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Dog vaccination with EgM proteins against Echinococcus granulosus

Zhuang-Zhi Zhang, Gang Guo, Jun Li, Bao-Xin Shi, Li Zhao, Bao-Ping Guo, Xu Zhang, Jun-Wei Wang, Xue-Ting Zheng, Wen-Jing Qi, Li He, Wen-Bao Zhang
2018 Infectious Diseases of Poverty  
Dogs play a pivotal role in the transmission of cystic echinococcosis (CE), a zoonosis caused by the tapeworm Echinococcus granulosus. We showed previously that dogs vaccinated with two E. granulosus adult-worm specific proteins, EgM9 and EgM123, emulsified with Freund's adjuvants induced significant protective efficacy in terms of reduction in worm burden and egg production after 45 days post-infection. It was not known whether this protection can be sustained using adjuvants suitable for use
more » ... n dogs. Methods: Recombinant EgM9 and EgM123 were mixed with Quil A or ISCOMs for vaccinating dogs. After three vaccine injections, all the dogs were orally challenge-infected with 200 000 protoscoleces of E. granulosus. After 45 days of infection, all the dogs were euthanized and necropsied for collecting and counting E. granulosus worms. Immunoglobins, including the IgG subclasses IgG1 and IgG2, were detected in the sera of vaccinated dogs by ELISA. To determine whether the protection efficacy could be maintained after 45 days post-infection, we implemented a longevity trial to count eggs in dog faeces for 170 days after infection. Results: The dogs vaccinated with EgM9 and EgM123 mixed with Quil A and ISCOMs showed similar protective efficacy as the proteins emulsified with Freund's adjuvants in our previous study in terms of reduction of worms and eggs at 45 days post-infection. The longevity trial showed that EgM9 protein-vaccinated group released lower number of eggs per gram compared with the egg counts in the control dogs during the dog trial study. Conclusion: EgM9 and EgM123 are thus suitable vaccine candidates against E. granulosus infection in dogs.
doi:10.1186/s40249-018-0425-4 pmid:29895318 pmcid:PMC5998577 fatcat:zb73jcya4vfwdiityjxisrt6r4

Preparation and near-infrared luminescence properties of Bi-doped BaO-B2O3glasses

Liu Jun-Fang, Su Liang-Bi, Tang Hui-Li, Xu Jun
2012 Wuli xuebao  
BaO-B 3) ( , 201800 ) ( 2011 8 2 ; 2011 11 8 )  ...  . , BaO-B 2 O 3 , Bi , Raman . 2 Bi BaO-B 2 O 3 , BaO/B 2 O 3 ( ) 2:1, 1:1, 1:2 1:4, 67BaO-33B 2 O 3 - 1Bi 2 O 3 , 50BaO-50B 2 O 3 -1Bi 2 O 3 , 33BaO-67B 2 O 3 - 1Bi 2 O 3 , 20BaO-80B 2 O 3 -1Bi 2 O 3  ...  2 O 3 Raman 925-927 cm −1 , 1163 cm −1 , 1361- 1445 cm −1 : (non- bridging oxygen, NBO) . , BaB2:1, BaB1:1, BaB1:2 , , , NBO . , Bi Raman , , BaO B 2 O 3 BaO-B 2 O 3 , .  ... 
doi:10.7498/aps.61.127806 fatcat:p5vclqbn4ncrbn5kzy3tozykfi

Nucleon effective masses in neutron-rich matter

Bao-An Li, Bao-Jun Cai, Lie-Wen Chen, Jun Xu
2018 Progress in Particle and Nuclear Physics  
Various kinds of isovector nucleon effective masses are used in the literature to characterize the momentum/energy dependence of the nucleon symmetry potential or self-energy due to the space/time non-locality of the underlying isovector strong interaction in neutron-rich nucleonic matter. The multifaceted studies on nucleon isovector effective masses are multi-disciplinary in nature. Besides structures, masses and low-lying excited states of nuclei as well as nuclear reactions, studies of the
more » ... sospin dependence of short-range correlations in nuclei from scatterings of high-energy electrons and protons on heavy nuclei also help understand nucleon effective masses especially the so-called E-mass in neutron-rich matter. A thorough understanding of all kinds of nucleon effective masses has multiple impacts on many interesting issues in both nuclear physics and astrophysics. We review some of the significant progresses made in recent years by the nuclear physics community in resolving some of the hotly debated and longstanding issues regarding nucleon effective masses especially in dense neutron-rich matter.
doi:10.1016/j.ppnp.2018.01.001 fatcat:4sbdpbe4jfezzehzejfl4gfsxy


