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An Operative Case of Dropped Head Syndrome Proceeding to Cervical Myelopathy

Eiichiro Honda, Tatsuya Tanaka, Keiji Tsunoda
2020 Spinal Surgery  
isolated neck extensor myopathy INEM INEM 1 69 2016 1 1 3 3 VOL. 34 NO. 3 2020 12 286 1 2 3 , Abstract The causes of dropped head syndrome are roughly classified into neurogenic and myogenic factors. Diseases due to neurogenic factors include amyotrophic lateral sclerosis, Parkinson s disease, and spondylosis. Isolated neck extensor myopathy INEM , a myogenic disease noted here, was named by Katz, which is based on idiopathic and localized posterior neck extensor muscle atrophy. The clinical
more » ... tures of INEM reveal that onset in the elderly, and cervical spinal kyphosis and myelopathy develop over one year after the dropped head phenomenon. We present the case of a 69 year old woman with dropped head syndrome due to INEM, who had cervical myelopathy. The first operation anterior and posterior fusion of three vertebral bodies failed and thus, a second operation posterior long fusion was necessary for the treatment of INEM.
doi:10.2531/spinalsurg.34.286 fatcat:ip4mxmr2kvbl5neosi2o7tlmn4

Morphological Changes of Intraovarian Arteries in Horses

Noboru MACHIDA, Kazuyoshi TAYA, Hiroyuki TANIYAMA, Nobuo TSUNODA, Keiji KIRYU
1996 Journal of Equine Science  
Morphological changes of the arteries in the ovaries of fillies and mares were studied histologically. The major histological features were intimal thickening due to fibromuscular hyperplasia and medial fibroelastotic changes resulting in narrowing of the vascular lumen. These changes in the vascular structure occurred principally in the regressed corpora lutea and cicatric scars of the corpora lutea of both pregnancy and nonpregnancy, and their degree and extent were severer in the small
more » ... es in the vascular colonies left behind by the regressed corpora lutea of pregnancy compared to those of nonpregnancy. Only rarely were changes of the vessels found in the cortical regions except for those in the regressed and cicatrized corpora lutea. These findings suggest that the hemodynamic effects during the presence of a functional corpus luteum may contribute to or be responsible for the vascular lesions in the ovary.
doi:10.1294/jes.7.59 fatcat:bfhvcibaxjfbvm3qplxszj5y3u

Wave effect in gravitational lensing by a cosmic string

Kazuhiro Yamamoto, Keiji Tsunoda
2003 Physical Review D, Particles and fields  
The wave effect in the gravitational lensing phenomenon by a straight cosmic string is investigated. The interference pattern is expressed in terms of a simple formula. We demonstrate that modulations of the interfered wave amplitude can be a unique signature of the wave effect. We briefly mention a possible chance of detecting the wave effect in future gravitational wave observatories.
doi:10.1103/physrevd.68.041302 fatcat:732cjl37nvebbpqjr5o3iwzkmq

SPORT AND GENDER Part 2
スポーツとジェンダー (2)

Yoshitaka KONDO, Kyoko RAITA, Minako YAMADA, Satomi Tsunoda, Keiji Matsuda
2004 Journal of the Philosophy of Sport and Physical Education  
doi:10.9772/jpspe1979.26.35 fatcat:xt6ccezrcvgwnolvjute55nvwu

Distribution of Guaiacyl and Syringyl Lignins in Japanese Beech (Fagus Crenata): Variation Within an Annual Ring

