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Exploiting social evolution in biofilms

Kerry E Boyle, Silja Heilmann, Dave van Ditmarsch, Joao B Xavier
2013 Current Opinion in Microbiology  
(e) P. aeruginosa macrocolonies in obstructed cystic fibrosis bronchus (reprinted with permission from [38] ).  ...  (f) Cystic fibrosis lung P. aeruginosa macrocolonies stained with antibodies against P. aeruginosa (reprinted with permission from [38] ) (scale: c -50 mm, e -100 mm, f -10 mm).  ... 
doi:10.1016/j.mib.2013.01.003 pmid:23357558 pmcid:PMC3646963 fatcat:fk7zc3zp7jhc5hvbbjmlx5o73a

Metabolism and the Evolution of Social Behavior

Kerry E. Boyle, Hilary T. Monaco, Maxime Deforet, Jinyuan Yan, Zhe Wang, Kyu Rhee, Joao B. Xavier
2017 Molecular biology and evolution  
(E) Summary of mutations from 20 isolates from day 7 identified by whole genome sequencing.  ...  This supports previous revelations that P. aeruginosa regulates intracellular carbon to ensure homeostasis whether it produces rhamnolipids or not (Boyle et al. 2015) .  ... 
doi:10.1093/molbev/msx174 pmid:28595344 pmcid:PMC5850603 fatcat:h2xx6s4muvbzflxe65ezsvmac4

Convergent Evolution of Hyperswarming Leads to Impaired Biofilm Formation in Pathogenic Bacteria

Dave van Ditmarsch, Kerry E. Boyle, Hassan Sakhtah, Jennifer E. Oyler, Carey D. Nadell, Éric Déziel, Lars E.P. Dietrich, Joao B. Xavier
2013 Cell Reports  
Biofilm formation is, therefore, being studied extensively in search of novel therapeutic approaches (reviewed in Boyle et al., 2013) . Swarming motility raises equally interesting implications.  ...  P. aeruginosa, both in environmental and clinical settings (Costerton et al., 1999; Kolter and Greenberg, 2006) , and is known to be inversely regulated to swarming motility (Baraquet et al., 2012; Boyle  ... 
doi:10.1016/j.celrep.2013.07.026 pmid:23954787 pmcid:PMC3770465 fatcat:xwgj652625at7nqpvwxnpohkl4

Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network

Jinyuan Yan, Maxime Deforet, Kerry E. Boyle, Rayees Rahman, Raymond Liang, Chinweike Okegbe, Lars E. P. Dietrich, Weigang Qiu, Joao B. Xavier, Oleg A. Igoshin
2017 PLoS Computational Biology  
,E n ) T .  ...  = (E 1 ,. . .  ... 
doi:10.1371/journal.pcbi.1005677 pmid:28767643 pmcid:PMC5555705 fatcat:buccwim4ffhs7irbzgluwgmxm4

Intersecting Sexual, Gender, and Professional Identities Among Social Work Students: The Importance of Identity Integration

Shelley L. Craig, Gio Iacono, Megan S. Paceley, Michael P. Dentato, Kerrie E. H. Boyle
2017 Journal of Social Work Education  
An e-mail containing a request for distribution and the survey link was sent twice to the dean or director of each social work school, department, or program as well as directly to student electronic mailing  ... 
doi:10.1080/10437797.2016.1272516 fatcat:2lld56dtqvblddswwtk7jdin2m

Integration of Metabolic and Quorum Sensing Signals Governing the Decision to Cooperate in a Bacterial Social Trait

Kerry E. Boyle, Hilary Monaco, Dave van Ditmarsch, Maxime Deforet, Joao B. Xavier, Jennifer L. Reed
2015 PLoS Computational Biology  
P rhlAB -gfp expression of the population shown in E. over time. The majority of GFP production occurs during phase II, when the population growth rate has slowed.  ...  Growth is similar in different quorum sensing concentrations E. GFP production in nitrogen limiting media in different concentrations of quorum sensing signals.  ... 
doi:10.1371/journal.pcbi.1004279 pmid:26102206 pmcid:PMC4477906 fatcat:hcwjjvn2wrajhin4rdkaubzcj4

