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Autoimmune Hepatitis Accompanied by Systemic Lupus Erythematosus

Jun TOJO, Hiromasa OHIRA, Kazumichi ABE, Junko YOKOKAWA, Junko TAKIGUCHI, Tsuyoshi RAI, Shoichiro SHISHIDO, Yukio SATO, Reiji KASUKAWA
2004 Internal medicine (Tokyo. 1992)  
We report a series of five patients with autoimmune hepatitis (AIH) accompanied by systemic lupus erythematosus (SLE) (AIH-SLE overlap). Serologic tests showed that all patients were positive for antinuclear antibody and double-stranded DNA antibody. Histological examination of the liver showed that three of the patients had chronic hepatitis with severe activity. One of the other two had acute and severe hepatitis with submassive necrosis in both portal and lobular areas. The last patient
more » ... dy had liver cirrhosis. All patients had a mild form of SLE and showed a rapid response to corticosteroid. There was no serious involvement of organs other than the liver in any of the patients, and the prognoses were comparatively good in all patients. (Internal Medicine 43: [258][259][260][261][262] 2004)
doi:10.2169/internalmedicine.43.258 pmid:15098613 fatcat:qmiajb4x4zeefkkwzoqgxdu3gy

Cholesterol Sulfate Inhibits Proteases that are Involved in Desquamation of Stratum Corneum

Junko Sato, Mitsuhiro Denda, Jotaro Nakanishi, Junko Nomura, Junichi Koyama
1998 Journal of Investigative Dermatology  
We previously reported that desmosomes play a key role in the adhesion of corneocytes, and their digestion by two types of serine proteases leads to desquamation. Patients with recessive X-linked ichthyosis show hyperkeratosis attributable to desmosomes, associated with an increased content of cholesterol sulfate (CS) and an increased thickness of stratum corneum. In this study, therefore, we examined the possibility that CS provokes the abnormal desquamation, acting as a protease inhibitor.
more » ... ling was induced on mice after topical application of chymostatin and leupeptin. Visible scale was also observed on mice after topical application of CS. We found that the stratum corneum thickness of CStreated mice was increased in comparison with that of vehicle-treated mice. The thickness of the epidermis and the labeling index with proliferating cell nuclear antigen
doi:10.1046/j.1523-1747.1998.00244.x pmid:9699715 fatcat:kj4uvusjzfc2njktcgnwa2i7ba

ADHESION MOLECULES AND CXC CHEMOKINES IN ENDOTOXIN-INDUCED LIVER INJURY

HIROMASA OHIRA, KAZUMICHI ABE, JUNKO YOKOKAWA, JUNKO TAKIGUCHI, TSUYOSHI RAI, SHOICHIRO SHISHIDO, YUKIO SATO
2003 Fukushima Journal of Medical Science  
Interactions between leukocytes and sinusoidal endothelial cells are known to be involved in the pathogenesis of acute liver injury. Various adhesion molecules and chemokines play key roles in these celI-to-celI interactions, and the expression of these adhesion molecules and the production of chemokines are regulated by inflammatory cytokines such as tumor necrosis factor-a (TNF -a), interleukin-1 (IL-1), and interferon-y (IFN-y). We have shown that the expression of intercellular adhesion
more » ... cule-1 (I CAM -I) on cultured rat sinusoidal endothelial cells stimulated with TNF -a increases in a dose-dependent manner. The number of neutrophils that adhered to sinusoidal endothelial cells pretreated with TNF-a also increased in a dose-dependent manner and significantly decreased upon incubation with an anti -ICAM -1 antibody. In endotoxin-induced rat liver injury, the number of neutrophils infiltrating the sinusoids increased after serum TNF -a, macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (CINC) reached their peak levels. In addition, the level of ICAM-1 expression on sinusoidal endothelial cells greatly increased from 8 h after exposure to endotoxin, and these cells were adhered to neutrophils that expressed both LF A-1 and Mac-l. Moreover, lipo-prostaglandin E1 (PGE1) reduced the extent of liver injury, and also reduced the number of neutrophils that infiltrated the liver, was reduced the production of MIP-2 and CINC, but not that of TNF-a, in rats injected with endotoxin.
doi:10.5387/fms.49.1 fatcat:trlchyu2dzax7o7ijyswbsilbe

