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Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model

H Tsuchiya, K Orimoto, K Kobayashi, O Hino
1996 Cancer Research  
The Eker insertional mutation (intron 30) disrupts their transcriptional activity.  ...  The Eker rat hereditary renal carcinoma is an excellent example of Mendelian dominant predisposition to a specific cancer in an experimental animal.  ...  k @ @ pSVGALHAVP @@I-___ 92. 5) Cl) U) @ @ @ @ 6 29 @. I- @-• @- RsplGAPhomology .  ... 
pmid:8564946 fatcat:y733y7i2ufhf7l7sfxklbolilu

Tumor-Specific Efficacy of Transforming Growth Factor- RI Inhibition in Eker Rats

N. J. Laping, J. I. Everitt, K. S. Frazier, M. Burgert, M. J. Portis, C. Cadacio, L. I. Gold, C. L. Walker
2007 Clinical Cancer Research  
Results TGF-b signaling in Eker rat uterine leiomyomas.  ...  Eker rats carry a germ line defect in the tuberous sclerosis complex 2 (Tsc2) tumor suppressor gene (32, 33) .  ...  Inhibition in Eker Rats Click on "Request Permissions" which will take you to the Copyright Clearance Center's . http://clincancerres.aacrjournals.org/content/13/10/3087 To request permission to re-use  ... 
doi:10.1158/1078-0432.ccr-06-1811 pmid:17505012 fatcat:4pefwpikajcethttfti5feppby

Carcinogen-Specific Gene Expression Profiles in Short-term Treated Eker and Wild-type Rats Indicative of Pathways Involved in Renal Tumorigenesis

K. Stemmer, H. Ellinger-Ziegelbauer, H.-J. Ahr, D. R. Dietrich
2007 Cancer Research  
Eker rats are more sensitive to carcinogeninduced changes in gene expression.  ...  Male Eker and wild-type rats were gavaged daily with AA (10 mg/kg body weight) or OTA (210 Mg/kg body weight).  ...  The 5.9-fold up-regulation of GMFB in Eker rats, shown here, and the known reduced 8-oxoguanine-DNA glycosylase expression in Eker rats (34) may suggest that Eker rats are more susceptible to oxidative  ... 
doi:10.1158/0008-5472.can-06-3587 pmid:17483316 fatcat:r5ybgr5q7zd4rfhldfb3534ejy

Effects of Prolactin onTSC2-Null Eker Rat Cells and in Pulmonary Lymphangioleiomyomatosis

Yasuhiro Terasaki, Kinnosuke Yahiro, Gustavo Pacheco-Rodriguez, Wendy K. Steagall, Mario P. Stylianou, Jilly F. Evans, Ameae M. Walker, Joel Moss
2010 American Journal of Respiratory and Critical Care Medicine  
Tsc2 2/2 Eker rat embryonic fibroblasts expressed more prolactin receptor than did Tsc2 1/1 cells, and responded to prolactin with increased proliferation and activation of the same signaling pathways  ...  Thomas Darling for the Eker rat embryonal fibroblast (EEF) Tsc2 2/2 and EEF Tsc2 1/1 cells. This study was supported by the Intramural Research Program, NIH/NHLBI.  ...  (A) Western blot analysis of PRLr in Eker rat embryonal fibroblast (EEF) Tsc2 2/2 cells and Tsc2 1/1 cells.  ... 
doi:10.1164/rccm.200911-1737oc pmid:20413627 pmcid:PMC2937243 fatcat:orihd57lwzb4bojeiwy3k6td6u

Radio Source Angular Sizes and Cosmology

R. D. Ekers, G. K. Miley
1977 Symposium - International astronomical union  
In each case the same exponential of form k exp(-£/300) is shown.  ...  Data is from Westerbork (Ekers et al., in preparation), #, and Katgert (1976), + , Ooty (Kapahi, 1975b), o, BDFL (Bridle et al., 1972), x, and all sky (Robertson, 1973), a.  ...  Ekers: Yes. We could obtain a complete sample of angular sizes for the Southern hemisphere sources.  ... 
doi:10.1017/s0074180900016090 fatcat:jmdmd7rppbeetnhp22otmuroki

SUBCLASSES OF k-UNIFORMLY CONVEX AND k-STARLIKE FUNCTIONS DEFINED BY SĂLĂGEAN OPERATOR

Bilal Seker, Mugur Acu, Sevtap Sumer Eker
2011 Bulletin of the Korean Mathematical Society  
The main object of this paper is to introduce and investigate new subclasses of normalized analytic functions in the open unit disc U, which generalize the familiar class of k-starlike functions.  ...  Thus we can write [(1 + k)j m − (k + α)j n ]b j ≤ [(1 + k)j m − (k + α)j n ]a j . Therefore, ∞ ∑ j=2 [(1 + k)j m − (k + α)j n ]b j ≤ ∞ ∑ j=2 [(1 + k)j m − (k + α)j n ]a j ≤ 1 − α.  ...  We consider the class k − ST , 0 ≤ k < ∞, of k-starlike functions (see [5] ) which are associated with k-uniformly convex functions by the relation f ∈ k − UCV ⇔ zf ′ ∈ k − ST .  ... 
doi:10.4134/bkms.2011.48.1.169 fatcat:ab2mqmoelfe5dcfni75d7vgfi4

A Simple State-Based Prognostic Model for Filter Clogging

Zakwan Skaf, Omer F. Eker, Ian K. Jennions
2015 Procedia CIRP  
The implementation of SBPD approach has three stages, as shown in Figure 2 : the first stage is clustering the health state of the system. k-means clustering technique is used in this work for its simplicity  ... 
doi:10.1016/j.procir.2015.08.094 fatcat:qr2trr2k3vdfrop3ulnkxrbu6e