Keiji Takabe, Kazumi Fukazawa, Ryuichi Tsunoda, Shigeru Miyauchi
1992 IAWA Journal  
Microspectrometry is the most definitive technique for obtaining both ultraviolet (UV) and visible light absorption spectra from a very limited area, and this technique allows the determination of lignin distribution throughout an individual cell wall. It is generally accepted that hardwood lignin .is composed mainly of guaiacyl and syringyl moieties. Our microspectrometric investigations revealed variation of lignin distribution within an annual ring in beech (Fagus crenatai. Distribution of
more » ... aiacyl and syringyllignins in vessel and fibre secondary walls differs between earlywood and latewood. The proportion of guaiacyl units in the lignin in the vessel secondary wall is high in earlywood, especially in the initial zone of an annual ring (first formed earlywood); it is lower in latewood. In contrast , the proportion of syringyl units in the lignin in the vessel secondary wall is quite low in earlywood, but becomes appreciable in latewood. The content of syringyl units in the lignin in the fibre secondary wall is high in earlywood, becomes lower in latewood , and again increases in the terminal zone of an annual ring (last formed latewood). Guaiacyllignin is present in appreciable amounts in the terminal zone.
doi:10.1163/22941932-90000561 fatcat:sfvbxou3kjbgnb7nbb6cq7vwu4

Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system

Maki Morishita, Tomoki Muramatsu, Yumiko Suto, Momoki Hirai, Teruaki Konishi, Shin Hayashi, Daichi Shigemizu, Tatsuhiko Tsunoda, Keiji Moriyama, Johji Inazawa
2016 OncoTarget  
Chromothripsis is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event, rather than an accumulation of a series of subsequent and random alterations. Chromothripsis occurs commonly in various human cancers and is thought to be associated with increased malignancy and carcinogenesis. However, the causes and consequences of chromothripsis remain unclear. Therefore, to identify the mechanism underlying the generation of chromothripsis, we
more » ... ted whether chromothripsis could be artificially induced by ionizing radiation. We first elicited DNA double-strand breaks in an oral squamous cell carcinoma cell line HOC313-P and its highly metastatic subline HOC313-LM, using Single Particle Irradiation system to Cell (SPICE), a focused vertical microbeam system designed to irradiate a spot within the nuclei of adhesive cells, and then established irradiated monoclonal sublines from them, respectively. SNP array analysis detected a number of chromosomal copy number alterations (CNAs) in these sublines, and one HOC313-LM-derived monoclonal subline irradiated with 200 protons by the microbeam displayed multiple CNAs involved locally in chromosome 7. Multicolor FISH showed a complex translocation of chromosome 7 involving chromosomes 11 and 12. Furthermore, whole genome sequencing analysis revealed multiple de novo complex chromosomal rearrangements localized in chromosomes 2, 5, 7, and 20, resembling chromothripsis. These findings suggested that localized ionizing irradiation within the nucleus may induce chromothripsis-like complex chromosomal alterations via local DNA damage in the nucleus. Oncotarget 10183
doi:10.18632/oncotarget.7186 pmid:26862731 pmcid:PMC4891112 fatcat:wqqqkehh4ffypl5yestt7pfygi

Ixodid ticks on Sika deer Cervus nippon Temminck in Chiba Prefecture
千葉県におけるニホンジカ Cervus nippon Temminck 寄生マダニ類

Keiji MORI, Takashi TSUNODA, Masato FUJIMAGARI
1995 Medical Entomology and Zoology  
doi:10.7601/mez.46.313 fatcat:hxuaz2wsafhg7l5zca4ugxapfy

Tick-caused injury on the evidence of identification in Chiba Prefecture
10 同定依頼検査よりみた千葉県におけるマダニ被害

Takashi Tsunoda, Keiji Mori, Masato Fujimagari
1999 Medical Entomology and Zoology  
10 同 定 依 頼 検 査 よ り み た 千 葉 県 に お け る マ ダ = 被 害 O 角 田 隆 、森 啓 至 、藤 曲 正 登 (千 葉 県 衛 生 研 究 所 l TICk ・ caused injUfV on the evidence of identification in Chiba Prefecture Taka曲 i Tsunoda , Ktiji Mori , anti  ... 
doi:10.7601/mez.50.186_2 fatcat:3kaaskagtnf7fgidj5varubvye

A possible role for Ca2+/calmodulin-dependent protein kinase IV during pancreatic acinar stimulus–secretion coupling

