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Dry Wearable Textile Electrodes for Portable Electrical Impedance Tomography

Chang-Lin Hu, I-Cheng Cheng, Chih-Hsien Huang, Yu-Te Liao, Wei-Chieh Lin, Kun-Ju Tsai, Chih-Hsien Chi, Chang-Wen Chen, Chia-Hsi Wu, I-Te Lin, Chien-Ju Li, Chii-Wann Lin
2021 Sensors  
Electrical impedance tomography (EIT), a noninvasive and radiation-free medical imaging technique, has been used for continuous real-time regional lung aeration. However, adhesive electrodes could cause discomfort and increase the risk of skin injury during prolonged measurement. Additionally, the conductive gel between the electrodes and skin could evaporate in long-term usage and deteriorate the signal quality. To address these issues, in this work, textile electrodes integrated with a
more » ... g belt are proposed to achieve EIT lung imaging along with a custom portable EIT system. The simulation and experimental results have verified the validity of the proposed portable EIT system. Furthermore, the imaging results of using the proposed textile electrodes were compared with commercial electrocardiogram electrodes to evaluate their performance.
doi:10.3390/s21206789 pmid:34696002 fatcat:zq62sb3eejeo5dl7rmgpjr4uiy

Prognosis of Multifocal Papillary Thyroid Carcinoma

Sheng-Fong Kuo, Shu-Fu Lin, Tzu-Chieh Chao, Chuen Hsueh, Kun-Ju Lin, Jen-Der Lin
2013 International Journal of Endocrinology  
Acknowledgments This work was supported by grants to Jen-Der Lin from the National Science Council in Taiwan (NMRPD1B0311) and Chang Gung Memorial Hospital Grants CMRPG3B1942.  ... 
doi:10.1155/2013/809382 pmid:24489543 pmcid:PMC3892555 fatcat:rjjmft3dlvh3dgy2d56z5ypdtm

A White Random Laser

Shu-Wei Chang, Wei-Cheng Liao, Yu-Ming Liao, Hung-I Lin, Hsia-Yu Lin, Wei-Ju Lin, Shih-Yao Lin, Packiyaraj Perumal, Golam Haider, Chia-Tse Tai, Kun-Ching Shen, Cheng-Han Chang (+3 others)
2018 Scientific Reports  
Random laser with intrinsically uncomplicated fabrication processes, high spectral radiance, anglefree emission, and conformal onto freeform surfaces is in principle ideal for a variety of applications, ranging from lighting to identification systems. In this work, a white random laser (White-RL) with high-purity and high-stability is designed, fabricated, and demonstrated via the cost-effective materials (e.g., organic laser dyes) and simple methods (e.g., all-solution process and
more » ... d structures). Notably, the wavelength, linewidth, and intensity of White-RL are nearly isotropic, nevertheless hard to be achieved in any conventional laser systems. Dynamically fine-tuning colour over a broad visible range is also feasible by on-chip integration of three free-standing monochromatic laser films with selective pumping scheme and appropriate colour balance. With these schematics, White-RL shows great potential and high application values in high-brightness illumination, full-field imaging, full-colour displays, visible-colour communications, and medical biosensing. The hope of next-generation illuminants goes on the application of random laser. As an unconventional laser system, random laser is naturally endowed with two key superiorities, namely, laser-level intensity and broad-angular emissions 1-4 , which are mutually exclusive in thermal light sources, light-emitting-diodes (LEDs), and lasers. Nowadays, white LEDs, undoubtedly, lead the mainstream lighting marketplace 5,6 . The current standard of white LEDs is dominated by the high-brightness InGaN blue LEDs integrated with wavelength-downconverting phosphors, which have been introduced the highest luminous efficacy of all white light source 7 . However, the recognized limitation in InGaN blue LEDs was not able to be overcome: A nonthermal drop in efficiency under increasing input energy density. The "efficiency drop" restricts operation only under relatively low input energy densities, which is a stark contrast with the motive for producing more photons per unit area of the LEDs chips (i.e., reducing the cost per lumen of the illuminations) 8 . Lasers, with higher efficiency and output than LEDs or thermal light sources, are potential and promising alternatives 9,10 . Multi-wavelength lasers spanning the full visible spectrum have been significantly addressed in the state-of-the-art optical technologies. Previous prototypes of simultaneous red, green, and blue (RGB) emissions include a flute-type hollow-cathode He-CD laser, an Ar-Kr mixed gas laser, a cascaded optical superlattice for wavelength conversion, a combination of inorganic semiconductor laser diodes and a second harmonic Nd3þ-doped yttrium aluminum garnet (Nd: YAG), a monolithic multisegment ZnCdSSe-based semiconductor nanosheet, a single-chip dye-doped polymer, and so on 11-16 . However, there remains several significant challenges that the integration, operation, and production of nonlinear optical processes of laser modules are somewhat bulky, costly, and intricate. Besides, the constructions of conventional lasers in a single chip or a film, in which intentional gratings, waveguides, and resonators need to be precisely designed and constructed, are arduous techniques. The last and the worst, directionality, a significant nature of lasers, sets a hurdle for lighting, imaging, and display uses. These shortcomings create and promote interests in developing a strong-luminous and high-efficiency light source with competitive cost, simple design, compact size, and low spatial coherent emission. A white random laser (White-RL) is a promising and feasible approach. Such unconventional laser lases when multiple light scattering in the disordered materials lets the gain surpass the loss 2,4 . Notably, random laser systems can generate spatially incoherent and laser-level radiation, in contrast to those existing illuminant modules (e.g., incandescent bulb, LEDs, superluminescent diodes, and broadband lasers). This angle-free emission is in principle ideal for not only general lighting (e.g., laser headlights) but also consumer products (e.g., spotlight, laser display, and digital laser projector) and even imaging applications (e.g., full-field microscopy and medical sensing). Additionally, based on the unique mechanism, random lasers hold limitless potential beyond the scope of conventional lasers, bringing new possibilities and innovative designs to advanced illuminants 3,17-20 . Since
doi:10.1038/s41598-018-21228-w pmid:29426912 pmcid:PMC5807428 fatcat:f5jixmewwjfctlgoci34mx4xsq

