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Re-appraisal of Nertera (Rubiaceae) in Taiwan

Wei-Chih Chen, Chih-Chiang Wang, Kun-Cheng Chang
2021 PhytoKeys  
Nertera granadensis has often been referred to as N. depressa Banks & Sol. ex Gaertn, the type of the genus (Chen and Taylor 2011) .  ...  Fukuyama 19242 (TAI); Hsintien, 15 Dec 2000, Chen et al. 3771 (TAIF); Hsinchu: Mt. Tapachienshan, 6 Sept 1993, C. L. Huang 71 Figure 2 . 2 Figure 2.  ... 
doi:10.3897/phytokeys.182.70685 pmid:34629929 pmcid:PMC8476481 fatcat:kzzpkhteqbbx3i6zl2gqigf524

Arecoline Promotes Migration of A549 Lung Cancer Cells through Activating the EGFR/Src/FAK Pathway

Chih-Hsiang Chang, Mei-Chih Chen, Te-Huan Chiu, Yu-Hsuan Li, Wan-Chen Yu, Wan-Ling Liao, Muhammet Oner, Chang-Tze Yu, Chun-Chi Wu, Tsung-Ying Yang, Chieh-Lin Teng, Kun-Yuan Chiu (+6 others)
2019 Toxins  
Chen, Institute of Molecular Biology, National Chung Hsing University.  ...  Chen, Institute of Molecular Biology, National Chung Hsing University.  ... 
doi:10.3390/toxins11040185 pmid:30925742 pmcid:PMC6521018 fatcat:htjhha4uefhopjmi7ukykowcoe

Bioinspired assembly of functional block-copolymer nanotemplates

I.-Hong Lin, Chih-Chia Cheng, Wei-Tsung Chuang, Jem-Kun Chen, U.-Ser Jeng, Fu-Hsiang Ko, Chih-Wei Chu, Chih-Feng Huang, Feng-Chih Chang
2013 Soft Matter  
A new concept on bioinspired assembly of functional diblock copolymers, capable of forming different microstructures through nucleobase-induced supramolecular interactions, has been explored. In this paper, a new series of uracil-functionalized poly(3-caprolactone)-b-(4-vinylbenzyl uracil)s (PCL-b-PVBU) have been prepared which exhibit a high self-complementary ability in solution and solid states owing to the formation of uracil-uracil pairs by induced hierarchical self-assembly. The ordered
more » ... rphologies of PCL-b-PVBU diblock copolymers changed from a lamellar, hexagonally packed cylinder to a sphere with respect to the content of the hydrogen bond segment. Moreover, we further show that the PCL segment could be easily extracted by enzymatic degradation, leading to a cylinder porous structure of long-range order, which gives a facile method for the fabrication of uracil-functionalized nanotemplates. In addition, bio-complementary PCL-b-PVBU/9-hexadecyladenine (AC16) hierarchical supramolecular complexes formed through strong cooperative hydrogen bonding between the uracil group of PVBU and the adenine group of A-C16. When the mixing ratios of PCL-b-PVBU/AC16 differ from the stoichiometric ratio, these complexes self-assemble into well-ordered lamellar and hexagonal structures; the changing morphology at different AC16 loadings reveals that the molecular structures of the PCL-b-PVBU/AC16 complexes are readily tailored.
doi:10.1039/c3sm51870a pmid:26029768 fatcat:njszeitny5gnrfhn2v6k6fyxiy

Nucleobase-grafted polycaprolactones as reversible networks in a novel biocompatible material

I.-Hong Lin, Chih-Chia Cheng, Cheng-Wei Huang, Mei-Chih Liang, Jem-Kun Chen, Fu-Hsiang Ko, Chih-Wei Chu, Chih-Feng Huang, Feng-Chih Chang
2013 RSC Advances  
A series of nucleobase-grafted polycaprolactones have been prepared which exhibits a high complementary ability in solution and solid states owing to the formation of uracil-adenine pairs by induced hierarchical self-assembly. In addition, they can selforganize into spherical structure and result in excellent biomaterial properties.
doi:10.1039/c3ra41412d fatcat:76kiifrbynf3nbdf4ax67eb2e4

Biomechanical evaluation of patellar tendon repair using Krackow suture technique

Chen-Yo Yen, Yi-Jung Tsai, Chih-Kun Hsiao, Feng-Chen Kao, Yuan-Kun Tu
2019 BioMedical Engineering OnLine  
The authors thank Yi-Ching Chen and Wen-Ting Lin for their help in data collection.  ... 
doi:10.1186/s12938-019-0680-z fatcat:xlf4luuypjhnzll235h36ezvoe

Effects of Kinesio taping on forearm supination/pronation performance fatigability

