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Intelligent Photographing Interface with On-Device Aesthetic Quality Assessment [chapter]

Kuo-Yen Lo, Keng-Hao Liu, Chu-Song Chen
2013 Lecture Notes in Computer Science  
This paper proposes a efficient method for instant photo aesthetics quality assessment that can be implemented on general portable devices. The classification performance is guaranteed to 0.89 on benchmark photo database. We also port our method onto a middle-level tablet computer to execute instantly and we find it reaches good acceptable efficiency. Moreover, an aesthetic information display to present the aesthetics evaluation results to users is introduced.
doi:10.1007/978-3-642-37484-5_43 fatcat:ppc4fgefmzdjtmkp3tfnupjkay

Well-Dispersed Silver Nanoparticles on Cellulose Filter Paper for Bacterial Removal

Hsiu-Wen Chien, Ming-Yen Tsai, Chia-Jung Kuo, Ching-Lo Lin
2021 Nanomaterials  
In this study, a polydopamine (PDA) and polyethyleneimine (PEI)-assisted approach was developed to generate well-distributed PDA/PEI/silver (PDA/PEI/Ag) nanocomplexes on the surfaces of commercial cellulose filter papers to achieve substantial bacterial reduction under gravity-driven filtration. PDA can bind to cellulose paper and act as a reducer to produce silver nanoparticles (AgNPs), while PEI can react with oxidative dopamine and act as a dispersant to avoid the aggregation of AgNPs. The
more » ... ccessful immobilization of PDA/PEI/Ag nanocomplexes was confirmed by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were used as pathogen models to test the efficacy of the PDA/PEI/Ag nanocomplex-incorporated filter papers. The PDA/PEI/Ag nanocomplex-incorporated filter papers provided a substantial bacterial removal of up to 99% by simple gravity filtration. This work may be useful to develop a feasible industrial production process for the integration of biocidal AgNPs into cellulose filter paper and is recommended as a local-condition water-treatment technology to treat microbial-contaminated drinking water.
doi:10.3390/nano11030595 pmid:33673629 fatcat:qjdfpw3x2rgvfkdzjti3xcvi3y

Sibling recurrence risk ratio analysis of the metabolic syndrome and its components over time

Wei J Chen, Pi-Hua Liu, Yen-Yi Ho, Kuo-Liong Chien, Min-Tzu Lo, Wei-Liang Shih, Yu-Chun Yen, Wen-Chung Lee
2003 BMC Genetics  
The purpose of this study was to estimate both cross-sectional sibling recurrence risk ratio (λ s ) and lifetime λ s for the metabolic syndrome and its individual components over time among sibships in the prospectively followed-up cohorts provided by the Genetic Analysis Workshop 13. Five measures included in the operational criteria of the metabolic syndrome by the Adult Treatment Panel III were examined. A method for estimating sibling recurrence risk with correction for complete
more » ... t was used to estimate the numerator, and the prevalence in the whole cohort was used as the denominator of λ s . Results: Considerable variability in the λ s was found in terms of different time-points for the crosssectional definition, the times of fulfilling the criterion for lifetime definition, and different components. Obesity and hyperglycemia had the highest cross-sectional λ s of the five components. Both components also had the largest slopes in the linear trend of the lifetime λ s . However, the magnitudes of the lifetime λ s were similar to that of the mean cross-sectional λ s , which were <2. The results of nonparametric linkage analysis showed only suggestive evidence of linkage between one marker and lifetime diagnosis of low high-density lipoprotein cholesterol and metabolic syndrome, respectively.
doi:10.1186/1471-2156-4-s1-s33 pmid:14975101 pmcid:PMC1866469 fatcat:qi2u65wfkbdfrdhtdd3faikpsu