Immunotherapy with Immunomodulatory Agents Prolong Survival of Advanced Ovarian Cancer with Brain Metastatis

Hsiu Huei Peng, Kun Ju Lin, Cheng Tao Lin
2016 Gynecology & Obstetrics  
Acknowledgment • The study was supported by grants CRRPG3C0911, CRRPG3D0051-3, CMRPG3F0251 (Cheng-Tao Lin), which were provided by Chang Gung Memorial Hospital (Taoyuan, Taiwan). • This study was approved  ...  This result showed an increasing trend in host immunogenicity and efficient anticancer response after priming surgery and effector phase ( Figure Citation : Peng H, Lin K, Lin C (2016) Immunotherapy  ... 
doi:10.4172/2161-0932.1000411 fatcat:gtw4hxnf3ngvpa77xx7k3cjn7i

Animal Models for Studying Stone Disease

Szu-Ju Chen, Kun-Yuan Chiu, Huey-Yi Chen, Wei-Yong Lin, Yung-Hsiang Chen, Wen-Chi Chen
2020 Diagnostics  
Lin et al. used this model to study extracts of Flos carthami for stone prevention [11] .  ... 
doi:10.3390/diagnostics10070490 pmid:32708380 fatcat:srnbebnmzjgt3lh7spdvkrqssm

PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine

Shu-Yun Kuo, Chia-Lin Wu, Min-Yen Hsieh, Chen-Ta Lin, Rong-Kun Wen, Lien-Cheng Chen, Yu-Hui Chen, Yhu-Wei Yu, Horng-Dar Wang, Yi-Ju Su, Chun-Ju Lin, Cian-Yi Yang (+4 others)
2015 Nature Communications  
Male sexual desire typically declines with ageing. However, our understanding of the neurobiological basis for this phenomenon is limited by our knowledge of the brain circuitry and neuronal pathways controlling male sexual desire. A number of studies across species suggest that dopamine (DA) affects sexual desire. Here we use genetic tools and behavioural assays to identify a novel subset of DA neurons that regulate age-associated male courtship activity in Drosophila. We find that increasing
more » ... A levels in a subset of cells in the PPL2ab neuronal cluster is necessary and sufficient for increased sustained courtship in both young and aged male flies. Our results indicate that preventing the age-related decline in DA levels in PPL2ab neurons alleviates diminished courtship behaviours in male Drosophila. These results may provide the foundation for deciphering the circuitry involved in sexual motivation in the male Drosophila brain.
doi:10.1038/ncomms8490 pmid:26123524 pmcid:PMC4491191 fatcat:p6lp7ich2zhvdfvaijtej5kl6m

Buccal osseous choristoma in a 5-year-old boy

Yuk-Kwan Chen, Yee-Hsiung Shen, Yu-Ju Lin, Yu-Tien Li, Kun-Bo Tsai, Li-Min Lin
2005 Oral Oncology Extra  
· 1.2 Difficulty in opening and closing mouth Right Mintz et al. (1995) Female 16 White 1 2.5 · 2 · 2 Painless swelling Right Male 67 White 1 2.5 · 2 · 1.5 Painless swelling Right Lin  ... 
doi:10.1016/j.ooe.2005.05.006 fatcat:le2fexl53ncrrbqrytfn7v6c6m

The Feasibility of Differentiating Lewy Body Dementia and Alzheimer's Disease by Deep Learning Using ECD SPECT Images

Yu-Ching Ni, Fan-Pin Tseng, Ming-Chyi Pai, Ing-Tsung Hsiao, Kun-Ju Lin, Zhi-Kun Lin, Chia-Yu Lin, Pai-Yi Chiu, Guang-Uei Hung, Chiung-Chih Chang, Ya-Ting Chang, Keh-Shih Chuang (+1 others)
2021 Diagnostics  
The correct differential diagnosis of dementia has an important impact on patient treatment and follow-up care strategies. Tc-99m-ECD SPECT imaging, which is low cost and accessible in general clinics, is used to identify the two common types of dementia, Alzheimer's disease (AD) and Lewy body dementia (LBD). Two-stage transfer learning technology and reducing model complexity based on the ResNet-50 model were performed using the ImageNet data set and ADNI database. To improve training
more » ... the three-dimensional image was reorganized into three sets of two-dimensional images for data augmentation and ensemble learning, then the performance of various deep learning models for Tc-99m-ECD SPECT images to distinguish AD/normal cognition (NC), LBD/NC, and AD/LBD were investigated. In the AD/NC, LBD/NC, and AD/LBD tasks, the AUC values were around 0.94, 0.95, and 0.74, regardless of training models, with an accuracy of 90%, 87%, and 71%, and F1 scores of 89%, 86%, and 76% in the best cases. The use of transfer learning and a modified model resulted in better prediction results, increasing the accuracy by 32% for AD/NC. The proposed method is practical and could rapidly utilize a deep learning model to automatically extract image features based on a small number of SPECT brain perfusion images in general clinics to objectively distinguish AD and LBD.
doi:10.3390/diagnostics11112091 pmid:34829438 pmcid:PMC8624770 fatcat:els7uvmak5c2nbdun3zykl3fyi

Unit Commitment Accommodating Large Scale Green Power

Yuntao Ju, Jiankai Wang, Fuchao Ge, Yi Lin, Mingyu Dong, Dezhi Li, Kun Shi, Haibo Zhang
2019 Applied Sciences  
Mingyu Dong and Kun Shi also belong to China Electric Power Research Institute, Haidian District, Beijing 100192, China.  ...  Acknowledgments: Yuntao Ju and Dezhi Li also belong to Beijing Key Laboratory of Demand Side Multi-Energy Carriers Optimization and Interaction Technique, Beijing 100192, China.  ... 
doi:10.3390/app9081611 fatcat:rtujtb53azhfzeq7msmzccjxoy

