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We analyze the prices of owner-occupied housing in 97 metropolitan areas between 1980 and 2011. Our tests indicate that price changes exhibit positive serial correlation at the one year intervals, with subsequent reversals of price changes over longer intervals. Consistent with our simple model, regional differences in observed price patterns reflect differences in the serial correlation of the demand shocks as well as the elasticity of supply responses.doi:10.2139/ssrn.2199115 fatcat:hdgucwgsifc47csktavgtm7xhy
The authors thank Ms Ya-Ju Yang and Ms Ya-Hsueh Chuang for their assistance in data collection. ... It has been postulated that shockwaves induce hyperstimulation analgesia by increasing the threshold of pain. 10 Recently, Wang et al 20, 21 demonstrated that shockwaves induce neovascularization associated ...doi:10.1177/0363546505281811 pmid:16556754 fatcat:oapdrtyvavh7bgc6d32oh2ig6m
Due to the growing number of clinical antibiotic resistance cases in recent years, novel antimicrobial peptides (AMPs) can become ideal for next-generation antibiotics. This study trained a deep convolutional generative adversarial network (GAN) with known AMPs to generate novel AMP candidates. The quality of the GAN-designed peptides was evaluated in silico, and eight of them named GAN-pep 1~8 were chosen to be synthesized for further experiments. Disk diffusion testing and minimum inhibitorydoi:10.1101/2021.11.22.469634 fatcat:lnc7cbrkpnhqbgfahmg5wkslbe
more »... oncentration (MIC) determination were used to determine the antibacterial effects of the synthesized GAN-designed peptides. Seven out of the eight synthesized GAN-designed peptides showed antibacterial activities. Additionally, GAN-pep 3 and GAN-pep 8 had a broad spectrum of antibacterial effects. Both of them were also effective against antibiotic-resistant bacteria strains such as methicillin-resistant Staphylococcus aureus (S. aureus) and carbapenem-resistant Pseudomonas aeruginosa (P. aeruginosa). GAN-pep 3, the most promising GAN-designed peptide candidate, had low MICs against all the tested bacteria.
The radioactive tracer technique was applied to investigate the migration and adsorption behaviors of metallic impurities (i.e., Ba, Cs, Zn, and Mn) out of chemically amplified photoresist onto silicon-based underlying substrates. Two important process parameters, i.e., baking temperatures and substrate types (e.g., bare silicon, polysilicon, oxide, and nitride) were evaluated. Our results indicated that the transition metals (Zn and Mn) have lower migration ratios than alkali metal (Cs) anddoi:10.1149/1.1393985 fatcat:2rqrsdp7yfhefb2xxktlruk3my
more »... aline earth metal (Ba), irrespective of the substrate types and baking temperatures. The transition metals form stable complexes with the coexisting solvents and/or hydrolysis species in the photoresist layer. The size of the metal complex, the drag force in solvent evaporation, and the baking process were found to have significant effects on impurity migration. A new model, together with the metal migration in the chemically amplified photoresist and the subsequent adsorption onto the underlying substrate, was proposed to explain the pathway of the metal migration. This model could explain the migration ratios of metallic impurities out of the photoresist layer onto the substrate surface.