Adhesion molecules and CXC chemokines in endotoxin-induced liver injury

Hiromasa Ohira, Kazumichi Abe, Junko Yokokawa, Junko Takiguchi, Tsuyoshi Rai, Shoichiro Shishido, Yukio Sato
2003 Fukushima Journal of Medical Science  
Interactions between leukocytes and sinusoidal endothelial cells are known to be involved in the pathogenesis of acute liver injury. Various adhesion molecules and chemokines play key roles in these cell-to-cell interactions, and the expression of these adhesion molecules and the production of chemokines are regulated by inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interferon-gamma (IFN-gamma). We have shown that the expression of
more » ... r adhesion molecule-1 (ICAM-1) on cultured rat sinusoidal endothelial cells stimulated with TNF-alpha increases in a dose-dependent manner. The number of neutrophils that adhered to sinusoidal endothelial cells pretreated with TNF-alpha also increased in a dose-dependent manner and significantly decreased upon incubation with an anti-ICAM-1 antibody. In endotoxin-induced rat liver injury, the number of neutrophils infiltrating the sinusoids increased after serum TNF-alpha, macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (CINC) reached their peak levels. In addition, the level of ICAM-1 expression on sinusoidal endothelial cells greatly increased from 8 h after exposure to endotoxin, and these cells were adhered to neutrophils that expressed both LFA-1 and Mac-1. Moreover, lipo-prostaglandin E1 (PGE1) reduced the extent of liver injury, and also reduced the number of neutrophils that infiltrated the liver, was reduced the production of MIP-2 and CINC, but not that of TNF-alpha, in rats injected with endotoxin.
pmid:14603947 fatcat:qmyfmdqpdfhclgjx7ms54ygaou

Hepatocellular Carcinoma Associated with Wilson's Disease

Haruyo IWADATE, Hiromasa OHIRA, Tomohiro SUZUKI, Kazumichi ABE, Junko YOKOKAWA, Junko TAKIGUCHI, Tsuyoshi RAI, Hiroshi ORIKASA, Atsushi IRISAWA, Katsutoshi OBARA, Reiji KASUKAWA, Yukio SATO
2004 Internal medicine (Tokyo. 1992)  
A 23-year-old man was admitted to our department due to hemorrhage from gastric varices. He had been diagnosed as having Wilson's disease at the age of 17. Abdominal ultrasonography and computed tomography (CT) showed portal thrombosis and a large mass occupying most of the right lobe in the liver. The tumor was diagnosed as hepatocellular carcinoma (HCC) by image views and tumor markers. He died 3 months after the diagnosis, and an autopsy was performed. Histologic examination of the tumor
more » ... ed moderately to poorly differentiated HCC. The nontumorous lesion of the liver revealed cirrhosis. HBX-DNA sequence was not detected in the liver. Hepatic cirrhosis is a well-recognized complication of Wilson's disease, but HCC is extremely rare. We describe the clinical findings of this patient and discuss the relationship of the development of HCC with a review of the relevant literature.
doi:10.2169/internalmedicine.43.1042 pmid:15609699 fatcat:lud77sr2grbbvbrvnbgknrldei

PMDA医薬品・医療機器アジアトレーニングセンターについて

Junko Sato
2016 Iryo To Shakai  
doi:10.4091/iken.26.137 fatcat:uygvepkpmbfn7nvlv4jzm7qufy

Cultivable Anaerobic Microbiota of Infected Root Canals

Takuichi Sato, Keiko Yamaki, Naoko Ishida, Kazuhiro Hashimoto, Yasuhisa Takeuchi, Megumi Shoji, Emika Sato, Junko Matsuyama, Hidetoshi Shimauchi, Nobuhiro Takahashi
2012 International Journal of Dentistry  
Sato and K. Yamaki share first authorship.  ... 
doi:10.1155/2012/609689 pmid:22548063 pmcid:PMC3324152 fatcat:s2nexjg3ufdyjbkgqbv2rplbpy

Summary

Junko SATO, Hajime YASUHARA
2008 Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics  
doi:10.3999/jscpt.39.49s fatcat:xxporthgkrdnvg5z7gtyc3tevu

6) Directions and Possibilities of New Drug Development

Junko Sato
2019 Nihon Naika Gakkai Zasshi  
Junko Sato:Pharmaceuticals and Medical Devices Agency, Japan.  ... 
doi:10.2169/naika.108.1830 fatcat:doixkuqfo5hvrdsw76rdvaebmu

