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Local Reweighting for Adversarial Training
[article]
2021
arXiv
pre-print
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Instances-reweighted adversarial training (IRAT) can significantly boost the robustness of trained models, where data being less/more vulnerable to the given attack are assigned smaller/larger weights during training. However, when tested on attacks different from the given attack simulated in training, the robustness may drop significantly (e.g., even worse than no reweighting). In this paper, we study this problem and propose our solution--locally reweighted adversarial training (LRAT). The
arXiv:2106.15776v1
fatcat:o3vndlnw2far5a7hsdnpxp2l2y
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... tionale behind IRAT is that we do not need to pay much attention to an instance that is already safe under the attack. We argue that the safeness should be attack-dependent, so that for the same instance, its weight can change given different attacks based on the same model. Thus, if the attack simulated in training is mis-specified, the weights of IRAT are misleading. To this end, LRAT pairs each instance with its adversarial variants and performs local reweighting inside each pair, while performing no global reweighting--the rationale is to fit the instance itself if it is immune to the attack, but not to skip the pair, in order to passively defend different attacks in future. Experiments show that LRAT works better than both IRAT (i.e., global reweighting) and the standard AT (i.e., no reweighting) when trained with an attack and tested on different attacks.
Mutagenesis facilitated crystallization of GLP-1R
2019
IUCrJ
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Stevens and Professor Zhi-Jie Liu for their mentoring and assistance on this project.
Funding information Xu et al. ...
doi:10.1107/s2052252519013496
pmid:31709055
pmcid:PMC6830218
fatcat:sakulrng4ben7ctnruwia3fxo4
Deep Reinforcement Learning for Orienteering Problems Based on Decomposition
[article]
2022
arXiv
pre-print
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Wei Liu, Tao Zhang, Rui Wang, Kaiwen Li, Wenhua Li and Kang Yang are with the College of System Engineering, National University of Defense Technology, Changsha 410073, PR China, and with the Hunan Key ...
arXiv:2204.11575v1
fatcat:hplcreteivdx5l4pk3llrbpb2e
Anti-parity-time topologically undefined state
[article]
2021
arXiv
pre-print
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We constructed an anti-parity-time-symmetric photonic lattice by using perturbations. The results show the topological state will appear when the waveguide coupling constants κ_1<κ_2; Interestingly, a state with undefined winding numbers occurs when κ_1=κ_2, in which the light distributes only in the wide waveguides with equal magnitude distribution. Further studies show that the edge state will be strengthened by introducing defect for the topologically non-trivial case, while it will not
arXiv:2107.02533v1
fatcat:pgy4ce727nh2dcxa6b3vm4zmzy
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... t the equal intensity transmission for the topologically undefined state. Our work provides a new way to realize the topological state and equally divided light transmission and might be applicable in optical circuits and optical interconnect.
Guaranteed Sufficient Decrease for Stochastic Variance Reduced Gradient Optimization
[article]
2018
arXiv
pre-print
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Supplementary Materials for "Guaranteed Sufficient Decrease for
Stochastic Variance Reduced Gradient Optimization"
Fanhua Shang, Yuanyuan Liu, Kaiwen Zhou, James Cheng, Kelvin K.W. ...
Liu, F. Shang, and J. Cheng. Accelerated vari-
ance reduced stochastic ADMM. In AAAI, pages
2287-2293, 2017.
[31] Y. Nesterov. ...
arXiv:1802.09933v1
fatcat:l2umcy4oyffqxf3fyy5zm5ey6y
Deep learning methods improve linear B-cell epitope prediction
2020
BioData Mining
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51.22
51.03
50.61
52.18
51.4
50.32
55.79
61.88
Bepipred2.0
51.89
52.10
51.26
52.8
54.02
53.85
53.23
55.33
DLBEpitope
88.80
89.98
90.85
91.58
93.95
95.68
73.83
65.5
Liu ...
doi:10.1186/s13040-020-00211-0
pmid:32699555
pmcid:PMC7371472
fatcat:cjbjjzgdrzhnllrj3mxvtwyj7a
A Proteomic View of Salmonella Typhimurium in Response to Phosphate Limitation
2018
Proteomes
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Acknowledgments: We thank the members of the Liu laboratory for critical reading of this manuscript.
