5,137 Hits in 3.3 sec

Judge Posner, Judge Wilkinson, and Judicial Critique of Constitutional Theory

Marc O. DeGirolami, Kevin C. Walsh
2014 Social Science Research Network  
But both Posner and Wilkinson also deny that they are offering a theory at all. This is puzzling.  ...  Harvie Wilkinson III has lambasted constitutional theory for the way in which its "cosmic" aspirations threaten democratic self-governance. Many other judges hold similar views.  ...  Kevin C.  ... 
doi:10.2139/ssrn.2399487 fatcat:ctchvhfue5gczn753ibda234jq

Modification and movement

Kevin A. Wilkinson, Filip Konopacki, Jeremy M. Henley
2012 Communicative & Integrative Biology  
doi:10.4161/cib.19195 pmid:22808340 pmcid:PMC3376071 fatcat:lrvwwgc7lzcxtgr4ztbj7rfc5y

When are metal complexes bioavailable?

Chun-Mei Zhao, Peter G.C. Campbell, Kevin J. Wilkinson
2016 Environmental Chemistry  
Kevin J. Wilkinson is a Professor at the Universite ´de Montre ´al. His research is aimed at gaining a molecular-level understanding of contaminant bioavailability and mobility.  ...  Kevin is currently an Editor of Environmental Chemistry.  ... 
doi:10.1071/en15205 fatcat:z2hvnnt6lfgltiey4cmrbamic4

Ubiquitin regulation of neuronal excitability

Sriharsha Kantamneni, Kevin A Wilkinson, Jeremy M Henley
2011 Nature Neuroscience  
Sriharsha Kantamneni, Kevin A. Wilkinson and Jeremy M.  ...  Notably, both octopamine signaling and Sriharsha Kantamneni, Kevin A Wilkinson & Jeremy M Henley Demonstrating the common mechanism of proteasome-dependent degradation of ion channels, two studies in  ... 
doi:10.1038/nn0211-126 pmid:21270777 pmcid:PMC3308140 fatcat:fp5nufslpff2fm224r3tkkthcq

Bioavailability and toxicity of manufactured nanomaterials

Jason M. Unrine, Jamie Lead, Kevin J. Wilkinson
2014 Environmental Chemistry  
Unrine, Jamie Lead, Kevin J. Wilkinson Editors, Environmental Chemistry  ... 
doi:10.1071/env11n3_fo fatcat:ua5ind6yuzgyjijfyquitmenve

Effects of Deception on Exercise Performance

2012 Medicine & Science in Sports & Exercise  
Purpose: The aim of this study was to investigate whether it was possible to reduce the time taken to complete a 4000-m cycling time trial by misleading participants into believing they were racing against a previous trial, when, in fact, the power output was 2% greater. Methods: Nine trained male cyclists each completed four 4000-m time trials. The first trial was a habituation and the data from the second trial was used to form a baseline (BL). During trials 3 and 4, participants raced
more » ... an avatar, which they were informed represented their BL performance. However, whereas one of these trials was an accurate (ACC) representation of BL, the power output in the other trial was set at 102% of BL and formed the deception condition (DEC). Oxygen uptake and RER were measured continuously and used to determine aerobic and anaerobic contributions to power output. Results: There was a significant difference between trials for time to completion (F = 15.3, P = 0.00). Participants completed DEC more quickly than BL (90% CI = 2.1-10.1 s) and ACC (90% CI = 1.5-5.4 s) and completed ACC more quickly than BL (90% CI = 0.5-4.8 s). The difference in performance between DEC and ACC was attributable to a greater anaerobic contribution to power output at 90% of the total distance (F = 5.3, P = 0.02, 90% CI = 4-37 W). Conclusions: The provision of surreptitiously augmented feedback derived from a previous performance reduces time taken for cyclists to accomplish a time trial of known duration. This suggests that cyclists operate with a metabolic reserve even during maximal time trials and that this reserve can be accessed after deception. FIGURE 3-Mean (dark line) and individual (gray lines) differences in time to complete the 4000-m distance (BL, DEC, and ACC). A significant reduction in time to completion compared with BL is denoted by an asterisk, and a dagger denotes a significant reduction in time to completion compared with ACC (P G 0.05).
doi:10.1249/mss.0b013e318232cf77 pmid:21886012 fatcat:3bj6xqrbwnhtvjjgag6ftzsr24


