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The title of Susan Neiman's 2008 book suggests that she will provide the reader some answers, or at least a lens through which they might gain clearer understanding of what is right and wrong in today's world. Neiman argues that moral clarity can be obtained if the reader has the courage to examine critically the world around them and to take required action. Neiman uses historical writings from the past two centuries, religious and secular, to force the reader to reflect on the current statedoi:10.26522/brocked.v18i2.96 fatcat:ltovppmjqjhmhdjkeyvd6eyb6y
more »... society. Aspects of society which are good, evil, or, at the very least, disparate, are discussed. This leads readers to reflect on their place within that society. The purpose of which is to suggest alternative possibilities for a framework with which to examine contemporary events.
For materials which are incorrectly predicted by density functional theory to be metallic, an iterative procedure must be adopted in order to perform GW calculations. In this paper we test two iterative schemes based on the quasi-particle and pseudopotential approximations for a number of inorganic semiconductors whose electronic structures are well known from experiment. Iterating just the quasi-particle energies yields a systematic, but modest overestimate of the band gaps, confirmingarXiv:cond-mat/0507013v1 fatcat:mq3hckxjszbj7cqm7tn544kuhe
more »... ons drawn earlier for CaB_6 and YH_3. Iterating the quasi-particle wave functions as well gives rise to an imbalance between the Hartree and Fock potentials and results in bandgaps in far poorer agreement with experiment.
Brock in Florida coastal waters revealed that L. mucor was rare or absent on sea weeds from waters in the Gulf of Mexico, Atlantic Ocean, and Florida Bay. ... Data for some of the cool-water strains were published by Brock and Mandel (2) , and data for the rest were reported by Kelly (Ph.D. Thesis, Indiana Univ., Bloomington, 1969) . ... Brock, T. D. 1966. The habitat of Leucothrix mucor, a widespread marine microorganism. Limnol. Oceanogr. 11:303-307. 2. Brock, T. D., and M. Mandel. 1966. ...doi:10.1128/jb.98.3.1402-1403.1969 fatcat:47hcmytw7bdxnj67hgg7gifgqa
The characteristics of this strain are reported in greater detail elsewhere (Kelly & Brock, 1969) . For strain no. ... One strain (no. 19) isolated from warmer waters in the Florida Keys had temperature relations different from the others (Kelly & Brock, 1969) . ...doi:10.1099/00221287-59-2-153 pmid:5370292 fatcat:lgk3wky77jdvnfo66lscd3odom
Canada's Great Military Leaders from Brock to Dextraze (Whitby [ON], McGraw-Hill Ryerson Ltd, 1997).. ... Canada's Great Military Leaders from Brock to Dextraze (Whitby [ON], McGraw-Hill Ryerson Ltd, 1997). À en croire Arthur Bishop, l'auteur de Salute! ...doi:10.7202/005391ar fatcat:6ltqivz4r5ep5dze4fz4v65mei
Data for some of the cool-water strains were published by Brock and Mandel (2) , and data for the rest were reported by Kelly (Ph.D. Thesis, Indiana Univ., Bloomington, 1969) . ... Brock in Florida coastal waters revealed that L. mucor was rare or absent on sea weeds from waters in the Gulf of Mexico, Atlantic Ocean, and Florida Bay. ...pmid:5788711 pmcid:PMC315340 fatcat:ycgh7t5uezbozjgzzaeeoxl6vq
doi:10.1103/physrevlett.85.2989 pmid:11005985 fatcat:zeorhmpl4vdvli6zodemo7jkey
AbstractNatural evolution encodes rich information about the structure and function of biomolecules in the genetic record. Previously, statistical analysis of co-variation patterns in natural protein families has enabled the accurate computation of 3D structures. Here, we explored whether similar information can be generated by laboratory evolution, starting from a single gene and performing multiple cycles of mutagenesis and functional selection. We evolved two bacterial antibiotic resistancedoi:10.1101/667790 fatcat:h4px64h4ync5bdszoilqnfu4le
more »... roteins, β-lactamase PSE1 and acetyltransferase AAC6, and obtained hundreds of thousands of diverse functional sequences. Using evolutionary coupling analysis, we inferred residue interactions in good agreement with contacts in the crystal structures, confirming genetic encoding of structural constraints in the selected sequences. Computational protein folding with contact constraints yielded 3D structures with the same fold as that of natural relatives. Evolution experiments combined with inference of residue interactions from sequence information opens the door to a new experimental method for the determination of protein structures.
High-throughput experimental techniques have made possible the systematic sampling of the single mutation landscape for many proteins, defined as the change in protein fitness as the result of point mutation sequence changes. In a more limited number of cases, and for small proteins only, we also have nearly full coverage of all possible double mutants. By comparing the phenotypic effect of two simultaneous mutations with that of the individual amino acid changes, we can evaluate epistaticdoi:10.1101/320721 fatcat:rczuuib3wbgtflyamzq32dyk74
more »... ts that reflect non-additive cooperative processes. The observation that epistatic residue pairs often are in contact in the 3D structure led to the hypothesis that a systematic epistatic screen contains sufficient information to identify the 3D fold of a protein. To test this hypothesis, we examined experimental double mutants for evidence of epistasis and identified residue contacts at 86% accuracy, including secondary structure elements and evidence for an alternative all-alpha-helical conformation. Positively epistatic contacts - corresponding to compensatory mutations, restoring fitness - were the most informative. Folded models generated from top-ranked epistatic pairs, when compared with the known structure, were accurate within 2.4 A over 53 residues, indicating the possibility that 3D protein folds can be determined experimentally with good accuracy from functional assays of mutant libraries, at least for small proteins. These results suggest a new experimental approach for determining protein structure.