Heart Rhythm Complexity Impairment in Patients with Pulmonary Hypertension

Cheng-Hsuan Tsai, Hsi-Pin Ma, Yen-Tin Lin, Chi-Sheng Hung, Mi-Chia Hsieh, Ting-Yu Chang, Ping-Hung Kuo, Chen Lin, Men-Tzung Lo, Hsao-Hsun Hsu, Chung-Kang Peng, Yen-Hung Lin
2019 Scientific Reports  
Pulmonary hypertension is a fatal disease, however reliable prognostic tools are lacking. Heart rhythm complexity analysis is derived from non-linear heart rate variability (HRV) analysis and has shown excellent performance in predicting clinical outcomes in several cardiovascular diseases. However, heart rhythm complexity has not previously been studied in pulmonary hypertension patients. We prospectively analyzed 57 patients with pulmonary hypertension (31 with pulmonary arterial hypertension
more » ... and 26 with chronic thromboembolic pulmonary hypertension) and compared them to 57 age- and sex-matched control subjects. Heart rhythm complexity including detrended fluctuation analysis (DFA) and multiscale entropy (MSE) and linear HRV parameters were analyzed. The patients with pulmonary hypertension had significantly lower mean RR, SDRR, pNN20, VLF, LF, LF/HF ratio, DFAα1, MSE slope 5, scale 5, area 1-5 and area 6-20 compared to the controls. Receiver operating characteristic curve analysis showed that heart rhythm complexity parameters were better than traditional HRV parameters to predict pulmonary hypertension. Among all parameters, scale 5 had the greatest power to differentiate the pulmonary hypertension patients from controls (AUC: 0.845, P < 0.001). Furthermore, adding heart rhythm complexity parameters significantly improved the discriminatory power of the traditional HRV parameters in both net reclassification improvement and integrated discrimination improvement models. In conclusion, the patients with pulmonary hypertension had worse heart rhythm complexity. MSE parameters, especially scale 5, had excellent single discriminatory power to predict whether or not patients had pulmonary hypertension.
doi:10.1038/s41598-019-47144-1 pmid:31341216 pmcid:PMC6656770 fatcat:xs2a3wgnujdide63t7cqe5wj7q

A Rectifying Acceptance Sampling Plan Based on the Process Capability Index

Ching-Ho Yen, Chun-Chia Lee, Kuo-Hung Lo, Yeou-Ren Shiue, Shu-Hua Li
2020 Mathematics  
Yen et al. [4, 12] , Aslam et al. [6, 13] , Lee et al.  ...  Yen et al. [17] used a single sampling scheme to develop a rectifying sampling plan based on a one-sided PCI.  ... 
doi:10.3390/math8010141 fatcat:4pbv46os55gffjd7t6sogpvkwa

Diagnostic Value of EBUS-TBNA for Lung Cancer with Non-Enlarged Lymph Nodes: A Study in a Tuberculosis-Endemic Country

Chih-Hsi Kuo, Hao-Cheng Chen, Fu-Tsai Chung, Yu-Lun Lo, Kang-Yun Lee, Chih-Wei Wang, Wen-Han Kuo, Tzu-Chen Yen, Han-Pin Kuo, Juri Gelovani
2011 PLoS ONE  
In tuberculosis (TB)-endemic areas, contrast-enhanced computed tomography (CT) and positron emission tomography (PET) findings of lung cancer patients with non-enlarged lymph nodes are frequently discrepant. Endobronchial ultrasound-guided transbronchial aspiration (EBUS-TBNA) enables real-time nodal sampling, and thereby improves nodal diagnosis accuracy. This study aimed to compare the accuracy of nodal diagnosis by using EBUS-TBNA, and PET. Methods: We studied 43 lung cancer patients with
more » ... defined non-enlarged mediastinal and hilar lymph nodes and examined 78 lymph nodes using EBUS-TBNA. Results: The sensitivity, specificity, positive predictive value, and negative predictive value of EBUS-TBNA were 80.6%, 100%, 100%, and 85.7%, respectively. PET had low specificity (18.9%) and a low positive predictive value (44.4%). The diagnostic accuracy of EBUS-TBNA was higher than that of PET (91% vs. 47.4%; p,0.001). Compared to CT-based nodal assessment, PET yielded a positive diagnostic impact in 36.9% nodes, a negative diagnostic impact in 46.2% nodes, and no diagnostic impact in 16.9% nodes. Patients with lymph nodes showing negative PET diagnostic impact had a high incidence of previous pulmonary TB. Multivariate analysis indicated that detection of hilar nodes on PET was an independent predictor of negative diagnostic impact of PET.
doi:10.1371/journal.pone.0016877 pmid:21364919 pmcid:PMC3045379 fatcat:sjkakax57bapnn47uyagqwoyp4