ACKR4 restrains antitumor immunity by regulating CCL21

Carly E. Whyte, Maleika Osman, Ervin E. Kara, Caitlin Abbott, Jade Foeng, Duncan R. McKenzie, Kevin A. Fenix, Yuka Harata-Lee, Kerrie L. Foyle, Sarah T. Boyle, Marina Kochetkova, Amelia Roman Aguilera (+7 others)
2020 Journal of Experimental Medicine  
(E and F) Frequency and number of migratory (E) CD103 + DCs and (F) CD172a + cDC2s in dLNs.  ...  (E-H) Representative gating strategy of intratumor CD8 + T cells for (E) granzyme B, (F) TIM-3, (G) LAG-3, (H) PD-1 + LAG-3 + , and (I) PD-1 + TIM-3 + (data in Fig. 2 , C and E-G).  ... 
doi:10.1084/jem.20190634 pmid:32289156 fatcat:4u6ruodxdzghbkeut4aqlxyila

Historic recombination in a durum wheat breeding panel enables high-resolution mapping of Fusarium head blight resistance quantitative trait loci

Ehsan Sari, Ron E. Knox, Yuefeng Ruan, Maria Antonia Henriquez, Santosh Kumar, Andrew J. Burt, Richard D. Cuthbert, David J. Konkin, Sean Walkowiak, Heather L. Campbell, Asheesh K. Singh, Jay Ross (+8 others)
2020 Scientific Reports  
The durum wheat line DT696 is a source of moderate Fusarium head blight (FHB) resistance. Previous analysis using a bi-parental population identified two FHB resistance quantitative trait loci (QTL) on chromosome 5A: 5A1 was co-located with a plant height QTL, and 5A2 with a major maturity QTL. A Genome-Wide Association Study (GWAS) of DT696 derivative lines from 72 crosses based on multi-environment FHB resistance, plant height, and maturity phenotypic data was conducted to improve the mapping
more » ... resolution and further elucidate the genetic relationship of height and maturity with FHB resistance. The Global Tetraploid Wheat Collection (GTWC) was exploited to identify durum wheat lines with DT696 allele and additional recombination events. The 5A2 QTL was confirmed in the derivatives, suggesting the expression stability of the 5A2 QTL in various genetic backgrounds. The GWAS led to an improved mapping resolution rendering the 5A2 interval 10 Mbp shorter than the bi-parental QTL mapping interval. Haplotype analysis using SNPs within the 5A2 QTL applied to the GTWC identified novel haplotypes and recombination breakpoints, which could be exploited for further improvement of the mapping resolution. This study suggested that GWAS of derivative breeding lines is a credible strategy for improving mapping resolution.
doi:10.1038/s41598-020-64399-1 pmid:32372012 fatcat:y65guzhtzfc4raeishk3bh4cmi

Characterization of the Genetic Architecture for Fusarium Head Blight Resistance in Durum Wheat: The Complex Association of Resistance, Flowering Time, and Height Genes

Yuefeng Ruan, Wentao Zhang, Ron E. Knox, Samia Berraies, Heather L. Campbell, Raja Ragupathy, Kerry Boyle, Brittany Polley, Maria Antonia Henriquez, Andrew Burt, Santosh Kumar, Richard D. Cuthbert (+3 others)
2020 Frontiers in Plant Science  
The model is implemented as: P iy = µ + G i + E y + (G i XE y ) + E iy , where, P iy are the values of the tested phenotypic trait, µ is the population mean, G i is the effect of genotypes, E y is the  ...  effect of environments (here, by Year), E iy is the residual, where i is the genotype, y is the year.  ...  Copyright © 2020 Ruan, Zhang, Knox, Berraies, Campbell, Ragupathy, Boyle, Polley, Henriquez, Burt, Kumar, Cuthbert, Fobert, Buerstmayr and DePauw.  ... 
doi:10.3389/fpls.2020.592064 pmid:33424887 pmcid:PMC7786293 fatcat:554uy3zztrab7deueqixj35jdq

Understanding Effects of Whale-Watching Vessel Noise on Humpback Whale Song in the North Pacific Coast of Colombia With Propagation Models of Masking and Acoustic Data Observations