Reappraisal of the Therapeutic Role of Celecoxib in Cholangiocarcinoma

Chun-Nan Yeh, Kun-Chun Chiang, Horng-Heng Juang, Jong-Hwei S. Pang, Chung-Shan Yu, Kun-Ju Lin, Ta-Sen Yeh, Yi-Yin Jan, Luis Eduardo M. Quintas
2013 PLoS ONE  
Cholangiocarcinoma (CCA), a lethal disease, affects many thousands worldwide yearly. Surgical resection provides the best chance for a cure; however, only one-third of CCA patients present with a resectable tumour at the time of diagnosis. Currently, no effective chemotherapy is available for advanced CCA. Cyclooxygenase-2 (COX-2) is a potential oncogene expressing in human CCA tissues and represents a candidate target for treatment; however, COX-2 inhibitors increase the risk of negative
more » ... vascular events as application for chemoprevention aim. Here, we re-evaluated the effectiveness and safety of celecoxib, one widely used COX-2 inhibitor, in treating CCA. We demonstrated that celecoxib exhibited an antiproliferative effect on CGCCA cells via cell cycle arrest at G2 phase and apoptosis induction. Treatment for 5 weeks high dose celecoxib (160 mg/kg) significantly repressed thioacetamide-induced CCA tumour growth in rats as monitored by animal positron emission tomography through apoptosis induction. No obviously observable side effects were noted during the therapeutic period. As retrospectively reviewing 78 intrahepatic mass-forming CCA patients, their survival was strongly and negatively associated with a positive resection margin and high COX-2 expression. Based on our result, we concluded that short-term high dose celecoxib may be a promising therapeutic regimen for CCA. Yet its clinical application still needs more studies to prove its safety.
doi:10.1371/journal.pone.0069928 pmid:23922859 pmcid:PMC3724720 fatcat:updovz2slzcp7cwsevixnxma7u

Comparison of Low Urinary Tract Symptoms during Pregnancy between Primiparous and Multiparous Women

Kun-Ling Lin, Ching-Ju Shen, Ming-Ping Wu, Cheng-Yu Long, Chin-Hu Wu, Chiu-Lin Wang
2014 BioMed Research International  
and Purpose.Low urinary tract symptoms (LUTS) are a common problem during pregnancy. This study aimed to compare changes in the prevalence of LUTS during pregnancy between primiparous and multiparous women.Methods. A chart review of consecutive pregnant women who attended our antenatal clinic from March 2002 to January 2006 was performed. All of the women were asked to respond to a LUTS questionnaire in either of the three trimesters.Results.Of the 270 women included, 164 were nullipara and 106
more » ... were multipara. The most common LUTS during pregnancy were frequency (77%), followed by nocturia (75.6%), stress urinary incontinence (SUI) (51.1%), incomplete emptying (43.7%), dysuria (17.8%), and urgency incontinence (10.4%). There was a significantly higher prevalence of SUI (P<0.001) and urgency incontinence (P=0.005) in the multiparous compared to the nulliparous women. Increasing prevalence rates of frequency, nocturia, SUI, and incomplete emptying were reported with gestational age in both the nulliparous and multiparous women.Conclusions. Frequency and nocturia were the two most common LUTS during pregnancy. The prevalence rates of all LUTS increased with increasing gestational age except for frequency in the nulliparous women during the second trimester. In addition, multipara was a predictor of SUI during pregnancy.
doi:10.1155/2014/303697 pmid:25431763 pmcid:PMC4241740 fatcat:su3p4etw6jdinaqkt6wgwsfuwe

Prediction of Cerebral Amyloid Pathology Based on Plasma Amyloid and Tau Related Markers

Ting-Bin Chen, Kun-Ju Lin, Szu-Ying Lin, Yi-Jung Lee, Yi-Cheng Lin, Chen-Yu Wang, Jun-Peng Chen, Pei-Ning Wang
2021 Frontiers in Neurology  
All the PET images were interpreted by an experienced nuclear medicine physician (Kun-Ju Lin) who did not have access to clinical data.  ... 
doi:10.3389/fneur.2021.619388 pmid:34671305 pmcid:PMC8520900 fatcat:pvzrpt6exbagvasz4wrz6mg74u