Chih-Kun Hsiao, Yi-Jung Tsai, Chih-Wei Lu, Jen-Chou Hsiung, Hao-Yuan Hsiao, Yung-Chuan Chen, Yuan-Kun Tu
2022 BMC Musculoskeletal Disorders  
Background Repetitive exertion in supination/pronation could increase the risk of forearm diseases due to fatigue. Kinesio taping (KT) is a physical therapy technique that decreases muscle tone and musculoskeletal disorders (MSDs) risk. Many assumptions about taping have been made and several studies have considered the taping applications; however, the effect of KT on strength and fatigue of the forearm supination/pronation remains unclear. The purpose of this study was to evaluate the effect
more » ... f KT on forearm performance fatigability. Methods A screwing test was constructed to measure the forearm force loss and screwing efficiency during repetitive supination/pronation. Data from 18 healthy adults who underwent both KT and no taping (NT) sessions were used to investigate the forearm strength change in terms of grip force (GF), driving torque (DT), and push force (PF). The maximal isometric forces before and after the screwing test and force decreasing rate (efficiency) during screwing were evaluated to assess the performance fatigability in KT and NT conditions. Results A statistically significant force loss (FL) in maximal isometric GF (p = 0.039) and maximal isometric DT (p = 0.044); however, no significant difference was observed in maximal isometric PF (p = 0.426) between NT and KT. KT provides greater screwing efficiency than NT. Conclusions KT could not improve FL in the maximal muscle strength of the forearm in healthy subjects. KT on the forearm was associated with a lesser decline in DT efficiency than NT, implying that KT could decrease the loss rate of muscle strength and delay the development of fatigue; however, the KT did not yield improvements in PF while performing screwing tasks.
doi:10.1186/s12891-022-05068-4 pmid:35139848 pmcid:PMC8826704 fatcat:ss42n4zygzd7vkf3shaqw557we

Influence of Heat Sink on the Mold Temperature of Gypsum Mold Used in Injection Molding

Chung-Chih Lin, Kun-Chen Chen, Hon-Chih Yeh
2020 Polymers  
Chih-Chun Cheng at National Chun-Cheng University for his encouragement to our team. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/polym12030701 pmid:32245279 pmcid:PMC7183277 fatcat:q3k5bgzxlnbkpc6nouwrbvvfw4

Nucleobase-grafted supramolecular polymers for tuning the surface properties

I.-Hong Lin, Chih-Chia Cheng, Ke-Fong Li, Jem-Kun Chen, Chih-Wei Chiu, Feng-Chih Chang
2014 Polymer Chemistry  
Nucleobase-grafted polycaprolactone has been prepared which exhibits amorphous nature, rapid photoresponse and controlled surface properties in the solid state owing to the formation of uracil-diamidopyridine (U-DAP) pairs by induced physical cross-linking. In addition, they can self-organize to alter material behavior with light, switching both optical and thermal properties. Remarkable changes in the surface morphology and the contact angle with water were also observed.
doi:10.1039/c3py01176c fatcat:sai5y4ndnbajhnccjyb7ebftfm

Low cholesterol level associated with severity and outcome of spontaneous intracerebral hemorrhage: Results from Taiwan Stroke Registry

Yu-Wei Chen, Chen-Hua Li, Chih-Dong Yang, Chung-Hsiang Liu, Chih-Hung Chen, Jau-Jiuan Sheu, Shinn-Kuang Lin, An-Chih Chen, Ping-Kun Chen, Po-Lin Chen, Chung-Hsin Yeh, Jiunn-Rong Chen (+12 others)
2017 PLoS ONE  
The relationship between cholesterol level and hemorrhagic stroke is inconclusive. We hypothesized that low cholesterol levels may have association with intracerebral hemorrhage (ICH) severity at admission and 3-month outcomes. This study used data obtained from a multi-center stroke registry program in Taiwan. We categorized acute spontaneous ICH patients, based on their baseline levels of total cholesterol (TC) measured at admission, into 3 groups with <160, 160-200 and >200 mg/dL of TC. We
more » ... aluated risk of having initial stroke severity, with National Institutes of Health Stroke Scale (NIHSS) >15 and unfavorable outcomes (modified Rankin Scale [mRS] score >2, 3-month mortality) after ICH by the TC group. A total of 2444 ICH patients (mean age 62.5±14.2 years; 64.2% men) were included in this study and 854 (34.9%) of them had baseline TC <160 mg/dL. Patients with TC <160
doi:10.1371/journal.pone.0171379 pmid:28422955 pmcid:PMC5396870 fatcat:ycyy3rwjvvfzlksdzix55sbjq4