Maria Paula Rey-Baquero, Laura Valentina Huertas-Amaya, Kerri D. Seger, Natalia Botero-Acosta, Andrea Luna-Acosta, Christina E. Perazio, John K. Boyle, Sarah Rosenthal, Ann Carole Vallejo
2021 Frontiers in Marine Science  
Ecohotel Punta Brava is located on a cliff-side where R&E Ocean Community Conservation used a land-based theodolite station (5 • 29'1"N, 77 • 32'14"W).  ...  Copyright © 2021 Rey-Baquero, Huertas-Amaya, Seger, Botero-Acosta, Luna-Acosta, Perazio, Boyle, Rosenthal and Vallejo.  ... 
doi:10.3389/fmars.2021.623724 fatcat:zdz2lvwci5c33h3qxrccukfpki

Target Product Profiles for a Micronutrient Assessment Tool and Associated Blood Collection Device for Use in Population-Based Surveys: An Expert Consensus [article]

Emily R. Smith, Joanne Lee, Lindsay H. Allen, David S. Boyle, Eleanor Brindle, Neal E. Craft, Nita Dalmiya, Juergen Erhardt, Dean Garrett, Maria Elena Jefferds, Festo Kavishe, David W. Killilea (+14 others)
2021 medRxiv   pre-print
Micronutrient deficiencies are a significant public health problem affecting a large portion of the world population. Disproportionately affected populations, namely infants, young children, adolescents and women of reproductive age including pregnant women, are especially susceptible to the health consequences of insufficient micronutrient intakes. However, assessment of micronutrient deficiencies is not routinely included in population health surveys. This nutrition data gap hampers policy,
more » ... ogram, and promotion efforts to prevent and treat micronutrient deficiencies. To address one of the barriers to micronutrient assessment, an expert group created a consensus of a target product profile (TPP) for a micronutrient assessment tool and associated blood collection device for use in population surveys. Experts in laboratory medicine, micronutrient assessment, population-based surveys, and product development reviewed proposed TPP standards and collaboratively established minimum and optimal characteristics. These experts defined the target population as infants and children from 6-59 months, adolescents and women of reproductive age 12-49 years including pregnant women. At minimum, the assessment tool should be a multiplex ELISA formatted for >1 analyte that uses a serum or plasma sample prepared from venous blood obtained by a phlebotomist with a 2-week training. Given the use case was specific for population surveys, experts agreed the minimum tool could be semi-quantitative, with analytical specificity of 99%. The TPP also considers the variable field environments for testing (e.g. storage conditions and time to results). The consensus TPP developed can be used to guide selection of existing technologies into population-based surveys, as well as future investment in product development. Partnerships focused on research and development, including industry, public sector, nonprofit, and academic institutions, can help advance the field and fill the micronutrient data gap.
doi:10.1101/2021.05.13.21257124 fatcat:v7s4hjwmrzgu7crhsf5vl5lhsi

Translating research into practice: outcomes from the Healthy Living after Cancer partnership project

Elizabeth G. Eakin, Marina M. Reeves, Ana D. Goode, Elisabeth A. H. Winkler, Janette L. Vardy, Frances Boyle, Marion R. Haas, Janet E. Hiller, Gita D. Mishra, Michael Jefford, Bogda Koczwara, Christobel M. Saunders (+15 others)
2020 BMC Cancer  
Background Healthy Living after Cancer (HLaC) was a national dissemination and implementation study of an evidence-based lifestyle intervention for cancer survivors. The program was imbedded into existing telephone cancer information and support services delivered by Australian state-based Cancer Councils (CC). We report here the reach, effectiveness, adoption, implementation, and maintenance of the program. Methods In this phase IV study (single-group, pre-post design) participants - survivors
more » ... of any type of cancer, following treatment with curative intent - received up to 12 nurse/allied health professional-led telephone health coaching calls over 6 months. Intervention delivery was grounded in motivational interviewing, with emphasis on evidence-based behaviour change strategies. Using the RE-AIM evaluation framework, primary outcomes were reach, indicators of program adoption, implementation, costs and maintenance. Secondary (effectiveness) outcomes were participant-reported anthropometric, behavioural and psychosocial variables including: weight; physical activity; dietary intake; quality-of-life; treatment side-effects; distress; and fear of cancer recurrence and participant satisfaction. Changes were evaluated using linear mixed models, including terms for timepoint (0/6 months), strata (Cancer Council), and timepoint x strata. Results Four of 5 CCs approached participated in the study. In total, 1183 cancer survivors were referred (mostly via calls to the Cancer Council telephone information service). Of these, 90.4% were eligible and 88.7% (n = 791) of those eligible consented to participate. Retention rate was 63.4%. Participants were mostly female (88%), aged 57 years and were overweight (BMI = 28.8 ± 6.5 kg/m2). Improvements in all participant-reported outcomes (standardised effect sizes of 0.1 to 0.6) were observed (p < 0.001). The program delivery costs were on average AU$427 (US$296) per referred cancer survivor. Conclusions This telephone-delivered lifestyle intervention, which was feasibly implemented by Cancer Councils, led to meaningful and statistically significant improvements in cancer survivors' health and quality-of-life at a relatively low cost. Trial registration Australian and New Zealand Clinical Trials Registry (ANZCTR) - ACTRN12615000882527 (registered on 24/08/2015).
doi:10.1186/s12885-020-07454-4 pmid:33023538 fatcat:y4clu2wgordxtekdhguomz5cji