Brain Imaging of Vesicular Monoamine Transporter Type 2 in Healthy Aging Subjects by 18F-FP-(+)-DTBZ PET

Kun-Ju Lin, Yi-Hsin Weng, Chia-Ju Hsieh, Wey-Yil Lin, Shiaw-Pyng Wey, Mei-Ping Kung, Tzu-Chen Yen, Chin-Song Lu, Ing-Tsung Hsiao, Gayle E. Woloschak
2013 PLoS ONE  
18 F-FP-(+)-DTBZ is a novel PET radiotracer targeting vesicular monoamine transporter type 2 (VMAT2). The goal was to explore the image features in normal human brains with 18 F-FP-(+)-DTBZ as a reference of molecular landmark for clinical diagnosis in Parkinson's disease (PD) and related disorders. Materials and Methods: A total of 22 healthy subjects (59.366.0 years old) including 7 men and 15 women were recruited for MRI and 18 F-FP-(+)-DTBZ PET scans. A total number of 55 brain VOIs were
more » ... ected for quantitation analysis. The regional specific uptake ratio (SUR) was calculated with occipital as reference from MRI-based spatially normalized 18 F-FP-(+)-DTBZ images. Regional percentage SUR to that of anterior putamen was calculated. Average SUR images were displayed in 2D and 3D space to illustrate the image patterns. The correlation between age and regional VMAT2 uptake was also examined. Results: Visual assessment showed symmetric uptake of 18 F-FP-(+)-DTBZ and obviously highest in striatum, followed by nucleus accumbens, hypothalamus, substantia nigra, and raphe nuclei. Quantification analysis revealed striatal VMAT2 density of anterior putamen.posterior putamen.caudate nucleus. Other subcortical regions were with moderate VMAT2 distribution (6,51% SUR of anterior putamen), while slightly lower VMAT2 was observed in cerebellum (10.60% SUR) and much lower in neocortex (,5% SUR). No significant correlation of SUR to age was found in subcortical regions. Conclusion: Using 18 F-FP-(+)-DTBZ PET, we showed the 2D and 3D imaging features of the VMAT2 distribution in vivo in healthy aging brains. The in vivo imaging characteristics of VMAT2 is consistent with the expression of VMAT2 in a recent autopsy study. Therefore, 3D visualization and higher image quality of 18 F-FP-(+)-DTBZ PET imaging might potentially be a powerful biomarker in detecting VMAT2 distribution of subcortical regions, and for Parkinson's disease and related neuropsychiatric disorders involving related monoaminergic systems.
doi:10.1371/journal.pone.0075952 pmid:24098749 pmcid:PMC3786914 fatcat:sw2xm4blizge5deb3f4vk5dhlm

Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy

Po-Yen Lin, Ya-Ling Chiu, Jing-Huei Huang, Er-Yuan Chuang, Fwu-Long Mi, Kun-Ju Lin, Jyuhn-Huarng Juang, Hsing-Wen Sung, Kam W. Leong
2018 Advanced Science  
because of patient compliance and repeatable administration. To translate, nonviral delivery would be the way to go. However, despite glimpses of promise, [4, 5] success of nonviral oral gene delivery has been elusive. Oral delivery of gene vectors faces one of the most challenging hurdles because of the physiological (harsh gastric pH and many degrading enzymes) and anatomical (mucosal epithelium) barriers in the GI tract. Furthermore, the rapid self-renewal of the intestinal epithelial cells
more » ... 2-3 d) would prevent sustained therapeutic gene expression. [6] Therefore, to treat chronic diseases such as diabetes mellitus, nonviral vectors must be delivered across the mucosal epithelium, transported through the bloodstream, and then accumulated in the systemic tissues to have a chance of prolonging the typical transgene expression observed for several days. Chitosan (CS) is an attractive gene carrier because of its low toxicity to cells [7] and tunable physicochemical characteristics. Varying the molecular weight (M W ) and degree of deacetylation (DA) of CS can yield a polysaccharide with different biodegradability and charge density at physiological pH. Cationic at pH below 6, CS can readily complex plasmid DNA (pDNA), small interfering RNA (siRNA) or micro RNA (miRNA) to form nanoparticles (NPs; polyplex). However, the in vitro transfection efficiency of CS is mediocre compared with many other Efficient nonviral oral gene delivery offers an attractive modality for chronic protein replacement therapy. Herein, the oral delivery of insulin gene is reported by a nonviral vector comprising a copolymer with a high degree of substitution of branched polyethylenimine on chitosan (CS-g-bPEI). Protecting the plasmid from gastric acidic degradation and facilitating transport across the gut epithelium, the CS-g-bPEI/insulin plasmid DNA nanoparticles (NPs) can achieve systemic transgene expression for days. A single dose of orally administered NPs (600 µg plasmid insulin (pINS)) to diabetic mice can protect the animals from hyperglycemia for more than 10 d. Three repeated administrations spaced over a 10 d interval produce similar glucose-lowering results with no hepatotoxicity detected. Positron-emission-tomography and computedtomography images also confirm the glucose utilization by muscle cells. While this work suggests the feasibility of basal therapy for diabetes mellitus, its significance lies in the demonstration of a nonviral oral gene delivery system that can impact chronic protein replacement therapy and DNA vaccination.
doi:10.1002/advs.201701079 pmid:30128227 pmcid:PMC6096992 fatcat:ypinitwewrhdbmq2wucnkmqnsu

Classification differentiates clinical and neuroanatomic features of cerebral small vessel disease

Kun-Hsien Chou, Pei-Lin Lee, Li-Ning Peng, Wei-Ju Lee, Pei-Ning Wang, Liang-Kung Chen, Ching-Po Lin, Chih-Ping Chung
2021 Brain Communications  
Age-related cerebral small vessel disease involves heterogeneous pathogenesis, such as arteriosclerosis/lipohyalinosis and cerebral amyloid angiopathy. MRI can visualize the brain lesions attributable to small vessel disease pathologies, including white-matter hyperintensities, lacune and cerebral microbleeds. However, these MRI markers usually coexist in small vessel disease of different aetiologies. Currently, there is no available classification integrating these neuroimaging markers for
more » ... erentiating clinical and neuroanatomic features of small vessel disease yet. In this study, we tested whether our proposed stratification scheme could characterize specific clinical, neuroanatomic and potentially pathogenesis/aetiologies in classified small vessel disease subtypes. Cross-sectional analyses from a community-based non-demented non-stroke cohort consisting of ≥50 years old individuals were conducted. All participants were scanned 3T brain MRI for small vessel disease detection and neuroanatomic measurements and underwent physical and cognitive assessments. Study population were classified into robust and four small vessel disease groups based on imaging markers indicating (i) bleeding or non-bleeding; (ii) specific location of cerebral microbleeds; and (iii) the severity and combination of white-matter hyperintensities and lacune. We used whole-brain voxel-based morphometry analyses and tract-based spatial statistics to evaluate the regional grey-matter volume and white-matter microstructure integrity for comparisons among groups. Among the 735 participants with eligible brain MRI images, quality screening qualified 670 for grey-matter volume analyses and 617 for white-matter microstructural analyses. Common and distinct patterns of the clinical and neuroimaging manifestations were found in the stratified four small vessel disease subgroups. Hierarchical clustering analysis revealed that small vessel disease type 4 had features distinct from the small vessel disease types 1, 2 and 3. Abnormal white-matter microstructures and cognitive function but preserved physical function and grey-matter volume were found in small vessel disease type 4. Among small vessel disease types 1, 2 and 3, there were similar characteristics but different severity; the clinical features showed both physical frail and cognitive impairment and the neuroanatomic features revealed frontal–subcortical white-matter microstructures and remote, diffuse cortical abnormalities. This novel stratification scheme highlights the distinct clinical and neuroanatomic features of small vessel disease and the possible underlying pathogenesis. It could have potential application in research and clinical settings.
doi:10.1093/braincomms/fcab107 pmid:34131645 pmcid:PMC8196251 fatcat:ewihdeji2vaptidoc642sdihma
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