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Disability Evaluation
2008
Journal of Korean Medical Association
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Lee KS Table 1 . ...
doi:10.5124/jkma.2008.51.7.664
fatcat:h7uh62qq7fhdvofpxadkocmbrq
Virus Incidence of Sweet Potato in Korea from 2011 to 2014
2017
The Plant Pathology Journal
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Identification of Novel Biomarker for Early Detection of Diabetic Nephropathy
2021
Biomedicines
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Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus. After development of DN, patients will progress to end-stage renal disease, which is associated with high morbidity and mortality. Here, we developed early-stage diagnostic biomarkers to detect DN as a strategy for DN intervention. For the DN model, Zucker diabetic fatty rats were used for DN phenotyping. The results revealed that DN rats showed significantly increased blood glucose, blood urea nitrogen
doi:10.3390/biomedicines9050457
pmid:33922243
fatcat:nrvbh7ufcjfifekmzepgcaxf4e
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... , and serum creatinine levels, accompanied by severe kidney injury, fibrosis and microstructural changes. In addition, DN rats showed significantly increased urinary excretion of kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Transcriptome analysis revealed that new DN biomarkers, such as complementary component 4b (C4b), complementary factor D (CFD), C-X-C motif chemokine receptor 6 (CXCR6), and leukemia inhibitory factor (LIF) were identified. Furthermore, they were found in the urine of patients with DN. Since these biomarkers were detected in the urine and kidney of DN rats and urine of diabetic patients, the selected markers could be used as early diagnosis biomarkers for chronic diabetic nephropathy.
Silicon nanodisk array design for effective light trapping in ultrathin c-Si
2014
Optics Express
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The use of ultrathin c-Si (crystalline silicon) wafers thinner than 20 μm for solar cells is a very promising approach to realize dramatic reduction in cell cost. However, the ultrathin c-Si requires highly effective light trapping to compensate optical absorption reduction. Conventional texturing in micron scale is hardly applicable to the ultrathin c-Si wafers; thus, nano scale texturing is demanded. In general, nanotexturing is inevitably accompanied by surface area enlargements, which must
doi:10.1364/oe.22.0a1431
pmid:25607300
fatcat:m2sim6yu6jcivnip46rhyxkgvq
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... e minimized in order to suppress surface recombination of minority carriers. In this study, we demonstrate using optical simulations that periodic c-Si nanodisk arrays of short heights less than 200 nm and optimal periods are very useful in terms of light trapping in the ultrathin c-Si wafers while low surface area enlargements are maintained. Double side texturing with the nanodisk arrays leads to over 90% of the Lambertian absorption limit while the surface area enlargement is kept below 1.5.
History of Chronic Subdural Hematoma
2015
Korean Journal of Neurotrauma
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Am J Phys Anthropol 152:484-494, 2013 31) Lee KS. Natural history of chronic subdural haematoma. Brain Inj 18:351-358, 2004 32) Lee KS. ...
J Korean Med Sci 15:560-568, 2000 34) Lee KS, Bae WK, Park YT, Yun IG. The pathogenesis and fate of traumatic subdural hygroma. Br J Neurosurg 8:551-558, 1994 35) Lee KS, Doh JW, Bae HG, Yun IG. ...
doi:10.13004/kjnt.2015.11.2.27
pmid:27169062
pmcid:PMC4847516
fatcat:2runydxrvzbebfoqtgq4sjukt4
Repeat Vertebroplasty for the Subsequent Refracture of Procedured Vertebra
2013
The Korean Journal of Pain
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Vertebroplasty (VP) can effectively treat pain and immobility caused by vertebral compression fracture. Because of complications such as extravasation of bone cement (polymethylmethacrylate, PMMA) and adjacent vertebral fractures, some practitioners prefer to inject a small volume of PMMA. In that case, however, insufficient augmentation or a subsequent refracture of the treated vertebrae can occur. A 65-year-old woman visited our clinic complaining of unrelieved severe low back and bilateral
doi:10.3344/kjp.2013.26.1.94
pmid:23342217
pmcid:PMC3546220
fatcat:lkcmgh5g4ngbriniz2gyiu3wzi
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... ank pain even after she had undergone VP on the 1 st and 4 th (L1 and L4) lumbar vertebrae a month earlier. Radiologic findings showed the refracture of L1. We successfully performed the repeat VP by filling the vertebra with a sufficient volume of PMMA, and no complications occurred. The patient's pain and immobility resolved completely three days after the procedure and she remained symptom-free a month later. In conclusion, VP with small volume cement impaction may fail to relieve fracture-induced symptoms, and the refracture of an augmented vertebral body may occur. In this case, repeat VP can effectively resolve both the persistent symptoms and problems of new onset resulting from refracture of the augmented vertebral body due to insufficient volume of bone cement. (Korean J Pain 2013; 26: 94-97)
