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Network-centered homeostasis through inhibition maintains hippocampal spatial map and cortical circuit function [article]

Klara Kaleb, Victor Pedrosa, Claudia Clopath
2020 bioRxiv   pre-print
Despite ongoing experiential change, neural activity maintains remarkable stability. Such stability is thought to be mediated by homeostatic plasticity and is deemed to be critical for normal neural function. However, what aspect of neural activity does homeostatic plasticity conserve, and how it still maintains the exibility necessary for learning and memory, is not fully understood. Homeostatic plasticity is often studied in the context of neuron-centered control, where the deviations from
more » ... target activity for each individual neuron are suppressed. However, experimental studies suggest that there are additional, network-centered mechanisms. These may act through the inhibitory neurons, due to their dense network connectivity. Here we use a computational framework to study a potential mechanism for such homeostasis, using experimentally inspired, input-dependent inhibitory plasticity (IDIP). In a hippocampal CA1 spiking model, we show that IDIP in combination with place tuned input can explain the formation of active and silent place cells, as well as place cells remapping following optogenetic silencing of active place cells. Furthermore, we show that IDIP can also stabilise recurrent network dynamics, as well as preserve network firing rate heterogeneity and stimulus representation. Interestingly, in an associative memory task, IDIP facilitates persistent activity after memory encoding, in line with some experimental data. Hence, the establishment of global network balance with IDIP has diverse functional implications and may be able to explain experimental phenomena across different brain areas.
doi:10.1101/2020.08.04.236042 fatcat:mgg3ndfc4vhulp2twqtmixv4ta

Expanding the Orthologous Matrix (OMA) programmatic interfaces: REST API and the OmaDB packages for R and Python

Klara Kaleb, Alex Warwick Vesztrocy, Adrian Altenhoff, Christophe Dessimoz
2019 F1000Research  
gene.expr.tissue.ids <- unlist(expr.data$gene2anatomy[trfl_ens_id], use.names = F) tissues <- https://doi.org/10.5256/f1000research.19190.r42908Laurent GattoUniversity of Louvain (UCLouvain), Brussels, Belgium Kaleb  ... 
doi:10.12688/f1000research.17548.2 fatcat:vax5govrmfexjkxthkhsd4gtf4

Expanding the Orthologous Matrix (OMA) programmatic interfaces: REST API and the OmaDB packages for R and Python

Klara Kaleb, Alex Warwick Vesztrocy, Adrian Altenhoff, Christophe Dessimoz
2019 F1000Research  
The Orthologous Matrix (OMA) is a well-established resource to identify orthologs among many genomes. Here, we present two recent additions to its programmatic interface, namely a REST API, and user-friendly R and Python packages called OmaDB. These should further facilitate the incorporation of OMA data into computational scripts and pipelines. The REST API can be freely accessed at https://omabrowser.org/api. The R OmaDB package is available as part of Bioconductor at
more » ... ackages/OmaDB/, and the omadb Python package is available from the Python Package Index (PyPI) at https://pypi.org/project/omadb/.
doi:10.12688/f1000research.17548.1 pmid:31001419 pmcid:PMC6464060 fatcat:3ypgyy5qkzh7xefrhv6d6lcxdi

The OMA orthology database in 2018: retrieving evolutionary relationships among all domains of life through richer web and programmatic interfaces

Adrian M Altenhoff, Natasha M Glover, Clément-Marie Train, Klara Kaleb, Alex Warwick Vesztrocy, David Dylus, Tarcisio M de Farias, Karina Zile, Charles Stevenson, Jiao Long, Henning Redestig, Gaston H Gonnet (+1 others)
2017 Nucleic Acids Research  
The Orthologous Matrix (OMA) is a leading resource to relate genes across many species from all of life. In this update paper, we review the recent algorithmic improvements in the OMA pipeline, describe increases in species coverage (particularly in plants and early-branching eukaryotes) and introduce several new features in the OMA web browser. Notable improvements include: (i) a scalable, interactive viewer for hierarchical orthologous groups; (ii) protein domain annotations and domain-based
more » ... inks between orthologous groups; (iii) functionality to retrieve phylogenetic marker genes for a subset of species of interest; (iv) a new synteny dot plot viewer; and (v) an overhaul of the programmatic access (REST API and semantic web), which will facilitate incorporation of OMA analyses in computational pipelines and integration with other bioinformatic resources. OMA can be freely accessed at https://omabrowser.org.
doi:10.1093/nar/gkx1019 pmid:29106550 pmcid:PMC5753216 fatcat:s5iawo2arvaq3dvcvtubr3v53a

