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Immunoblot analysis of antibody response before and after treatment of human strongyloidiasis

SHUICHI SHIMABUKURO, YOSHIYA SATO, JUN KOBAYASHI, ISAO SHIMABUKURO, YOSHIYUKI SHIROMA
1993 Japanese Journal of Tropical Medicine and Hygiene  
Qualitative analysis of antibody response before and 12 months after treatment of human strongyloidiasis was performed to identify the antigenic component which may be useful for serological evaluation of the effectiveness of postchemotherapy. The immunoblotting patterns changed significantly after successful treatment in almost all patients; some responses decreased in their intensity and some disappeared. Whereas, the patterns of reactivity after treatment could not be distinguished from
more » ... before treatment in patients who were interpreted to be equivocal for complete cure because their antibody levels did not show a significant decrease after treatment. The immunoblotting patterns, however, varied considerably for each patient and it was difficult to identify the antigenic component which may be effective to detect reduced antibody responses early after treatment.
doi:10.2149/tmh1973.21.149 fatcat:atk2mzqsnrb57nssmoydxd2hj4

Tendinopatias, Smartphones e dispositivos eletrônicos: relato de quatro casos

Luis Guilherme Rosifini Alves Rezende, Filipe Jun Shimaoka, Gunter Shin Iti Takamori Shimabukuro, Luiz Garcia Mandarano-Filho, Nilton Mazzer, Cláudio Henrique Barbieri
2021 ARCHIVES OF HEALTH INVESTIGATION  
O aumento do uso de celulares do tipo smartphones e de dispositivos eletrônicos secundários ao aumento das atividades do tipo home office e atividades remotas gerou um aumento nas queixas de dores nas mãos durante o último ano. Isto se encontra relacionado ao aumento do tempo de uso destes dispositivos. Apresentamos uma série de quatro casos de pacientes com queixas de dores nas mãos associados ao uso de dispositivos eletrônicos e a forma como foram manejados, bem como uma revisão sobre a
more » ... tura disponível sobre estas afecções, com o objetivo de conscientizar os autores sobre uma possível correlação das queixas de dores nas mãos associadas ao uso excessivo de dispositivos eletrônicos.
doi:10.21270/archi.v10i9.5532 fatcat:oiszw3y5jna2pgg536zo3yiy7e

Lesão por armlock em atleta amador de jiu-jitsu: relato de caso

Luis Guilherme Rosifini Alves Rezende, Filipe Jun Shimaoka, Gunter Shin Iti Takamori Shimabukuro, Luiz Garcia Mandarano-Filho, Nilton Mazzer, Cláudio Henrique Barbieri
2021 ARCHIVES OF HEALTH INVESTIGATION  
O jiu-jitsu brasileiro é uma modalidade de arte marcial que utiliza o princípio da imobilização para a execução de seus golpes. Este esporte tem apresentado aumento do número de praticantes nas últimas duas décadas. Isto implica no aumento do número de lesões, principalmente quando se considera o perfil dos atletas amadores. As lesões do cotovelo no jiu-jitsu estão entre as lesões mais comuns nesta modalidade esportiva. O mecanismo de trauma mais observado é a hiperextensão forçada durante a
more » ... icação da chave de braço (armlock ou armbar). Apresentamos um relato de caso de um paciente de 26 anos com uma lesão aguda do complexo ligamentar medial por chave de braço durante uma luta de jiu-jitsu. O paciente foi submetido ao tratamento conservador, com imobilização e fortalecimento da musculatura flexo-pronadora. Realizou-se o retorno gradual ao esporte, apresentando bom resultado funcional do cotovelo e do membro superior após quatro anos de seguimento.
doi:10.21270/archi.v10i3.5335 fatcat:3sfhzzosyvfdnbx6aure4lugvy

Lesão do ligamento colateral ulnar da articulação metacarpofalangeana do polegar: série de casos

