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Research Finland Anita Lehikoinen, Ministry of Education, Markku Mattila, President of Research Council The outreach and dissemination activities are described more in detail in Deliverable Kimmo Koski ... D2.5.2 Report on links with HPC Ecosystem 5 Annex 5.1 PRACE Message Document: PRACE -RI-211528 34 21.12.2008 draft Proposal to be used in Stakeholder meetings Kimmo Koski September 26th This document ...doi:10.5281/zenodo.6543061 fatcat:6drszvvhkvbbfc77nkxzkdqvmu
Koski of CSC). ... Existing RI Organization Name Contact Person Main Interlocutor from PRACE CERN Robert Aymar Achim Bachem, FZJ EBI Janet Thornton Kimmo Koski, Leif Laaksonen CSC, Modesto Oruzco BSC ECMWF Walter Zwiefelhofer ...doi:10.5281/zenodo.6542961 fatcat:ribhysgm4jb2dcyp3bfdrgkhma
Sixth International Symposium on Parallel and Distributed Computing (ISPDC'07) 0-7695-2936-4/07 $20.00doi:10.1109/ispdc.2007.9 dblp:conf/ispdc/Koski07 fatcat:iqp2tcrrprfafm4j24aaaznoy4
BMC Public Health
The incidence of type 1 diabetes is increasing worldwide. Since so little is known about work life of individuals with type 1 diabetes, we examined incidence and prevalence trends of type 1 diabetes among working-aged Finns. We also investigated the employment rate and how workers with type 1 diabetes perceive their health and work ability, and their intended retirement age. Methods: We analyzed changes in the incidence, prevalence, and employment rate using nationwide multiregister-based FinDMdoi:10.1186/s12889-017-4723-8 pmid:29025404 pmcid:PMC5639775 fatcat:w5azl6m4frbsnaqwx7az5b2itu
more »... data, and estimated a Self-Rated Health, Work Ability Score, and inquired about retirement intentions of 767 working individuals with type 1 diabetes in a cross-sectional survey. All estimates were compared to the corresponding data of the Finnish general population. Results: The average annual age-standardized incidence rate of type 1 diabetes among men aged 18-39 was 29 per 100,000/year; the incidence rate has increased by 33% from 1992 to 2007. Among women, the incidence remained at 16 per 100,000/year. Among working-aged (18-64) people, the age-standardized prevalence of type 1 diabetes increased by 39% among women and 33% among men. Two out of every three working aged individuals with type 1 diabetes were in the labor force; this is about 10% lower than in the Finnish population. The average age-standardized employment rate among those individuals with type 1 diabetes belonging to the labor force was 82%, compared to 84% in the general population. Working individuals with type 1 diabetes rated their health and work ability as being slightly lower than the general working population, but nonetheless, there were no significant differences in retirement intentions. Conclusions: Between 1992 and 2007, the number of working-aged people and workers with type 1 diabetes increased by 35%. Most workers with type 1 diabetes manage as well at work as the general population. Special attention should be paid to workers with type 1 diabetes when they are diagnosed and/or report moderate or poor work ability.
Individuals with attention-deficit/hyperactivity disorder (ADHD) have difficulties navigating dynamic everyday situations that contain multiple sensory inputs that need to either be attended to or ignored. As conventional experimental tasks lack this type of everyday complexity, we administered a film-based multi-talker condition with auditory distractors in the background. ADHD-related aberrant brain responses to this naturalistic stimulus were identified using intersubject correlations (ISCs)doi:10.1016/j.neuroimage.2019.116352 pmid:31730921 fatcat:b7jf7etofjfaxewbncmxzxr7be
more »... in functional magnetic resonance imaging (fMRI) data collected from 51 adults with ADHD and 29 healthy controls. A novel permutation-based approach introducing studentized statistics and subject-wise voxel-level null-distributions revealed that several areas in cerebral attention networks and sensory cortices were desynchronized in participants with ADHD (n = 20) relative to healthy controls (n = 20). Specifically, desynchronization of the posterior parietal cortex occurred when irrelevant speech or music was presented in the background, but not when irrelevant white noise was presented, or when there were no distractors. We also show regionally distinct ISC signatures for inattention and impulsivity. Finally, post-scan recall of the film contents was associated with stronger ISCs in the default-mode network for the ADHD and in the dorsal attention network for healthy controls. The present study shows that ISCs can further our understanding of how a complex environment influences brain states in ADHD.