Cerebral Aneurysms in Judicial Precedents
2018
Journal of Korean Neurosurgical Society
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Objective : From November 30, 2016, the Korean Government carried the revised Medical Dispute Mediation and Arbitration Act into effect. Mediation will start automatically without agreements of the defendant, when the outcome of the patient was death, coma more than a month or severe disability. Cerebral aneurysm has a definite risk of bad outcome, especially in the worst condition. Any surgical intervention to this lesion has its own high risk of complications. Recently, Seoul central district
doi:10.3340/jkns.2017.0404.012
pmid:29631385
pmcid:PMC6046580
fatcat:peq5ig4si5d7dpi4iocz6kdiu4
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... court decided 50% responsibility of the doctors who made a rupture of the aneurysm during coiling (2015Ga-Dan5243104). We reviewed judicial precedents related to cerebral aneurysms in lawsuit using a web search. Methods : We searched judicial precedents at a web search of the Supreme Court, using the key words, "cerebral aneurysm". Results : There were 15 precedents, six from the Supreme Court, seven from the High Court, and two from district courts. Seven precedents were related to the causation analysis, such as work-relationship. Five precedents were malpractice suits related bad results or complications. Remaining three precedents were related to the insurance payment. In five malpractice precedents, two precedents of the Supreme Court reversed former two precedents of the High Court. Conclusion : Judicial precedents on the cerebral aneurysm included not only malpractice suits, but also causation analysis or insurance payment. Attention to these subjects is needed. We also need education of the independent medical examination. To avoid medical disputes, shared decision making seems to be useful, especially in cases of high risk condition or procedures.
Everolimus improves neuropsychiatric symptoms in a patient with tuberous sclerosis carrying a novel TSC2 mutation
2016
Molecular Brain
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Tuberous sclerosis complex (TSC) is a neurocutaneous disorder characterized by multiple symptoms including neuropsychological deficits such as seizures, intellectual disability, and autism. TSC is inherited in an autosomal dominant pattern and is caused by mutations in either the TSC1 or TSC2 genes, which enhance activation of the mammalian target of rapamycin (mTOR) signaling pathway. Recent studies have suggested that mTOR inhibitors such as rapamycin can reverse TSC-associated deficits in
doi:10.1186/s13041-016-0222-6
pmid:27216612
pmcid:PMC4878062
fatcat:ye2cnohjybd7lbqxinviupl5km
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... ent models of TSC. In addition, clinical trials are ongoing to test the efficacy of mTOR inhibitors toward the psychiatric symptoms associated with TSC. Here, we report a case study of a Korean patient with TSC, who exhibited multiple symptoms including frequent seizures, intellectual disability, language delays, and social problems. We performed whole exome sequencing and identified a novel small deletion mutation in TSC2. Expressing the novel deletion mutant in HEK293T cells significantly increased mTOR pathway activation. Furthermore, everolimus treatment showed not only reduction in SEGA size, but dramatically improved behavioral deficits including autism related behaviors in the patient. In summary, we identified a novel small deletion mutation in TSC2 associated with severe TSC in a Korean family that enhances the activation of mTOR signaling in vitro. Everolimus treatment improved behavioral deficits in the patient.
Fabrication of parabolic Si nanostructures by nanosphere lithography and its application for solar cells
2017
Scientific Reports
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We demonstrated fabrication of a parabola shaped Si nanostructures of various periods by combined approach of nanosphere lithography and a single step CF 4 /O 2 reactive ion etch (RIE) process. Silica nanosphere monolayers in a hexagonal array were well deposited by a solvent controlled spin coating technique based on binary organic solvents. We showed numerically that a parabolic Si nanostructure of an optimal period among various-shaped nanostructures overcoated with a dielectric layer of a
doi:10.1038/s41598-017-07463-7
pmid:28779077
pmcid:PMC5544770
fatcat:xvj4kwbom5csjobaquu6d3vdiq
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... nm thickness provide the most effective antireflection. As the simulation results as a design guide, we fabricated the parabolic Si nanostructures of a 520 nm period and a 300 nm height exhibiting the lowest weighted reflectance of 2.75%. With incorporation of such parabolic Si nanostructures, a damage removal process for 20 sec and SiN x antireflection coating of a 70 nm thickness, the efficiency of solar cells increased to 17.2% while that of the planar cells without the nanostructures exhibited 16.2%. The efficiency enhancement of the cell with the Si nanostructures was attributed to the improved photocurrents arising from the broad spectral antireflection which was confirmed by the external quantum efficiency (EQE) measurements. Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 Scientific REpORtS | 7: 7336 |