Luis Guilherme Rosifini Alves Rezende, Filipe Jun Shimaoka, Gunter Shin Iti Takamori Shimabukuro, Luiz Garcia Mandarano-Filho, Nilton Mazzer, Cláudio Henrique Barbieri
2021 ARCHIVES OF HEALTH INVESTIGATION  
A lesão do ligamento colateral ulnar da articulação metacarpofalangeana do polegar é uma lesão comum no esquiador e outros esportes que envolvem trauma do polegar. Estas lesões, quando negligenciadas acarretam instabilidade articular, trazendo prejuízo funcional e debilidade aos pacientes. O diagnóstico precoce é fundamental, para caracterizar o padrão da lesão. As lesões completas são manejadas preferencialmente de forma cirúrgica, geralmente com excelentes resultados funcionais
more » ... . Apresentamos o relato de caso de quatro pacientes do sexo feminino, praticantes de esportes de diferentes modalidades com lesões do ligamento colateral ulnar da articulação metacarpofalangeana do polegar. Uma das pacientes apresentava lesão bilateral. O tratamento foi realizado de forma cirúrgica e todos os pacientes apresentaram bons resultados funcionais pós-operatórios. Nossos resultados são condizentes com os resultados observados na literatura, onde o tratamento cirúrgico acarreta bom resultado funcional, possibilitando, inclusive, o retorno ao esporte.
doi:10.21270/archi.v10i3.5334 fatcat:g5pltlwdxnfklngipl34mwtkk4

Síndrome do canal de Guyon por aneurisma da artéria ulnar: relato de caso

Luis Guilherme Rosifini Alves Rezende, Filipe Jun Shimaoka, Gunter Shin Iti Takamori Shimabukuro, Luiz Garcia Mandarano-Filho, Nilton Mazzer, Cláudio Henrique Barbieri
2020 ARCHIVES OF HEALTH INVESTIGATION  
Dentre os fatores que podem desencadear a compressão do canal de Guyon inclui-se o aneurisma da artéria ulnar. Uma das abordagens cirúrgicas é a reconstrução microcirúrgica através da ressecção e arteriorrafia término-terminal ou enxerto venoso de interposição. O objetivo deste trabalho é relatar o caso de paciente que desenvolveu neuropatia do nervo ulnar secundária à presença de aneurisma da artéria ulnar no canal de Guyon. Foi realizada a descompressão cirúrgica através de uma abertura do
more » ... al e a ressecção do segmento lesionado. A artéria ulnar foi reconstruída através da anastomose término-terminal microcirúrgica. O resultado foi o alívio completo dos sintomas no pós-operatório com manutenção do fluxo vascular. Descritores: Nervo Ulnar; Neuropatia Radial; Ferimentos e Lesões; Aneurisma. Referências Guyon F. Note sur une disposition anatomique proper à la face antérieure de la région du poignet et non encour décrite. Bulletins de la Societé anatomique de Paris, Second Series, 1861;6:184-86. Caetano EB, Brandi S, Oliveira Junior WM. Compressão do nervo ulnar no canal de Guyon por aneurisma verdadeiro: relato de um caso. Rev Bras Ortop. 2004;39(7):398-400. Shea JD, McClain EJ. Ulnar-nerve compression syndromes at and below the wrist. J Bone Joint Surg Am. 1969;51(6):1095-103. Rothkopf DM, Bryan DJ, Cuadros CL, May JW Jr. Surgical management of ulnar artery aneurysms. J Hand Surg Am. 1990;15(6):891-97. Harris EJ Jr, Taylor LM Jr, Edwards JM, Mills JL, Porter JM. Surgical treatment of distal ulnar artery aneurysm. Am J Surg. 1990;159(5):527-30. Dethmers RS, Houpt P. Surgical management of hypothenar and thenar hammer syndromes: a retrospective study of 31 instances in 28 patients. J Hand Surg Br. 2005;30(4):419-23. Aguiar PH, Bor-Seng-Shu E, Gomes-Pinto F, Almeida- Leme RJ, Freitas ABR, Martins RS et al. Surgical management of Guyon's canal syndrome, an ulnar nerve entrapment at the wrist: report of two cases. Arq Neuro-Psiquiatr. 2001;59(1):106-11. Jose RM, Bragg T, Srivastava S. Ulnar nerve compression in Guyon's canal in the presence of a tortuous ulnar artery. J Hand Surg Br. 2006;31(2):200-2. Galati G, Cosenza UM, Sammartino F, Benvenuto E, Caporale A. True aneurysm of the ulnar artery in a soccer goalkeeper: a case report and surgical considerations. Am J Sports Med. 2003;31(3):457-58. Rothkopf DM, Bryan DJ, Cuadros CL, May JW Jr. Surgical management of ulnar artery aneurysms. J Hand Surg Am. 1990;15(6):891-97.
doi:10.21270/archi.v9i6.5274 fatcat:6wp25y72wvc5phwboijvlg4teq