Human Brain Mapping
Anniina Koski: Selection, recruitment, and diagnosis of the patients. DATA AVAILABILITY STATEMENT We used codes implemented in FSL toolbox. ... Kimmo Alho: Experiment design; commented the data-analyses. Viljami Salmela: Experiment design; commented the data-analyses. Susanne M. Jaeggi: Experiment design; commented the data-analyses. ...doi:10.1002/hbm.25164 pmid:32813290 pmcid:PMC7643386 fatcat:2tiabw3gcfcg7cq2u7yvkhchju
Blast-phase chronic myeloid leukemia (BP-CML) is associated with additional chromosomal aberrations, RUNX1 mutations being one of the most common. Tyrosine kinase inhibitor therapy has only limited efficacy in BP-CML, and characterization of more defined molecular subtypes is warranted in order to design better treatment modalities for this poor prognosis patient group. Using whole-exome and RNA sequencing we demonstrate that PHF6 and BCORL1 mutations, IKZF1 deletions, and AID/RAG-mediateddoi:10.1038/s41375-020-01011-5 pmid:32782381 fatcat:6kyapf6rsvhftdvehvg6tmwja4
more »... angements are enriched in RUNX1mut BP-CML leading to typical mutational signature. On transcriptional level interferon and TNF signaling were deregulated in primary RUNX1mut CML cells and stem cell and B-lymphoid factors upregulated giving a rise to distinct phenotype. This was accompanied with the sensitivity of RUNX1mut blasts to CD19-CAR T cells in ex vivo assays. High-throughput drug sensitivity and resistance testing revealed leukemia cells from RUNX1mut patients to be highly responsive for mTOR-, BCL2-, and VEGFR inhibitors and glucocorticoids. These findings were further investigated and confirmed in CRISPR/Cas9-edited homozygous RUNX1-/- and heterozygous RUNX1-/mut BCR-ABL positive cell lines. Overall, our study provides insights into the pathogenic role of RUNX1 mutations and highlights personalized targeted therapy and CAR T-cell immunotherapy as potentially promising strategies for treating RUNX1mut BP-CML patients.
Although a great majority of patients with cervical radiculopathy syndrome can successfully be treated non-operatively, a considerable proportion experience persistent symptoms, severe enough to require neurosurgical intervention. During the past decade, cervical spine procedures have increasingly been performed on an outpatient basis and retrospective database analyses have shown this to be feasible and safe. However, there are no randomised controlled studies comparing outpatient care withdoi:10.1136/bmjopen-2019-032575 pmid:31772100 pmcid:PMC6886918 fatcat:oyh3745lerfoxi3llafyuev3l4
more »... atient care, particularly with emphasis on the patients' perception of symptom relief and their ability to return to normal daily activities and work. This is a prospective, randomised, controlled, parallel group non-inferiority trial comparing the traditional hospital surveillance (inpatient, patients staying in the hospital for 1-3 nights after surgery) with outpatient care (discharge on the day of the surgery, usually within 6-8 hours after procedure) in patients who have undergone anterior cervical decompression and fusion procedure. To determine whether early discharge (outpatient care) is non-inferior to inpatient care, we will randomise 104 patients to these two groups and follow them for 6 months using the Neck Disability Index (NDI) as the primary outcome. We expect that early discharge is not significantly worse than the current care in terms of change in NDI. Non-inferiority will be declared if the mean improvement for outpatient care is no worse than the mean improvement for inpatient care, by a margin of 17.3%. We hypothesise that a shorter hospital stay results in more rapid return to normal daily activities, shorter duration of sick leave and decreased secondary costs to healthcare system. Secondary outcomes in our study are arm pain and neck pain using the Numeric Rating Scale, operative success (Odom's criteria), patient's satisfaction to treatment, general quality of life (EQ-5D-5L), Work Ability Score, sickness absence days, return to previous leisure activities and complications. The study was approved by the institutional review board of the Helsinki and Uusimaa Hospital District on 6 June 2019 (1540/2019) and duly registered at ClinicalTrials.gov. We will disseminate the findings of this study through peer-reviewed publications and conference presentations. NCT03979443.
A prospective randomized long-term follow-up study of bioactive glass (BG)-S53P4 and autogenous bone (AB) used as bone graft substitutes in benign bone tumor surgery during 1993-1997 was conducted. Twenty-one patients (11 in the BG group, 10 in the AB group) participated in a 14-year follow-up. X-rays and MRI scans were obtained, and in the BG group, CT scans were also performed. In the BG group, the filled cavity had a dense appearance on X-ray. MRI showed a mainly or partly fatty bone marrow,doi:10.1002/jbm.b.31636 pmid:20524190 fatcat:i43k3g2dgbaorlh6j2ubwzelh4
more »... and in the large bone tumor group, remnants of glass granules were also observed. Increased cortical thickness was seen in nonossifying fibromas and enchondromas. BG-S53P4 is a safe and well-tolerated bone substitute with good long-term results. BG-S53P4 does not disturb the growth of bone in children. V C 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 94B:157-164, 2010.