2010 International Journal of Modern Physics E  
The incompressibility K_sat(δ) of isospin asymmetric nuclear matter at its saturation density. Our results show that in the expansion of K_sat(δ) in powers of isospin asymmetry δ, i.e., K_sat(δ )=K_0+K_sat,2δ^2+K_sat,4δ^4+O(δ^6), the magnitude of the 4th-order K_sat,4 parameter is generally small. The 2nd-order K_sat,2 parameter thus essentially characterizes the isospin dependence of the incompressibility of asymmetric nuclear matter at saturation density. Furthermore, the K_sat,2 can be
more » ... sed as K_sat,2=K_sym-6L-J_0/K_0L in terms of the slope parameter L and the curvature parameter K_sym of the symmetry energy and the third-order derivative parameter J_0 of the energy of symmetric nuclear matter at saturation density, and we find the higher order J_0 contribution to K_sat,2 generally cannot be neglected. Also, we have found a linear correlation between K_sym and L as well as between J_0/K_0 and K_0. Using these correlations together with the empirical constraints on K_0 and L, the nuclear symmetry energy E_sym(ρ_0) at normal nuclear density, and the nucleon effective mass, we have obtained an estimated value of K_sat,2=-370 +- 120 MeV for the 2nd-order parameter in the isospin asymmetry expansion of the incompressibility of asymmetric nuclear matter at its saturation density.
doi:10.1142/s0218301310016090 fatcat:rrhkt5bshzapvlmucp3qpjyaaq

Hydromorphone for cancer pain

Yan J Bao, Wei Hou, Xiang Y Kong, Liping Yang, Jun Xia, Bao J Hua, Roger Knaggs
2016 The Cochrane library  
doi:10.1002/14651858.cd011108.pub2 pmid:27727452 fatcat:etjihni7rna5jlyarmxow6u3oq

Review Helpfulness Prediction with Embedding-Gated CNN [article]

Cen Chen, Minghui Qiu, Yinfei Yang, Jun Zhou, Jun Huang, Xiaolong Li, Forrest Bao
2018 arXiv   pre-print
Product reviews, in the form of texts dominantly, significantly help consumers finalize their purchasing decisions. Thus, it is important for e-commerce companies to predict review helpfulness to present and recommend reviews in a more informative manner. In this work, we introduce a convolutional neural network model that is able to extract abstract features from multi-granularity representations. Inspired by the fact that different words contribute to the meaning of a sentence differently, we
more » ... consider to learn word-level embedding-gates for all the representations. Furthermore, as it is common that some product domains/categories have rich user reviews, other domains not. To help domains with less sufficient data, we integrate our model into a cross-domain relationship learning framework for effectively transferring knowledge from other domains. Extensive experiments show that our model yields better performance than the existing methods.
arXiv:1808.09896v1 fatcat:fvriatmeyncipef27jxvnqsqdi

Dark Energy and Hubble Constant From the Latest SNe Ia, BAO and SGL [article]

Qing-Jun Zhang, Yue-Liang Wu
2009 arXiv   pre-print
Based on the latest MLCS17 SNe Ia data provided by Hicken et al. (2009), together with the Baryon Acoustic Oscillation (BAO) and strong gravitational lenses (SGL), we investigate the dark energy equation-of-state  ...  A joint analysis of SNe Ia data and BAO is made to break the degeneracy between w and Ω_M, and it provides a stringent constrain with the likelihoods: w = -0.88^+0.07_-0.09 and Ω_M=0.29^+0.02_-0.03.  ...  ) for the (SNe + BAO + SGL) case.  ... 
arXiv:0905.1234v1 fatcat:4r6vxci2r5hvjb3zr2dxjkp5bm

