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Motif switches: decision-making in cell regulation

Kim Van Roey, Toby J Gibson, Norman E Davey
<span title="">2012</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/uzv6ve6frfevrcjkqzfvw36bfu" style="color: black;">Current Opinion in Structural Biology</a> </i> &nbsp;
Acknowledgements This work was supported by an FP7 Health grant (No. 242129; SyBoSS) from the European Commission (to Kim Van Roey) and an EMBL Interdisciplinary PostDoc fellowship (EIPOD) (to Norman E  ...  Roey, Gibson and Davey 383 www.sciencedirect.com Current Opinion in Structural Biology 2012, 22:378-385 Motif switches: decision-making in cell regulation Van Roey, Gibson and Davey 385 www.sciencedirect.com  ...  Dinkel H, Michael S, Weatheritt RJ, Davey NE, Van Roey K, Altenberg B, Toedt G, Uyar B, Seiler M, Budd A et al.: ELM -the database of eukaryotic linear motifs.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.sbi.2012.03.004">doi:10.1016/j.sbi.2012.03.004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22480932">pmid:22480932</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/62b5o5qvsvgc7dzr3lxikbqc2e">fatcat:62b5o5qvsvgc7dzr3lxikbqc2e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170808160751/http://www.bio-toolkit.com/media/journal_club/pdfs/1-s2.0-s0959440x12000401-main.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/52/94/52946b651906eedb5c49ef1418a241aff9bc38c7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.sbi.2012.03.004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation

Kim Van Roey, Norman E. Davey
<span title="">2015</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/pbps77kxyzcydcpqkgnedc5jae" style="color: black;">Cell Communication and Signaling</a> </i> &nbsp;
Roey and Davey Cell Communication and Signaling (2015) 13:45 Motif Motif sequence Binding domain/partner Function Protein short linear motifs Cyclin docking motif [187] 19 RRLF 22 Cyclin fold  ...  Roey and Davey Cell Communication and Signaling (2015) 13:45 CDX binding site [167] Three TTTAT within −471 to −434 Homeobox domain of Homeobox protein CDX-2 Activation of p21 gene transcription by  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12964-015-0123-9">doi:10.1186/s12964-015-0123-9</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26626130">pmid:26626130</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4666095/">pmcid:PMC4666095</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/beiixrnpk5dd3jiw5jx6qzst7i">fatcat:beiixrnpk5dd3jiw5jx6qzst7i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170809115515/https://biosignaling.biomedcentral.com/track/pdf/10.1186/s12964-015-0123-9?site=biosignaling.biomedcentral.com" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/56/dd/56dd9cefd34c4d9a000f4df62fa6b74bc040e581.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12964-015-0123-9"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666095" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Capturing cooperative interactions with the PSI-MI format

Kim Van Roey, Sandra Orchard, Samuel Kerrien, Marine Dumousseau, Sylvie Ricard-Blum, Henning Hermjakob, Toby J. Gibson
<span title="2013-01-01">2013</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ejkvir3kzbdojf5kygupkidsca" style="color: black;">Database: The Journal of Biological Databases and Curation</a> </i> &nbsp;
The complex biological processes that control cellular function are mediated by intricate networks of molecular interactions. Accumulating evidence indicates that these interactions are often interdependent, thus acting cooperatively. Cooperative interactions are prevalent in and indispensible for reliable and robust control of cell regulation, as they underlie the conditional decision-making capability of large regulatory complexes. Despite an increased focus on experimental elucidation of the
more &raquo; ... molecular details of cooperative binding events, as evidenced by their growing occurrence in literature, they are currently lacking from the main bioinformatics resources. One of the contributing factors to this deficiency is the lack of a computerreadable standard representation and exchange format for cooperative interaction data. To tackle this shortcoming, we added functionality to the widely used PSI-MI interchange format for molecular interaction data by defining new controlled vocabulary terms that allow annotation of different aspects of cooperativity without making structural changes to the underlying XML schema. As a result, we are able to capture cooperative interaction data in a structured format that is backward compatible with PSI-MI-based data and applications. This will facilitate the storage, exchange and analysis of cooperative interaction data, which in turn will advance experimental research on this fundamental principle in biology. Database URL: http://psi-mi-cooperativeinteractions.embl.de/ .
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/database/bat066">doi:10.1093/database/bat066</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24067240">pmid:24067240</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3782717/">pmcid:PMC3782717</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/whkmaq6mmnhwvh3jvpdanjvwby">fatcat:whkmaq6mmnhwvh3jvpdanjvwby</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180730102038/https://watermark.silverchair.com/bat066.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAb4wggG6BgkqhkiG9w0BBwagggGrMIIBpwIBADCCAaAGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMM1tdtdou41lDyYh0AgEQgIIBcd2LeD58_Fbm0EZg2YTqph3Lhbn3T1suTqqzndRAUt39fUjpefpzy4dI5sHC_hHgB5OVe5MqBCG-7XfPbuJKYpkfyEHRoOtXfBlk9hizzNErZ0lMTPffIW0Jkok-ycoB3MqNZicdel_o_uVfYpfyYJ4xfQddQxnyAjVJUHoMfVn6FllLUsQEI-E2Ks8Zj6QhIUxTfR_gA064ac4P8hHYzDLI58k6Vzdeza3zjWbrosV646mK_LQjHKubOJV6UuErxRhnHcIEzvYM8amS7tUZQAPZlmr7H8kLEZUgg5cVcWjLlLggBNTX-eA5lXt-aPQF1PDtV9SidwcEFQfAJHrw1lDCg2s8PWdz2Y9b6z8k-QxzMpJ-edh42c_FN7ACf6XRHNrLXPFcEAeq5F3UYxqZ8zk8_bMFyF4SugsKpRWvLhyfowg0ts0SLMI-aW8foRDiVe8q5pOuQdhduZmy_mb-0eTqWLJoEKs2MjSUJgwsdDjE2A" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c1/61/c161387345d46640844961c7caaa6a760836bc06.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/database/bat066"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782717" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad

Toby J. Gibson, Holger Dinkel, Kim Van Roey, Francesca Diella
<span title="2015-11-18">2015</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/pbps77kxyzcydcpqkgnedc5jae" style="color: black;">Cell Communication and Signaling</a> </i> &nbsp;
It has become clear in outline though not yet in detail how cellular regulatory and signalling systems are constructed. The essential machines are protein complexes that effect regulatory decisions by undergoing internal changes of state. Subcomponents of these cellular complexes are assembled into molecular switches. Many of these switches employ one or more short peptide motifs as toggles that can move between one or more sites within the switch system, the simplest being on-off switches.
more &raquo; ... doxically, these motif modules (termed short linear motifs or SLiMs) are both hugely abundant but difficult to research. So despite the many successes in identifying short regulatory protein motifs, it is thought that only the "tip of the iceberg" has been exposed. Experimental and bioinformatic motif discovery remain challenging and error prone. The advice presented in this article is aimed at helping researchers to uncover genuine protein motifs, whilst avoiding the pitfalls that lead to reports of false discovery.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12964-015-0121-y">doi:10.1186/s12964-015-0121-y</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26581338">pmid:26581338</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4652402/">pmcid:PMC4652402</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/w5wodctemndmhdmsjcoljcruxa">fatcat:w5wodctemndmhdmsjcoljcruxa</a> </span>
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Spatial clustering and risk factors of malaria infections in Ratanakiri Province, Cambodia

Vincent Sluydts, Somony Heng, Marc Coosemans, Karel Van Roey, Charlotte Gryseels, Lydie Canier, Saorin Kim, Nimol Khim, Sovannaroth Siv, Vanna Mean, Sambunny Uk, Koen Grietens (+3 others)
<span title="">2014</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/52kcjpkb45hmrlgxcm4joetsym" style="color: black;">Malaria Journal</a> </i> &nbsp;
Anna-Rosanas Urgell and Frederick Van den Broeck are acknowledged for their support in the interpretation of the genotyping results.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1475-2875-13-387">doi:10.1186/1475-2875-13-387</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25269827">pmid:25269827</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4190307/">pmcid:PMC4190307</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rpytxduyd5fvzogx4hk3alshui">fatcat:rpytxduyd5fvzogx4hk3alshui</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190320155323/https://core.ac.uk/download/pdf/58762867.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/62/a4/62a43c7356e297ac805046f54a0213a3652d05f5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1475-2875-13-387"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190307" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The eukaryotic linear motif resource ELM: 10 years and counting