The wide variety of scientific user communities work with data since many years and thus have already a wide variety of data infrastructures in production today. The aim of this paper is thus not to create one new general data architecture that would fail to be adopted by each and any individual user community. Instead this contribution aims to design a reference model with abstract entities that is able to federate existing concrete infrastructures under one umbrella. A reference model is andoi:10.1186/1869-0238-4-1 fatcat:wq5xiuj56ffvvmkqm7vl2fas7u
more »... stract framework for understanding significant entities and relationships between them and thus helps to understand existing data infrastructures when comparing them in terms of functionality, services, and boundary conditions. A derived architecture from such a reference model then can be used to create a federated architecture that builds on the existing infrastructures that could align to a major common vision. This common vision is named as 'ScienceTube' as part of this contribution that determines the high-level goal that the reference model aims to support. This paper will describe how a well-focused use case around data replication and its related activities in the EUDAT project aim to provide a first step towards this vision. Concrete stakeholder requirements arising from scientific end users such as those of the European Strategy Forum on Research Infrastructure (ESFRI) projects underpin this contribution with clear evidence that the EUDAT activities are bottom-up thus providing real solutions towards the so often only described 'high-level big data challenges'. The followed federated approach taking advantage of community and data centers (with large computational resources) further describes how data replication services enable data-intensive computing of terabytes or even petabytes of data emerging from ESFRI projects.
Executive summary The European collaboration in creating data infrastructures is the key enabler for state-of-the-art research. Novel disruptive innovations and scientific breakthroughs are often born when fragments of data are unified unconventionally. Accessibility and interoperability of various data repositories across geographical and disciplinary borders significantly impact the competitiveness of the European research. Data can be equated with money that has value only if it is used andfatcat:mhlclmizljaj7asocuztw7i4gy
more »... irculated. As the different currencies can be stored in the globally interrelated bank infrastructures, we need persistent, highly available and compatible data infrastructures where data from various disciplines can be stored and fetched from. Although several progressive and collaborative data initiatives, launched, e.g., by the ESFRI roadmap, are under way, the field remains compartmentalised. This hinders adjacent user communities and data service providers to learn from each other and fully benefit from the best practices. The ultimate consequences are financial due to overlapping work. This White Paper suggests a European strategy for data related services and outlines a persistent, multidisciplinary European Data Infrastructure, based on the needs of user communities. Seamless collaboration between the user communities, data service providers, various ongoing data initiatives, industrial partners, and financial bodies is the prerequisite for a cost-effective and obliging data infrastructure. We propose a governance structure where the user communities, data service providers and funding bodies work closely together, and we present a model for roles and responsibilities of the communities and service providers. Furthermore, the congruent and consolidative interests with academic and industrial stakeholders are identified and discussed. Building of mutual trust among all stakeholders is of utmost importance to realise the European data infrastructure strategy. The following objectives are essential: Develop and improve common data services Establish and nurture a close collaboration among user communities in a data service infrastructure Establish a common persistent European data service infrastructure, taking into account the requirements of the different user communities. Sustainable national funding is fundamental since data typically preserves far beyond the technology cycles. The impacts from a permanent European Data Infrastructure include: Strengthening European competitiveness as the infrastructure enables lateral research and innovation Increasing the usability of data from high cost or long-lasting experiments, computational simulations, observations and cultural repositories Enhancing worldwide interoperability in science and research by establishing a leading common European data services infrastructure Defining standards or de-facto standards for data service providers (exchange of data, communication between service providers, meta data structure) Giving an excellent example of how science can meet the industry expectations. This White Paper has been produced in coordination with the members of the data initiative PARADE (the Partnership for Accessing Data in Europe). 2
Media & viestintä
Koski 1998) ja teknopälpätyksen (vrt. ...doaj:66e8c33830074170be9e40af6ac0f0f5 fatcat:httt4sz6t5h6zeitndl2kvjiqy
Linjaus oli osa kaupungin laajempaa strategiaa edistää toiminnoiltaan sekoittunutta kaupunkirakennetta ja se koski kaikkea maankäyttöä, ei vain asuinkohteita. ... Kimmo Kurunmäki & Aija Tasa Kirjoittajat työskentelevät RAKLI ry:ssä, Kimmo Kurunmäki yhdyskunta ja infran ja Aija Tasa asumisen johtajana. ...doi:10.33357/ys.95394 fatcat:eld7r7xbjragrafoypqac3nhcq
LÄHTEET KUUSELA, KIMMO 2005: Open access ja tieteellisen julkaisemisen avoimuus. -Acatiimi 8(3): 26-27. ... Teemanumeron ovat toimittaneet toimituskunnan kuolema-tutkijat Kaarina Koski ja Outi Fingerroos. Kokoelman aloittaa pitkän linjan kuolema-asiantuntijan, professori Juha Pentikäisen kolumni. ...doi:10.30666/elore.78491 fatcat:5zv72kcffzcbnmmttpbvjtfyi4
Media & viestintä
SALMINEN, Kimmo Nuorten ja varhaisnuorten musiikkimaku keväällä 1990. -Helsinki : Yleisradio, 1990. -60 s. -(Yleisradio, Tutkimus-ja kehitysosasto, Sarja B, 1990, 4). ... Heiskanen: Televisio-ohjelmiin viettymisestä, katselun nautinnosta ja ilosta; Jussi Tuormaa: Nuorten kuvat, sanat ja tarinat; Tuike Alitalo: Nautintoa ja kapinaa-(naisena) kuvaruudun äärellä; Markku Koski ...doaj:4ecffae3a2e34982a892aa2a5b4fa530 fatcat:7qy7bkelqraplds7ey5eh24bua
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