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Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477-42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA polymerase (RNAP). In the late 1990s, structural information pertaining to bacterial RNAP has emerged that provided unprecedented insights into the function and mechanism of RNA transcription. In this review, I list all structures related to bacterialdoi:10.3390/biom5020848 pmid:25970587 pmcid:PMC4496699 fatcat:hlrewsddhrfibddief6pp2glgq
more »... AP (as determined by X-ray crystallography and NMR methods available from the Protein Data Bank), describe their contributions to bacterial transcription research and discuss the role that small molecules play in inhibiting bacterial RNA transcription.
. solfataricus E/F binds tightly to its core (their interaction is maintained in the presence of 3.5 M urea at 70 °C) suggesting stoichiometric association regardless of growth conditions (Hirata and Murakami ... Fe-S cluster in the S. solfataricus D subunit (1 Fe-S cluster, group 1) is oxygen stable whereas the Fe-S cluster in the A. fulgidus D subunit (2 Fe-S clusters, group 2) is oxygen-labile (Hirata and Murakami ...doi:10.1016/j.sbi.2009.10.006 pmid:19880312 pmcid:PMC2806685 fatcat:734j2a7tjfewvngzi45g7jnh5y
Proc Natl Acad Sci U S A 113, E1787-1795, (2016). 336 24 Pupov, D., Petushkov, I., Esyunina, D., Murakami, K. S. & Kulbachinskiy, A. ... Nucleic acids research 46, 11477-11487, (2018). 339 25 Murakami, K. S., Masuda, S. & Darst, S. A. Structural basis of transcription initiation: of ribosomal RNA transcription. ...doi:10.1101/2020.06.05.136721 fatcat:iq7jhe42jve3bo4ssvye7spfei
This paper demonstrates how effective re-analysis of the results of multiple gene finding programs is. Four simple algorithms to integrate the results of some programs are proposed and tested. Our experiments show that it is effective to use multiple gene finding programs simultaneously. We also developed a client program by which one can easily use the algorithm through the Internet.doi:10.11234/gi1990.8.308 fatcat:nuun4dzfjrhevnnvj6lzgizd24
村 上 忠幸 Tadayuki MURAKAMI 兵 庫 県 立姫 路 東 高 等 学 校 ・教 諭 高分 子45巻10月 号(1996年) 739 特集-高分子教育の現状と将来 予 備 校 にお け る化 学教 育 の一 例 An Example of Chemical Education in a Preparatory School 高等 学 校 の化 学 教 育 に用 い られ る教科 書 ...doi:10.1295/kobunshi.45.736 fatcat:srextzcdazbvtm5gumoihrupaq
Recently, obese subjects have increased because of the change of lifestyles such as westernization of the eating habits or the lack of exercise in Japan. Prevention of obesity is important to prevent metabolic syndrome such as dyslipidemia, hyperglycemia, hypertention and arteriosclerotic disease. Obesity, which is induced by multiple causes, is mainly determined by the interaction between genetic and environmental factors. To search the gene associated with obesity, candidate gene analysis anddoi:10.5650/oleoscience.10.351 fatcat:tyabxq6c45bmjbe7egdtmuawhi
more »... whole genome analysis are carried out using the single nucleotide polymorphisms (SNPs). As the result, several candidate genes have been reported to associate with obesity. It is necessary to diagnose multiple SNPs associated with obesity in many subjects to prevent obesity as the personalized medicine for the future. The SmartAmp (Smart Amplification Process) method is expected to be applied clinically for personalized medicine because of the simple, rapid and accurate diagnosis of SNPs.
Inclusion particles in stainless steel were investigated in continuously cast slabs in a full scale caster and ingots cast in several kinds of molds under laboratory conditions. Under such conditions particle size near slab surfaces was seen to be smaller. However, it was increasing with increasing depth going into the slab interior. In order to understand the mechanism of inclusion particle growth we applied four different mathematical models to predict the size distribution of particles. Ofdoi:10.2355/isijinternational.41.247 fatcat:cp55ywx75ncidfpjeiqu7lg5xy
more »... e four, the Ostwald ripening model, usually only applied to aqueous colloid phenomena, provided the best correlation with experimental results. This suggests that particles formed during solidification grow by "diffusion coalescence" due to the difference in solubility of neighboring particles which in turn is dependent on particle size.
Recent structural and biophysical results have provided unprecedented insights into the structure and function of the bacterial RNA polymerase holoenzyme as it goes through the steps of transcription initiation. Comparisons with structural analyses of evolutionarily unrelated RNA polymerases reveal unexpected general features of the initiation process.doi:10.1016/s0959-440x(02)00005-2 pmid:12581657 fatcat:tq56z2jfqvc4jiyazgieryy3ey
I thank Nobuyuki Fujita and Shoko Murakami for technical advice for constructing an RNAP-overexpressing vector (pGEMABC). ...doi:10.1074/jbc.m112.430900 pmid:23389035 pmcid:PMC3610985 fatcat:axeli2vfnzg2fiues5xczlxq4y
Turnbough, Jr, Catherine Sutherland and Shoko Murakami for critically reading the manuscript. This work was supported by NIH grants R01 GM087350 and R35 GM131860 (K.S.M.). ...doi:10.1101/732214 fatcat:76afmwk2mbgyvaq3gszhq7anbi
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