Healthy Living after Cancer: a dissemination and implementation study evaluating a telephone-delivered healthy lifestyle program for cancer survivors

Elizabeth G. Eakin, Sandra C. Hayes, Marion R. Haas, Marina M. Reeves, Janette L. Vardy, Frances Boyle, Janet E. Hiller, Gita D. Mishra, Ana D. Goode, Michael Jefford, Bogda Koczwara, Christobel M. Saunders (+14 others)
2015 BMC Cancer  
Given evidence shows physical activity, a healthful diet and weight management can improve cancer outcomes and reduce chronic disease risk, the major cancer organisations and health authorities have endorsed related guidelines for cancer survivors. Despite these, and a growing evidence base on effective lifestyle interventions, there is limited uptake into survivorship care. Methods/Design: Healthy Living after Cancer (HLaC) is a national dissemination and implementation study that will
more » ... the integration of an evidence-based lifestyle intervention for cancer survivors into an existing telephone cancer information and support service delivered by Australian state-based Cancer Councils. Eligible participants (adults having completed cancer treatment with curative intent) will receive 12 health coaching calls over 6 months from Cancer Council nurses/allied health professionals targeting national guidelines for physical activity, healthy eating and weight control. Using the RE-AIM evaluation framework, primary outcomes are service-level indicators of program reach, adoption, implementation/costs and maintenance, with secondary (effectiveness) outcomes of patient-reported anthropometric, behavioural and psychosocial variables collected at pre-and post-program completion. The total participant accrual target across four participating Cancer Councils is 900 over 3 years. Discussion: The national scope of the project and broad inclusion of cancer survivors, alongside evaluation of service-level indicators, associated costs and patient-reported outcomes, will provide the necessary practice-based evidence needed to inform future allocation of resources to support healthy living among cancer survivors.
doi:10.1186/s12885-015-2003-5 pmid:26690258 pmcid:PMC4687340 fatcat:tx6nz6ksqbdjrgu3bgkarxk7na

Page 183 of Notes and Queries Vol. 162, Issue 11 [page]

1932 Notes and Queries  
» 1932, mniesetietaiel 1563 en the ge she before uge he. e been d time y, 1536 irl of penser, where- lluded by Sil- and 0 show would ot the name, Whilst nusual ntly a nmedi- e, and named ‘overed garet’  ...  There was a well- | known Kerry family of Segerson of which | this Richard was much more probably a member.  ... 

Page 168 of The Metropolitan Magazine Vol. 1, Issue 4 [page]

1831 The Metropolitan Magazine  
Richard Boyle, Hon. R. King. Cork—Hon, John Boyle, D. Callaghan. Cavan County—Henry Maxwell, John Young. Clare County—William Nugent Macnamara, Maurice O'Connell. Donegal County—Sir E. S, Hayes, E.  ...  Kerry County—Daniel O'Connell, Frederick William Mallins. Kildare County—R. Moore O’Ferrall, Sir J. W. Hort. Kilkenny County — Hon. J. W. Ponsonby, Earl of Ossory.  ... 
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