Low-surface-free-energy polybenzoxazine/polyacrylonitrile fibers for biononfouling membrane

Tzu-Hao Kao, Jem-Kun Chen, Chih-Chia Cheng, Ching-Iuan Su, Feng-Chih Chang
2013 Polymer  
We blended poly(3-phenyl-3,4-dihydro-2H-1,3-benzoxazine) (PBA) into polyacrylonitrile (PAN) to generate low-surface-free-energy fibers without fluorine and silicon elements for electrospinning. Liquid-state BA at room temperature can be solidified in electrospinning process using PAN as a medium through their miscible behavior. Results indicate that the mixing below 50 wt% BA into PAN matrix for electrospinning has no significant dropping beads, indicated a miscible PAN/BA system. Above 70 wt%
more » ... A in PAN solution could not be solidified completely after electrospinning, revealed apparent beaded fibers. The PAN/PBA blend fibers, obtained after curing at 300 C, generated a superhydrophobicity because of the low-surface-free-energy PBA. In addition, laser scanning confocal microscope (LSCM) measurements were included to determine the relative amount of antibody that adsorbed to these PAN/PBA fibers to examine the biofouling-resistant property. The results showed an obviously decreased protein adsorption with increasing PBA fraction. The correlations between PAN and PBA would provide insight into the designing and developing of low-surface-free-energy fibers without fluorine and silicon elements to improve biofouling-resistant property.
doi:10.1016/j.polymer.2012.11.020 fatcat:4bojqejotrelbgiw4tgm75p76u

Efficiency of a Marine Towed Electrical Resistivity Method

Chih-Wen Chiang, Tada-nori Goto, Chien-Chih Chen, Shu-Kun Hsu
2011 Terrestrial, Atmospheric and Oceanic Sciences  
In contrast to marine sediments, because of large electrical resistivity anomalies found in sulfide deposits and methane hydrates, resistivity measurements such as marine towed electrical resistivity (MTER) might be a feasible method for discovering those natural minerals. To determine the feasibility of the MTER method we examined arrays consisting of a pole electrical dipole (PED), vertical electrical dipole (VED) and horizontal electrical dipole (HED). The VED array showed a maximum
more » ... e in electric fields of 36% and 105% in the resistive and conductive models, respectively, while the PED and HED arrays yielded worse results of around 13% to 19%, respectively. The VED array showed a higher difference in electric fields than both the HED and PED arrays in the two models. Therefore, we suggest that a VED array with a large electrical current would be most conducive leading to the discovery of such minerals during MTER surveys.
doi:10.3319/tao.2011.02.16.01(t) fatcat:3desk5sovva2pkdgx233uhobxq

Amniotic Fluid Stem Cells from EGFP Transgenic Mice Attenuate Hyperoxia-Induced Acute Lung Injury

Shih-Tao Wen, Wei Chen, Hsiao-Ling Chen, Cheng-Wei Lai, Chih-Ching Yen, Kun-Hsiung Lee, Shinn-Chih Wu, Chuan-Mu Chen, Andreas Zirlik
2013 PLoS ONE  
High concentrations of oxygen aggravate the severity of lung injury in patients requiring mechanical ventilation. Although mesenchymal stem cells have been shown to effectively attenuate various injured tissues, there is limited information regarding a role for amniotic fluid stem cells (AFSCs) in treating acute lung injury. We hypothesized that intravenous delivery of AFSCs would attenuate lung injury in an experimental model of hyperoxia-induced lung injury. AFSCs were isolated from EGFP
more » ... genic mice. The in vitro differentiation, surface markers, and migration of the AFSCs were assessed by specific staining, flow cytometry, and a co-culture system, respectively. The in vivo therapeutic potential of AFSCs was evaluated in a model of acute hyperoxia-induced lung injury in mice. The administration of AFSCs significantly reduced the hyperoxia-induced pulmonary inflammation, as reflected by significant reductions in lung wet/dry ratio, neutrophil counts, and the level of apoptosis, as well as reducing the levels of inflammatory cytokine (IL-1β, IL-6, and TNF-α) and early-stage fibrosis in lung tissues. Moreover, EGFPexpressing AFSCs were detected and engrafted into a peripheral lung epithelial cell lineage by fluorescence microscopy and DAPI stain. Intravenous administration of AFSCs may offer a new therapeutic strategy for acute lung injury (ALI), for which efficient treatments are currently unavailable.
doi:10.1371/journal.pone.0075383 pmid:24040409 pmcid:PMC3770548 fatcat:2vk3q5ylubgtvkpb5dndw7d6lm