Petar Jovanovic, Alkis Simitsis, Kevin Wilkinson
2014 Proceedings of the 2014 ACM SIGMOD international conference on Management of data - SIGMOD '14  
A complex analytic data flow may perform multiple, inter-dependent tasks where each task uses a different processing engine. Such a multi-engine flow, termed a hybrid flow, may comprise subflows written in more than one programming language. However, as the number and variety of these engines grow, developing and maintaining hybrid flows at the physical level becomes increasingly challenging. To address this problem, we present BabbleFlow, a system for enabling flow design at a logical level
more » ... automatic translation to physical flows. BabbleFlow translates a hybrid flow expressed in a number of languages to a semantically equivalent hybrid flow expressed in the same or a different set of languages. To this end, it composes the multiple physical flows of a hybrid flow into a single logical representation expressed in a unified flow language called xLM. In doing so, it enables a number of graph transformations such as (de-)composition and optimization. Then, it converts the, possibly transformed, xLM data flow graph into an executable form by expressing it in one or more target programming languages. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution.
doi:10.1145/2588555.2594534 dblp:conf/sigmod/0001SW14 fatcat:ekuvom7odvgtzapeb5suwuzyji

Organisational change and employee turnover

Kevin M. Morrell, John Loan‐Clarke, Adrian J. Wilkinson
2004 Personnel Review  
This paper investigates employee turnover, using data from a recent study of 352 NHS nurse leavers. We explore individual decisions to quit in a context characterised by change, and suggest a mechanism whereby organisational and contextual change can prompt individual leaving decisions. We develop and test hypotheses designed to shed light on the links between organisational change and individual decisions to quit. We then develop a theoretical, heuristic model describing the relationship
more » ... n organisational change and turnover. The managerial implications of this model are outlined and the paper concludes with an agenda for future research.
doi:10.1108/00483480410518022 fatcat:hsftg4pr6fhr5mitxtilun4ff4

Extranuclear SUMOylation in Neurons

Jeremy M. Henley, Ruth E. Carmichael, Kevin A. Wilkinson
2018 Trends in Neurosciences  
General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: Abstract Posttranslational modification of substrate proteins by conjugation of SUMO regulates a diverse array of cellular processes. While predominantly a nuclear protein modification, there is growing appreciation that SUMOylation of proteins outside the nucleus plays direct roles in controlling synaptic
more » ... ssion, neuronal excitability and adaptive responses to cell stress. Furthermore, alterations in protein SUMOylation are observed in a wide range of neurological and neurodegenerative diseases, and several extranuclear disease-associated proteins have been shown to be directly SUMOylated. Here, focusing mainly on SUMOylation of synaptic and mitochondrial proteins, we outline recent developments and discoveries, and present our opinion as to the most exciting avenues for future research to define how SUMOylation of extranuclear proteins regulates neuronal and synaptic function.
doi:10.1016/j.tins.2018.02.004 pmid:29530319 fatcat:3r2dchxg7rdr3bxfdxg2tpmywq

Tropical cyclones over the western north Pacific since the mid-nineteenth century

Hisayuki Kubota, Jun Matsumoto, Masumi Zaiki, Togo Tsukahara, Takehiko Mikami, Rob Allan, Clive Wilkinson, Sally Wilkinson, Kevin Wood, Mark Mollan
2021 Climatic Change  
AbstractTropical cyclone (TC) activities over the western North Pacific (WNP) and TC landfall in Japan are investigated by collecting historical TC track data and meteorological observation data starting from the mid-nineteenth century. Historical TC track data and TC best track data are merged over the WNP from 1884 to 2018. The quality of historical TC data is not sufficient to count the TC numbers over the WNP due to the lack of spatial coverage and different TC criteria before the 1950s. We
more » ... focus on TC landfall in Japan using a combination of TC track data and meteorological data observed at weather stations and lighthouses from 1877 to 2019. A unified TC definition is applied to obtain equivalent quality during the whole analysis period. We identify lower annual TC landfall numbers during the 1970s to the 2000s and find other periods have more TC landfall numbers including the nineteenth century. No trend in TC landfall number is detected. TC intensity is estimated by an annual power dissipation index (APDI). High APDI periods are found to be around 1900, in the 1910s, from the 1930s to 1960s, and after the 1990s. When we focus on the period from 1977 to 2019, a significant increasing trend of ADPI is seen, and significant northeastward shift of TC landfall location is detected. On the other hand, TC landfall location shifts northeastward and then southwestward in about 100-year interval. European and US ships sailed through East and Southeast Asian waters before the weather station network was established in the late nineteenth century. Then, we focus on TC events in July 1853 observed by the US Naval Japan Expedition of Perry's fleet and August 1863 by a UK Navy ship that participated in two wars in Japan. A TC moved slowly westward over the East China Sea south of the Okinawa Islands from 21 to 25 July 1853. Another TC was detected in the East China Sea on 15–16 August 1863 during the bombardment of Kagoshima in southern Japan. Pressure data are evaluated by comparing the observations made by 10 naval ships in Yokohama, central Japan during 1863–1864. The deviation of each ship pressure data from the 10 ships mean is about 2.7–2.8 hPa.
doi:10.1007/s10584-021-02984-7 fatcat:d4ffybpauzeytb67n5hfhpbrgu