Holger Dinkel, Kim Van Roey, Sushama Michael, Norman E. Davey, Robert J. Weatheritt, Diana Born, Tobias Speck, Daniel Krüger, Gleb Grebnev, Marta Kubań, Marta Strumillo, Bora Uyar (+8 others)
<span title="2013-11-07">2013</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hfp6p6inqbdexbsu4r7usndpte" style="color: black;">Nucleic Acids Research</a> </i> &nbsp;
The eukaryotic linear motif (ELM http://elm.eu.org) resource is a hub for collecting, classifying and curating information about short linear motifs (SLiMs). For >10 years, this resource has provided the scientific community with a freely accessible guide to the biology and function of linear motifs. The current version of ELM contains $200 different motif classes with over 2400 experimentally validated instances manually curated from >2000 scientific publications. Furthermore, detailed
more &raquo; ... ion about motif-mediated interactions has been annotated and made available in standard exchange formats. Where appropriate, links are provided to resources such as switches.elm.eu.org and KEGG pathways.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/nar/gkt1047">doi:10.1093/nar/gkt1047</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24214962">pmid:24214962</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3964949/">pmcid:PMC3964949</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/boz7kpa2xfb2dkjhffkva4racm">fatcat:boz7kpa2xfb2dkjhffkva4racm</a> </span>
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An innovative tool for moving malaria PCR detection of parasite reservoir into the field

Lydie Canier, Nimol Khim, Saorin Kim, Vincent Sluydts, Somony Heng, Dany Dourng, Rotha Eam, Sophy Chy, Chanra Khean, Kaknika Loch, Malen Ken, Hokkean Lim (+14 others)
<span title="">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/52kcjpkb45hmrlgxcm4joetsym" style="color: black;">Malaria Journal</a> </i> &nbsp;
To achieve the goal of malaria elimination in low transmission areas such as in Cambodia, new, inexpensive, high-throughput diagnostic tools for identifying very low parasite densities in asymptomatic carriers are required. This will enable a switch from passive to active malaria case detection in the field. Methods: DNA extraction and real-time PCR assays were implemented in an "in-house" designed mobile laboratory allowing implementation of a robust, sensitive and rapid malaria diagnostic
more &raquo; ... tegy in the field. This tool was employed in a survey organized in the context of the MalaResT project (NCT01663831). Results: The real-time PCR screening and species identification assays were performed in the mobile laboratory between October and November 2012, in Rattanakiri Province, to screen approximately 5,000 individuals in less than four weeks and treat parasite carriers within 24-48 hours after sample collection. An average of 240 clinical samples (and 40 quality control samples) was tested every day, six/seven days per week. Some 97.7% of the results were available <24 hours after the collection. A total of 4.9% were positive for malaria. Plasmodium vivax was present in 61.1% of the positive samples, Plasmodium falciparum in 45.9%, Plasmodium malariae in 7.0% and Plasmodium ovale in 2.0%. Conclusions: The operational success of this diagnostic set-up proved that molecular testing and subsequent treatment is logistically achievable in field settings. This will allow the detection of clusters of asymptomatic carriers and to provide useful epidemiological information. Fast results will be of great help for staff in the field to track and treat asymptomatic parasitaemic cases. The concept of the mobile laboratory could be extended to other countries for the molecular detection of malaria or other pathogens, or to culture vivax parasites, which does not support long-time delay between sample collection and culture.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1475-2875-12-405">doi:10.1186/1475-2875-12-405</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24206649">pmid:24206649</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3829804/">pmcid:PMC3829804</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jnpz3h24ufgnle4vibeqpqdkka">fatcat:jnpz3h24ufgnle4vibeqpqdkka</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201107144123/https://doc.anet.be/docman/docman.phtml?file=.irua.ddd1e4.133692.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/63/f5/63f5bf7a116f8ff5cdc922e719653777a03f6ae4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1475-2875-12-405"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829804" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

ELM 2016—data update and new functionality of the eukaryotic linear motif resource

Holger Dinkel, Kim Van Roey, Sushama Michael, Manjeet Kumar, Bora Uyar, Brigitte Altenberg, Vladislava Milchevskaya, Melanie Schneider, Helen Kühn, Annika Behrendt, Sophie Luise Dahl, Victoria Damerell (+12 others)
<span title="2015-11-28">2015</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hfp6p6inqbdexbsu4r7usndpte" style="color: black;">Nucleic Acids Research</a> </i> &nbsp;
The Eukaryotic Linear Motif (ELM) resource (http: //elm.eu.org) is a manually curated database of short linear motifs (SLiMs). In this update, we present the latest additions to this resource, along with more improvements to the web interface. ELM 2016 contains more than 240 different motif classes with over 2700 experimentally validated instances, manually curated from more than 2400 scientific publications. In addition, more data have been made available as individually searchable pages and are downloadable in various formats.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/nar/gkv1291">doi:10.1093/nar/gkv1291</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26615199">pmid:26615199</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4702912/">pmcid:PMC4702912</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hobd55xn4bdu5dxvwlyh6ihcda">fatcat:hobd55xn4bdu5dxvwlyh6ihcda</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190307191645/http://pdfs.semanticscholar.org/e5b3/7ac8eca08104ce1f7a845b961cad87008599.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e5/b3/e5b37ac8eca08104ce1f7a845b961cad87008599.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/nar/gkv1291"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702912" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Efficacy of topical mosquito repellent (picaridin) plus long-lasting insecticidal nets versus long-lasting insecticidal nets alone for control of malaria: a cluster randomised controlled trial