Bioinspired supramolecular fibers for mercury ion adsorption

Yeh-Sheng Wang, Chih-Chia Cheng, Jem-Kun Chen, Fu-Hsiang Ko, Feng-Chih Chang
2013 Journal of Materials Chemistry A  
A novel photo-cross-linkable nanofiber based on a uracil-functionalized polymer, poly[1-(4-vinylbenzyl uracil)] (PVBU), was prepared using the electrospinning technique. This PVBU nanofiber can be converted into a covalent network nanofiber through exposure to UV light at a wavelength of 254 nm. This PVBU nanofiber is able to distinguish and selectively remove mercury ions (Hg 2+ ) from other metal ions in aqueous solution. The maximum Hg 2+ adsorption capacity of the PVBU nanofiber is 543.9 mg
more » ... g À1 , which is significantly higher than that of cyclic imide derivatives. The improved adsorption of Hg 2+ allows a detection limit of less than 1 ppm, which has rarely been achieved for Hg 2+ sensing. Furthermore, the PVBU fiber can be reused for 10 consecutive cycles using 1.0 M HCl treatment. This new material has significant potential for the simultaneous detection and separation of Hg 2+ in environmental and industrial fields.
doi:10.1039/c3ta11072a fatcat:fgzpnt4w7rbzpar2f7nd6h5tsq

Expression and Characterization of Rice-produced Recombinant Porcine Lactoferrin and its Antioxidant Activities

Kuan-Chih Lee, Kun-Ting Hsieh, Ray-Bin Chen, Wei-Chih Lin, Chang-Sheng Wang, Tzu-Tai Lee, Liang-Jwu Chen
2020 Open Biotechnology Journal  
Lactoferrin (LF) exhibits multiple beneficial biological activities and thus has been used as a health food and additive. To broaden its application in the food industry, the porcine LF (pLF) gene has been engineered into rice to produce recombinant LF (rpLF) for use as a food additive. The iron-binding and antimicrobial activities of rpLF and its positive effects on early weaned piglets have been previously evaluated, yet several features, such as the signal peptide removal, glycosylation
more » ... and antioxidant activity of rpLF, have not been fully characterized. Objective: In this work, the rice-produced rpLF was purified and its biochemical structure and antioxidant activities characterized. Methods: HPLC, Western blot, PAS/VVL/PNA staining, Edman degradation assay, MALDI-TOF, LC-MS/MS and antioxidant activity assays were performed. Results: The results showed that this purified rpLF is a mature form of LF; its signal peptide was correctly removed, and two N-glycosylation sites located at N365 and N472 were identified. The molecular mass heterogeneity of rpLF could be eliminated by treatment with PNGase glycosidase, suggesting that different degrees of N-glycosylation occur in rpLF. A series of assays including the iron chelating activity, reducing power assay, lipid peroxidase activity and radical-scavenging activity showed that the antioxidant activity of rice-produced rpLF was equivalent to that of bovine LF. Conclusion: Rice-produced rpLF was correctly processed post-translationally and displayed antioxidant activity equivalent to that of bovine LF; thus, rice-produced rpLF can be recognized as a plant-based antioxidant to be used as a functional additive in animal feed and for the food industry.
doi:10.2174/1874070702014010094 fatcat:xortnfuqnbdbxd3rribj4gxlre

Synthesis of Poly(ε-caprolactone)-Based Miktoarm Star Copolymers through ROP, SA ATRC, and ATRP

Venkatesan Sathesh, Jem-Kun Chen, Chi-Jung Chang, Junko Aimi, Zong-Cheng Chen, Yu-Chih Hsu, Yi-Shen Huang, Chih-Feng Huang
2018 Polymers  
The synthesis of novel branched/star copolymers which possess unique physical properties is highly desirable. Herein, a novel strategy was demonstrated to synthesize poly(ε-caprolactone) (PCL) based miktoarm star (μ-star) copolymers by combining ring-opening polymerization (ROP), styrenics-assisted atom transfer radical coupling (SA ATRC), and atom transfer radical polymerization (ATRP). From the analyses of gel permeation chromatography (GPC), proton nuclear magnetic resonance (1H NMR), and
more » ... rix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), well-defined PCL-μ-PSt (PSt: polystyrene), and PCL-μ-PtBA (PtBA: poly(tert-butyl acrylate) μ-star copolymers were successfully obtained. By using atomic force microscopy (AFM), interestingly, our preliminary examinations of the μ-star copolymers showed a spherical structure with diameters of ca. 250 and 45 nm, respectively. We successfully employed combinations of synthetic techniques including ROP, SA ATRC, and ATRP with high effectiveness to synthesize PCL-based μ-star copolymers.
doi:10.3390/polym10080858 pmid:30960783 pmcid:PMC6403792 fatcat:nxjo5dwuj5bfrbixkuku7bnniq
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