A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is
To elucidate the host genetic loci affecting severity of SARS-CoV-2 infection, or Coronavirus disease 2019 (COVID-19), is an emerging issue in the face of the current devastating pandemic. Here, we report a genome-wide association study (GWAS) of COVID-19 in a Japanese population led by the Japan COVID-19 Task Force, as one of the initial discovery GWAS studies performed on a non-European population. Enrolling a total of 2,393 cases and 3,289 controls, we not only replicated previously reporteddoi:10.1101/2021.05.17.21256513 fatcat:y72edbfkw5borbwmfjni2mktqm
more »... COVID-19 risk variants (e.g., LZTFL1, FOXP4, ABO, and IFNAR2), but also found a variant on 5p35 (rs60200309-A at DOCK2) that was significantly associated with severe COVID-19 in younger (<65 years of age) patients with a genome-wide significant p-value of 1.2 × 10-8 (odds ratio = 2.01, 95% confidence interval = 1.58-2.55). This risk allele was prevalent in East Asians, including Japanese (minor allele frequency [MAF] = 0.097), but rarely found in Europeans. Cross-population Mendelian randomization analysis made a causal inference of a number of complex human traits on COVID-19. In particular, obesity had a significant impact on severe COVID-19. The presence of the population-specific risk allele underscores the need of non-European studies of COVID-19 host genetics.
Alcoholic Fatty Liver Disease (NAFLD) Is Associated with an Increased Risk for Diabetic Nephropathy MARIKO HIGA, KAORU YAMASHITA, RYO IGA, AYUMI YOSHIFUJI, EIKO YOSH-IDA, TAKAMASA ICHIJO, HIROMI OUCHI, ... MOTOSHI OUCHI, KAZUNARI SUZUKI, KENICHI SEKIMIZU, KENTARO WATANABE, TATSUYA SUZUKI, HIROSHI NAKANO, KENZO OBA, Tokyo, Japan Early Detection of Nerve Damage by Skin Biopsy Compared with Quantitative Small ...doi:10.2337/db11-478-715 fatcat:pa4wgetmzjftdh2epf2q5b3nz4