Shockwave was shown to enhance the healing of anterior cruciate ligament (ACL) reconstruction in rabbits. This study evaluated the effect of extracorporeal shockwave therapy (ESWT) on ACL reconstruction in human subjects. We hypothesized that ESWT may improve human ACL reconstruction. Methods : Fifty-three patients were randomized into two groups with 26 patients in ESWT group and 27 patients in control group. The ESWT group underwent single-bundle hamstring autograft ACL reconstruction anddoi:10.1016/j.jss.2014.01.050 pmid:24560350 fatcat:zyswqewmtbaqjo3ratwr5wcd7q
more »... ived ESWT immediately after surgery. The control group underwent ACL surgery without ESWT. Both groups received the same rehabilitation postoperatively. The evaluations included Lysholm score, IKDC score and KT-1000, radiograph, bone mineral density, and magnetic resonance imaging. Results: ESWT group showed significantly better Lysholm score than control group at 1 and 2 y postoperatively (P < 0.001 and 0.001, respectively). No significant difference was noted in IKDC score between the two groups (P ¼ 0.080 and 0.076, respectively). The KT-1000 values were significantly better in ESWT group than control group at 2 y postoperatively (P ¼ 0.027). The tibia tunnel on X-ray was significantly smaller in ESWT group compared with control group at 2 y (P ¼ 0.018). The bone mineral density values showed no discernable difference between the two groups at 6 mo and 2 y (P ¼ 0.522 and 0.984, respectively). On magnetic resonance imaging, ESWT group showed significant decrease in tibia tunnel enlargement at 6 mo and 2 y compared with the control group (P ¼ 0.024 and <0.001, respectively). Conclusions: ESWT significantly improves the subjective Lysholm score and decreases the middle 1/3 tibia tunnel enlargement after single hamstring autograft ACL reconstruction.
With the rapid advent of Virtual Reality (VR) technology and virtual tour applications, there is a research need on spatial queries tailored for simultaneous movements in both the physical and virtual worlds. Traditional spatial queries, designed mainly for one world, do not consider the entangled dual worlds in VR. In this paper, we first investigate the fundamental shortest-path query in VR as the building block for spatial queries, aiming to avoid hitting boundaries and obstacles in thearXiv:1908.08691v1 fatcat:s7olbhgttzazhcyba67lnxcs5u
more »... cal environment by leveraging Redirected Walking (RW) in Computer Graphics. Specifically, we first formulate Dual-world Redirected-walking Obstacle-free Path (DROP) to find the minimum-distance path in the virtual world, which is constrained by the RW cost in the physical world to ensure immersive experience in VR. We prove DROP is NP-hard and design a fully polynomial-time approximation scheme, Dual Entangled World Navigation (DEWN), by finding Minimum Immersion Loss Range (MIL Range). Afterward, we show that the existing spatial query algorithms and index structures can leverage DEWN as a building block to support kNN and range queries in the dual worlds of VR. Experimental results and a user study with implementation in HTC VIVE manifest that DEWN outperforms the baselines with smoother RW operations in various VR scenarios.
Yang, MD, PhD,7 Feng-Sheng Wang, PhD,i Jih-Yang Ko, MD,* and Chung-Cheng Huang, MD§ Abstract: This article reported a case of systemic lupus erythematosis (SLE) with osteonecrosis of the femoral heads ... Wang CJ, Wang FS, Yang KD, et al. Shock wave therapy induces neovascularization at the tendon bone junction. J Orthop Res 2003;21:984. Wang CJ, Yang KD, Wang FS, et al. ...doi:10.1016/j.arth.2005.11.004 pmid:16950049 fatcat:yigj2efq3vbgzm5246f3bisqci
Recent transcriptome studies suggest that long noncoding RNAs (lncRNAs) are key components of the mammalian genome, and their study has become a new frontier in biomedical research. In fact, lncRNAs in the mammalian genome were identified and studied at particular epigenetic loci, including imprinted loci and X-chromosome inactivation center, at least two decades ago-long before development of high throughput sequencing technology. Since then, researchers have found that lncRNAs play essentialdoi:10.3390/biom3010124 pmid:24970160 pmcid:PMC4030888 fatcat:fzo2kv7pszeqlhy42e2zfiai2q
more »... oles in various biological processes, mostly during development. Since much of our understanding of lncRNAs originates from our knowledge of these well-established lncRNAs, in this review we will focus on lncRNAs from the X-chromosome inactivation center and the Dlk1-Dio3 imprinted cluster as examples of lncRNA mechanisms functioning in the epigenetic regulation of mammalian genes.
