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Network-centered homeostasis through inhibition maintains hippocampal spatial map and cortical circuit function
[article]
2020
bioRxiv
pre-print
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Despite ongoing experiential change, neural activity maintains remarkable stability. Such stability is thought to be mediated by homeostatic plasticity and is deemed to be critical for normal neural function. However, what aspect of neural activity does homeostatic plasticity conserve, and how it still maintains the exibility necessary for learning and memory, is not fully understood. Homeostatic plasticity is often studied in the context of neuron-centered control, where the deviations from
doi:10.1101/2020.08.04.236042
fatcat:mgg3ndfc4vhulp2twqtmixv4ta
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... target activity for each individual neuron are suppressed. However, experimental studies suggest that there are additional, network-centered mechanisms. These may act through the inhibitory neurons, due to their dense network connectivity. Here we use a computational framework to study a potential mechanism for such homeostasis, using experimentally inspired, input-dependent inhibitory plasticity (IDIP). In a hippocampal CA1 spiking model, we show that IDIP in combination with place tuned input can explain the formation of active and silent place cells, as well as place cells remapping following optogenetic silencing of active place cells. Furthermore, we show that IDIP can also stabilise recurrent network dynamics, as well as preserve network firing rate heterogeneity and stimulus representation. Interestingly, in an associative memory task, IDIP facilitates persistent activity after memory encoding, in line with some experimental data. Hence, the establishment of global network balance with IDIP has diverse functional implications and may be able to explain experimental phenomena across different brain areas.
Expanding the Orthologous Matrix (OMA) programmatic interfaces: REST API and the OmaDB packages for R and Python
2019
F1000Research
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gene.expr.tissue.ids <-
unlist(expr.data$gene2anatomy[trfl_ens_id], use.names = F)
tissues <-
https://doi.org/10.5256/f1000research.19190.r42908Laurent GattoUniversity of Louvain (UCLouvain), Brussels, Belgium Kaleb ...
doi:10.12688/f1000research.17548.2
fatcat:vax5govrmfexjkxthkhsd4gtf4
Expanding the Orthologous Matrix (OMA) programmatic interfaces: REST API and the OmaDB packages for R and Python
2019
F1000Research
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The Orthologous Matrix (OMA) is a well-established resource to identify orthologs among many genomes. Here, we present two recent additions to its programmatic interface, namely a REST API, and user-friendly R and Python packages called OmaDB. These should further facilitate the incorporation of OMA data into computational scripts and pipelines. The REST API can be freely accessed at https://omabrowser.org/api. The R OmaDB package is available as part of Bioconductor at
doi:10.12688/f1000research.17548.1
pmid:31001419
pmcid:PMC6464060
fatcat:3ypgyy5qkzh7xefrhv6d6lcxdi
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... ackages/OmaDB/, and the omadb Python package is available from the Python Package Index (PyPI) at https://pypi.org/project/omadb/.
The OMA orthology database in 2018: retrieving evolutionary relationships among all domains of life through richer web and programmatic interfaces
2017
Nucleic Acids Research
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The Orthologous Matrix (OMA) is a leading resource to relate genes across many species from all of life. In this update paper, we review the recent algorithmic improvements in the OMA pipeline, describe increases in species coverage (particularly in plants and early-branching eukaryotes) and introduce several new features in the OMA web browser. Notable improvements include: (i) a scalable, interactive viewer for hierarchical orthologous groups; (ii) protein domain annotations and domain-based
doi:10.1093/nar/gkx1019
pmid:29106550
pmcid:PMC5753216
fatcat:s5iawo2arvaq3dvcvtubr3v53a
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... inks between orthologous groups; (iii) functionality to retrieve phylogenetic marker genes for a subset of species of interest; (iv) a new synteny dot plot viewer; and (v) an overhaul of the programmatic access (REST API and semantic web), which will facilitate incorporation of OMA analyses in computational pipelines and integration with other bioinformatic resources. OMA can be freely accessed at https://omabrowser.org.
Expanding the Orthologous Matrix (OMA) programmatic interfaces: REST API and the OmaDB packages for R and Python: [version 2; peer review: 2 approved]
2019
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University of Louvain (UCLouvain), Brussels, Belgium Kaleb et al. present two packages, namely R/Bioconductor OmoDB and python omadb, that allow users to query and use data from the Orthologous Matrix ...
doi:10.3929/ethz-b-000419621
fatcat:e7f7m6ofbjchjcdopeom5z4dty
Novi mediji urbanosti
2003
Urbani Izziv
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Televizija i DVD-i također nisu toliko zastupljeni (Šulentić Begić, Kaleb, 2012, str. 182). ...
Djeca četvrtoga razreda osnovne škole Sveta Klara u Zagrebu imala su priliku sudjelovati na medijskoj radionici "e-folklor". ...
doi:10.5379/urbani-izziv-2003-14-02-003
fatcat:xpocjqoi4zgxpjq5waxm6y3iuq
Etiopiešu maltīte kā sakrālās ainavas veidošanas līdzeklis Hērodota Vēsturē
2020
Akadēmiskā Dzīve
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Tas pamatojams ar arheoloģisku izpēti, kas liecina par hellēņu praksi izmantot kanalizācijas saturu lauksaimniecības mēslojumā. 23 Šim viedoklim gan nepiekrīt Klāra Bosaka-Šrēdere (Clara Bosak-Schroeder ...