Hitoshi Yoshida, Fumihiko Nozu, Tim O. Lankisch, Keiji Mitamura, Chung Owyang, Yasuhiro Tsunoda
2000 BBA - Molecular Cell Research  
Ca 2 /calmodulin-dependent protein kinases (CaMKs) are important intracellular mediators in the mediation of stimulusŝ ecretion coupling and excitation^contraction coupling in a wide variety of cell types. We attempted to identify and characterize the functional roles of CaMK in mediating pancreatic enzyme secretion. Immunoprecipitation and immunoblotting studies using a CaMKII or CaMKIV antibody showed that rat pancreatic acini expressed both CaMKII and CaMKIV. Phosphotransferase activities of
more » ... CaMKs were measured by a radioenzyme assay (REA) using autocamtide II, peptide Q and myosin P-light chain as substrates. Although CaMKII and CaMKIV use autocamtide II as a substrate, peptide Q is more efficiently phosphorylated by CaMKIV than by CaMKII. Intact acini were stimulated with cholecystokinin (CCK)-8, carbachol (CCh) and the high-affinity CCK-A receptor agonist, CCK-OPE, and the cell lysates were used for REA. CCK-8, CCh and CCK-OPE caused a concentration-dependent increase in CaMKs activities. When autocamtide II was used, maximal increases were 1.5^1.8-fold over basal (20.2 þ 2.0 pmol/min/mg protein), with peaks occurring at 20 min after cell stimulation. In separate studies that used peptide Q, CCK-8, CCh and CCK-OPE dose-dependently increased CaMKIV activities. Maximal increases were 1.5^2.4-fold over basal (30.7 þ 3.2 pmol/min/mg protein) with peaks occurring at 20 min after cell stimulation. Peak increases after cell stimulation induced by peptide Q were 1.8^2.8-fold higher than those induced by autocamtide II. CCK-8, CCh and CCK-OPE also significantly increased phosphotransferase activities of myosin light chain kinase (MLCK) substrate (basal: 4.4 þ 0.7 pmol/min/mg protein). However, maximal increases induced by MLCK substrate were less than 10% of those occurring in peptide Q. Characteristics of the phosphotransferase activity were also different between autocamtide II and peptide Q. When autocamtide II was used, elimination of medium Ca 2 in either cell lysates or intact cells resulted in a significant decrease in the activity, whereas it had no or little effect when peptide Q was used. This suggests that Ca 2 influx from the extracellular space is not fully required for CaMKIV activity and Ca 2 is not a prerequisite for phosphotransferase activity once CaMKIV is activated by either intracellular Ca 2 release or intracellular Ca 2 oscillations. The specific CaMKII inhibitor KN-62 (50 WM) had no effect on the CaMKIV activity and pancreatic enzyme secretion elicited by CCK-8, CCh and CCK-OPE. The specific MLCK inhibitor, ML-9 (10 WM), also did not inhibit CCK-8-stimulated pancreatic amylase secretion. In contrast, wide spectrum CaMK inhibitors, K-252a (1 WM) and KT5926 (3 WM), significantly inhibited CaMKIV activities and enzyme secretion evoked by secretagogues. Thus, CaMKIV appears to be an important intracellular mediator during stimulus^secretion coupling of rat pancreatic acinar cells. ß 2000 Elsevier Science B.V. All rights reserved. 0167-4889 / 00 / $^see front matter ß 2000 Elsevier Science B.V. All rights reserved. PII: S 0 1 6 7 -4 8 8 9 ( 0 0 ) 0 0 0 5 1 -3 * Corresponding
doi:10.1016/s0167-4889(00)00051-3 pmid:10838169 fatcat:gl6iyrdm5rf5lcfjqdjr4sf3kq

Remnant Lipoprotein Levels in Fasting Serum Predict Coronary Events in Patients With Coronary Artery Disease