Teacher professional development aims to bolster effective instructional practices that enhance student learning. The development of the Sustained Investment and Teacher Engagement Scale for Professional Development (SITES-PD) grew out of a need to understand how teachers respond to opportunities for professional learning in ways that contribute to skill improvement. One hundred and eight elementary teachers participated in a sustained professional development coaching intervention. Prior todoi:10.5296/jei.v8i1.19636 fatcat:tny2fwbgmfgd7mwnv3dnbkmgka
more »... following the intervention, data were collected from multiple sources (e.g., teacher report, blind classroom observations). For the development of this instrument, coaches rated teacher engagement with opportunities for professional learning. Exploratory factor analysis reveals a one factor solution and that a summed composite of eight items is appropriate. Reliability and validity results suggest the SITES-PD instrument may be a useful tool for investigating the underlying mechanisms that mediate the efficacy of teacher professional development interventions.
In this article, we present a statistical analysis of the electrostatic properties of 298 protein-protein complexes and 356 domain-domain structures extracted from the previously developed database of protein complexes (ProtCom, http:// www.ces.clemson.edu/compbio/protcom). For each structure in the dataset we calculated the total electrostatic energy of the binding and its two components, Coulombic and reaction field energy. It was found that in a vast majority of the cases (.90%), the totaldoi:10.1529/biophysj.107.112367 pmid:17693468 pmcid:PMC2072065 fatcat:62ev62cairholpjgks4iamrs3u
more »... ectrostatic component of the binding energy was unfavorable. At the same time, the Coulombic component of the binding energy was found to favor the complex formation while the reaction field component of the binding energy opposed the binding. It was also demonstrated that the components in a wild-type (WT) structure are optimized/anti-optimized with respect to the corresponding distributions, arising from random shuffling of the charged side chains. The degree of this optimization was assessed through the Z-score of WT energy in respect to the random distribution. It was found that the Z-scores of Coulombic interactions peak at a considerably negative value for all 654 cases considered while the Z-score of the reaction field energy varied among different types of complexes. All these findings indicate that the Coulombic interactions within WT protein-protein complexes are optimized to favor the complex formation while the total electrostatic energy predominantly opposes the binding. This observation was used to discriminate WT structures among sets of structural decoys and showed that the electrostatic component of the binding energy is not a good discriminator of the WT; while, Coulombic or reaction field energies perform better depending upon the decoy set used.
Brock was a Research Career Development Awardee of the Public Health Service. LITERATURE CITED ... Each L. mucor strain was analyzed eight times, and the average per cent difference in mobility from the reference strain was calculated. 16 KELLY AND BROCK J. BACTERIOL. ... Brock, Cape Reykjanes, Iceland, 1965 T.D. Brock, Portugal, 1966 T.D. Brock, Naples, Italy, 1966 T.D. Brock, Ischia, Italy, 1966 T.D. Brock, Iceland, 1966 T.D. Brock, Iceland, 1966 T.D. ...pmid:5344093 pmcid:PMC315351 fatcat:n26pofodbjdr5o4dapmujnzjkq
Online forums sponsored by electronic networks of practice (ENPs) have become an important platform for technology-mediated knowledge exchange, yet relatively little is known about how ENP participants filter and evaluate information they encounter on these forums. This study integrates perspectives from expectation disconfirmation theory, prospect theory, and neuroscience research to explore how ENP forum filtering judgments are influenced when expectations formed on the basis of contextualdblp:conf/amcis/FadelMK18 fatcat:omd24mdhszbm5jnaqo4rhmo24e
more »... s are confirmed or disconfirmed by examination of solution quality. We report the results of an fMRI experiment that paired both positive and negative contextual cues with high and low quality solutions on a mock ENP forum interface. Results suggest that evaluation judgments are strongest in conditions where initial contextual cue judgments are confirmed by examination of solution quality. Moreover, our results offer evidence of differences in filtering behaviors and underlying cognitions with respect to expected and unexpected gains and losses.
Brock was a Research Career Development Awardee of the Public Health Service. LITERATURE CITED ... Brock, Cape Reykjanes, Iceland, 1965 T.D. Brock, Portugal, 1966 T.D. Brock, Naples, Italy, 1966 T.D. Brock, Ischia, Italy, 1966 T.D. Brock, Iceland, 1966 T.D. Brock, Iceland, 1966 T.D. ... Brock, Long Is- land Sound, 1965 T.D. Brock, Long Is- land Sound, 1965 T.D. Brock, Cape Reykjanes, Iceland, 1965 T.D. Brock, Cape Reykjanes, Iceland, 1965 T.D. ...doi:10.1128/jb.100.1.14-21.1969 fatcat:mmf4vknzhvbrxpbulayernwkkq
Citation: Hodgson A, Kelly N, Peel D (2013) Unmanned Aerial Vehicles (UAVs) for Surveying Marine Fauna: A Dugong Case Study. PLoS ONE 8(11): e79556. ...doi:10.1371/journal.pone.0079556 pmid:24223967 pmcid:PMC3817127 fatcat:fuypqgcrszbt7h4akddh347sle
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