Safety and efficacy of a new tourniquet system

Junko Sato, Yoshinori Ishii, Hideo Noguchi, Mitsuhiro Takeda
2012 BMC Surgery  
In upper limb surgery, the pneumatic tourniquet is an essential tool to provide a clean, bloodless surgical field, improving visualization of anatomical structures and preventing iatrogenic failure. Optimal inflation pressure to accomplish these objects without injuring normal tissue and inducing complications is not yet established. Use of the minimum tourniquet pressure necessary to produce a bloodless surgical field is preferable in order to prevent injury to normal tissue. Various methods
more » ... ve been implemented in an effort to lower effective cuff pressure. The purpose of this study is to report clinical experience with a new tourniquet system in which pressure is synchronized with systolic blood pressure (SBP) using a vital information monitor. Methods: We routinely used the tourniquet system in 120 consecutive upper limb surgeries performed under general anaesthesia in our operating room instead of our clinic. Cuff pressure was automatically regulated to additional 100 mmHg based on the SBP and was renewed every 2.5 minutes intervals. Results: An excellent bloodless field was obtained in 119 cases, with the exception of one case of a 44-year-old woman who underwent internal screw fixation of metacarpal fracture. No complications, such as compartment syndrome, deep vein disorder, skin disorder, paresis, or nerve damage, occurred during or after surgery. Conclusions: This new tourniquet system, synchronized with SBP, can be varied to correspond with sharp rises or drops in SBP to supply adequate pressure. The system reduces labor needed to deflate and re-inflate to achieve different pressures. It also seemed to contribute to the safety in upper limb surgery, in spite of rare unexpected oozing mid-surgery, by reducing tissue pressure.
doi:10.1186/1471-2482-12-17 pmid:22894765 pmcid:PMC3465201 fatcat:iqpovli5pzdynbempsf6eamyzy

Color visual acuity in preperimetric glaucoma and open-angle glaucoma

Junko Ouchi, Hiroshi Kunikata, Kazuko Omodaka, Haruka Sato, Hiroyuki Sato, Azusa Ito, Naoko Aizawa, Yoshiki Tanaka, Kazuo Ichikawa, Toru Nakazawa, Sanjoy Bhattacharya
2019 PLoS ONE  
The principal investigator, Junko Ouchi, had full access to all the data in the study and takes responsibility for the integrity of the data (S2 Table) and the accuracy of the data analysis.  ...  Shoji T, Nagaoka Y, Sato H, Chihara E. Impact of high myopia on the performance of SD-OCT parameters to detect glaucoma.  ... 
doi:10.1371/journal.pone.0215290 pmid:30995280 pmcid:PMC6469804 fatcat:x3totwwk3rdhzoizyh3kotzera

Study of "Individuality" on Nursing Care Job

Kimiko YAMAMOTO, Miwako HIRAKAWA, Chigusa OMORI, Tomoko Sato, Masami AMANO, Yukiko SATO, Junko OTA, Saori MATSUZAKI, Yoshiyuki INOUE, Takahito TAKEUCHI
2018 Asian Journal of Human Services  
A s i a n J o u r n a l o f HUMAN ABSTRACT The objective of this research is to clarify how nursing care staff perceive the user's "individuality" based on their shared view in nursing care practices. The survey with paper questionnaire was conducted among 114 nursing care staff who worked at a care giving facility. As a result, 95 (83.3%) commented they had an experience of using the word, "individuality," 22 (19.3%) commented they provided nursing care with "individuality" all the time, and
more » ... (59.6%) commented sometimes. In addition, we conducted the self-assessment and others-assessment personality test (BigFive short version) among 12 users who were engaged with all 9 nursing care staff in the same team, and then analyzed with Friedman test. As a result, it was clear that nursing care staff had different user perception on four factors, extroversion, openness, sincerity, and harmonicity, whereas they had a common perception on one factor, emotional unstableness. This indicates that it has high potential of providing consistent emotional care; however, it is also considered that they tend to provide care focusing on emotion. individuality, personality, nursing care job, elderly, user kimi31ko@ks.kyorin-u.ac.jp(Kimiko YAMAMOTO; Japan) Asian J Human Services, 2018, 15:52-65.
doi:10.14391/ajhs.15.52 fatcat:e4lqxoneizfove45qys72zwpga

