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Aging and Disease
Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients with acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) providers could reduce onset to needle time (ONT) and improve neurological outcome in AIS patients who received IVT. We prospectively collected the consecutive clinical and timedoi:10.14336/ad.2017.0601 pmid:29896430 pmcid:PMC5988597 fatcat:jtf7fsgbcbh73bxviu5nrjqtoy
more »... a of AIS patients who received IVT during one year after the initiation of prehospital notification procedure (PNP). Patients were divided into three groups, including patients that transferred by EMS with and without PNP and other means of transportation (non-EMS). We then compared the effect of EMS with PNP and EMS use only on ONT, and the subsequent neurological outcome. Good outcome was defined as modified Rankin Scale score of 0-2 at 3-months. In 182 patients included in this study, 77 (42.3%) patients were transferred by EMS, of whom 41 (53.2%) patients entered PNP. Compared with non-EMS group, EMS without PNP group greatly shortened the onset to door time (ODT), but EMS with PNP group showed both a significantly shorter DNT (41.3 ± 10.7 min vs 51.9±23.8 min, t=2.583, p=0.012) and ODT (133.2 ± 90.2 min vs 174.8 ± 105.1 min, t=2.228, p=0.027) than non-EMS group. Multivariate analysis showed that the use of EMS with PNP (OR=2.613, p=0.036), but not EMS (OR=1.865, p=0.103), was independently associated with good outcome after adjusting for age and baseline NIHSS score. When adding ONT into the regression model, ONT (OR=0.994, p=0.001), but not EMS with PNP (OR=1.785, p=0.236), was independently associated with good outcome. EMS with PNP, rather than EMS only, improved stroke outcome by shortening ONT. PNP could be a feasible strategy for better stroke care in Chinese urban area.
Burns & Trauma
In 2008, Zhang et al. identified a stem cell population in urine, with an expansion potential for up to ten passages in vitro  . ... et al.  W + + + \ + \ − \ \ − − \ − Chen et al.  + + + + \ \ + \ \ \ − − \ − Xing et al.  \ \ + + \ + \ \ \ \ \ − − − Cao et al.  \ + + + + \ \ − \ \ − − \ − Zhang et al.  \ + + + ...doi:10.1093/burnst/tkab039 pmid:34859109 pmcid:PMC8633594 fatcat:kgiydkpjund4tk4j3kx4zeunsi
BackgroundsThe timely identification of large vessel occlusion (LVO) in the prehospital stage is extremely important given the disease morbidity and narrow time window for intervention. The current evaluation strategies still remain challenging. The goal of this study was to develop a machine learning (ML) model to predict LVO using prehospital accessible data.MethodsConsecutive acute ischaemic stroke patients who underwent CT or MR angiography and received reperfusion therapy within 8 hoursdoi:10.1136/svn-2021-001096 pmid:34702747 pmcid:PMC9067264 fatcat:mhcnz3nmwrgnxhtmnoie5ey24u
more »... m symptom onset in the Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation-II dataset from January 2016 to August 2021 were included. We developed eight ML models to integrate National Institutes of Health Stroke Scale (NIHSS) items with demographics, medical history and vascular risk factors to identify LVO and validate its efficiency.ResultsFinally, 15 365 patients were included in the training set and 4215 patients were included in the test set. On the test set, random forests (RF), gradient boosting machine and extreme gradient boosting presented area under the curve (AUC) of 0.831 (95% CI 0.819 to 0.843), which were higher than other models, and RF presented the highest specificity (0.827). In addition, the AUC of RF was higher than other scales, and the accuracy of the model was improved by 6.4% compared with NIHSS. We also found the top five items of identifying LVO were total NIHSS score, gaze deviation, level of consciousness (LOC), LOC commands and motor left leg.ConclusionsOur proposed model could be a useful screening tool to predict LVO based on the prehospital accessible medical data.Trial registration numberNCT04487340.
Following Mahler's framework forinformation fusion, this paper develops a implementationof cardinalized probability hypothesis density (CPHD)filter for bearings-only multitarget tracking.Rao-Blackwellized method is introduced in the CPHDfiltering framework for mixed linear/nonlinear state spacemodels. The sequential Monte Carlo (SMC) method is usedto predict and estimate the nonlinear state of targets.Kalman filter (KF) is adopted to estimate the linear stateswith the information embedded indoi:10.46300/9106.2020.14.141 fatcat:zdcbqrnpgfanznvh2rzufwyhuy
more »... estimated nonlinearstates. The multitarget state estimates are extracted byutilizing the kernel density estimation (KDE) theory andmean-shift algorithm to enhance tracking performance.Moreover, the computational load of the filter is analyzedby introducing equivalent flop measure. Finally, theperformance of the proposed Rao-Blackwellized particleCPHD filter is evaluated through a challengingbearings-only multitarget tracking simulation experiment.