Clinical Features of Interhemispheric Subdural Hematomas
2017
Korean Journal of Neurotrauma
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Objective: Interhemispheric subdural hematoma (IHSDH) is uncommon, because of their unusual location. However, it is a distinct lesion with its unique characteristics. We investigated clinical features and outcomes of consecutive 42 patients with IHSDH, retrospectively. Methods: From 2006 to 2015, we treated 105 patients with IHSDH. All patients were diagnosed by computed tomography (CT) or magnetic resonance imaging. We selected 42 patients with thick (3 mm or more) IHSDH. We retrospectively
doi:10.13004/kjnt.2017.13.2.103
pmid:29201842
pmcid:PMC5702743
fatcat:eiwt65btazbkrjxd4ctnx4bph4
more »
... viewed the clinical and radiological findings, management and outcomes. Results: The male to female ratio was 2:1. Two thirds of the patients were over 60 years old. Slip or fall was the most common cause of trauma. The level of consciousness on admission was Glasgow Coma Scale (GCS) 13 to 15 in 25 patients. The most common symptom was headache. All IHSDH was hyperdense in CT at the time of diagnosis. IHSDH frequently accompanied convexity subdural hematoma. The outcome was favorable in 27 patients, however, six patients were expired. Twenty-two patients were managed conservatively. Surgery was performed in ten patients to remove the concurrent lesion. The outcome was poor in spontaneous one, patients with low GCS, and patients with conservative treatment. Conclusion: IHSDH is rare especially the isolated one. The outcome was dependent to the severity of injury. Surgery may be helpful to remove the concurrent mass lesion, however, conservative treatment is generally preferred. (Korean J Neurotrauma 2017;13(2):103-107) KEY WORDS: Craniocerebral trauma ㆍGlasgow outcome scale ㆍHematoma, subdural ㆍSymptom assessment. CLINICAL ARTICLE Korean
Results of Isotope Cisternography in 175 Patients with a Suspected Hydrocephalus
2015
Korean Journal of Neurotrauma
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Prognostic Value of the C-reactive Protein Levels in the Head Injury
2005
Journal of Korean Neurotraumatology Society
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Objective: C-reactive protein (CRP) is an acute-phase protein, whose the blood levels increase rapidly in response to infection, trauma, and other inflammatory conditions. The relation of CRP levels to TBI is not well known. This study is to assess the association of early serum CRP concentrations, with the degree of the brain damage and the prognosis of the patients with the diffuse head injury. Material & Method: From September 2004 to March 2004, we measured serum CRP at least twice, the
doi:10.13004/jknts.2005.1.1.57
fatcat:yrew77wxzzgl5lmsgad2sg4xkm
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... t within 2 days (initial; CRPi) and the second between 3 to 7 days (early; CRPe) after the trauma. Serum CRP was measured by immunoturbidity method. In 187 patients, the relationship between the clinical features and serum CRP level was analyzed. Results: The serum levels of CRPi were not significantly different according to the age, the initial Glasgow Coma Scale (GCS) score, the outcome, and the operative intervension. High serum levels (20 mg/l<) of CRPe were more common in patients with low GCS (3-12), in patients who underwent surgery, and in patients with poor outcome. Conclusion: CRPe can be a useful adjuvant, especially in cases of diffuse brain injury where imaging studies are usually less optimal to reveal the severity of TBI.
Noncoding de novo mutations contribute to autism spectrum disorder via chromatin interactions
[article]
2019
bioRxiv
pre-print
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,Lee, N.H. & Quackenbush, J. ...
Lee, H.J. et al. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. Behav Brain Funct 1, 15 (2005). 35. Uezato, A. et al. ...
doi:10.1101/2019.12.15.877324
fatcat:2bfa5vslsvdapebpvdeq27uzfq
Photocurrent enhancements of organic solar cells by altering dewetting of plasmonic Ag nanoparticles
2015
Scientific Reports
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Lee, W.S. Lee and K.-S. Lee performed the FDTD simulations and contributed to the optical analysis. J. Li, T. Alford and I. Kim designed the experiments and analyzed the data. ...
doi:10.1038/srep14250
pmid:26388104
pmcid:PMC4585705
fatcat:tjf2wyfy2jg6plaltvu7pjcvmq
A Room‐Temperature Ferroelectric Ferromagnet in a 1D Tetrahedral Chain Network
2019
Advanced Materials
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2019 pre-print arXiv:1905.02931v1 fatcat:dooataxvd5ftbjdnrjsdjadjzm
, Yoon Seok Oh, Jaekwang Lee, Jaejun Yu, Jong Seok Lee, and Woo Seok Choi* Orientation of the SrFeO2.5 epitaxial thin film To realize and observe 1D combined polar distortion (CPD) in a brownmillerite ...
Kang, Chang Jae Roh, Jinyoung Lim, Taewon Min, Jun Han Lee, Kyoungjun Lee, Tae Yoon Lee, Seunghun Kang, Daehee Seol, Jiwoong Kim, Hiromichi Ohta, Amit Khare, Sungkyun Park, Yunseok Kim, Seung Chul Chae ...
doi:10.1002/adma.201808104
pmid:31034128
fatcat:q6whafybunc2niwgstqydcshqq
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