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Plant Communities Suitable for Green Roofs in Arid Regions
2018
Sustainability
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In extensive green roof settings, plant communities can be more robust than monocultures. ...
In addition, native plants might be hardier and more ecologically sound choices than non-native plants in green roof systems. ...
To date, few green roofs exist in the desert southwest region of the US, and few studies have explored the use of green roof plants for this zone. ...
doi:10.3390/su10061755
fatcat:3jn24dxj5ndgngbem2aijqwlqi
Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Dendritic Cell Maturation and Function
2018
Frontiers in Immunology
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We found a predominant association between MSC-EVs and DCs detected by the fluorescence staining overlap of PKH26 labeled MSC-EVs (red) and HLA-DR labeled DCs (green). ...
Representative images from confocal microscopy showing that EV-PKH26 + labeled MSC-EVs (red) are closely associated with DCs (green). No uptake of MSC-EVs by CD3 + T cells (blue) was detected. ...
doi:10.3389/fimmu.2018.02538
pmid:30473695
pmcid:PMC6237916
fatcat:qkmuc3j4avasnpowqhpni4uul4
Early Molecular Stratification of High-risk Primary Biliary Cholangitis
2016
EBioMedicine
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Pathological Scoring The scoring of pathological specimens was simultaneously performed by two pathologists (JGB and DGT) using H&E, Orcein and Sirius red fast green histological stains. ...
doi:10.1016/j.ebiom.2016.11.021
pmid:27913155
pmcid:PMC5161439
fatcat:3rgb5aucafavfgtdwuli7je7cu
Expression of Serum microRNAs is Altered During Acute Graft-versus-Host Disease
2017
Frontiers in Immunology
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Xiao et al. based their assessment on Sybr-green dye, which lacks specificity in comparison to the TaqMan low-density array employed by Gimondi et al. (17) . ...
doi:10.3389/fimmu.2017.00308
pmid:28392786
pmcid:PMC5364146
fatcat:43x6eh64ozhddpzvgvnjm35uvy
Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace
2019
Nature Communications
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square), intermediate (divided green square) and non-classical (open green square) monocytes. ...
blood and arise independently of monocyte- Fig. 3 CD1c + DCs in LPS-BAL are likely to be tissue-recruited blood CD1c + DCs. a Expression of surface antigens by flow cytometry on DC2/3 from HC blood (green ...
doi:10.1038/s41467-019-09913-4
pmid:31040289
pmcid:PMC6491485
fatcat:hvewjfqm2jevfp3v7hcz5ewjp4
Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis
2021
Journal of Immunology
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Right graph:The sedentary group (green line) shows a higher n6/n3 ratio correlates with a higher number of B220 + , B cells. ...
(G) SPSS correlations: Left graph: In the sedentary group (green line), a higher number of CD3 cells positively correlates with a higher n6/n3 ratio of PCs. ...
doi:10.4049/jimmunol.2001022
pmid:33441438
pmcid:PMC7851741
fatcat:ck74cttwlnearn6eemyvcevgki
Care pathway and prioritization of rapid testing for COVID-19 in UK hospitals: a qualitative evaluation
2021
BMC Health Services Research
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Following the results, the patients were cohorted accordingly into Red, Pink, Yellow, Green, or Hyper Green zones. Zones donated as a different colour, i.e. ...
In general, these areas can be split into 3 categories: Green, Yellow, and Red. ...
doi:10.1186/s12913-021-06460-x
pmid:34059036
fatcat:kh54bshhc5hkngvpqgcxdxajbi
Donor monocyte-derived macrophages promote human acute graft versus host disease
[article]
2019
biorxiv/medrxiv
pre-print
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(B) Whole-mount immunofluorescence of dermis from healthy controls and patients with GVHD, as indicated with antibodies to CD3 (red), CD11c, (green), and FXIIIA (blue). Scale bar: 50 μm. ...
doi:10.1101/787036
fatcat:ivqqmyxmgfdxvb3dywmp4mubjy
Utility of Routine Laboratory Biomarkers to Detect COVID-19: A Systematic Review and Meta-Analysis
2021
Viruses
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No routine laboratory biomarkers perform well enough in diagnosing COVID-19 in isolation for them to be used as a standalone diagnostic test or to help clinicians prioritize patients for treatment. Instead, other diagnostic tests are needed. The aim of this work was to statistically summarise routine laboratory biomarker measurements in COVID-19-positive and -negative patients to inform future work. A systematic literature review and meta-analysis were performed. The search included names of
doi:10.3390/v13050803
pmid:33946171
fatcat:yorrxetpbzgazmrh7wv7d7wbzy
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... monly used, routine laboratory tests in the UK NHS, and focused on research papers reporting laboratory results of patients diagnosed with COVID-19. A random effects meta-analysis of the standardized mean difference between COVID-19-positive and -negative groups was conducted for each biomarker. When comparing reported laboratory biomarker results, we identified decreased white blood cell, neutrophil, lymphocyte, eosinophil, and platelet counts; while lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase were elevated in COVID-19-positive compared to COVID-19-negative patients. Differences were identified across a number of routine laboratory biomarkers between COVID-19-positive and -negative patients. Further research is required to identify whether routine laboratory biomarkers can be used in the development of a clinical scoring system to aid with triage of patients.
Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response
2018
Nature Immunology
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Real-time PCR product was detected with SYBR Green (Life) measured continuously with a ViiA 7 Real-
Immunoglobulin sequencing and analysis Mice were treated twice with DMBA or TPA to the dorsal side ...
doi:10.1038/s41590-018-0161-8
pmid:30013146
pmcid:PMC6071860
fatcat:4mwvaqhb2nfa5ig73cie3a6tny
Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans
2020
Immunity
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The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the classical DC lineages cDC1 and cDC2. In humans, cDC2-related subsets have been described including AXL+SIGLEC6+ pre-DC, DC2 and DC3. The origin of this heterogeneity is unknown. Using high-dimensional analysis, in vitro differentiation, and an allelic series of human IRF8
doi:10.1016/j.immuni.2020.07.003
pmid:32735845
pmcid:PMC7447982
fatcat:vzz2mvd625dtdpntsb25hs2aqa
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... deficiency, we demonstrated that cDC2 (CD1c+DC) heterogeneity originates from two distinct pathways of development. The lymphoid-primed IRF8hi pathway, marked by CD123 and BTLA, carried pDC, cDC1, and DC2 trajectories, while the common myeloid IRF8lo pathway, expressing SIRPA, formed DC3s and monocytes. We traced distinct trajectories through the granulocyte-macrophage progenitor (GMP) compartment showing that AXL+SIGLEC6+ pre-DCs mapped exclusively to the DC2 pathway. In keeping with their lower requirement for IRF8, DC3s expand to replace DC2s in human partial IRF8 deficiency.
FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study
[article]
2020
medRxiv
pre-print
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Point-of-care (POC) tests for COVID-19 could relieve pressure on isolation resource, support infection prevention and control, and help commence more timely and appropriate treatment. We aimed to undertake a systematic review and pooled diagnostic test accuracy study of available individual patient data (IPD) to evaluate the diagnostic accuracy of a commercial POC test (FebriDx) in patients with suspected COVID-19. Methods: A literature search was performed on the 1st of October 2020 to
doi:10.1101/2020.10.15.20213108
fatcat:24dpgklru5fydpr6y2eqsmyxsm
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... studies reporting diagnostic accuracy statistics of the FebriDx POC test versus real time reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2. Studies were screened for risk of bias. IPD were sought from studies meeting the inclusion and exclusion criteria. Logistic regression was performed to investigate the study effect on the outcome of the RT-PCR test result in order to determine whether it was appropriate to pool results. Diagnostic accuracy statistics were calculated with 95% confidence intervals (CIs). Results: 15 studies were screened, and we included two published studies with 527 hospitalised patients. 523 patients had valid FebriDx results for Myxovirus resistance protein A (MxA), an antiviral host response protein. The FebriDx test produced a pooled sensitivity of 0.920 (95% CI: 0.875-0.950) and specificity of 0.862 (0.819-0.896) compared with RT-PCR, where there was an estimated true COVID-19 prevalence of 0.405 (0.364-0.448) and overall FebriDx test yield was 99.2%. Patients were tested at a median of 4 days [interquartile range: 2:9] after symptom onset. No differences were found in a sub-group analysis of time tested since the onset of symptoms. Conclusions: Based on a large sample of patients from two studies during the first wave of the SARS-CoV-2 pandemic, the FebriDx POC test had reasonable diagnostic accuracy in a hospital setting with high COVID-19 prevalence, out of influenza season. More research is required to determine how FebriDx would perform in other healthcare settings with higher or lower COVID-19 prevalence, different patient populations, or when other respiratory infections are in circulation.
Impact of Alemtuzumab Scheduling on Graft-versus-Host Disease after Unrelated Donor Fludarabine and Melphalan Allografts
2017
Biology of Blood and Marrow Transplantation
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Authorship contributions Kile Green analyzed data and produced figures Kim Pearce performed statistical analysis Rob S Sellar provided clinical data Laura Jardine analyzed data and produced figures Phillip ...
doi:10.1016/j.bbmt.2017.02.007
pmid:28212937
fatcat:kbbgsewjbfdllncuthyl5l27sm
How to Ease the Pain of Taking a Diagnostic Point of Care Test to the Market: A Framework for Evidence Development
2020
Micromachines
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Products below the diagonal green line (D1) may provide an opportunity for savings, while those above the line may not be good value. ...
The green diagonal line shows the threshold above which the product would be considered poor value (B1), and below which it would be considered good value (B2). ...
doi:10.3390/mi11030291
pmid:32164393
pmcid:PMC7142698
fatcat:ohj35m3aorbhjd2tj24g3n5eba
Human Dermal CD14 + Cells Are a Transient Population of Monocyte-Derived Macrophages
2014
Immunity
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(D) Pseudocolor images of whole-mount skin immunostained for LYVE-1 (green), CD209 (DCSIGN) (red), and FXIIIa (blue). ...
Lower panel; T48 depicts HLA-DR + (green) cells mainly located within lymphatic vessels but DCSIGN + cells are outside the lymphatic vessels. ...
doi:10.1016/j.immuni.2014.08.006
pmid:25200712
pmcid:PMC4175180
fatcat:v5x4pjwkpffr3i4hypff5c4rvq
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