Comparison of Operative Outcomes Among Laparoscopic, 3D-Laparoscopic, and Robotic Gastrectomy for Distal Gastric Cancer

Tung-Yen Wu, Yen-Ling Liu, Kuo-Hung Huang, Wen-Liang Fang, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Yi-Ming Shyr
2021 International surgery  
Acknowledgments Tung-Yen Wu and Yen-Ling Liu contributed equally to this work. This study was supported by Taipei Veterans General Hospital (V110C-172).  ... 
doi:10.9738/intsurg-d-21-00007.1 fatcat:o4f4drjyybemhkjpw2bl4pdvu4

Modeling Alzheimer's Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation

Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Ching-Chang Huang, Jia-Li Lin, Yi-Jing Chen, Pei-Chi Wei, Yen-Shi Lo, Chin-Fa Yao, Ming-Wei Kuo, Chiung-Mei Chen
2018 Molecular Neurobiology  
Alzheimer's disease (AD), probably caused by abnormal accumulation of β-amyloid (Aβ) and aberrant phosphorylation of tau, is the most common cause of dementia among older people. Generation of patient-specific neurons by induced pluripotent stem cell (iPSC) technology facilitates exploration of the disease features in live human neurons from AD patients. In this study, we generated iPSCs from two familial AD patients carrying a heterozygous D678H mutation in the APP gene (AD-iPSCs). The neurons
more » ... derived from our AD-iPSCs demonstrated aberrant accumulation of intracellular and secreted Aβ42 and Aβ40, reduction of serine 9 phosphorylation in glycogen synthase kinase 3β (GSK3β) hyperphosphorylation of threonine 181 and serine 396 in tau protein, impaired neurite outgrowth, downregulation of synaptophysin, and increased caspase 1 activity. The comparison between neurons derived from a sibling pair of wild-type and mutated iPSCs successfully recapitulated these AD phenotypes. Treatment with indole compound NC009-1 (3-((1H-Indole-3-yl)methyl)-4-(2-nitrophenyl)but-3-en-2-one), a potential Aβ aggregation reducer, normalized the Aβ levels and GSK3β and tau phosphorylation, attenuated caspase 1 activity, and improved neurite outgrowth in AD-iPSC-derived neurons. Thus, APP D678H iPSCs-derived neurons recapitulate the cellular characteristics relevant to AD and enable exploration of the underlying pathogenesis and therapeutic strategies for AD.
doi:10.1007/s12035-018-1336-x pmid:30238389 fatcat:nmeatl2qqvczjf4qycsifxssiq

Using MODIS/Terra and Landsat imageries to improve surface water quantification in Sylhet, Bangladesh

Kuo-Hsin Tseng, Chung-Yen Kuo, Min-Hui Lo, C. K. Shum, Md Mizanur Rahman, Yuanyuan Jia, Ting-Yi Yang, Po-Hung Shih
2019 Terrestrial, Atmospheric and Oceanic Sciences  
Second, the WL can be acquired from satellite altimetry or combined satellite images and digital elevation models (Maheu et al. 2003; Berry et al. 2005; Schumann et al. 2008; Hostache et al. 2009; Kuo  ... 
doi:10.3319/tao.2018.11.15.04 fatcat:jz26is3npzazfbwtfiu3aoznsy

Clinical and cytokine profile of adult acute necrotizing encephalopathy

Yi-Ying Lin, Kuang-Yung Lee, Long-Sun Ro, Yen-Shi Lo, Chin-Chang Huang, Kuo-Hsuan Chang
2019 Biomedical Journal  
Acute necrotizing encephalopathy (ANE), a fulminant encephalopathy, is often found in childhood. It is still uncertain whether adult patients with ANE display clinical features different from patients with typical pediatric onset. Furthermore, alterations in neuroinflammatory factors in patients with ANE have not been well-characterized. Here, we present an adult patient with ANE, and review all reported adult ANE cases in the literature.
doi:10.1016/ pmid:31466711 pmcid:PMC6717751 fatcat:jpxujeia3zbl3hfmsrquxm2vwe

