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Ketamine and pharmacological imaging

Eric A. Maltbie, Gopinath S. Kaundinya, Leonard L. Howell
2017 Behavioural Pharmacology  
., 2015; Gopinath et al., 2016) may be related to psychotomimetic effects, while persistent changes observed 24-hours post-infusion (Abdallah et al., 2016; Lv et al., 2016) may be more closely related  ...  Ketamine is a chiral compound consisting of a pair of (R,S) enantiomers and there is some evidence suggesting that R-ketamine may have greater antidepressant efficacy (Zhang et al., 2014) while also  ...  Thus, in the case of localized disinhibition of pyramidal neurons, as presumed with ketamine, the downstream areas receiving projections from the disinhibited region(s) may show the greatest enhancement  ... 
doi:10.1097/fbp.0000000000000354 pmid:29049083 pmcid:PMC5687297 fatcat:x4oxbpn2nbgnpb55fewjimyidy

A shift in perspective: Decentering through mindful attention to imagined stressful events

Lauren A.M. Lebois, Esther K. Papies, Kaundinya Gopinath, Romeo Cabanban, Karen S. Quigley, Venkatagiri Krishnamurthy, Lisa Feldman Barrett, Lawrence W. Barsalou
2015 Neuropsychologia  
A 6.9 s black screen appeared between the immersion and mindful attention blocks, and a 16 s black screen occurred at the end of each run.  ...  At the onset of a 10-event block, participants received a cue, "IMMERSION" or "MINDFUL," presented in white font on a black background that lasted for 2.3 s followed by 2.3 s of a black screen.  ... 
doi:10.1016/j.neuropsychologia.2015.05.030 pmid:26111487 pmcid:PMC4631025 fatcat:arjsq3y5kfcjpk6d6hfoplwncm

Word-finding impairment in veterans of the 1991 Persian Gulf War

Kristin Moffett, Bruce Crosson, Jeffrey S. Spence, Kimberly Case, Ilana Levy, Kaundinya Gopinath, Parina Shah, Aman Goyal, Yan Fang, Richard W. Briggs, John Hart, Anna Moore (+1 others)
2015 Brain and Cognition  
Approximately one quarter of 1991 Persian Gulf War Veterans experience cognitive and physiological sequelae that continue to be unexplained by known medical or psychological conditions. Difficulty coming up with words and names, familiar before the war, is a hallmark of the illness. Three Gulf War Syndrome subtypes have been identified and linked to specific war-time chemical exposures. The most functionally impaired veterans belong to the Gulf War Syndrome 2 (Syndrome 2) group, for which
more » ... tical damage due to toxic nerve gas exposure is the suspected cause. Subcortical damage is often associated with specific complex language impairments, and Syndrome 2 veterans have demonstrated poorer vocabulary relative to controls. 11 Syndrome 1 , 16 Syndrome 2, 9 Syndrome 3, and 14 agematched veteran controls from the Seabees Naval Construction Battalion were compared across three measures of complex language. Additionally, functional magnetic resonance imaging (fMRI) was collected during a covert category generation task, and whole-brain functional activity was compared between groups. Results demonstrated that Syndrome 2 veterans performed significantly worse on letter and category fluency relative to Syndrome 1 veterans and controls. They also exhibited reduced activity in the thalamus, putamen, and amygdala, and increased activity in the right hippocampus relative to controls. Syndrome 1 and Syndrome 3 groups tended to show similar, although smaller, differences than the Syndrome 2 group. Hence, these results further demonstrate specific impairments in complex language as well as subcortical and hippocampal involvement in Syndrome 2 veterans. Further research is required to determine the extent of language impairments in this population and the significance of altered neurologic activity in the aforementioned brain regions with the purpose of better characterizing the Gulf War Syndromes.
doi:10.1016/j.bandc.2015.05.005 pmid:26114921 fatcat:g3c6lekpsfdvxkumkfalmsdiia

Donepezil Effects on Hippocampal and Prefrontal Functional Connectivity in Alzheimer's Disease: Preliminary Report

Liam Zaidel, Greg Allen, C. Munro Cullum, Richard W. Briggs, Linda S. Hynan, Myron F. Weiner, Roderick McColl, Kaundinya S. Gopinath, Elizabeth McDonald, Craig D. Rubin, Pravat K. Mandal
2012 Journal of Alzheimer's Disease  
We used functional connectivity magnetic resonance imaging (fcMRI) to investigate changes in interhemispheric brain connectivity in 11 patients with mild Alzheimer's disease (AD) following eight weeks of treatment with the cholinesterase inhibitor donepezil. We examined functional connectivity between four homologous temporal, frontal, and occipital regions. These regions were selected to represent sites of AD neuropathology, sites of donepezil-related brain activation change in prior studies,
more » ... nd sites that are minimally affected by the pathologic changes of AD. Based on previous findings of selective, localized frontal responses to donepezil, we predicted that frontal connectivity would be most strongly impacted by treatment. Of the areas we examined, we found that treatment had a significant effect only on functional connectivity between right and left dorsolateral prefrontal cortices. Implications for understanding the impact of donepezil treatment on brain functioning and behavior in patients with AD are discussed. This preliminary report suggests that fcMRI may provide a useful index of treatment outcome in diseases affecting brain connectivity. Future research should investigate these treatment-related changes in larger samples of patients and age-matched controls.
doi:10.3233/jad-2012-120709 pmid:22886013 pmcid:PMC3749074 fatcat:tnpvkdcyajcbvatq64ogv6rqu4