Extragalactic Ionized Hydrogen in the Fornax Cluster

J. Bland-Hawthorn, R. D. Ekers, W. van Breugel, A. Koekemoer, K. Taylor
1995 Astrophysical Journal  
This compares with the energy equipartition field strength, ͱ16n e kT e 2 1.3 f Ϫ0.25 G, for an electron temperature of T e ϭ 10 4 K.  ...  The postshock temperature, T 1 1 2.6 ϫ 10 6 (v s /400) 2 K, will produce mostly hard UV radiation with very little in the ROSAT (0.2-2.4 keV) bandpass.  ... 
doi:10.1086/309575 fatcat:ff22hhpuufadrcozacf7pmo3eu

PATHWAY LOGIC MODELING OF PROTEIN FUNCTIONAL DOMAINS IN SIGNAL TRANSDUCTION

C. TALCOTT, S. EKER, M. KNAPP, P. LINCOLN, K. LADEROUTE
2003 Biocomputing 2004  
Ras S:Soup := N-Ras K-Ras H-Ras . Proceedings of the Computational Systems Bioinformatics (CSB'03) 0-7695-2000-6/03 $17.00 © 2003 IEEE  ... 
doi:10.1142/9789812704856_0053 fatcat:66gi2bqcujfepimw7zb2o4nzt4

A New Hybrid Prognostic Methodology

Omer F. Eker, Fatih Camci, Ian K. Jennions
2019 International Journal of Prognostics and Health Management  
𝑥 𝑘 , 𝑣 𝑘 ) (8) 𝑔 𝑘 : : Dynamic state transition equation 𝑥 𝑘 , 𝑥 𝑘−1 : State vectors at discrete time points k and k-1 𝜃 𝑘 : Model parameter vector 𝑤 𝑘 : Process noise ℎ 𝑘 : : Measurement  ...  ., 1979 ) and the second one has been reported in (Eker et al., 2016) .  ... 
doi:10.36001/ijphm.2019.v10i2.2727 fatcat:utz2cp5gqrfvbni45g53q6s2pm

Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10

R. S. Yeung, K. H. Buetow, J. R. Testa, A. G. Knudson
1993 Proceedings of the National Academy of Sciences of the United States of America  
Genomic DNA from parental and backcross animals was extracted from livers by using standard proteinase K/phenol extraction (23) and digested with appropriate restriction enzymes.  ...  Mapping of the RC locus in the Eker rat was accomplished by linkage analysis using backcross progeny segregating for the Eker phenotype.  ... 
doi:10.1073/pnas.90.17.8038 pmid:8103600 pmcid:PMC47283 fatcat:zqmmaarep5dsrcadeixdghai7y

Physics-based prognostic modelling of filter clogging phenomena

Omer F. Eker, Fatih Camci, Ian K. Jennions
2016 Mechanical systems and signal processing  
equation, is the measurement at time point k, and is the measurement noise.  ...  = ℎ ( , ) where : × × → is the dynamic state transition equation, -is the state vector at discrete time points k and k-1, is the model parameter vector, is the process noise, ℎ : × → is the measurement  ... 
doi:10.1016/j.ymssp.2015.12.011 fatcat:ltoiunbc7vaszpckfgn7c7xb3y

State-based Prognostics with State Duration Information of Cracks in Structures

Omar F. Eker, Zakwan Skaf, Fatih Camci, Ian K. Jennions
2014 Procedia CIRP  
The k-means clustering method gives the discrete health states number of each training specimen at any time.  ...  The K-means clustering method aims to group the samples of the dataset into clusters by optimizing the dispersion between the samples of the dataset and the centre of the identified cluster [25] .  ... 
doi:10.1016/j.procir.2014.07.128 fatcat:okcik5zt3bh6zoebum73vh3sfi

Consumer understanding of cigarette emission labelling

K. Gallopel-Morvan, C. Moodie, D. Hammond, F. Eker, E. Beguinot, Y. Martinet
2010 European Journal of Public Health  
The optimal way to display constituent levels (e.g. tar) on tobacco packaging has not received adequate attention but has important policy implications. Adult smokers and non-smokers (n = 836) were surveyed in France using Computer Assisted Personal Interviewing to assess perceptions of constituent levels displayed numerically (brand-specific tar and nicotine numbers from smoking machines and the current format in European Union), descriptively (a short sentence describing chemicals and their
more » ... alth effects but without any brand-specific numbers) or as a pack insert (a card placed on the inside of the pack describing the presence of chemicals and their health effects in more detail, as well as information on cessation). We also assessed perceptions of identically packaged cigarettes differing only on nicotine levels. Displaying information regarding ingredients either descriptively or on pack inserts was perceived as more comprehensible and informative than displaying them numerically. Numeric yields were associated with false beliefs: almost half the sample perceived packs with lower nicotine levels (0.8 mg vs. 0.9 mg) to be safer.
doi:10.1093/eurpub/ckq087 pmid:20601380 pmcid:PMC3098895 fatcat:kbha5ziz6nfwlnzosy7v6ffqvm

DNA photoreactivating enzyme from the cyanobacterium Anacystis nidulans

A P Eker, P Kooiman, J K Hessels, A Yasui
1990 Journal of Biological Chemistry  
Eker, J. K. C. Hessels, and A.Yasui, unpublished results.) 700 2 Wavelength Inml FIG. 8.  ...  Eker, unpublished results. by guest on March 24, 2016 http://www.jbc.org/ Downloaded from , 9-16 by guest on March 24, 2016 http://www.jbc.org/ Downloaded from  ... 
pmid:2110564 fatcat:bjn2f5sq2bfphb7vncwl4hjvyu
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