In radar target tracking application, the observation noise is usually non-Gaussian, which is also referred to as glint noise. The performances of conventional trackers degrade severely in the presence of glint noise. An improved particle filter, Markov chain Monte Carlo iterated extended Kalman particle filter (MCMC-IEKPF), is applied to this problem. The tracking performance of the filter is evaluated and compared to the particle filter (PF) and the Markov chain Monte Carlo particle filterdoi:10.1109/icsmc.2009.5346071 dblp:conf/smc/ZhangJX09 fatcat:4vdbzaoawrdbpcntxadt2y65im
more »... MC-PF) via simulations. It is shown that the MCMC-IEKPF has better tracking performance.
Heatstress transcription factor A-2/B-1, the key regulator alleviating oxidative damage caused by heat stress negatively regulated by cold stress in Arabidopsis (Zhang et al., 2009) , was downregulated ...doi:10.3389/fpls.2016.01281 pmid:27621739 pmcid:PMC5002408 fatcat:5mpinzrtmnc6hlyytyyr4siwl4
Furan (C 4 H 4 O) has been classified as a possible animal and human carcinogen by many international agencies. The formation of furan in three sugar-glycine models using glucose, fructose, and sucrose was investigated using headspace gas chromatography mass spectrometry method (HS-GC-MS) with various dual combinations of three important heat processing conditions, i.e. pH, temperature, and heating time. Results indicated that furan levels from sugar-glycine model systems during the thermaldoi:10.1016/j.fshw.2013.05.001 fatcat:iim4pd6kc5dexdxp5szprjjrcu
more »... essing can be attributed to selective sugar types, pH, temperature, and heating time. In glucose-glycine and fructose-glycine system, the lowest furan level was detected in acid condition but in sucrose-glycine system furan formed significantly lower (P < 0.05) in acidic conditions the lowest furan level was found in alkaline conditions. The furan levels were observed to increase with heating time in all three model systems. Furthermore, less furan was generated in non-reducing sugar system (sucrose) than in reducing sugar system (glucose and fructose). Therefore, they demonstrate the possibility of limiting the formation of furan in heat processed foods by both the careful selection of carbohydrates (i.e. non-reducing sugars and reducing sugars) ingredients and appropriate processing conditions.
The dominant male sterility gene Ms-cd1 is identified in Brassica oleracea. Electron microscopical observations revealed that abortion of pollen development starts after tetrad formation. This important male sterility phenotype is characterized by lack of degradation of the primary pollen mother cell (PMC) wall and delayed degradation of callose surrounding the tetrads and thus arrest of microspore release. Gene expression of the male sterile and fertile buds was analyzed by heterologousdoi:10.1007/s11103-007-9261-9 pmid:18040866 fatcat:jtd5eldbv5gv7bxutz44cpmgfy
more »... zation of Brassica oleracea cRNA onto an Arabidopsis whole genome oligonucleotide microarray. A total of 277 suppressed genes including 40 kinase-, 32 cell wall modification and 29 transport related genes were found to be significantly down regulated [3-fold in the male sterile mutant. The vast majority of the differentially expressed transcripts are found to present late pollen stage specific genes. Kinase genes, cell wall modification genes and ion transport genes were greatly over-represented when compared to their percentage of all flower bud expressed genes and represent 36.5% of the genes suppressed by Ms-cd1. Our results also suggest that Ms-cd1 may blocks an anther developmental pathway with a small number of genes suppressed in tapetum cells which prevent the degradation of callose and PMC wall, which further leads to the suppression of a large number of genes involved in signaling pathways, cell wall modification and ion transport in pollen grains.
Cabbage Fusarium wilt is a major disease worldwide that can cause severe yield loss in cabbage (Brassica olerecea). Although markers linked to the resistance gene FOC1 have been identified, no candidate gene for it has been determined so far. In this study, we report the fine mapping and analysis of a candidate gene for FOC1 using a double haploid (DH) population with 160 lines and a F 2 population of 4000 individuals derived from the same parental lines. Results: We confirmed that thedoi:10.1186/1471-2164-15-1094 pmid:25495687 pmcid:PMC4299151 fatcat:tqcckf2t4bhntjk6ptwgih6xue
more »... e to Fusarium wilt was controlled by a single dominant gene based on the resistance segregation ratio of the two populations. Using InDel primers designed from whole-genome re-sequencing data for the two parental lines (the resistant inbred-line 99-77 and the highly susceptible line 99-91) and the DH population, we mapped the resistance gene to a 382-kb genomic region on chromosome C06. Using the F 2 population, we narrowed the region to an 84-kb interval that harbored ten genes, including four probable resistance genes (R genes): Bol037156, Bol037157, Bol037158 and Bol037161 according to the gene annotations from BRAD, the genomic database for B. oleracea. After correcting the model of the these genes, we re-predicted two R genes in the target region: re-Bol037156 and re-Bol0371578. The latter was excluded after we compared the two genes' sequences between ten resistant materials and ten susceptible materials. For re-Bol037156, we found high identity among the sequences of the resistant lines, while among the susceptible lines, there were two types of InDels (a 1-bp insertion and a 10-bp deletion), each of which caused a frameshift and terminating mutation in the cDNA sequences. Further sequence analysis of the two InDel loci from 80 lines (40 resistant and 40 susceptible) also showed that all 40 R lines had no InDel mutation while 39 out of 40 S lines matched the two types of loci. Thus re-Bol037156 was identified as a likely candidate gene for FOC1 in cabbage. Conclusions: This work may lay the foundation for marker-assisted selection as well as for further function analysis of the FOC1 gene.
