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Delayed diagnosis of adult indolent systemic mastocytosis

Carsten Sauer Mikkelsen, Andrew Nybo, Kristian Bakke Arvesen, Johan Holk-Poulsen
2014 Dermatology Reports  
Systemic mastocytosis (SM) is a rare, heterogeneous disorder characterized by infiltration and accumulation of mast cells within multiple organs, most commonly the skin. Given the rarity of the disease and the fact that many of its symptoms are shared by more common disorders, a diagnosis may be delayed or hindered. These patients have an elevated risk of developing potentially life-threatening anaphylactoid reactions, thus underscoring the importance of keeping SM in mind as a differential
more » ... nosis when a patient presents with chronic, itchy skin lesions and a history of multiple allergic reactions to bites, drugs, and anesthesia. We present a case illustrating that features of SM common to many disorders may hinder or delay its diagnosis.
doi:10.4081/dr.2014.5199 pmid:25386326 pmcid:PMC4224005 fatcat:3dlp22j35vcyxcvcie7wiettuu

Graph visualization with latent variable models

Juuso Parkkinen, Kristian Nybo, Jaakko Peltonen, Samuel Kaski
2010 Proceedings of the Eighth Workshop on Mining and Learning with Graphs - MLG '10  
Graphs are central representations of information in many domains including biological and social networks. Graph visualization is needed for discovering underlying structures or patterns within the data, for example communities in a social network, or interaction patterns between protein complexes. Existing graph visualization methods, however, often fail to visualize such structures, because they focus on local details rather than global structural properties of graphs. We suggest a novel
more » ... ling-driven approach to graph visualization: As usually in modeling, choose the (generative) model such that it captures what is important in the data. Then visualize similarity of the graph nodes with a suitable multidimensional scaling method, with similarity given by the model; we use a multidimensional scaling method optimized for a rigorous visual information retrieval task. We show experimentally that the resulting method outperforms existing graph visualization methods in finding and visualizing global structures in graphs.
doi:10.1145/1830252.1830265 dblp:conf/mlg/ParkkinenNPK10 fatcat:xb6jiqjcobfchfymuworsh6hc4

Transitioning remote Arctic settlements to renewable energy systems – A modelling study of Longyearbyen, Svalbard

Hans-Kristian Ringkjøb, Peter M. Haugan, Astrid Nybø
2020 Applied Energy  
We present a new stochastic long-term energy model for a remote Arctic settlement. • We show the importance of a proper representation of solar and wind variability. • An energy system based on renewables is found feasible, reliable and affordable. • Energy efficiency plays an important role in a transition to a low carbon settlement. • Allowing some CO 2 emissions reduces costs and improves energy security.
doi:10.1016/j.apenergy.2019.114079 fatcat:ethar6hoifegrekjdht6vovkym

Urinary metabolite profiling identifies biomarkers for risk of progression of diabetic nephropathy in 2,670 individuals with type 1 diabetes [article]

Stefan Mutter, Erkka Valo, Viljami Aittomäki, Kristian Nybo, Lassi Raivonen, Lena M Thorn, Carol Forsblom, Niina Sandholm, Peter Würtz, Per-Henrik Groop
2020 medRxiv   pre-print
Aims: This study examines associations between 51 urinary metabolites and risk of progression of diabetic nephropathy in individuals with type 1 diabetes by employing an automated nuclear magnetic resonance (NMR) metabolomics technique suitable for large-scale urine sample collections. Methods: For 2,670 individuals with type 1 diabetes from the FinnDiane Study, we collected 24-hour urine samples and measured metabolite concentrations by NMR. Individuals were followed for 9.0 +- 5.0 years until
more » ... their first sign of progression of diabetic nephropathy, end-stage kidney disease or study end. Cox regression analyses were performed on the entire study population (overall progression), on 1,999 individuals with normoalbuminuria and 347 individuals with macroalbuminuria at baseline. Results: Seven urinary metabolites were associated with overall progression after adjustment for baseline albuminuria and chronic kidney disease stage (p < 8 * 10^-4): Leucine (hazard ratio 1.47, 95% confidence interval [1.30, 1.66] per 1-SD creatinine-scaled metabolite concentration), valine (1.38 [1.22, 1.56]), isoleucine (1.33 [1.18, 1.50]), pseudouridine (1.25 [1.11, 1.42]), threonine (1.27 [1.11, 1.46]) and citrate (0.84 [0.75, 0.93]). 2-hydroxyisobutyrate was associated with overall (1.30 [1.16, 1.45]) and also progression from normoalbuminuria (1.56 [1.25, 1.95]). Six amino acids and pyroglutamate were associated with progression from macroalbuminuria. Conclusions: Branched-amino acids and other urinary metabolites were associated with the progression of diabetic nephropathy on top of baseline albuminuria and chronic kidney disease. We found differences in associations for overall progression and progression from normo- and macroalbuminuria. These novel biomarker discoveries illustrate the utility of analysing urinary metabolites in entire population cohorts.
doi:10.1101/2020.10.21.20215921 fatcat:emz3f4nfarfn5aqqavoxp6w3ji

Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population

Kristian Hillert Winther, Steen Joop Bonnema, Frederik Cold, Birgit Debrabant, Mads Nybo, Søren Cold, Laszlo Hegedüs
2015 European Journal of Endocrinology  
Author contribution statement S Cold designed the research; K H Winther, F Cold, and S Cold conducted the research; K H Winther, S J Bonnema, M Nybo, and L Hegedü s analyzed the data; B Debrabant performed  ... 
doi:10.1530/eje-15-0069 pmid:25740851 fatcat:pm6sijfsajgh5fy5ihbyqaz3wq

Changes in metabolism but not myocellular signaling by training with CHO-restriction in endurance athletes

Kasper D. Gejl, Kristian Vissing, Mette Hansen, Line Thams, Torben Rokkedal-Lausch, Peter Plomgaard, Anne-Kristine Meinild Lundby, Lars Nybo, Kurt Jensen, Hans-Christer Holmberg, Niels Ørtenblad
2018 Physiological Reports  
Carbohydrate (CHO) restricted training has been shown to increase the acute training response, whereas less is known about the acute effects after repeated CHO restricted training. On two occasions, the acute responses to CHO restriction were examined in endurance athletes. Study 1 examined cellular signaling and metabolic responses after seven training-days including CHO manipulation (n = 16). The protocol consisted of 1 h high-intensity cycling, followed by 7 h recovery, and 2 h of
more » ... tensity exercise (120SS). Athletes were randomly assigned to low (LCHO: 80 g) or high (HCHO: 415 g) CHO during recovery and the 120SS. Study 2 examined unaccustomed exposure to the same training protocol (n = 12). In Study 1, muscle biopsies were obtained at rest and 1 h after 120SS, and blood samples drawn during the 120SS. In Study 2, substrate oxidation and plasma glucagon were determined. In Study 1, plasma insulin and proinsulin C-peptide were higher during the 120SS in HCHO compared to LCHO (insulin: 0 min: +37%; 60 min: +135%; 120 min: +357%, P = 0.05; proinsulin C-peptide: 0 min: +32%; 60 min: +52%; 120 min: +79%, P = 0.02), whereas plasma cholesterol was higher in LCHO (+15-17%, P = 0.03). Myocellular signaling did not differ between groups. p-AMPK and p-ACC were increased after 120SS (+35%, P = 0.03; +59%, P = 0.0004, respectively), with no alterations in p-p38, p-53, or p-CREB. In Study 2, glucagon and fat oxidation were higher in LCHO compared to HCHO during the 120SS (+26-40%, P = 0.03; +44-76%, P = 0.01 respectively). In conclusion, the clear respiratory and hematological effects of CHO restricted training were not translated into superior myocellular signaling after accustomization to CHO restriction.
doi:10.14814/phy2.13847 pmid:30175557 pmcid:PMC6119686 fatcat:74gtz3zgezdpjeom72b2ilndtq

No Superior Adaptations to Carbohydrate Periodization in Elite Endurance Athletes