Distributed Transaction Management in Jasmin

Ming-Yee Lai, W. Kevin Wilkinson
1984 Very Large Data Bases Conference  
dblp:conf/vldb/LaiW84 fatcat:vj3q635renayhcow6nl7b5nsb4

ASL sign lowering as undershoot: A corpus study

Kevin Russell, Erin Wilkinson, Terry Janzen
2011 Laboratory Phonology  
AbstractAmerican Sign Language (ASL) signs that are located on the forehead in their canonical form are often articulated lower during natural signing. Previous studies have examined this phenomenon from a phonetic perspective, treating it as a form of undershoot, and from a variationist sociolinguistic perspective, treating it as a categorical process. This study sees if the findings and explanations of these studies can be extended to the lowering of signs formed in locations other than the
more » ... rehead. In a corpus of natural conversational signing from six signers, we measure the vertical displacement of over 3000 tokens of signs canonically formed at the face, head, or neck. While there is some apparent evidence for a categorical lowering process in a minority of signs and considerable evidence for undershoot, neither alone can explain the full range of displacement patterns across all signs and locations. Undershoot must be carefully planned and controlled: no matter how sloppy the signing, signers systematically avoid contacting their eyes. The results can be explained if there is a somatosensory forward-modelling mechanism that can veto undesirable gestural scores and whose decisions are incorporated during learning into the phonological distributions representing the locations of signs.
doi:10.1515/labphon.2011.015 fatcat:ce2ehsynjjcqbb4plsvqguyoba

Mechanisms, regulation and consequences of protein SUMOylation

Kevin A. Wilkinson, Jeremy M. Henley
2010 Biochemical Journal  
The post-translational modification SUMOylation is a major regulator of protein function that plays an important role in a wide range of cellular processes. SUMOylation involves the covalent attachment of a member of the SUMO (small ubiquitin-like modifier) family of proteins to lysine residues in specific target proteins via an enzymatic cascade analogous to, but distinct from, the ubiquitination pathway. There are four SUMO paralogues and an increasing number of proteins are being identified
more » ... s SUMO substrates. However, in many cases little is known about how SUMOylation of these targets is regulated. Compared with the ubiquitination pathway, relatively few components of the conjugation machinery have been described and the processes that specify individual SUMO paralogue conjugation to defined substrate proteins are an active area of research. In the present review, we briefly describe the SUMOylation pathway and present an overview of the recent findings that are beginning to identify some of the mechanisms that regulate protein SUMOylation. Key words: post-translational modification, sentrin/small ubiquitin-like modifier-specific protease (SENP), small ubiquitin-like modifier (SUMO), small ubiquitin-like-modifier-activating enzyme (SAE), ubiquitin, ubiquitin-conjugating 9 (Ubc9), ubiquitin-like modifiers.
doi:10.1042/bj20100158 pmid:20462400 pmcid:PMC3310159 fatcat:6tzkjza2gbefxmkdkkjrrpmrim


Enrico Iori, Alkis Simitsis, Themis Palpanas, Kevin Wilkinson, Stavros Harizopoulos
2012 Proceedings of the 2012 international conference on Management of Data - SIGMOD '12  
Cloud computing has emerged as a promising environment capable of providing flexibility, scalability, elasticity, failover mechanisms, high availability, and other important features to applications. Compute clusters are relatively easy to create and use, but tools to effectively share cluster resources are lacking. CloudAlloc addresses this problem and schedules workloads to cluster resources using allocation algorithms. It also monitors resource utilization and thus, provides accountability
more » ... r actual usage. CloudAlloc is a lightweight, flexible, easy-to-use tool for cluster resource allocation that has also proved useful as a research platform. We demonstrate its features and also discuss its allocation algorithms that minimize power usage. CloudAlloc was implemented and is in use at HP Labs.
doi:10.1145/2213836.2213942 dblp:conf/sigmod/IoriSPWH12 fatcat:ak472fdqfvgi3ajidbxf2bvp7e

Measuring Adequacy of Retirement Savings

John Burnett, Kevin Thomas Davis, Carsten Murawski, Roger Wilkins, Nicholas Wilkinson
2014 Social Science Research Network  
This article introduces four metrics quantifying the adequacy of retirement savings taking into account all major sources of retirement income. The metrics are applied to a representative sample of the Australian population aged 40 and above. Employers in Australia currently make compulsory contributions of 9.25 per cent of wages and salaries to tax-advantaged defined-contribution employee retirement savings accounts. Our analysis reveals that compulsory retirement savings, even when
more » ... d by the means-tested government pension and private wealth accumulation, are not in general sufficient to fund a comfortable lifestyle during retirement. We further find that omitting one or more 'pillars' of saving will significantly bias estimates of retirement savings adequacy. Our analysis also points to several shortcomings of the widely-used income replacement ratio as an indicator of savings adequacy.
doi:10.2139/ssrn.2418729 fatcat:k2uur3wj25eo5ffhizrs3xboyu
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