double-porosity medium

Liang Bao-Jun
2014 Wuli xuebao  
A new algorithm for P-wave reverse time migration (RTM) in a fracture-induced TTI double-porosity medium is proposed in this paper, by combining RTM with the method of P-and S-wave field separation in high-order staggered grid finitedifference scheme. Simulation results show that for the fracture-induced TTI double-porosity medium the conventional migration with a background velocity without fractures would cause the imaging position to be under the true interface. To study the influence of
more » ... ture parameters, the phase velocity formulae are derived from Christoffel equations, and the effects of fracture angles and density are analyzed. In the 2D case, the imaging position gets closer to the real interface along with increasing fracture dip angles, while a bigger fracture density can cause much more deviation.
doi:10.7498/aps.63.119101 fatcat:2cpuc3rnabgjflvtw3lmgt7r2u

Advanced understanding of stickiness on superhydrophobic surfaces

Jun Wu, Jun Xia, Wei Lei, Bao-ping Wang
2013 Scientific Reports  
This study explores how contact angle hysteresis and titling angle relate with stickiness on superhydrophobic surfaces. The result indicates that contact angle hysteresis could not be mentioned as a proper factor to evaluate the surface stickiness. By analyzing the system pinning force of droplet placed on a titled surface, we concluded that both solid fraction and surface geometric factor are the critical factors determining the surface stickiness. O ver last decades, some special surfaces in
more » ... ature feature high water contact angle (.150u) attracted enormous interests for both fundamental research and practical application 1-8 . Some of these surfaces, lotus leaves for instance, not only exhibit high water contact angle, but also have extremely low sliding angle, which cause water droplets to bead and roll off from the surface by slightly titling it 1 . This behavior provides extreme water repellency and self-cleaning characteristics 2-5 . Meanwhile, some other surfaces, i.e. rose-petal surface, with large water droplet sliding angles have the ability to make water droplet pinned on the surfaces at any tilting angle (TA) 6 . Such high-adhesion surfaces also possess many potential applications, no-loss fluid transportation for example 7, 8 . According to the different values of TA, the above mentioned surfaces fall into two categories, which are "slippery" and "sticky" ones, featuring low TA and high TA respectively, all these surfaces are uniformly named as "superhydrophobic" surfaces in litheture though. Meanwhile, people found that there exists a wide range of "metastable" contact angles when a liquid meniscus scans the solid surface 9 . Because there are free energy barriers which exist between these metastable states, a true "equilibrium" contact angle is almost impossible to measure in real time. The famous Wenzel's and Cassie's theories are therefore only valuable in predicting the thermodynamically stable contact angles in theory 10,11 . Therefore, contact angle hysteresis (CAH) defined as the difference of advancing angle and receding angle is usually measured to fully characterize any surface 12 . Recently, however, it seems CAH has a new function and already somehow been treated as a criterion to evaluate the stickiness of superhydrophobic surfaces by researchers and students [13] [14] [15] [16] . People believe that increase in stickiness will absolutely result in a corresponding increase in CAH. As mentioned in the previous section, TA value has widely been used to describe the surface stickiness. Since both these two parameters have been mentioned in publications to describe the same physical phenomena, it is also naturally concluded by researchers that TA and CAH share the same changing tendency with the stickiness 15 . However, we achieved an opposite conclusion according to our recent experimental investigation. We fabricated several posts arrays with different solid fractions. The TA increases with the solid fraction, which proves that the stickiness/pinning force increases with solid fraction [17] [18] [19] . Nevertheless, the CAH shows a decreasing tendency while the solid fraction increases. This result is of particular interest from theory point of view. It reveals that CAH may not be the proper factor to describe the surface stickiness, and it is not necessary to take extra effects to make low CAH surface to achieve good slip performance.
doi:10.1038/srep03268 pmid:24253402 pmcid:PMC3834362 fatcat:qjgll7sadzbvtbchmxh7lmn5r4

Simulation and optimization of the cascaded luminescent solar concentrator photovoltaic system