Expanding the Orthologous Matrix (OMA) programmatic interfaces: REST API and the OmaDB packages for R and Python: [version 2; peer review: 2 approved]

Klara Kaleb, Alex Warwick Vesztrocy, Adrian Michael Altenhoff, Christophe Dessimoz
2019
University of Louvain (UCLouvain), Brussels, Belgium Kaleb et al. present two packages, namely R/Bioconductor OmoDB and python omadb, that allow users to query and use data from the Orthologous Matrix  ... 
doi:10.3929/ethz-b-000419621 fatcat:e7f7m6ofbjchjcdopeom5z4dty

Novi mediji urbanosti

Laurant-Paul Robert, Vesna Petrešin Robert
2003 Urbani Izziv  
Televizija i DVD-i također nisu toliko zastupljeni (Šulentić Begić, Kaleb, 2012, str. 182).  ...  Djeca četvrtoga razreda osnovne škole Sveta Klara u Zagrebu imala su priliku sudjelovati na medijskoj radionici "e-folklor".  ... 
doi:10.5379/urbani-izziv-2003-14-02-003 fatcat:xpocjqoi4zgxpjq5waxm6y3iuq

Etiopiešu maltīte kā sakrālās ainavas veidošanas līdzeklis Hērodota Vēsturē

Rūdolfs Reinis Vītoliņš, Latvijas Universitātes Vēstures un filozofijas fakultāte
2020 Akadēmiskā Dzīve  
Tas pamatojams ar arheoloģisku izpēti, kas liecina par hellēņu praksi izmantot kanalizācijas saturu lauksaimniecības mēslojumā. 23 Šim viedoklim gan nepiekrīt Klāra Bosaka-Šrēdere (Clara Bosak-Schroeder  ...  Kad Kambīsa sūtņi paziņojuši, ka persieši audzē labību, cep maizi un dzīvo līdz 80 gadiem, etiopieši uz to atbildējuši, ka persieši ēd mēslus (kopros), tādēļ tie arī dzīvo tik īsu mūžu. 22 Kā uzskata Kalebs  ... 
doi:10.22364/adz.56.15 fatcat:rhhdp2kdarfv5esozy73ph27xm

Bibliography of the Vjeverica Book Series
Bibliografija biblioteke Vjeverice

Vesna Radošević
2016 Libri et Liberi  
Fehér, Klára. 1980. Imat ću svoj otok. Indijančev vrt. Prev. s mađarskoga Ljerka Damjanov. Ilus. Nedeljko Dragić. 129 str. 1 202. Pavičić, Josip. 1980. Poletarci. Ilus.  ...  Prev. s talijanskoga Vjekoslav Kaleb. Ilus. Gita Rosenzweig. 145 str. 12 (13?) 70. Rodari, Gianni. 1963. Đelsomino u zemlji lažljivaca. Prev. s talijanskoga Nikola Babić. Ilus.  ... 
doi:10.21066/carcl.libri.2016-05(01).0009 fatcat:dhs2kcx4afabbl2l3mihrqdghy

Den nya juden och judiska exilen i Judisk Tidsskrift 1933–1950

Anders Englund
1996 Scandinavian Jewish Studies  
De som medverkade i Judisk Tidskrift hade i mångt och mycket, från dess början till dess sista nummer, en ton av att vara intellektuella och objektiva och väldigt klara i sina resonemang kring det de skriver  ...  Jacob Klatzkin Om Hugo Valentin var vag i sitt resonemang så fanns det andra som var helt på det klara med judarnas förestående utplåning i galuth.  ...  Ropen till 19 Ibid. s. 47-48. 20 Idem, 21 När Moses skickade ut spanare för att undersöka möjligheten att intaga Palestina och dessa kommo tillbaka och talade om svårigheterne, sade en av dem, Kaleb  ... 
doi:10.30752/nj.69528 fatcat:uof7wykpyzfe7hoxk2g7qmttcy