When we submitted our article, we were not aware that Zhang et al. 1 had just reported a high-level ab initio calculation of the hyperfine structure of the v + = 0 − 4, N + = 1, 2 levels of the X 2 + g ... This procedure leads to hyperfine levels that agree within better than 1 MHz of, but which are presumably less accurate than, the values reported by Zhang et al., 1 in particular because the scaling procedure ...doi:10.1063/1.4882661 fatcat:ijo3ttjmbrc4hironbbazjcxlq
(Diyarbakir) 2 147 Diagnose und Management eines multiplen Karzinosarkoms der Brust bei einer jungen chinesischen Patientin Tian, W.; Xu, D. ... (Mannheim) 3 193 Brustkrebs bei jungen Frauen -eine klinische Herausforderung, auf die in einem multidisziplinären Umfeld eingegangen werden sollte Cardoso, F. (Lisbon); Harbeck, N. ...doi:10.1159/000250039 fatcat:zxspppdbtvfvpp5phijgstdwge
Um überhaupt über die Runden zu kommen, fressen die Pandas besonders die Bambussprossen im Frühjahr, wandern dann in höhere Gebiete, in denen eine andere Bambusart später jungen Sprossen zu bieten hat, ... Nie Y, Speakman JR, Wu Q, Zhang C, Hu Y, Xia M, Yan L, Hambly C, Wang L, Wie W, Zhang J, Wie F. Exceptionally low daily energy expenditure in the bamboo-eating giant panda. ... dere Bambusart später jungen Sprossen zu bieten hat, und wechseln im Sommer dann zu Bambusblättern, weil die Sprossen nur sehr wenig Kalzium enthalten, das die Pan- das aber brauchen. ...doi:10.1055/s-0038-1627617 fatcat:c4jsammsrfehpklqnoan3ojwla
Ost-westliche Erfahrungen der Modernität
In seinem um die Jahrhundertwende erschienenen Buch Aufzeichnungen eines Beraters aus der Residenz des Gouverneurs Zhang können wir nachlesen: Ohne Eile, ohne Stagnation wie das Gestirn am Himmel wirken ... Die darin beschriebene unerfüllte Liebe des jungen Paares Reinhard und Elisabeth fand große Resonanz bei vielen jungen Chinesen, die unter dem traditionellen Ehemodell, nämlich unter der von Familien und ...doi:10.1515/9783110682427-009 fatcat:xczgzn55y5herjqymatrdrbgpa
Der Überlebensvorteil war allerdings auf Patientinnen mit hormonrezeptornegativen Tumoren bzw. ohne Hormontherapie beschränkt. ■ Zhang F. F. et al. Cancer 2017, online 6. ... . ■ JAMA 2017;317(8):836-846 2 Frühe Folgeschäden Kinder mit Typ-2-Diabetes besonders gefährdet Eine Diabeteserkrankung in der Kindheit ist o schon im jungen Erwachsenenalter mit Komplikationen und Begleiterkrankungen ...doi:10.1007/s15006-017-9353-7 pmid:28321761 fatcat:py4zbz5yjfa4zef2ox6igejtwi
(Rotterdam) 6 297 Hirnmetastasen bei sehr jungen Lungenkrebspatienten sind immer noch Hirnmetastasen Gore, E.M. (Milwaukee, WI) 6 300 Behandlung des malignen Glioms -quo vadis? Stupp, R. ... (Magdeburg) 1-2 37 Vorhersage von Beckenlymphknotenmetastasen bei Peniskarzinompatienten: Vergleich von Computertomographie, Cloquet-Knoten und Tumorlast der Leistenlymphknoten Zhu, Y.; Zhang, S.L.; Ye ... , R.; Zhang, S.J.; Qian, S.X. ...doi:10.1159/000183747 fatcat:f3zq2ybx2rhwfpsep75ddkybte
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