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/proteomes6020019
pmid:29693629
pmcid:PMC6027262
fatcat:7xd4rvn2mzaxtcmmbhf5haizgm
CoDiM: Learning with Noisy Labels via Contrastive Semi-Supervised Learning
[article]
2021
arXiv
pre-print
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C2D (Zheltonozhskii et al. 2021) evaluates its effectiveness to initialize the model for different LNL methods such as DivideMix and ELR+ (Liu et al. 2020) . ...
criterions such as small-loss (Jiang et al. 2018; Han et al. 2018) and prediction disagreement (Malach and Shalev-Shwartz 2017) , or directly applying regularization through early-stop strategy (Liu ...
arXiv:2111.11652v1
fatcat:4qfk4z4eazbxviswhwjb5lvawy
Progress in Animal Models of Pancreatic Ductal Adenocarcinoma
2020
Journal of Cancer
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As a common gastrointestinal tumor, the incidence of pancreatic cancer has been increasing in recent years. The disease shows multi-gene, multi-step complex evolution from occurrence to dissemination. Furthermore, pancreatic cancer has an insidious onset and an extremely poor prognosis, so it is difficult to obtain cinical specimens at different stages of the disease, and it is, therefore, difficult to observe tumorigenesis and tumor development in patients with pancreatic cancer. At present,
doi:10.7150/jca.37529
pmid:32047562
pmcid:PMC6995380
fatcat:qqb5gjmruzd2llemmlcfdc2v5q
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... standard protocols stipulate clinical treatment of pancreatic cancer, and the benefit rate of new targeted therapies is low. For this reason, a well-established preclinical model of pancreatic cancer must be established to allow further exploration of the occurrence, development, invasion, and metastasis mechanism of pancreatic cancer, as well as to facilitate research into new therapeutic targets. A large number of animal models of pancreatic cancer are currently available, including a cancer cell line-based xenograft, a patient-derived xenograft, several mouse models (including transgenic mice), and organoid models. These models have their own characteristics, but they still cannot perfectly predict the clinical outcome of the new treatment. In this paper, we present the distinctive features of the currently popular pancreatic cancer models, and discuss their preparation methods, clinical relations, scientific purposes and limitations.
Identification of a NovelSalmonellaType III Effector by Quantitative Secretome Profiling
2017
Molecular & Cellular Proteomics
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Acknowledgments-We thank the members of the Liu laboratory for careful review of this manuscript. We also thank Dr. Xing Chen for the use of the Zeiss LSM700 confocal microscope and Dr. ...
doi:10.1074/mcp.ra117.000230
pmid:28887382
fatcat:i3dysdtqfzexhdmrd3yn6n263e
Effects of Diabetes on Inflammatory Status and Prognosis in Cancer Patients
2022
Frontiers in Nutrition
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BackgroundCancer and diabetes mellitus (DM) are prevalent, but there still a lack of convinced evidence clearly explaining the extent of the effect of diabetes in cancer.Data and MethodsClinical data of 2,929 cancer patients were collected. Diabetes were diagnosed according to the Diabetes Diagnosis and Treatment Criteria. BMI was classified by the BMI standards for Chinese adults published by the Working Group on Obesity. All involved patients were classified into the non-DM group and DM
doi:10.3389/fnut.2022.792577
pmid:35308284
pmcid:PMC8931397
fatcat:erosxuuu45aezmauarvfu3odce
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... The Kaplan–Meier curve, log-rank test and Cox regression analyses were used to perform survival analysis.ResultsCompared with non-DM patients, OS in DM patients was significant shorter in lung cancer (HR = 2.076, P = 0.001 in early stage; HR = 2.118, P < 0.001 in advanced stage), digestive tract cancer (HR = 1.768, P = 0.020 in early stage; HR = 2.454, P = 0.005 in advanced stage), leukemia (HR = 2.636, P < 0.001), breast cancer (HR = 2.495, P = 0.047 in early stage; HR = 2.929, P = 0.019 in advanced stage) and liver cancer (HR = 3.086, P < 0.001 in early stage; HR = 2.219, P = 0.049 in advanced stage). DM negatively influenced OS when the BMI was within the normal range in overall cancer (HR = 2.468, P < 0.001), lung cancer (HR = 2.297, P < 0.001), digestive tract cancer (HR = 2.354, P < 0.001), liver cancer (HR = 2.406, P = 0.001), leukemia (HR = 4.039, P < 0.001) and breast cancer (HR = 4.222, P = 0.008). Among those with BMI ≥ 24 kg/m2, DM played a role only in lung cancer (HR = 1.597, P = 0.037).ConclusionsPatients with diabetes tend to combine worse body composition and inflammation status, and that glycemic control can ameliorate the impairment of diabetes to some extent.