Kad Kambīsa sūtņi paziņojuši, ka persieši audzē labību, cep maizi un dzīvo līdz 80 gadiem, etiopieši uz to atbildējuši, ka persieši ēd mēslus (kopros), tādēļ tie arī dzīvo tik īsu mūžu. 22 Kā uzskata Kalebs ...
doi:10.22364/adz.56.15
fatcat:rhhdp2kdarfv5esozy73ph27xm
Bibliography of the Vjeverica Book Series
Bibliografija biblioteke Vjeverice
2016
Libri et Liberi
Bibliografija biblioteke Vjeverice
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Fehér, Klára. 1980. Imat ću svoj otok. Indijančev vrt. Prev. s
mađarskoga Ljerka Damjanov. Ilus. Nedeljko Dragić. 129 str.
1
202.
Pavičić, Josip. 1980. Poletarci. Ilus. ...
Prev. s talijanskoga Vjekoslav Kaleb. Ilus. Gita
Rosenzweig. 145 str.
12 (13?)
70.
Rodari, Gianni. 1963. Đelsomino u zemlji lažljivaca. Prev. s
talijanskoga Nikola Babić. Ilus. ...
doi:10.21066/carcl.libri.2016-05(01).0009
fatcat:dhs2kcx4afabbl2l3mihrqdghy
Den nya juden och judiska exilen i Judisk Tidsskrift 1933–1950
1996
Scandinavian Jewish Studies
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De som medverkade i Judisk Tidskrift hade i mångt och mycket, från dess början till dess sista nummer, en ton av att vara intellektuella och objektiva och väldigt klara i sina resonemang kring det de skriver ...
Jacob Klatzkin Om Hugo Valentin var vag i sitt resonemang så fanns det andra som var helt på det klara med judarnas förestående utplåning i galuth. ...
Ropen till
19 Ibid. s. 47-48.
20 Idem, 21
När Moses skickade ut spanare för att undersöka möjligheten att intaga Palestina och dessa kommo tillbaka och talade om svårigheterne, sade en av dem, Kaleb ...
doi:10.30752/nj.69528
fatcat:uof7wykpyzfe7hoxk2g7qmttcy
Ponzonijevih deset slika u svodu glavnog oltara splitske katedrale: razmatranja o stilsko-oblikovnim svojstvima, izvornoj funkciji i ikonografsko-ikonološkom aspektu
2019
Radovi Instituta za Povijest Umjetnosti
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Klara postaje kršćanska heroina koja brani kršćanstvo glavnim simbolom posttridentinske katoličke teologije, odnosno posvećenom hostijom. ...
Dok su se ostale redovnice prepale tako da im se »srce topilo od straha«, sveta se Klara, premda bolesna, hrabro suprotstavila neprijatelju. ...
doi:10.31664/ripu.2018.42.09
fatcat:tet4kvycovdg5hgapja6mj36yq
A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease
[article]
2020
bioRxiv
pre-print
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Amanda Foust, Klara 533 Kaleb and Grace Ang. This work was supported by Mrs Anne Uren and the Michael 534 Uren Foundation. 535 ...
doi:10.1101/2020.10.08.330928
fatcat:2txaxo5hfzcrtimq7cc2547egu
A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease
2021
PLoS Computational Biology
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Amanda Foust, Klara Kaleb and Grace Ang. ...
doi:10.1371/journal.pcbi.1009115
pmid:34133417
fatcat:xg7vnq3pqfhpnapuy5b3lvdq4y
Tekuća onomastička bibliografija (2012.)
2013
Folia Onomastica Croatica
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TOPONIMIJA / TOPONYMY
Buršić-Matijašić, Klara: Gradine podno Žbevnice [Hillforts under Žbevnica].
Buzetski zbornik, 38, Buzet, 2011, 11-20. ...
Kaleb, Zorislav: Rasprava o podrijetlu imena rijeke Neretve [Discussion on the
origin of the Neretva river name]. Hrvatski neretvanski zbornik, 3, Zagreb,
2011, 57-63. ...
doaj:ca0e5d54d4ca43039f0b4071682a2f27
fatcat:yexs7a2nove7zndhqivxm3uzai
I. Mahmud Dönemi'nde Avrupalı Devletler ile yapılan ticaret antlaşmaları ile verilen imtiyazlara dair değerlendirmeler
2017
OTAM(Ankara
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Devam nda bu e k yalardan kurtulduklar n ve gemilerinde kalan 6 ki iyi zmir'e getirerek kalebent edilmeleri hakk nda takrirleri bulunmaktad r 96 . ...
Kelime köken olarak "caput, capitulum" kelimesinden türetilmi olup, Latince "capitulatio" dan gelir ve "ba l klara, bölümlere ayr lm vesika" ya da "kar l kl ortaya konulmu devletleraras bir antla ma" anlam ...
doi:10.1501/otam_0000000723
fatcat:d2kyqqpm4naizetjidewjm6cwq
Ikonografiskt register
unpublished
Preserved Fulltext
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tavlor
81/2:75-19
Lagens tavlor
76/3:7 7,21
82/3 -.26-28
Guldkalven
80/2:75
Förbundsarken
79/3:19-20
(Pagtens ark)
80/2:76
Spejarna med druvklasen 80/2:15-76
80/4:31
81/2:16-19
Josua och Kaleb ...
78/1:17,19,41
78/2:2-3
78/4:34
80/1:2
81/2:70-77
83/2:17,7<9-79
84/4:26,27-2<9,
29,32
K atarina av Siena
79/2:23
K atarina av V adstena
77/3-4:7,9
79/1:18
82/4:8,27-22
83/4:22
84/4:7
Klara ...
fatcat:23qkb2bh2zdlleudpyaqyeexra
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