Kiyotaka Kugiyama, Hideki Doi, Keiji Takazoe, Hiroaki Kawano, Hirofumi Soejima, Yuji Mizuno, Ryusuke Tsunoda, Tomohiro Sakamoto, Takamitsu Nakano, Katsuyuki Nakajima, Hisao Ogawa, Seigo Sugiyama (+2 others)
1999 Circulation  
Background-Remnant lipoproteins are atherogenic, but assays of remnants have not been available in routine clinical laboratories because of the lack of practical and validated methods. A simple and reliable method for such an assay, using an immunochemical approach, has recently been developed. This study prospectively examined whether remnant lipoprotein levels in fasting serum, measured by our method, may have prognostic value in patients with coronary artery disease (CAD). Methods and
more » ... -Remnant lipoprotein levels in fasting serum were measured in 135 patients with CAD by an immunoaffinity mixed gel containing anti-apolipoprotein (apo) A-1 and anti-apoB-100 monoclonal antibodies. Patients were followed up for Յ36 months until occurrence of 1 of the following clinical coronary events: recurrent or refractory angina pectoris requiring coronary revascularization, nonfatal myocardial infarction, or cardiac death. Kaplan-Meier analysis demonstrated a significantly higher probability of developing coronary events in patients with the highest tertile of remnant levels (Ͼ5.1 mg cholesterol/dL; 75th percentile of distribution of remnant levels) than in those with the lowest tertile of remnant levels (Յ3.3 mg cholesterol/dL; 50th percentile of the distribution). Higher levels of remnants were a significant and independent predictor of developing coronary events in multivariate Cox hazard analysis including the following covariates: extent of coronary artery stenosis, age, sex, smoking, hypertension, diabetes mellitus, hypercholesterolemia, low HDL cholesterol, and hypertriglyceridemia. Conclusions-Higher levels of remnant lipoproteins in fasting serum predict future coronary events in patients with CAD independently of other risk factors. Thus, measurement of fasting remnant levels, assessed by the current immunoseparation method, may be helpful in assessment of CAD risk. (Circulation. 1999;99:2858-2860.)
doi:10.1161/01.cir.99.22.2858 pmid:10359727 fatcat:he2hpxeg3rbbjljck3uo4a7xma

Heights of attachment to host in Haemaphysalis megaspinosa Saito and H. longicornis Neumann (Metastigmata : Ixodidae)
オオトゲチマダニ Haemaphysalis megaspinosa Saito とフタトゲチマダニ H. longicornis Neumann (Metastigmata : Ixodidae) が宿主に付着する高さ

Takashi TSUNODA, Keiji MORI
1995 Medical Entomology and Zoology  
引用文献 浅 沼 靖 ( 1965 ) ダニ 類 ( 々 学 編 ) , 486pp . , 東 京 大 学 出 版 会 Takashi TsuNODA and Keiji MORI * P 幼 砒 Heal'ゐ ム α 加 厂 刎 ory 己 ゾ C ゐf∂α Prefecture ,2靴 o π α 一 c んo , Chuo ・ 々u , Chiba 260 , 」ヒ zPan ( Received  ...  と フ ラ ッ ギ ン グ法 を 行 っ た 揚合 , Ixodes 属 で は 成 虫 が 幼 虫 と比 べ て 付着 し づ ら い こ と が示 唆 され て い る ,ま た ,千 葉県 南 部で の 両 種 成 虫 の 植 物 上 で の 行 動 か ら , 成 虫 の 活 動 性 が 調 査 し た 時 期 に は ま だ 低 い こ と も原 因 の 一 つ と考 え られ る ( Tsunoda  ... 
doi:10.7601/mez.46.381 fatcat:ce7ia6qxojcyhkm73hn4uga37e

A Case of Acute Pharyngitis Caused by Corynebacterium Ulcerans in Ibaraki Prefecture
茨城県で発見されたコリネバクテリウム・ウルセランスの1症例