2017 Medicine & Science in Sports & Exercise  
Purpose: The present study investigated the effects of periodic CHO restriction on endurance performance and metabolic markers in elite endurance athletes. Methods: Twenty-six male elite endurance athletes (VO 2max : 65.0 ml O 2 •kg -1 •min -1 ) completed 4 weeks of regular endurance training, while matched and randomized into two groups training with (Low) or without (High) carbohydrate (CHO) manipulation three days a week. The CHO manipulation days consisted of a 1-hr high intensity bike
more » ... on in the morning, recovery for 7 hrs while consuming isocaloric diets containing either high CHO (414±2.4 g) or low CHO (79.5±1.0 g), and a 2-hr moderate bike session in the afternoon with or without CHO. VO 2max , maximal fat oxidation and power output during a 30-min time trial (TT) were determined before and after the training period. The TT was undertaken after 90 mins of intermittent exercise with CHO provision before the training period and both CHO and placebo after the training period. Muscle biopsies were analyzed for glycogen, citrate synthase (CS) and β-hydroxyacyl-coenzyme A dehydrogenase (HAD) activity, carnitine palmitoyltransferase (CPT1b) and phosphorylated acetyl-CoA carboxylase (pACC). Results: The training effects were similar in both groups for all parameters. On average, VO 2max and power output during the 30-min TT increased by 5 ± 1% (P<0.05) and TT performance was similar after CHO and placebo during the preload phase. Training promoted overall increases in glycogen content (18 ± 5%), CS activity (11 ± 5%) and pACC (38 ± 19%) (P<0.05) with no differences between groups. HAD activity and CPT1b protein content remained unchanged. Conclusion: Superimposing periodic CHO restriction to 4 weeks of regular endurance training had no superior effects on performance and muscle adaptations in elite endurance athletes. 9. Cochran AJ, Little JP, Tarnopolsky MA, Gibala MJ. Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of highintensity interval exercise in humans.
doi:10.1249/mss.0000000000001377 pmid:28723843 fatcat:qda5mqmllzcclmv6abpg6yzgcu

Atlas of plasma nuclear magnetic resonance biomarkers for health and disease in 118,461 individuals from the UK Biobank [article]

Heli Julkunen, Anna Cichońska, Mika Tiainen, Harri Koskela, Kristian Nybo, Valtteri Mäkelä, Jussi Nokso-Koivisto, Kati Kristiansson, Markus Perola, Veikko Salomaa, Pekka Jousilahti, Annamari Lundqvist (+4 others)
2022 medRxiv   pre-print
Blood lipids and metabolites are both markers of current health and indicators of risk for future disease. Here, we describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 participants in the UK Biobank, an open resource for public health research with extensive clinical and genomic data. The biomarkers cover 249 measures of lipoprotein lipids, fatty acids, and small molecules such as amino acids, ketones, and glycolysis metabolites. We provide a systematic atlas of
more » ... ons of these biomarkers to prevalence, incidence, and mortality of over 700 common diseases. The results reveal a plethora of biomarker associations, including susceptibility to infectious diseases and risk for onset of various cancers, joint disorders, and mental health outcomes, indicating that abundant circulating lipids and metabolites are risk markers well beyond cardiometabolic diseases. Clustering analyses indicate similar biomarker association patterns across different types of diseases, such as liver diseases and polyneuropathies, suggesting latent systemic connectivity in the susceptibility to a diverse set of diseases. The release of NMR biomarker data at scale in the UK Biobank highlights the promise of metabolic profiling in large cohorts for public health research and translation.
doi:10.1101/2022.06.13.22276332 fatcat:ifi6iwxh3bc6vfqufjge23jhdq

Evidence of perturbed germinal center dynamics, but preserved antibody diversity, in end-stage renal disease

Kristian Assing, Christian Nielsen, Marianne Jakobsen, Alexandra Scholze, Mads Nybo, Grete Soerensen, Sussie Mortensen, Knud Vejen, Torben Barington, Claus Bistrup
2016 Immunity, Inflammation and Disease  
Mads Nybo performed biochemical analyses. Grete Soerensen organized patients on hemodialysis. Sussie Mortensen performed next-generation sequencing.  ...  Kristian Assing wrote the paper and rest of the authors critically reviewed the manuscript.  ... 
doi:10.1002/iid3.108 pmid:27957330 pmcid:PMC4879468 fatcat:v4amyyukdbh7vbl5ilu5w4ibku

Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population

Frederik Cold, Kristian H. Winther, Roberto Pastor-Barriuso, Margaret P. Rayman, Eliseo Guallar, Mads Nybo, Bruce A. Griffin, Saverio Stranges, Søren Cold
2015 British Journal of Nutrition  
AbstractAlthough cross-sectional studies have shown a positive association between Se and cholesterol concentrations, a recent randomised controlled trial in 501 elderly UK individuals of relatively low-Se status found that Se supplementation for 6 months lowered total plasma cholesterol. The Danish PRECISE (PREvention of Cancer by Intervention with Selenium) pilot study ( ID: NCT01819649) was a 5-year randomised, double-blinded, placebo-controlled trial with four groups
more » ... ation ratio 1:1:1:1). Men and women aged 60–74 years (n491) were randomised to 100 (n124), 200 (n122) or 300 (n119) μg Se-enriched yeast or matching placebo-yeast tablets (n126) daily for 5 years. A total of 468 participants continued the study for 6 months and 361 participants, equally distributed across treatment groups, continued for 5 years. Plasma samples were analysed for total and HDL-cholesterol and for total Se concentrations at baseline, 6 months and 5 years. The effect of different doses of Se supplementation on plasma lipid and Se concentrations was estimated by using linear mixed models. Plasma Se concentration increased significantly and dose-dependently in the intervention groups after 6 months and 5 years. Total cholesterol decreased significantly both in the intervention groups and in the placebo group after 6 months and 5 years, with small and nonsignificant differences in changes in plasma concentration of total cholesterol, HDL-cholesterol, non-HDL-cholesterol and total:HDL-cholesterol ratio between intervention and placebo groups. The effect of long-term supplementation with Se on plasma cholesterol concentrations or its sub-fractions did not differ significantly from placebo in this elderly population.
doi:10.1017/s0007114515003499 pmid:26420334 fatcat:iddker2zcngp5ilfznnkiehjca

Lipid-lowering therapy and low-density lipoprotein cholesterol goal attainment after acute coronary syndrome: a Danish population-based cohort study

Marie Skov Kristensen, Anders Green, Mads Nybo, Simone Møller Hede, Kristian Handberg Mikkelsen, Gunnar Gislason, Mogens Lytken Larsen, Annette Kjær Ersbøll
2020 BMC Cardiovascular Disorders  
Patients with acute coronary syndrome (ACS) are at high risk of recurrent cardiovascular (CV) event. The European guidelines recommend low-density lipoprotein cholesterol (LDL-C) levels < 1.8 mmol/L and early initiation of intensive lipid-lowering therapy (LLT) to reduce CV risk. In order to reduce the risk of further cardiac events, the study aimed to evaluate LDL-C goal attainment and LLT intensity in an incident ACS population. A cohort study of patients with residency at Funen in Denmark at
more » ... a first-ever ACS event registered within the period 2010-2015. Information on LLT use and LDL-C levels was extracted from national population registers and a Laboratory database at Odense University Hospital. Treatments and lipid patterns were evaluated during index hospitalization, at 6-month and 12-month follow-up. Among 3040 patients with an LDL-C measurement during index hospitalization, 40.7 and 39.0% attained the recommended LDL-C target value (< 1.8 mmol/L) within 6- and 12-month follow-up, respectively. During 6- and 12-month follow-up, a total of 89.2% (20.2%) and 88.4% (29.7%) used LLT (intensive LLT). Of the intensive LLT users, 43.4 and 47.7% reached the LDL-C target value at 6- and 12-month follow-up. The frequency of lipid monitoring was low: 69.5, 77.7 and 53.6% in patients with a first-ever ACS during index hospitalization, 6- and 12-month follow-up, respectively. Using national health registers and laboratory data, a considerably gap was observed between treatment guidelines and clinical practice in the management of dyslipidemia leaving very high-risk patients without adequate lipid management strategy. Therefore, improved lipid management strategies aimed at reaching treatment targets are warranted.
doi:10.1186/s12872-020-01616-9 pmid:32660429 fatcat:zehalsfzcfbjhfuwzflf5hizkm

Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study

Karin Sørig Hougaard, Ann Dyreborg Larsen, Harald Hannerz, Anne-Marie Nybo Andersen, Kristian Tore Jørgensen, Gunnar Vase Toft, Jens Peter Bonde, Morten Søndergaard Jensen
2014 BMC Urology  
Cryptorchidism (undescended testes) is associated with poor male fertility, but can be alleviated and fertility preserved to some degree by early detection and treatment. Here we assess the influence of socio-occupational class, geographical region, maternal age and birth cohort on time to detection and correction of cryptorchidism. Methods: All boys born in Denmark, 1981Denmark, to 1987Denmark, or 1988Denmark, to 1994, with a diagnosis of cryptorchidism were identified in nationwide registers.
more » ... The boys were followed for a diagnosis until their 16th birthday. The age at first diagnosis was noted and used as proxy for time to detection of cryptorchidism. Parental employment in the calendar year preceding birth was grouped into one of five socio-occupational classes. Geographical region was defined by place of birth in one of 15 Danish counties. Detection rate ratios of cryptorchidism were analyzed as a function of parental socio-occupational group, county, maternal age and birth cohort by use of Poisson regression. Results: Some 6,059 boys in the early and 5,947 boys in the late cohort received a diagnosis of cryptorchidism. Time to detection was independent of parental socio-occupational group and maternal age but differed slightly between geographical regions. A similar pattern was obtained for surgical correction after a diagnosis. Age at diagnosis decreased by 2.7 years from the early to the late cohort. Conclusions: These results indicate that childhood socio-occupational inequality in detection and correction of cryptorchidism would play a negligible role in male infertility in a life course perspective. Geographical region may have exerted some influence, especially for the oldest cohort.
doi:10.1186/1471-2490-14-23 pmid:24581337 pmcid:PMC4016268 fatcat:zvx6z3dxs5fm3ax5gag6nchmey

The self-organizing map as a visual neighbor retrieval method

Kristian Nybo, Jarkko Venna, Samuel Kaski
We have recently introduced rigorous goodness criteria for information visualization by posing it as a visual neighbor retrieval problem, where the task is to find proximate high-dimensional data based only on a low-dimensional display. Standard information retrieval criteria such as precision and recall can then be used for information visualization. We introduced an algorithm, Neighbor Retrieval Visualizer (NeRV), to optimize the total cost of retrieval errors. NeRV was shown to outperform
more » ... ernative methods, but the SOM was not included in the comparison. In empirical experiments of this paper the SOM turns out to be comparable to the best methods in terms of (smoothed) precision but not on recall. On a related measure called trustworthiness, the SOM outperforms all others. Finally, we suggest that for information visualization tasks the free parameters of the SOM could be optimized for information visualization with cross-validation.
doi:10.2390/biecoll-wsom2007-138 fatcat:g4xtsvpqgvgsbdqdd5g63q4aeu

Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri

Tammi C. Vesth, Jane L. Nybo, Sebastian Theobald, Jens C. Frisvad, Thomas O. Larsen, Kristian F. Nielsen, Jakob B. Hoof, Julian Brandl, Asaf Salamov, Robert Riley, John M. Gladden, Pallavi Phatale (+27 others)
2018 Nature Genetics  
Aspergillus section Nigri comprises filamentous fungi relevant to biomedicine, bioenergy, health, and biotechnology. To learn more about what genetically sets these species apart, as well as about potential applications in biotechnology and biomedicine, we sequenced 23 genomes de novo, forming a full genome compendium for the section (26 species), as well as 6 Aspergillus niger isolates. This allowed us to quantify both inter- and intraspecies genomic variation. We further predicted 17,903
more » ... hydrate-active enzymes and 2,717 secondary metabolite gene clusters, which we condensed into 455 distinct families corresponding to compound classes, 49% of which are only found in single species. We performed metabolomics and genetic engineering to correlate genotypes to phenotypes, as demonstrated for the metabolite aurasperone, and by heterologous transfer of citrate production to Aspergillus nidulans. Experimental and computational analyses showed that both secondary metabolism and regulation are key factors that are significant in the delineation of Aspergillus species.
doi:10.1038/s41588-018-0246-1 pmid:30349117 fatcat:banctmrai5e6lgtrq4647j2uyu

Page 181 of Bogens Verden Vol. 34, Issue 4 [page]

1952 Bogens Verden  
Den gâr betydelig langere end Nyboe Andersen's Den okono- miske sammenhang og Penge og penges veerd.  ...  Sprog- og Litteraturselskabet er gâet i gang med en fornem 4-binds udgave af vore niddelalderlige byretter og kobstadprivilegier op til Kristian 2.’s kobstadlovgivning.  ... 
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