Reduced Interference and Serial Dependency Effects for Naming in Older but not Younger Adults after 1 Hz rTMS of Right Pars Triangularis

Jonathan H. Drucker, Charles M. Epstein, Keith M. McGregor, Kyle Hortman, Kaundinya S. Gopinath, Bruce A. Crosson
2021 Neurobiology of Language  
s (2008) picture-naming findings in R PTr. (Recall that adults in the present study also were sedentary.)  ... 
doi:10.1162/nol_a_00063 fatcat:tr3rgfwjv5h2rmhzyhq2li3n5u

Semantic monitoring of words with emotional connotation during fMRI: Contribution of anterior left frontal cortex

BRUCE CROSSON, M. ALLISON CATO, JOSEPH R. SADEK, DIDEM GÖKÇAY, RUSSELL M. BAUER, IRA S. FISCHLER, LEEZA MARON, KAUNDINYA GOPINATH, EDWARD J. AUERBACH, SAMUEL R. BROWD, RICHARD W. BRIGGS
2002 Journal of the International Neuropsychological Society  
s (1996) finding in a comparison of animal and tool naming.  ...  Half cycles lasted 28 s, and stimuli were presented at precise intervals using a computerized playback system.  ... 
doi:10.1017/s1355617702801394 fatcat:a4cxquryafahlpeh42gcawxbrm

Functional MRI of Language in Aphasia: A Review of the Literature and the Methodological Challenges

Bruce Crosson, Keith McGregor, Kaundinya S. Gopinath, Tim W. Conway, Michelle Benjamin, Yu-Ling Chang, Anna Bacon Moore, Anastasia M. Raymer, Richard W. Briggs, Megan G. Sherod, Christina E. Wierenga, Keith D. White
2007 Neuropsychology Review  
In the latter part of the 1900's, dichotic listening also was used as an indication of hemispheric lateralization of language perception in aphasia.  ...  Gopinath et al. (2005) have developed a technique to compensate for differences in detection power of BOLD measures across sessions of the same paradigm.  ... 
doi:10.1007/s11065-007-9024-z pmid:17525865 pmcid:PMC2659355 fatcat:mqygnyk2fjg3xmxcyoiyuj63oq

Processing Words with Emotional Connotation: An fMRI Study of Time Course and Laterality in Rostral Frontal and Retrosplenial Cortices

M. Allison Cato, Bruce Crosson, Didem Gökçay, David Soltysik, Christina Wierenga, Kaundinya Gopinath, Nathan Himes, Heather Belanger, Russell M. Bauer, Ira S. Fischler, Leslie Gonzalez-Rothi, Richard W. Briggs
2004 Journal of Cognitive Neuroscience  
J., Cox, S. G., Ha, Y., Brammer, M. J., Williams, S. C. R., & Checkley, S. A. (1999). Functional MRI study of the cognitive generation of affect. American Journal of Psychiatry, 156, 209-215.  ...  The assessment and analysis of Press Paradiso, S., Johnson, D. L., Andreasen, N. C., O'Leary, D. S., Watkins, G. L., Ponto, L. L. B., & Hichwa, R. D. (1999).  ... 
doi:10.1162/089892904322984481 pmid:15068589 fatcat:dziwhcjcercbbhaoqxpmzgkhlu

Role of the Right and Left Hemispheres in Recovery of Function during Treatment of Intention in Aphasia

Bruce Crosson, Anna Bacon Moore, Kaundinya Gopinath, Keith D. White, Christina E. Wierenga, Megan E. Gaiefsky, Katherine S. Fabrizio, Kyung K. Peck, David Soltysik, Christina Milsted, Richard W. Briggs, Tim W. Conway (+1 others)
2005 Journal of Cognitive Neuroscience  
Role of the Right and Left Hemispheres in Recovery of Function during Treatment of Intention in Aphasia »2,3 Bruce Crosson’ , Anna Bacon Moore 12.5" Kaundinya Gopinath’, Keith D. White’, Christina E.  ...  Boston: Houghton Mifflin Gopinath, K. S. (2003). Reduction of noise associated with stimulus correlated motion in event related overt word generation paradigms.  ... 
doi:10.1162/0898929053279487 pmid:15814000 fatcat:dq2w72ljtvhilflrwol5yjvsdq

