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AGH Drilling Oil Gas
AGH Drilling Oil Gas
Acknowledgments This work was supported by the European Community from the European Social Fund (Paweł Lachor UDA-POKL.04. 01.01-00-106/09-00) and by The Foundation for Polish Science (Krzysztof Puszyński ...doi:10.5114/bta.2011.46543 fatcat:ivu3h5hzrfc2vplccbgovkzate
AGH Drilling Oil Gas
AGH Drilling Oil Gas
Increasing numbers of large scale single cell RNA-Seq projects are leading to a data explosion, which can only be fully exploited through data integration. Therefore, efficient computational tools for combining diverse datasets are crucial for biology in the single cell genomics era. A number of methods have been developed to assist data integration by removing technical batch effects, but most are computationally intensive. To overcome the challenge of enormous datasets, we have developeddoi:10.1101/397042 fatcat:dlvhqfceyrawpfnn5tbymk6f6m
more »... , an extremely fast graph-based data integration method. We illustrate the power of BBKNN for dimensionality-reduced visualisation and clustering in multiple biological scenarios, including a massive integrative study over several murine atlases. BBKNN successfully connects cell populations across experimentally heterogeneous mouse scRNA-Seq datasets, which reveals global markers of cell type and organ-specificity and provides the foundation for inferring the underlying transcription factor network. BBKNN is available at https://github.com/Teichlab/bbknn.
AbstractMultimodal data is rapidly growing in many fields of science and engineering, including single-cell biology. We introduce MultiMAP, an approach for the dimensionality reduction and integration of multiple datasets. MultiMAP recovers a single manifold on which all of the data resides and then projects the data into a single low-dimensional space so as to preserve the structure of the manifold. MultiMAP is based on a framework of Riemannian geometry and algebraic topology, and generalizesdoi:10.1101/2021.02.16.431421 fatcat:y2juiqzp7nfwzjguetpghbysyi
more »... the popular UMAP algorithm to the multimodal setting. MultiMAP can be used for visualization of multimodal data, and as an integration approach that enables joint analyses. MultiMAP has several advantages over existing integration strategies for single-cell data, including that MultiMAP can integrate any number of datasets, leverages features that are not present in all datasets (i.e. datasets can be of different dimensionalities), is not restricted to a linear mapping, can control the influence of each dataset on the embedding, and is extremely scalable to large datasets. We apply MultiMAP to the integration of a variety of single-cell transcriptomics, chromatin accessibility, methylation, and spatial data, and show that it outperforms current approaches in preservation of high-dimensional structure, alignment of datasets, visual separation of clusters, transfer learning, and runtime. On a newly generated single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) and single-cell RNA-seq (scRNA-seq) dataset of the human thymus, we use MultiMAP to integrate cells along a temporal trajectory. This enables the quantitative comparison of transcription factor expression and binding site accessibility over the course of T cell differentiation, revealing patterns of transcription factor kinetics.
Polański et al. ... 0.2 0.3 0.4 0.5 0.6 0.7 Standard Error g = 1.52 (0.67, 2.36) p = 0.000 Global quality of life Sensitivity analysis LL g UL Turcott JG et al. (2018) Arrieta O. et al. (2018) Polanski ...doi:10.3390/nu13103332 pmid:34684333 pmcid:PMC8539241 fatcat:22kefvpv4vg4fnxofuexjq4oee
AbstractMultimodal data is rapidly growing in many fields of science and engineering, including single-cell biology. We introduce MultiMAP, a novel algorithm for dimensionality reduction and integration. MultiMAP can integrate any number of datasets, leverages features not present in all datasets, is not restricted to a linear mapping, allows the user to specify the influence of each dataset, and is extremely scalable to large datasets. We apply MultiMAP to single-cell transcriptomics,doi:10.1186/s13059-021-02565-y pmid:34930412 pmcid:PMC8686224 fatcat:oq2cjzxwjzbddf2s4lxwxzlps4
more »... accessibility, methylation, and spatial data and show that it outperforms current approaches. On a new thymus dataset, we use MultiMAP to integrate cells along a temporal trajectory. This enables quantitative comparison of transcription factor expression and binding site accessibility over the course of T cell differentiation, revealing patterns of expression versus binding site opening kinetics.