Wang designed the study and gave final approval of the manuscript; Y. Xia drafted the manuscript and revised it critically for important intellectual content. ... Ko-Pen Wang proposed a map of the mediastinal and hilar lymph node stations for TBNA biopsy with CT and endobronchial correlations, identifying 11 lymph node stations which are consistently involved with ...doi:10.3978/j.issn.2072-1439.2013.09.11 pmid:24255782 pmcid:PMC3815731 fatcat:pr4t3sr6njd27ca54c4l22fc2u
Objectives. The effect of shockwave in osteonecrosis of the femoral head (ONFH) is poorly understood. The purpose of this study was to investigate the regeneration effects of shockwave in ONFH. Methods. This study consisted of 14 femoral heads from 14 patients undergoing total hip arthroplasty for ONFH. Seven patients with seven hips who received shockwave prior to surgery were designated as the study group, whereas, seven patients with seven hips who did not receive shockwave were assigned todoi:10.1093/rheumatology/ken020 pmid:18356180 fatcat:aipq7k435vbrro5pzd37xvh6fa
more »... he control group. Both groups showed similar demographic characteristics. The femoral heads were investigated with histopathological examination and immunohistochemical analysis with von Willebrand factor (vWF), VEGF, platelet endothelial cell adhesion molecule-1 (PECAM-1) also referred to as (CD 31) and vascular cell adhesion molecule (VCAM) for angiogenesis, and with proliferation cell nuclear antigen (PCNA), Dickkopf-1 (DKK1) and Winless 3a (Wnt 3) for bone remodelling and regeneration. Results. In histopathological examination, the study group showed significantly more viable bone and less necrotic bone, higher cell concentration and more cell activities including phagocytosis than the control group. In immunohistochemical analysis, the study group showed significant increases in vWF (P < 0.01), VEGF (P ¼ 0.0012) and CD 31 (P ¼ 0.0023), Wnt3 (P ¼ 0.008) and PCNA (P ¼ 0.0011), and decreases in VCAM (P ¼ 0.0013) and DKK1 (P ¼ 0.0007) than the control group. Conclusions. Shockwave treatment significantly promotes angiogenesis and bone remodelling than the control. It appears that application of shockwave results in regeneration effects in hips with ONFH.
Metrology, Inspection, and Process Control for Microlithography XIV
The novel radioactive tracer technique was applied to investigate the migration of cesium, manganese and zinc impurities from deep ultraviolet photoresist into underlying substrate. Two important process parameters, viz., baking temperatures and substrate types (i.e., bare silicon, polysilicon, silicon oxide and silicon nitride), were evaluated. Our results indicated that the migration ratios were all below 6%, irrespective ofbaking temperatures and substrate types. The substrate types did notdoi:10.1117/12.386507 fatcat:5kcaymqxbrf5znc2zghjfexkfq
more »... ppear to strongly affect the metallic impurity out-diffusion from deep ultraviolet photoresist. However, solvent and/or water evaporation due to temperature change was found to have a significant effect on metal migration. The net driving force of impurity changes with temperature and the impurity diffusion can be classified into four types. Based on the proposed types, the obtained migration ratios can be realized. A new model, together with a new parameter, was proposed to describe the out-diffusion behavior of impurities from deep ultraviolet photoresist. The diffusion profile of photoresist was depicted based on diffusion equations and the migration ratios. This model could explain the migration ratios of metallic impurities in photoresist layers under various baking conditions.