RELATIVISTIC ELECTRONS IN A ROTATING SPHERICAL MAGNETIC DIPOLE: LOCALIZED THREE-DIMENSIONAL STATES

JAMES M. GELB, KAUNDINYA S. GOPINATH, DALLAS C. KENNEDY
1999 International Journal of Modern Physics D  
Paralleling a previous paper, we examine single- and many-body states of relativistic electrons in an intense, rotating magnetic dipole field. Single-body orbitals are derived semiclassically and then applied to the many-body case via the Thomas-Fermi approximation. The many-body case is reminiscent of the quantum Hall state. Electrons in a realistic neutron star crust are considered with both fixed density profiles and constant Fermi energy. In the first case, applicable to young neutron star
more » ... rusts, the varying magnetic field and relativistic Coriolis correction lead to a varying Fermi energy and macroscopic currents. In the second, relevant to older crusts, the electron density is redistributed by the magnetic field.
doi:10.1142/s0218271899000201 fatcat:3gx2ogenfvchlliz4x4ticxd3a

RELATIVISTIC ELECTRONS ON A ROTATING SPHERICAL MAGNETIC DIPOLE: SURFACE ORBITALS

JAMES M. GELB, KAUNDINYA S. GOPINATH, DALLAS C. KENNEDY
1999 International Journal of Modern Physics D  
We now impose W-S quantization. Since P φ is conserved, the azimuthal quantization is trivial: P φ = n φh , (33) using the Bohr form of the W-S rule, valid for circular motion.  ...  The W-S semiclassical quantization is validated by the WKB approximation, with this restriction [9] .  ... 
doi:10.1142/s0218271899000195 fatcat:riqzqmfkqjewtbwi4kvf54kxna

Page 392 of Journal of Cognitive Neuroscience Vol. 17, Issue 3 [page]

2005 Journal of Cognitive Neuroscience  
Role of the Right and Left Hemispheres in Recovery of Function during Treatment of Intention in Aphasia »2,3 Bruce Crosson’ , Anna Bacon Moore 12.5" Kaundinya Gopinath’, Keith D. White’, Christina E.  ...  Gaiefsky’, Katherine S. Fabrizio”, Kyung K. Peck’, David Soltysik’, Christina Milsted*, Richard W. Briggs*, Tim W. Conway’, and Leslie J.  ... 

Selective detrending method for reducing task-correlated motion artifact during speech in event-related FMRI

Kaundinya Gopinath, Bruce Crosson, Keith McGregor, Kyung K. Peck, Yu-Ling Chang, Anna Moore, Megan Sherod, Christy Cavanagh, Ashley Wabnitz, Christina Wierenga, Keith White, Sergey Cheshkov (+2 others)
2009 Human Brain Mapping  
However, some TCM signal changes can last 8 s or more Gopinath et al., 2003; Palmer et al., 2001] .  ...  Time is expressed in units of image TR (TR ≈ 1.66 s).  ... 
doi:10.1002/hbm.20572 pmid:18465746 pmcid:PMC3010868 fatcat:kzbznxgbvbdtzcxn24sjrf67li

Discriminating brain activity from task-related artifacts in functional MRI: Fractal scaling analysis simulation and application

Jae-Min Lee, Jing Hu, Jianbo Gao, Bruce Crosson, Kyung K. Peck, Christina E. Wierenga, Keith McGregor, Qun Zhao, Keith D. White
2008 NeuroImage  
We thank Kaundinya Gopinath, Department of Radiology, University of Texas Southwestern Medical Center at Dallas, for useful discussions.  ...  1999 Mehta et al., 2006; Gopinath et al., 2003; Gopinath, 2003) .  ...  Ignoring such images does not work well, however, if temporal overlap exists between HDRs and artifacts due to reduced sensitivity for detecting HDRs (Birn et al., 1999; Gopinath et al., 2003; Gopinath  ... 
doi:10.1016/j.neuroimage.2007.11.016 pmid:18178485 pmcid:PMC2289872 fatcat:dvm4ywqt7jeexlnwjtgsnlzpei

Striatal functional connectivity networks are modulated by fMRI resting state conditions

Kaundinya Gopinath, Wendy Ringe, Aman Goyal, Kirstine Carter, Hubert R. Dinse, Robert Haley, Richard Briggs
2011 NeuroImage  
52% 0.0001 L somatosensory cortex 47 L, 28 P, 61 S 6291 34% 0.0001 R somatosensory cortex 43 R, 26P, 44 S 4941 27% 0.0004 Please cite this article as: Gopinath, K., et al., Striatal  ...  times = −12 s to + 12 s in steps of 2 s) in a single regression step.  ... 
doi:10.1016/j.neuroimage.2010.07.021 pmid:20637878 fatcat:vbafimr22fatti6vg5zuiptiha
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