Assessment of feeding preference for subtropical macrophytes in young Siganus fuscescens
亜熱帯藻場構成植物に対するアイゴ幼魚の摂食選択性評価

HIDEAKI YAMADA, HIROMORI SHIMABUKURO, JUN HAYAKAWA, KENTA NAKAMOTO, TOMOHIKO KAWAMURA, KOETSU KON
2016 Nippon Suisan Gakkaishi  
, 2 JUN HAYAKAWA, 3 KENTA NAKAMOTO, 3 TOMOHIKO KAWAMURA 3 AND KOETSU KON 4 1 キーワードアイゴ,亜熱帯,海草,海藻,植食動物 南西諸島沿岸の砂泥域に形成される藻場は,水産有用 種の成育場として重要な海域である。  ...  † 東北区水産研究所, 2 同 瀬戸内海区水産研究所, 3 東京大学大気海洋研究所国際沿岸海洋研究センター, 4 筑波大学下田臨海実験センター Assessment of feeding preference for subtropical macrophytes in young Siganus fuscescens HIDEAKI YAMADA, 1 HIROMORI SHIMABUKURO  ... 
doi:10.2331/suisan.16-00015 fatcat:k3ag4y66fbfbhaod5gvefsqrhi

Epidemiological features of strongyloides infection in Okinawa, Japan: Comparative study with other endemic areas

JUN KOBAYASHI, YOSHIYA SATO, HIROMU TOMA, ISAO SHIMABUKURO, TSUTOMU TASAKI, MASAHIRO TAKARA, YOSHIYUKI SHIROMA
2000 Japanese Journal of Tropical Medicine and Hygiene  
The epidemiological features of Strongyloides stercoralis infection in Okinawa, Japan, were studied by comparing with those in Thailand, Laos and Brazil. The prevalence rates of Strongyloides infection in the present study were 9.6% (133/1,380) in Okinawa, 47.6% (99/208) in Chiang Mai, Thailand, 23.8% (106/445) in Khammouane, Laos, and 12.0% (32/267) in Maceio, Brazil, respectively. The age inclination in aged subjects and sex dominance in males were significant features of Strongyloides
more » ... on in Okinawa, suggesting that new infection from the environment does not occur in present-day Okinawa. The epidemiological feature was considered to provide a favorable field to investigate therapeutic efficacy unaffected by reinfection from environment after treatment. Absence of helminth infection other than Strongyloides was an additional feature in Okinawa. The features may also be convenient to study host response and pathogenicity in the Strongyloides infection unaffected by concurrent infection with other helminths.
doi:10.2149/tmh1973.28.9 fatcat:6vf3cfjgzjflpndfgexz7hsr4a

Limb-Saving Surgery by Intraoperative Radiation and Vascularized Fibular Graft for Osteosarcoma
骨肉腫に対する術中照射と血管茎付きひ骨移植による患肢温存手術

Osamu Inoue, Akira Arakaki, Jun Asato, Hiroyuki Shimabukuro, Yoshisada Shingaki, Hideki Asato, Kunio Ibaraki, Masao Nakano
1992 Orthopedics & Traumatology  
by Osamu Inoue, Akira Arakaki, Jun Asato, Hiroyuki Shimabukuro, Yoshisada Shingaki , Hideki Asato  ... 
doi:10.5035/nishiseisai.40.1690 fatcat:nw2znxqdwvau7m6harhoyuqjry

The Metabolic Activity of Caudate and Prefrontal Cortex Negatively Correlates with the Severity of Idiopathic Parkinson's Disease