Marek Polański: XRD analysis, Investigation. Bogusław Budner: Raman spectroscopy analysis, Investigation. Table 1 1 Physicochemical properties of the studied (chloro)phenols. ...doi:10.1016/j.jece.2021.105568 fatcat:jloxjqmq5vfnbkt6twk53nxer4
and purpose: There has been growing interest in the sex-related differences in the impact of cardiovascular (CV) risk factors on carotid intima-media thickness (CIMT). Therefore, we aimed at examining the influence of CV risk factors on CIMT in men and women and identifying differences between males and females in the risk profiles affecting CIMT. Patients and methods: The study group consisted of 256 patients (mean age 54.7 years), including 134 females (52%), with the following CV riskdoi:10.2147/cia.s103521 pmid:27307718 pmcid:PMC4887056 fatcat:hdyoqvlhqve5jjyj2wz7stdcdi
more »... : arterial hypertension, type 2 diabetes mellitus, dyslipidemia, nicotine addiction, overweight, and obesity. Subjects with the history of any overt CV disease were excluded. CIMT was measured through B-mode ultrasound examination of the right common carotid artery. In the analysis of CIMT values at different ages, the patients were divided into three age groups: 1) 45 years, 2) 45-60 years, and 3) 60 years. Regression analysis was used to examine the influence of CV risk factors on CIMT in men and women. Results: CIMT increased with age in both men and women. Women had lower values of CIMT than men (0.54 mm vs 0.60 mm, P=0.011). The analysis in three age subgroups revealed that CIMT values were comparable in men and women in group 1 (0.48 mm vs 0.48 mm, P=0.861), but over the age of 45 years, CIMT values became significantly lower in women compared to men (group 2: 0.51 mm vs 0.63 mm, P=0.005; group 3: 0.63 mm vs 0.72 mm, P=0.020). Significant differences were observed between the sexes in terms of risk factor impact on CIMT. In men, only three factors significantly affected CIMT: age (b=+0.009, P0.0001), hypertension (b=+0.067, P0.05), and type 2 diabetes (b=+0.073, P0.05). In women, apart from age (b=+0.008, P0.0001) and type 2 diabetes (b=+0.111, P0.01), significant factors were pulse pressure (PP; b=+0.005, P0.0001), body mass index (b=+0.007, P0.05), increased waist circumference (b=+0.092, P0.01), and metabolic syndrome (b=+0.071, P0.05). In the multiple regression analysis, independent CIMT determinants for the entire group were age (β=0.497, P0.001) and body mass index (β=0.195, P=0.006). For males, age was the only independent determinant of CIMT (β=0.669, P0.001). For females, these were PP (β=0.317, P=0.014), age (β=0.242, P=0.03), and increased waist circumference (β=0.207, P=0.048). Conclusion: CIMT values are lower in women than in men, which is most pronounced over the age of 45 years. There are sex-related differences in the profile of CV risk factors affecting CIMT: in males, CIMT is mostly determined by age, while in females, by age, PP, and increased waist circumference. Background Recently, there has been a growing interest in the impact of sex differences on the structure and function of vascular tree. Some data indicate that age-related changes in the cardiovascular system occur differently in males and females.
As shown in clinical studies, combinations of first generation normothymics (carbamazepine CBZ) with atypical neuroleptics (olanzapine OLA) lead to improvements in approximately half of patients treated for relapses of bipolar affective disease. Our previous studies have shown OLA to have an antidepressant effect when administered at a dose of 0.5 mg/kg only upon single administration; the effect did not last throughout chronic administration, whereas CBZ administered at a dose of 30 mg/kgdoi:10.1016/s1734-1140(11)70503-5 pmid:21602592 fatcat:dfdt7r6csvdffjpcrxrhxtqrmi
more »... d an antidepressant effect only after 7 days of administration. As shown in our previous studies, both OLA and CBZ improve memory in rats but only after chronic administration. The improved antidepressant effect of many drugs, including OLA and CBZ used in combined therapy as observed in our clinic as well as confirmed evidence of OLAs and CBZs positive effects on cognitive functions in humans and animals substantiated commencement of research on defining the effect of combined administration of OLAand CBZ on sedation (tested in a locomotor activity test), antidepressant effect (Porsolt test) and spatial memory (Morris test) in animals. The tests were performed on male Wistar rats. It was found that in combined administration of CBZ and OLA for 7 and 14 days, OLA would completely prevent the CBZs sedative effect. With combined administration of CBZ and OLA, both as a single dose and after prolonged treatment for 7 days, a significant reduction in immobility time was observed. Combined administration of CBZ and OLA did not improve memory in rats that received these drugs in a single dose, whereas statistically significant differences were observed in the chronic experiments. It can be assumed that the observed effects of combined administration of CBZ and OLA may be due to the pharmacokinetic interactions, but further studies are necessary to confirm these assumptions.
AGH Drilling Oil Gas
The article presents the results of a numerical simulation of the deformation-stress state in the rock mass around a salt cavern which is a part of a CAES installation (Compressed Air Energy Storage). The model is based on the parameters of the Huntorf power plant installation. The influence of temperature and salt-creep speed on the stability of the storage cavern was determined on the basis of the three different stress criteria and the effort of the rock mass in three points of the cavern atdoi:10.3390/en14196197 fatcat:gvxaolsturd2xc4yajbk4eedsy
more »... different time intervals. The analysis includes two creep speeds, which represent two different types of salt. The solutions showed that the influence of temperature on the deformation-stress state around the CAES cavern is of importance when considering the stress state at a distance of less than 60 m from the cavern axis (at cavern diameter 30–35 m). With an increase in cavern diameter, it is possible that the impact range will be proportionately larger, but each case requires individual modeling that includes the shape of the cavern and the cavern working cycle.
This work investigates the effect of layer thickness on the microstructure and mechanical properties of M300 maraging steel produced by Laser Engineered Net Shaping (LENS®) technique. The microstructure was characterized using light microscopy (LM) and scanning electron microscopy (SEM). The mechanical properties were characterized by tensile tests and microhardness measurements. The porosity and mechanical properties were found to be highly dependent on the layer thickness. Increasing thedoi:10.3390/ma15020603 pmid:35057320 pmcid:PMC8780661 fatcat:szr42io3dbbgtkeudhpfibci4m
more »... thickness increased the porosity of the manufactured parts while degrading their mechanical properties. Moreover, etched samples revealed a fine cellular dendritic microstructure; decreasing the layer thickness caused the microstructure to become fine-grained. Tests showed that for samples manufactured with the chosen laser power, a layer thickness of more than 0.75 mm is too high to maintain the structural integrity of the deposited material.
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