Cytotoxic Constituents from the Leaves of Cinnamomum subavenium

Soong-Yu Kuo, Tian-Jye Hsieh, Yau-Der Wang, Wen-Li Lo, Yen-Ray Hsui, Chung-Yi Chen
2008 Chemical and pharmaceutical bulletin  
Cinnamomum subavenium MIQ. (Lauraceae) is a mediumsized evergreen tree, found in central to southern mainland China, Burma, Cambodia, Taiwan, Malaysia, and Indonesia. 1) The chemical constituents and the biological activity of the leaves of this plant have not yet been reported. Recently, we reported three new butanolides, subamolides A-C, a new secobutanolide, secosubamolide, along with 17 known compounds from the stems of C. subavenium. 2,3) We also reported the structural elucidation of the
more » ... ewly isolated butanolides and secobutanolide as well as their effects on DNA damage on a human colorectal cancer cell line, SW480. 2,3) In continuation of a program studying chemotaxonomy and biologically active components from Formosan Lauraceous plants, [2] [3] [4] [5] [6] [7] [8] [9] two new butanolides, namely, subamolide D [(4R,3Z)-4-hydroxy-5-methylene-3-undecylidenedihydrofuran-2-one] (1), and subamolide E [(4R,3E)-4-hydroxy-5methylene-3-undecylidenedihydrofuran-2-one] (2), and a new secobutanolide, secosubamolide A {methyl[(2E)-2-[(1S)-1-hydroxy-2-oxopropyl]-octadec-2-enoate]} (3), were isolated. Also confirmed were 21 known compounds, including the butanolides linderanolide B 8) and isolinderanolide B 10) ; one ionone, (ϩ)-abscisic acid 11) ; one sesquiterpenoid, caryophyllene oxide 12) ; one triterpenoid, squalene 13) ; six benzenoids, vanillin, 14) vanillic acid, 14) p-hydroxybenzoic acid, 14) p-hydroxybenzaldehyde, 14) syringic acid, 14) and eugenol 15) ; two polyprenols, ficaprenol-10, 16) and ficaprenol-11 16) ; two chlorophylls, pheophytin-a, 17) and aristophyll-C 18) ; four steroids, b-sitosterol, 19) stigmasterol, 19) b-sitosteryl-D-glucoside, 20) and stigmasteryl-D-glucoside 20) ; two aliphatic compounds, palmitic acid 21) and stearic acid 22) were isolated from the leaves of C. subanenium by MeOH extraction. In this paper, we report the structural elucidation of 1-3 and explore the cytotoxic effect of 1 and 2 on human colon cancer cells. Subamolide D was isolated as a pale yellowish liquid. Its molecular formula, C 16 H 26 O 3 , was established by HR-FAB-MS. The UV absorption at 228 nm was similar to that of linderanolide B, 10) indicating the presence of b-hydroxy-gmethylene-a,b-unsaturated g-lactone. 23) The IR spectrum showed absorption bands for a hydroxy group at 3450 cm Ϫ1 , and an a,b-unsaturated g-lactone moiety at 1770 and 1680 cm Ϫ1 . The 1 H-NMR spectrum of 1 was similar to that of linderanolide B, 10) indicating that 1 has the same b-hy-Two new butanolides, subamolide D (1) and subamolide E (2), and a new secobutanolide, secosubamolide A (3), along with 21 known compounds were isolated from the leaves of Cinnamomum subavenium. The structures of 1-3 were determined by spectroscopic analysis. Propidium iodide staining and cytometry analysis were used to evaluate the cell cycle progression of the treated SW480 cells and it was found that 1 and 2 caused DNA damage in a dose-and time-dependent manner.
doi:10.1248/cpb.56.97 pmid:18175985 fatcat:yashjpfkrfgtfpc7xq2v3x7r3a

A single-cell level and connectome-derived computational model of the Drosophila brain [article]

Yu-Chi Huang, Cheng-Te Wang, Ta-Shun Su, Kuo-Wei Kao, Yen-Jen Lin, Ann-Shyn Chiang, Chung-Chuan Lo
2018 bioRxiv   pre-print
Several theoretical studies suggested that a balanced state can improve functionality of a neural network compared to unbalanced one (Lo, Wang, and Wang 2015; C.-T.  ...  These challenges can be addressed by large-scale connectome projects (Milham 2012; Burns, Vogelstein, and Szalay 2014; Peng et al. 2015; Lo and Chiang 2016) , which aim to reconstruct a high-resolution  ... 
doi:10.1101/391474 fatcat:mcybdkfgobeyha5gd6zjwc3wzu