Yang). Fig. 1 . 1 Large-scaled straight and buckled plastic straws. ... Kai-Chung Ko was born in 1980 in Taichung, Taiwan. He received his BS degree in the Department of Mechanical & Electro-Mechanical Engineering, Tamkang University, Taiwan, in 2000. ...doi:10.1016/j.sna.2006.01.046 fatcat:mekgtzb4obhmxbbofujme47hma
PBS, HFD-fed ApoE KO mice treated with PBS; GFP-A, HFD-fed ApoE KO mice treated with Ad-GFP; NAMPT-A, HFD-fed ApoE KO mice treated with Ad-sh NAMPT. ... PBS, HFD-fed ApoE KO mice treated with PBS; GFP-A, HFD-fed ApoE KO mice treated with Ad-GFP; NAMPT-A, HFD-fed ApoE KO mice treated with Ad-sh NAMPT. HFD, high fat diet. ... PBS, HFD-fed ApoE KO mice treated with PBS; GFP-A, HFD-fed ApoE KO mice treated with Ad-GFP; NAMPT-A, HFD-fed ApoE KO mice treated with Ad-sh NAMPT. ...doi:10.1038/srep26746 pmid:27229177 pmcid:PMC4882618 fatcat:rk2bypbshbavpi5lgqndw5tkmu
In dye-sensitized solar cells based on anodic titania nanotube arrays, the low photocurrent in the backside-illuminated configuration has hindered their development. To increase the energy absorption and thus promote the photocurrent, a novel parallel configuration of dye-sensitized solar cells is proposed and achieved in this work on the basis of double-sided anodic nanotubes. The parallel connection is verified by electrochemical impedance spectroscopy measurements. The parallel cells exhibitdoi:10.1039/c1ee01196k fatcat:pke5hu4bnrcpvdue4btrdb2zhu
more »... an average 70% increment in photocurrent and 30% enhancement in efficiency as compared to the single cells, due to significantly increased surface area and highly reduced series resistance. Theoretical calculation and experimental fitting results demonstrate that a tube length of $30 mm is optimal for the nanotubes used in this study with backside-illuminated architecture. To reduce electron scattering and increase energy absorption, anodic titania nanotube arrays have been vigorously investigated in an attempt to substitute the conventional nanoparticle photoanodes used in dye-sensitized solar cells. However, the use of nanotubes is not as efficient as that of nanoparticles, for example, the highest efficiencies are $7% vs. $11%. One of the most important factors is the low dye loading amount for light harvesting in the nanotube photoanodes, which, in turn, gives rise to a low photocurrent as well as a low conversion efficiency. In this study, a novel parallel configuration of dye-sensitized solar cells is achieved based on doublesided anodic nanotubes. This structure doubles the dye loading amount and promotes the photocurrent in a unit solar cell. The parallel cells exhibit an average 70% increase in photocurrent and 30% increment in efficiency in contrast to the single cells, as a consequence of a highly increased surface area and considerably reduced series resistance.
Uni-knee arthroplasty (UKA) has shown better knee kinematics and motion that may better suit the activities of daily living in Eastern countries. The purpose of this study was to evaluate the functional outcomes of UKA for medial compartment knee arthropathy in Asian patients. Methods: The study cohort consisted of 48 patients with 51 UK A knees. Only one type of prosthesis was used and all components were cemented. Postoperative management included ambulation with weight bearing, range ofdoi:10.4103/2319-4170.132877 pmid:25179698 fatcat:ucjesn5neramxgq625l7wz7fly
more »... n, and muscle strengthening exercises as tolerated until full recovery. The average follow-up was 52.0 ± 24.0 (range 12-92) months. The evaluation included functional assessment, the Knee Society knee and functional scores, the International Knee Document Committee (IKDC) subjective and objective scores, and radiographs of the knee. Results: The overall clinical outcomes of the knee showed the functional outcome of the knee to be normal in 51%, nearly normal in 37%, abnormal in 8%, and severely abnormal in 4%. The functional activities included stair climbing in 96%, squatting in 76%, jogging in 71% and kneeling in 47%. Three-quarters of the patients were able to kneel for daily activities. Approximately 98% of the patients were satisfied with the operation. The survivorship of the prosthesis was 98% with one revision pending. Radiographic evaluations revealed the components were centered in 82% and off-centered in 18%. Osteoarthritis was 22% preoperative and 27% postoperative for the patellofemoral compartment, and 0% before and 4% after surgery for the lateral compartment. The functional outcomes showed no difference between patients with and without patellofemoral arthritis. The complications included one component malposition and one knee pain of undetermined origin. Conclusions: UKA provides excellent pain relief and restoration of knee function including kneeling, squatting, and sit-to-stand activities that perfectly fit the oriental lifestyle and high patient satisfaction in Asian patients at medium-term follow-up. The complications were rare and the survival rate was 98% at medium-term follow-up. (Biomed J 2014;37:406-410)
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