Jun-Sheng Chu, Ting-Hong Liu, Kai-Liang Wang, Chun-Lei Han, Yun-Peng Liu, Shimabukuro Michitomo, Jian-Guo Zhang, Tie Fang, Fan-Gang Meng
2019 Aging and Disease  
Positron emission tomography (PET) scan with tracer [18F]-fluorodeoxy-glucose (18F-FDG) is widely used to measure the glucose metabolism in neurodegenerative disease such as Idiopathic Parkinson's disease (IPD). Previous studies using 18F-FDG PET mainly focused on the motor or non-motor symptoms but not the severity of IPD. In this study, we aimed to determine the metabolic patterns of 18F-FDG in different stages of IPD defined by Hoehn and Yahr rating scale (H-Y rating scale) and to identify
more » ... gions in the brain that play critical roles in disease progression. Fifty IPD patients were included in this study. They were 29 men and 21 women (mean±SD, age 57.7±11.1 years, disease duration 4.0±3.8 years, H-Y 2.2±1.1). Twenty healthy individuals were included as normal controls. Following 18F-FDG PET scan, image analysis was performed using Statistical Parametric Mapping (SPM) and Resting-State fMRI Data Analysis Toolkit (REST). The metabolic feature of IPD and regions-of-interests (ROIs) were determined. Correlation analysis between ROIs and H-Y stage was performed. SPM analysis demonstrated a significant hypometabolic activity in bilateral putamen, caudate and anterior cingulate as well as left parietal lobe, prefrontal cortex in IPD patients. In contrast, hypermetabolism was observed in the cerebellum and vermis. There was a negative correlation (p=0.007, r=-0.412) between H-Y stage and caudate metabolic activity. Moreover, the prefrontal area also showed a negative correlation with H-Y (P=0.033, r=-0.334). Thus, the uptake of FDG in caudate and prefrontal cortex can potentially be used as a surrogate marker to evaluate the severity of IPD.
doi:10.14336/ad.2018.0814 pmid:31440389 pmcid:PMC6675526 fatcat:v3thqo6afvae3j4vkldgxtquie

Phenology of Sargassum duplicatum (Fucales, Phaeophyceae) from the southern coast of Satsuma Peninsula, Kagoshima, Japan
鹿児島県薩摩半島南部における褐藻フタエモクSargassum duplicatum (Fucales, Phaeophyceae) の季節的消長

HIROMORI SHIMABUKURO, RYUTA TERADA, JUN SOTOBAYASHI, GREGORY N. NISHIHARA, TADAHIDE NORO
2007 Nippon Suisan Gakkaishi  
0.84 1053 44.9 Cloudy 1303 0 Mar. 18 17.5 34.5 8.75 4.89 0.33 1154 68.5 Clear 1450 0 Apr. 8 18.3 33.5 8.35 ND ND 1234 106.9 Clear 1213 0 May. 14 24.6 32.9 8.40 3.39 0.02 1332 95.4 Clear 1245 0 Jun  ... 
doi:10.2331/suisan.73.454 fatcat:gnlm2xnmjjbqjapblbxwgb36ry

Effect of terfenadine on uremic itching in dialysis patients
透析症例のかゆみに対するテルフェナジンの効果

Motoyuki Ishiguro, Toshiharu Ikutaka, Hiroshi Nasu, Ryoei Fuji, Seiichi Shimabukuro, Takahiro Hirano, Naoki Goto, Jun Misao, Kiyoaki Inoue, Taro Minagawa, Nobuyuki Takada, Noriko Suzuki (+2 others)
1992 Journal of Japanese Society for Dialysis Therapy  
Effect of terfenadine on uremic itching in dialysis patients Motoyuki Ishiguro, Toshiharu lkutaka, Hiroshi Nasu, Ryoei Fuji, Seiichi Shimabukuro, 石 黒 源 之 平 野 総 合 病 院 人 工 透 析 セ ン タ ー 〒501-11岐 阜 市 黒 野176  ... 
doi:10.4009/jsdt1985.25.1329 fatcat:64gkyx3y6bguxmq3x5rrafznpq

Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study

Atsushi Tanaka, Toyoaki Murohara, Isao Taguchi, Kazuo Eguchi, Makoto Suzuki, Masafumi Kitakaze, Yasunori Sato, Tomoko Ishizu, Yukihito Higashi, Hirotsugu Yamada, Mamoru Nanasato, Michio Shimabukuro (+14 others)
2016 Cardiovascular Diabetology  
Type 2 diabetes mellitus is associated strongly with an increased risk of micro-and macro-vascular complications, leading to impaired quality of life and shortened life expectancy. In addition to appropriate glycemic control, multi-factorial intervention for a wide range of risk factors, such as hypertension and dyslipidemia, is crucial for management of diabetes. A recent cardiovascular outcome trial in diabetes patients with higher cardiovascular risk demonstrated that a SGLT2 inhibitor
more » ... ly reduced mortality, but not macro-vascular events. However, to date there is no clinical evidence regarding the therapeutic effects of SGLT2 inhibitors on arteriosclerosis. The ongoing PROTECT trial was designed to assess whether the SGLT2 inhibitors, ipragliflozin, prevented progression of carotid intima-media thickness in Japanese patients with type 2 diabetes mellitus. Methods: A total of 480 participants with type 2 diabetes mellitus with a HbA1c between 6 and 10 % despite receiving diet/exercise therapy and/or standard anti-diabetic agents for at least 3 months, will be randomized systematically (1:1) into either ipragliflozin or control (continuation of conventional therapy) groups. After randomization, ipragliflozin (50-100 mg once daily) will be added on to the background therapy in participants assigned to the ipragliflozin group. The primary endpoint of the study is the change in mean intima-media thickness of the common carotid artery from baseline to 24 months. Images of carotid intima-media thickness will be analyzed at a central core laboratory in a blinded manner. The key secondary endpoints include the change from baseline in other parameters of carotid intima-media thickness, various metabolic parameters, and renal function. Other cardiovascular functional tests are also planned for several sub-studies. Discussion: The PROTECT study is the first to assess the preventive effect of ipragliflozin on progression of carotid atherosclerosis using carotid intima-media thickness as a surrogate marker. The study has potential to clarify the protective effects of ipragliflozin on atherosclerosis. Ethics approval and consent to participate The study protocol was approved by the local institutional review boards and independent ethics committees. After initial screening using previous medical records, each participant is required to receive an adequate explanation of the study plan, with written informed consent then being obtained.
doi:10.1186/s12933-016-0449-7 pmid:27619983 pmcid:PMC5020545 fatcat:pzjl7is2evd2jlcdxx72dilv7y

Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial

Atsushi Tanaka, Michio Shimabukuro, Yosuke Okada, Isao Taguchi, Minako Yamaoka-Tojo, Hirofumi Tomiyama, Hiroki Teragawa, Seigo Sugiyama, Hisako Yoshida, Yasunori Sato, Atsushi Kawaguchi, Yumi Ikehara (+12 others)
2017 Cardiovascular Diabetology  
Type 2 diabetes mellitus (T2DM) is characterized by systemic metabolic abnormalities and the development of micro-and macrovascular complications, resulting in a shortened life expectancy. A recent cardiovascular (CV) safety trial, the EMPA-REG OUTCOME trial, showed that empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, markedly reduced CV death and all-cause mortality and hospitalization for heart failure in patients with T2DM and established CV disease (CVD). SGLT2 inhibitors
more » ... are known to not only decrease plasma glucose levels, but also favorably modulate a wide range of metabolic and hemodynamic disorders related to CV pathways. Although some experimental studies revealed a beneficial effect of SGLT2 inhibitors on atherosclerosis, there is a paucity of clinical data showing that they can slow the progression of atherosclerosis in patients with T2DM. Therefore, the EMBLEM trial was designed to investigate whether empagliflozin treatment can improve endothelial function, which plays a pivotal role in the pathogenesis of atherosclerosis, in patients with T2DM and established CVD. Methods: The EMBLEM trial is an ongoing, prospective, multicenter, placebo-controlled double-blind randomized, investigator-initiated clinical trial in Japan. A total of 110 participants with T2DM (HbA1c range 6.0-10.0%) and with established CVD will be randomized (1:1) to receive either empagliflozin 10 mg once daily or a placebo. The primary endpoint of the trial is change in the reactive hyperemia (RH)-peripheral arterial tonometry-derived RH index at 24 weeks from baseline. For comparison of treatment effects between the treatment groups, the baseline-adjusted means and their 95% confidence intervals will be estimated by analysis of covariance adjusted for the following allocation factors: HbA1c (<7.0 or ≥7.0%), age (<65 or ≥65 years), systolic blood pressure (<140 or ≥140 mmHg), and current smoking status (nonsmoker or smoker). Key secondary endpoints include the change from baseline for other vascular-related markers such as arterial stiffness, sympathetic nervous activity, and parameters of cardiac and renal function. Importantly, serious adverse effects independently on the causal relationship to the trial drugs and protocol will be also evaluated throughout the trial period. Discussion: EMBLEM is the first trial to assess the effect of empagliflozin on endothelial function in patients with T2DM and established CVD. Additionally, mechanisms associating empagliflozin-mediated actions with endothelial © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
doi:10.1186/s12933-017-0532-8 pmid:28403850 pmcid:PMC5389095 fatcat:ueo7kgx2ijc7lgsnmiu5uzju2e