Bombesin-like immunoreactivity in mammalian tissues

CHIZUKO YANAIHARA, ATSURO INOUE, TOHRU MOCHIZUKI, JUNKO OZAKI, HARUKO SATO, NOBORU YANAIHARA
1980 Biomedical research  
Antiserum directed to the amphibian bombesin was raised in a guinea pig using the conjugate of N"-glycyl-[1-Glutamine]-bombesin with bovine serum albumin. The major immunologic determinant of this antiserum GP-3303 was shown to reside in the 6-7 sequence of bombesin. Bombesin-like immunoreactivities in gastrointestinal tissue extracts of the pig, dog, monkey, rat and guinea pig were found to be extremely low when measured by the present radioimmunoassay system using antiserum GP-3303. The
more » ... e gastrin releasing peptide recently isolated has the same decapeptide sequence as bombesin (5-14) in the C-terminal region except for the amino acid in position 7 of the bombesin molecule. The very low concentrations of bombesin-like immunoreactivity in the mammalian tissue extracts examined in the present study seem to reflect, at least in part, this amino acid substitution in the position corresponding to position 7 of bombesin, since the amino acid is involved in the major immunologic determinant of antiserum GP-3303. The present result also suggests that the bombesin-like immunoreactivity detected in mammalian tissues may be due to a new group of peptides in which the porcine gastrin releasing peptide is included. KEY WORDS bombesin-like immunoreactivity / porcine gastrin releasing peptide / radioimmunoassay
doi:10.2220/biomedres.1.96 fatcat:udn5gl5i6vcalfzdsduebpb6yu

Gonadal macrophage infiltration in congenital lipoid adrenal hyperplasia

Tomohiro Ishii, Ryuji Fukuzawa, Takeshi Sato, Koji Muroya, Masanori Adachi, Kenji Ihara, Junko Igaki, Yukihiro Hasegawa, Seiji Sato, Toshikatsu Mitsui, Tomonobu Hasegawa
2016 European Journal of Endocrinology  
Objective Congenital lipoid adrenal hyperplasia (lipoid CAH) results in impairment of adrenal and gonadal steroidogenesis caused by STAR mutations. Our previous study revealed upregulation of genes associated with inflammatory or immune response and macrophage infiltration in the adrenal cortex of Star-knockout mice. This study aimed at investigating macrophage infiltration in the gonads from human patients with lipoid CAH. Design This study includes seven patients with lipoid CAH who underwent
more » ... gonadectomy: two XX women (age, 22 and 40 years) and five XY boys (1 year). Two women with ovarian cysts (32 and 40 years) and six boys with autopsy or tumor (1 year) were examined as controls. Immunohistochemical analysis of their gonads was performed to determine steroidogenic cells by NR5A1 or CYP17A1 and macrophages by IBA1 or CD68. Results An increased number of macrophages infiltrated into the ovaries of lipoid CAH and consisted of two subpopulations: one scattered within and around a layer of theca cells of maturing follicles and the other massively aggregated in the stroma. Abundant cytoplasmic lipid droplets were observed not only in the theca cells but also in the stromal macrophages. There was no significant difference in the number of macrophages in the testicular interstitium between lipoid CAH (95% confidence interval (95% CI: 19.3–47.7 per 0.2mm2) and controls (95% CI: 13.3–25.8 per 0.2mm2) (P=0.10). Conclusions These results demonstrate that macrophages infiltrate the ovaries of lipoid CAH, where the theca cells and the stromal macrophages have abundant cytoplasmic lipid droplets.
doi:10.1530/eje-16-0194 pmid:27190208 fatcat:b37l64ofdnawvgxssf6pj4lpvi

Construct of "Individuality" Perceived by Nursing Care Workers:

Kimiko YAMAMOTO, Miwako HIRAKWA, Masami AMANO, Chigusa OHMORI, Yukiko SATO, Tomoko SATO, Junko OHTA, Saori MATSUZAKI, Yoshiyuki INOUE, Takahito TAKEUCHI
2019 Asian Journal of Human Services  
The research objective is to clarify the awareness of nursing care workers how they perceive "Individuality" of users and what they actually do to respect "individuality" when providing cares. We had semi-structured interview among 20 nursing care workers who worked at care welfare facilities over three years. We prepared verbatim and qualitatively analyzed data using inductive approach. As a result, we had 52 codes, 13 sub-categories and 6 categories, and found that nursing care workers
more » ... essential care "now" and "here" for individual users. The word, "individuality" includes the consistency sought when providing cares and the uniqueness of individual nursing care workers with a certain balance, and this shows unique relationship of users and nursing care workers. individuality, nursing care job, elderly, users k_yamamto@t-junshin.ac.jp (Kimiko YAMAMOTO; Japan) Asian J Human Services, 2019, 16:58-67.
doi:10.14391/ajhs.16.58 fatcat:gtui5g5jszfqdi67wra2slhwk4
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