Vincent Sluydts, Lies Durnez, Somony Heng, Charlotte Gryseels, Lydie Canier, Saorin Kim, Karel Van Roey, Karen Kerkhof, Nimol Khim, Sokny Mao, Sambunny Uk, Siv Sovannaroth (+4 others)
<span title="">2016</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kowyypahlzcqxlzyk7nwiadqie" style="color: black;">Lancet. Infectious Diseases (Print)</a> </i> &nbsp;
Although eff ective topical repellents provide personal protection against malaria, whether mass use of topical repellents in addition to long-lasting insecticidal nets can contribute to a further decline of malaria is not known, particularly in areas where outdoor transmission occurs. We aimed to assess the epidemiological effi cacy of a highly eff ective topical repellent in addition to long-lasting insecticidal nets in reducing malaria prevalence in this setting. Methods A cluster randomised
more &raquo; ... controlled trial was done in the 117 most endemic villages in Ratanakiri province, Cambodia, to assess the effi cacy of topical repellents in addition to long-lasting insecticidal nets in controlling malaria in a low-endemic setting. We did a pre-trial assessment of village accessibility and excluded four villages because of their inaccessibility during the rainy season. Another 25 villages were grouped because of their proximity to each other, resulting in 98 study clusters (comprising either a single village or multiple neighbouring villages). Clusters were randomly assigned (1:1) to either a control (long-lasting insecticidal nets) or intervention (long-lasting insecticidal nets plus topical repellent) study group after a restricted randomisation. All clusters received one long-lasting insecticidal net per individual, whereas those in the intervention group also received safe and eff ective topical repellents (picaridin KBR3023, SC Johnson, Racine, WI, USA), along with instruction and promotion of its daily use. Cross-sectional surveys of 65 randomly selected individuals per cluster were done at the beginning and end of the malaria transmission season in 2012 and 2013. The primary outcome was Plasmodium species-specifi c prevalence in participants obtained by real-time PCR, assessed in the intention-to-treat population. Complete safety analysis data will be published seperately; any ad-hoc adverse events are reported here. This trial is registered with ClinicalTrials.gov, number NCT01663831. Findings Of the 98 clusters that villages were split into, 49 were assigned to the control group and 49 were assigned to the intervention group. Despite having a successful distribution system, the daily use of repellents was suboptimum. No post-intervention diff erences in PCR plasmodium prevalence were observed between study groups in 2012 (4·91% in the control group vs 4·86% in the intervention group; adjusted odds ratio [aOR] 1·01 [95% CI 0·60-1·70]; p=0·975) or in 2013 (2·96% in the control group vs 3·85% in the intervention group; aOR 1·31 [0·81-2·11]; p=0·266). Similar results were obtained according to Plasmodium species (1·33% of participants in the intervention group vs 1·10% in the intervention group were infected with Plasmodium falciparum; aOR 0·83 [0·44-1·56]; p=0·561; and 1·85% in the control group vs 2·67% in the intervention group were infected with Plasmodium vivax; aOR 1·51 [0·88-2·57]; p=0·133). 41 adverse event notifi cations from nine villages were received, of which 33 were classifi ed as adverse reactions (11 of these 33 were cases of repellent abuse through oral ingestion, either accidental or not). All participants with adverse reactions fully recovered and 17 were advised to permanently stop using the repellent. Interpretation Mass distribution of highly eff ective topical repellents in resource-suffi cient conditions did not contribute to a further decline in malaria endemicity in a pre-elimination setting in the Greater Mekong subregion. Daily compliance and appropriate use of the repellents remains the main obstacle.
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The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