Evaluation of two prognostic indices for adult T-cell leukemia/lymphoma in the subtropical endemic area, Okinawa, Japan

Keita Tamaki, Satoko Morishima, Shogo Nomura, Yukiko Nishi, Sawako Nakachi, Sakiko Kitamura, Sachie Uchibori, Shouhei Tomori, Taeko Hanashiro, Natsuki Shimabukuro, Iori Tedokon, Kazuho Morichika (+15 others)
2018 Cancer Science  
Aggressive adult T-cell leukemia/lymphoma (ATL) has an extremely poor prognosis and is hyperendemic in Okinawa, Japan. This study evaluated two prognostic indices (PIs) for aggressive ATL, the ATL-PI and Japan Clinical Oncology Group (JCOG)-PI, in a cohort from Okinawa. The PIs were originally developed using two different Japanese cohorts that included few patients from Okinawa. The endpoint was overall survival (OS). Multivariable Cox regression analyses in the cohort of 433 patients revealed
more » ... that all seven factors for calculating each PI were statistically significant prognostic predictors. Three-year OS rates for ATL-PI were 35.9% (low-risk, n = 66), 10.4% (intermediate-risk, n = 256), and 1.6% (high-risk, n = 111), and those for This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
doi:10.1111/cas.13641 pmid:29772611 pmcid:PMC6029833 fatcat:yi3e555zjvc4ncbudbls2k42rq

An autopsied case of primary macroglobulinemia whose heart failure and anemia were controlled with double filtration plasmapheresis (DFPP) for 7 years
7年にわたり維持二重ろ過血しょう交換療法により心不全と貧血を管理した原発性マクログロブリン血症の1剖検例

Kiyoaki Inoue, Motoyuki Ishiguro, Toshiharu Ikutaka, Naoki Goto, Jun Misao, Taro Minagwa, Nobuyuki Takada, Hiroki Tokuyama, Seiichi Shimabukuro, Noriko Suzuki, Takahiro Hirano, Yoshio Mori
1993 Journal of Japanese Society for Dialysis Therapy  
case of primary macroglobulinemia whose heart failure and anemia were controlled with double filtration plasmapheresls (DFPP) for 7 years Kiyoki Inoue, Motoyuki Ishiguro, Toshiharu Ikutaka, Naoki Goto, Jun  ...  Misao, Taro Minagwa, N Takada, Hiroki Tokuyama, Seiichi Shimabukuro, Noriko Suzuki, Takahiro Hirano, Yoshio Mor Dialysis Center, Hirano General Hospital; First Department of Pathology, School of Medicine  ... 
doi:10.4009/jsdt1985.26.1549 fatcat:5qkxeuuejvhf3n3a4ysl7xtrla
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