Ponzonijevih deset slika u svodu glavnog oltara splitske katedrale: razmatranja o stilsko-oblikovnim svojstvima, izvornoj funkciji i ikonografsko-ikonološkom aspektu

Ivana Čapeta Rakić
2019 Radovi Instituta za Povijest Umjetnosti  
Klara postaje kršćanska heroina koja brani kršćanstvo glavnim simbolom posttridentinske katoličke teologije, odnosno posvećenom hostijom.  ...  Dok su se ostale redovnice prepale tako da im se »srce topilo od straha«, sveta se Klara, premda bolesna, hrabro suprotstavila neprijatelju.  ... 
doi:10.31664/ripu.2018.42.09 fatcat:tet4kvycovdg5hgapja6mj36yq

A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease [article]

Natalie Ness, Simon R Schultz
2020 bioRxiv   pre-print
Amanda Foust, Klara 533 Kaleb and Grace Ang. This work was supported by Mrs Anne Uren and the Michael 534 Uren Foundation. 535  ... 
doi:10.1101/2020.10.08.330928 fatcat:2txaxo5hfzcrtimq7cc2547egu

A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease

Natalie Ness, Simon R. Schultz, Boris S. Gutkin
2021 PLoS Computational Biology  
Amanda Foust, Klara Kaleb and Grace Ang.  ... 
doi:10.1371/journal.pcbi.1009115 pmid:34133417 fatcat:xg7vnq3pqfhpnapuy5b3lvdq4y

Tekuća onomastička bibliografija (2012.)

Ines Virč, Branimir Brgles, Joža Horvat
2013 Folia Onomastica Croatica  
TOPONIMIJA / TOPONYMY Buršić-Matijašić, Klara: Gradine podno Žbevnice [Hillforts under Žbevnica]. Buzetski zbornik, 38, Buzet, 2011, 11-20.  ...  Kaleb, Zorislav: Rasprava o podrijetlu imena rijeke Neretve [Discussion on the origin of the Neretva river name]. Hrvatski neretvanski zbornik, 3, Zagreb, 2011, 57-63.  ... 
doaj:ca0e5d54d4ca43039f0b4071682a2f27 fatcat:yexs7a2nove7zndhqivxm3uzai

I. Mahmud Dönemi'nde Avrupalı Devletler ile yapılan ticaret antlaşmaları ile verilen imtiyazlara dair değerlendirmeler

KURTARAN Uğur
2017 OTAM(Ankara  
Devam nda bu e k yalardan kurtulduklar n ve gemilerinde kalan 6 ki iyi zmir'e getirerek kalebent edilmeleri hakk nda takrirleri bulunmaktad r 96 .  ...  Kelime köken olarak "caput, capitulum" kelimesinden türetilmi olup, Latince "capitulatio" dan gelir ve "ba l klara, bölümlere ayr lm vesika" ya da "kar l kl ortaya konulmu devletleraras bir antla ma" anlam  ... 
doi:10.1501/otam_0000000723 fatcat:d2kyqqpm4naizetjidewjm6cwq

Ikonografiskt register

Gamla
unpublished
tavlor 81/2:75-19 Lagens tavlor 76/3:7 7,21 82/3 -.26-28 Guldkalven 80/2:75 Förbundsarken 79/3:19-20 (Pagtens ark) 80/2:76 Spejarna med druvklasen 80/2:15-76 80/4:31 81/2:16-19 Josua och Kaleb  ...  78/1:17,19,41 78/2:2-3 78/4:34 80/1:2 81/2:70-77 83/2:17,7<9-79 84/4:26,27-2<9, 29,32 K atarina av Siena 79/2:23 K atarina av V adstena 77/3-4:7,9 79/1:18 82/4:8,27-22 83/4:22 84/4:7 Klara  ... 
fatcat:23qkb2bh2zdlleudpyaqyeexra
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