Sandra Orchard, Mais Ammari, Bruno Aranda, Lionel Breuza, Leonardo Briganti, Fiona Broackes-Carter, Nancy H. Campbell, Gayatri Chavali, Carol Chen, Noemi del-Toro, Margaret Duesbury, Marine Dumousseau (+23 others)
<span title="2013-11-13">2013</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hfp6p6inqbdexbsu4r7usndpte" style="color: black;">Nucleic Acids Research</a> </i> &nbsp;
IntAct (freely available at http://www.ebi.ac.uk/ intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMExand MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. Members of the IntAct team supply appropriate
more &raquo; ... s of training, perform quality control on entries and take responsibility for long-term data maintenance. Recently, the MINT and IntAct databases decided to merge their separate efforts to make optimal use of limited developer resources and maximize the curation output. All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset. Both IntAct and MINT are active contributors to the IMEx consortium
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A Stereochemical Rationale for the Activity of Anti-HIV Nucleosides

E. W. Taylor, P. Van Roey, R. F. Schinazi, C. K. Chu
<span title="">1990</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4dicye2cvvcyrj2rzu3bmk2pwi" style="color: black;">Antiviral Chemistry &amp; Chemotherapy</a> </i> &nbsp;
In the crystallographic observations of active anti-HIV compounds by Van Roey and collaborators (Van Roey et al., 1988; Chu et a/., 1989a; Van Roey et a/., 1989), out of all the observations having P >  ...  Van Roey, R. F. Schinazi and C. K. Chu Fig. 6.  ... 
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Absolute Configuration of the Antiviral Agent (−)-cis-5-Fluoro-1-[2-Hydroxymethyl)-1,3-Oxathiolan-5-yl]Cytosine

P. van Roey, W. A. Pangborn, R. F. Schinazi, G. Painter, D. C. Liotta
<span title="">1993</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4dicye2cvvcyrj2rzu3bmk2pwi" style="color: black;">Antiviral Chemistry &amp; Chemotherapy</a> </i> &nbsp;
Kim, H.O., Ahn, S.K., Alves, A.J., Beach, J.W., Jeong, L.S., Choi, B.G., Van Roey, P., Schinazi, R.F., and Chu, C.K. (1992).  ...  Roey et al.  ... 
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Page 1852 of Linguistics and Language Behavior Abstracts: LLBA Vol. 24, Issue 4 [page]

<span title="">1990</span> <i > <a target="_blank" rel="noopener" href="https://archive.org/details/pub_linguistics-and-language-behavior-abstracts-llba" style="color: black;">Linguistics and Language Behavior Abstracts: LLBA </a> </i> &nbsp;
False Fonds), 2 Langage et l'Homme, 1990, 25, 1, Mar, FRE/FRE 90103487 Van Roey, Jacques, 0888-8027/90 $1.50 Granger, Sylviane & Swallow, Helen Manning, Alain (Rev) 1989 Dictionnaire des faux-amis fi  ...  g Case in the ae of English, Lingua, 1990, 81, 1, May, 100. 90103486 Van Roey, Jacques, G , Sylviane & Swallow, Helen Loriaux, Christian (Rev) oe Dictionnaire des faux-amis oy tym (Dictionary of French-English  ... 
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The Crystal and Molecular Structure of 3′-Fluoro-3′-Deoxythymidine, a Potent Anti-HIV-1 Nucleoside

P. Van Roey, R. F. Schinazi
<span title="">1990</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4dicye2cvvcyrj2rzu3bmk2pwi" style="color: black;">Antiviral Chemistry &amp; Chemotherapy</a> </i> &nbsp;
Van Roey and R. F.  ...  Van Roey and R. F.  ... 
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Conformational Analysis of Substituent Effects on the Sugar Puckering Mode and the anti-HIV Activity of 2′,3′-Dideoxypyrimidine Nucleosides

D. H. Everaert, O. M. Peeters, C. J. De Ranter, N. M. Blaton, A. van Aerschot, P. Herdewijn
<span title="">1993</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4dicye2cvvcyrj2rzu3bmk2pwi" style="color: black;">Antiviral Chemistry &amp; Chemotherapy</a> </i> &nbsp;
The gauche effect Concerning the influence of C3’-substituents on the conformation of nucleosides Van Roey et al. (1989) and Final heat of formation (kcal mot™') “1 | 6!  ...  Taylor, E.W., Van Roey, P., Schinazi, R.F., and Chu, C.K. (1990) A stereochemical rationale for the activity of anti-HIV nucleo- sides. Antiviral Chem Chemother 1: 163-173.  ... 
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