and other inflammatory conditions. The relation of CRP levels to TBI is not well known. This study is to assess the association of early serum CRP concentrations, with the degree of the brain damage and the prognosis of the patients with the diffuse head injury. Material & Method: From September 2004 to March 2004, we measured serum CRP at least twice, the
more » ... t within 2 days (initial; CRPi) and the second between 3 to 7 days (early; CRPe) after the trauma. Serum CRP was measured by immunoturbidity method. In 187 patients, the relationship between the clinical features and serum CRP level was analyzed. Results: The serum levels of CRPi were not significantly different according to the age, the initial Glasgow Coma Scale (GCS) score, the outcome, and the operative intervension. High serum levels (20 mg/l<) of CRPe were more common in patients with low GCS (3-12), in patients who underwent surgery, and in patients with poor outcome. Conclusion: CRPe can be a useful adjuvant, especially in cases of diffuse brain injury where imaging studies are usually less optimal to reveal the severity of TBI.
doi:10.13004/jknts.2005.1.1.57 fatcat:yrew77wxzzgl5lmsgad2sg4xkm

Noncoding de novo mutations contribute to autism spectrum disorder via chromatin interactions [article]

Il Bin Kim, Taeyeop Lee, Junehawk Lee, Jonghun Kim, Hyunseong Lee, Woo Kyeong Kim, Young Seok Ju, Yongseong Cho, Seok Jong Yu, Soon Ae Kim, Miae Oh, Tae Hwan Kwak (+4 others)
2019 bioRxiv   pre-print
,Lee, N.H. & Quackenbush, J.  ...  Lee, H.J. et al. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. Behav Brain Funct 1, 15 (2005). 35. Uezato, A. et al.  ... 
doi:10.1101/2019.12.15.877324 fatcat:2bfa5vslsvdapebpvdeq27uzfq

Photocurrent enhancements of organic solar cells by altering dewetting of plasmonic Ag nanoparticles

Tyler Fleetham, Jea-Young Choi, Hyung Woo Choi, Terry Alford, Doo Seok Jeong, Taek Sung Lee, Wook Seong Lee, Kyeong-Seok Lee, Jian Li, Inho Kim
2015 Scientific Reports  
Lee, W.S. Lee and K.-S. Lee performed the FDTD simulations and contributed to the optical analysis. J. Li, T. Alford and I. Kim designed the experiments and analyzed the data.  ... 
doi:10.1038/srep14250 pmid:26388104 pmcid:PMC4585705 fatcat:tjf2wyfy2jg6plaltvu7pjcvmq

A Room‐Temperature Ferroelectric Ferromagnet in a 1D Tetrahedral Chain Network

Kyeong Tae Kang, Chang Jae Roh, Jinyoung Lim, Taewon Min, Jun Han Lee, Kyoungjun Lee, Tae Yoon Lee, Seunghun Kang, Daehee Seol, Jiwoong Kim, Hiromichi Ohta, Amit Khare (+8 others)
2019 Advanced Materials  
, Yoon Seok Oh, Jaekwang Lee, Jaejun Yu, Jong Seok Lee, and Woo Seok Choi* Orientation of the SrFeO2.5 epitaxial thin film To realize and observe 1D combined polar distortion (CPD) in a brownmillerite  ...  Kang, Chang Jae Roh, Jinyoung Lim, Taewon Min, Jun Han Lee, Kyoungjun Lee, Tae Yoon Lee, Seunghun Kang, Daehee Seol, Jiwoong Kim, Hiromichi Ohta, Amit Khare, Sungkyun Park, Yunseok Kim, Seung Chul Chae  ... 
doi:10.1002/adma.201808104 pmid:31034128 fatcat:q6whafybunc2niwgstqydcshqq
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