Multi-task Learning for Macromolecule Classification, Segmentation and Coarse Structural Recovery in Cryo-Tomography
[article]
2018
arXiv
pre-print
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In particular, Liu et al [15] have proposed a 3DCNN based segmentation network, named SSN3D-ED which is capable of masking out neighboring structures inside subtomograms while maintaining generalization ...
arXiv:1805.06332v1
fatcat:wqluw4qpprhilhed43ulir4kn4
An alternative route towards low-cost Cu2ZnSnS4 thin film solar cells
2013
Surface & Coatings Technology
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A non-vacuum and low-cost route to fabrication of Cu 2 ZnSnS 4 (CZTS) thin film as absorber layer for thin film solar cell is demonstrated. The process involves synthesis of Cu-Zn-Sn composite oxide nanoparticles, preparation of composite oxide ink, deposition of composite oxide thin film and subsequent sulfurization treatment. Cu-Zn-Sn composite oxide nanoparticles with proper composition and particle size can be obtained by controlling the chemical co-precipitation conditions. The effects of
doi:10.1016/j.surfcoat.2013.04.052
fatcat:g5dovw6lgfharjreeprslssyvi
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... ulfurization temperature on the compositional, structural, morphological, optical and electrical properties of the CZTS thin films were investigated. XRD, Raman and X-ray photoelectron spectroscopy analyses confirmed the formation of CZTS phase after sulfurization. The prepared CZTS thin films exhibit porous morphology and an optical band gap about 1.35 eV. The solar cells fabricated with the CZTS thin film sulfurized at 550°C showed a conversion efficiency of 1.22%.
Research on Operation Intention Based on Flexible Tactile Sensing Handle
2021
IEEE Access
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In order to obtain and analyze the operator's intention comprehensively and accurately in human-robot interaction, an array-type flexible tactile sensor was designed. The sensor was encapsulated into a tactile handle to sense the grasping state of the human hand in real time. According to the analysis of different operators' grasping posture and grasping habits, the grasping state was defined as 5 modes. Based on Harris feature point positioning and extraction, a method of grasping posture
doi:10.1109/access.2021.3050991
fatcat:66j34gheljcfzhd532bof23bly
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... rsion was proposed to ensure the completeness and standard of the extracted grasping features. A set of Convolutional Neural Networks (CNN) suitable for the real-time classification of the grasping intention was built to distinguish the grasping state sensed by the handle in real time, accurately determine the operator's intention, and complete the interaction with the robot. Using a UR collaborative robot as the experimental platform and the haptic handle as the intent sensing device, the intent-behaviour mapping relationship was constructed to control the motion of the UR collaborative robot. The experimental results show that the classification accuracy of operation intention is as high as 97.87%.
MiR-449a regulates caprine endometrial stromal cell apoptosis and endometrial receptivity
2017
Scientific Reports
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In this study, an RT-qPCR analysis showed that the expression levels of miR-449a in the pre-receptive endometrium were lower compared to the receptive endometrium, which is consistent with previous sequencing data (previous investigations). To detect the role of miR-449a in endometrial receptivity, we transfected caprine endometrial stromal cells (ESCs) cultured in vitro with miR-449a mimics. The results revealed that miR-449a decreased the mRNA and protein levels of LGR4 by targeting its
doi:10.1038/s41598-017-12451-y
pmid:28947781
pmcid:PMC5612931
fatcat:sz4uvwfduvegzotkr5d5j4v5ku
more »
... ranslated region. The miR-449a mimics significantly reduced the G 1 cell population from 52.56% (mimic NC) to 42.19% with a concordant increase in the G 2 and S cell populations from 47.44% (mimic NC) to 57.81%, suggesting that miR-449a caused ESC cell cycle arrest. In addition, the number of apoptotic cells was significantly higher in ESCs transfected with miR-449a mimics (P < 0.05) than in ESCs transfected with mimic NC. In vivo, rich pinopodes were observed on the endometrial surface in the miR-449a agomir group compared with the miR-449a antagomir group. The results of hematoxylin-eosin staining showed that endometrial thickness was significantly increased in the miR-449a agomir group compared with the miR-449a antagomir group. These results suggest that miR-449a could enhance endometrial receptivity. Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 Scientific RepoRts | 7: 12248 |
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