The Value of Heart Rhythm Complexity in Identifying High-Risk Pulmonary Hypertension Patients

Shu-Yu Tang, Hsi-Pin Ma, Chi-Sheng Hung, Ping-Hung Kuo, Chen Lin, Men-Tzung Lo, Hsao-Hsun Hsu, Yu-Wei Chiu, Cho-Kai Wu, Cheng-Hsuan Tsai, Yen-Tin Lin, Chung-Kang Peng (+1 others)
2021 Entropy  
Pulmonary hypertension (PH) is a fatal disease—even with state-of-the-art medical treatment. Non-invasive clinical tools for risk stratification are still lacking. The aim of this study was to investigate the clinical utility of heart rhythm complexity in risk stratification for PH patients. We prospectively enrolled 54 PH patients, including 20 high-risk patients (group A; defined as WHO functional class IV or class III with severely compromised hemodynamics), and 34 low-risk patients (group
more » ... . Both linear and non-linear heart rate variability (HRV) variables, including detrended fluctuation analysis (DFA) and multiscale entropy (MSE), were analyzed. In linear and non-linear HRV analysis, low frequency and high frequency ratio, DFAα1, MSE slope 5, scale 5, and area 6–20 were significantly lower in group A. Among all HRV variables, MSE scale 5 (AUC: 0.758) had the best predictive power to discriminate the two groups. In multivariable analysis, MSE scale 5 (p = 0.010) was the only significantly predictor of severe PH in all HRV variables. In conclusion, the patients with severe PH had worse heart rhythm complexity. MSE parameters, especially scale 5, can help to identify high-risk PH patients.
doi:10.3390/e23060753 pmid:34203737 pmcid:PMC8232109 fatcat:ee7xswsmhjgs7d5zzyv7lf5mqi

The effect of red light and far-red light conditions on secondary metabolism in Agarwood

Tony Chien-Yen Kuo, Chuan-Hung Chen, Shu-Hwa Chen, I-Hsuan Lu, Mei-Ju Chu, Li-Chun Huang, Chung-Yen Lin, Chien-Yu Chen, Hsiao-Feng Lo, Shih-Tong Jeng, Long-Fang O. Chen
2015 BMC Plant Biology  
Agarwood, a heartwood derived from Aquilaria trees, is a valuable commodity that has seen prevalent use among many cultures. In particular, it is widely used in herbal medicine and many compounds in agarwood are known to exhibit medicinal properties. Although there exists much research into medicinal herbs and extraction of high value compounds, few have focused on increasing the quantity of target compounds through stimulation of its related pathways in this species. Results: In this study, we
more » ... observed that cucurbitacin yield can be increased through the use of different light conditions to stimulate related pathways and conducted three types of high-throughput sequencing experiments in order to study the effect of light conditions on secondary metabolism in agarwood. We constructed genome-wide profiles of RNA expression, small RNA, and DNA methylation under red light and far-red light conditions. With these profiles, we identified a set of small RNA which potentially regulates gene expression via the RNA-directed DNA methylation pathway. Conclusions: We demonstrate that light conditions can be used to stimulate pathways related to secondary metabolism, increasing the yield of cucurbitacins. The genome-wide expression and methylation profiles from our study provide insight into the effect of light on gene expression for secondary metabolism in agarwood and provide compelling new candidates towards the study of functional secondary metabolic components.
doi:10.1186/s12870-015-0537-y pmid:26067652 pmcid:PMC4464252 fatcat:n7htxwcz7zclzcaknxp3dqisye

ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis

Kuo-Liang Chiu, Yu-Sen Lin, Ting-Ting Kuo, Chia-Chien Lo, Yu-Kai Huang, Hsien-Fang Chang, Eric Y. Chuang, Ching-Chan Lin, Wei-Chung Cheng, Yen-Nien Liu, Liang-Chuan Lai, Yuh-Pyng Sher
2017 OncoTarget  
Yen-Nien Liu, and this assay was conducted as previously described [19] .  ... 
doi:10.18632/oncotarget.17648 pmid:28537886 pmcid:PMC5564571 fatcat:mzxskqqrivh6tli2tjgp2fyhsa
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