Tomoko Kamada, Akio Hatanaka, Akihisa Tasaki, Keiji Honda, Atsunobu Tsunoda, Ken Kitamura
2012 Nippon Jibiinkoka Gakkai Kaiho  
Keiji Honda, M.D., Atsunobu Tsunoda , M.D. and Ken Kitamura , M.D.  ...  Hatanaka A, Tsunoda A, Okamoto M, et al : Corynebac- terium ulcerans Diphtheria in Japan. Emerg Infect Dis 2003 ; 9 : 752 753.  ... 
doi:10.3950/jibiinkoka.115.682 pmid:22991854 fatcat:auhyypgbn5foff4apqtrlcq6rq

Possible Lack of Carcinogenic Potential of 9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole (aminophenylnorharman) for the Pancreatic Duct Epithelium in Hamsters

Tadahiko Kubozoe, Masahiro Tsutsumi, Nao Murata, Toshifumi Tsujiuchi, Tsukasa Tsunoda, Takashi Sugimura, Keiji Wakabayashi, Yoichi Konishi
2002 Journal of Toxicologic Pathology  
The carcinogenic potential of 9-(4'-aminophenyl)-9H-pyrido [3,4-b]indole (aminophenylnorharman: APNH), a newly identified heterocyclic amine, was evaluated in a rapid production model for pancreatic duct adenocarcinoma in hamsters. In experiment 1, the initiation potential of APNH was examined. Hamsters received corn oil, 30 mg/kg body weight N-nitrosobis(2-oxopropyl)amine (BOP) or APNH (totally 50 and 100 mg/kg) as initiators followed by two cycles of augmentation pressure for pancreatic duct
more » ... arcinogenesis and were sacrificed 75 to 78 days after the beginning of the experiment. Ductal hyperplasia and atypical hyperplasias developed in hamsters receiving APNH but their numbers and incidences did not differ from the corn oil case. In experiment 2, promoting potential of APNH for pancreatic duct carcinogenesis was examined. Hamsters received 30 mg/kg body weight BOP as an initiator followed by augmentation pressures and thereafter diet containing 0, 25 or 50 ppm APNH for 50 days. All hamsters were sacrificed 100 days after the beginning of the experiment. The numbers and incidences of ductal lesions, including adenocarcinomas, did not differ among the experimental groups. The results suggest, APNH may not have initiation or promotion potential for pancreatic duct carcinogenesis in hamsters. (J Toxicol Pathol 2002; 15: 7-12)
doi:10.1293/tox.15.7 fatcat:d5i3yvq57vby3dssnjyup2wqly

Retroperitoneal Lavage in the Treatment of Infectious Necrotizing Pancreatitis. Report of a Case
後腹膜潅流が有効であった感染性壊死性すい炎の1例

Toshiya Ito, Kenya Chiba, Keiji Inoue, Kouichi Motoshima, Takashi Yamaguchi, Tsukasa Tsunoda, Takashi Kanematsu
1992 The Japanese Journal of Gastroenterological Surgery  
549, 1989 204: 122-127, 1986 6) Bradley EL III: Management of infected pan- Retroperitoneal Lavage in the Treatment of Infectious Necrotizing Pancreatitis Report of a Case- Toshiya Ito, Kenya Chiba*, Keiji  ...  Inoue**, Kouichi Motoshima**, Takashi Yamaguchi*, Tsukasa Tsunoda** and Takashi Kanematsu** The School of Allied Medical Sciences, Nagasaki University *Nishi-isahaya Hospital **Second Department of Surgery  ... 
doi:10.5833/jjgs.25.2397 fatcat:7vldd54cxje2fa4i7nk3xxpjsq

The expression of cytokines and their receptors in lymphoid tissues
ヒトリンパろ胞内サイトカイン及びサイトカイン・レセプターの発現

Kazuhiko Yamada, Mitsunori Yamakawa, Takashi Ogata, Tohru Tsuge, Hiroshi Ohrui, Takuya Tsunoda, Akihiko Suzuki, Keiji Niino, Michio Dobashi, Fumiaki Yuda, Yutaka Imai, Kouji Harada
1995 Journal of the Japan Society of the Reticuloendothelial System  
doi:10.3960/jslrt1961.35.309 fatcat:6ecl2qujn5blzf7vysban7maq4
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