Geng Jun-Jie, Zhang Jun, Zhang Yi, Ding Jian-Jun, Sun Song, Luo Zhen-Lin, Bao Jun, Gao Chen
2012 Wuli xuebao  
Luminescent solar concentrator (LSC) photovoltaic system can cut down the cost of photovoltaic electricity generation by reducing the consumption of solar cells. Compared with the single-layer LSC, the cascaded LSC can make use of the solar spectrum effectively and obtain high photoelectric conversion efficiency. In this paper, the physical processes of the single-layer and cascaded LSC are analyzed and the corresponding mathematical models are established. Based on the models, the simulation
more » ... ftware is developed to calculate the photoelectric conversion efficiencies of the LSC and the cascaded LSC. The effects of the size of the optical waveguide and the bandgap of solar cells on the total conversion efficiency are investigated.
doi:10.7498/aps.61.034201 fatcat:diycsgcvfvar5dkfvytv347uom

Effects of miR-21 on proliferation and apoptosis in human gastric adenocarcinoma cells

Jun-Bao Gu, Xue-Bin Bao, Zhao Ma
2017 Oncology Letters  
The present study investigated the expression of miR-21 in MGC803 gastric cancer cells and its effects on Bcl-2 expression and cell proliferation, apoptosis, and invasion. In total 50 patients were recruited with gastric cancer who were admitted to the Henan Province People's Hospital. The samples of gastric cancer and the adjacent normal tissues were collected after surgery. We found that mRNA levels of miR-21 and Bcl-2 were significantly elevated in tumor tissues compared to control tissue.
more » ... e expression of Bcl-2 protein was also elevated in cancerous tissue. This high expression of Bcl-2 was associated with clinical stage, lymph node metastasis, and tumor differentiation degree. Inhibition of miR-21 reduced the levels of miR-21 and Bcl-2 in MGC803 cells, and lowered cell proliferation and invasiveness. These results indicate that miR-21 and Bcl-2 may participate in the occurrence and development of gastric adenocarcinoma, suggesting their potential role as biomarkers and therapeutic targets.
doi:10.3892/ol.2017.6171 pmid:29403555 pmcid:PMC5780787 fatcat:gbp5g22ngzdqdl75vdzu33kdua

The Story in Your Eyes: An Individual-difference-aware Model for Cross-person Gaze Estimation [article]

Jun Bao, Buyu Liu, Jun Yu
2021 arXiv   pre-print
We propose a novel method on refining cross-person gaze prediction task with eye/face images only by explicitly modelling the person-specific differences. Specifically, we first assume that we can obtain some initial gaze prediction results with existing method, which we refer to as InitNet, and then introduce three modules, the Validity Module (VM), Self-Calibration (SC) and Person-specific Transform (PT)) Module. By predicting the reliability of current eye/face images, our VM is able to
more » ... ify invalid samples, e.g. eye blinking images, and reduce their effects in our modelling process. Our SC and PT module then learn to compensate for the differences on valid samples only. The former models the translation offsets by bridging the gap between initial predictions and dataset-wise distribution. And the later learns more general person-specific transformation by incorporating the information from existing initial predictions of the same person. We validate our ideas on three publicly available datasets, EVE, XGaze and MPIIGaze and demonstrate that our proposed method outperforms the SOTA methods significantly on all of them, e.g. respectively 21.7%, 36.0% and 32.9% relative performance improvements. We won the GAZE 2021 Competition on the EVE dataset. Our code can be found here
arXiv:2106.14183v1 fatcat:3nfokveknngwnd4vcnxxr27mmu

Boosting Generative Models by Leveraging Cascaded Meta-Models [article]

Fan Bao, Hang Su, Jun Zhu
2019 arXiv   pre-print
Deep generative models are effective methods of modeling data. However, it is not easy for a single generative model to faithfully capture the distributions of complex data such as images. In this paper, we propose an approach for boosting generative models, which cascades meta-models together to produce a stronger model. Any hidden variable meta-model (e.g., RBM and VAE) which supports likelihood evaluation can be leveraged. We derive a decomposable variational lower bound of the boosted
more » ... which allows each meta-model to be trained separately and greedily. Besides, our framework can be extended to semi-supervised boosting, where the boosted model learns a joint distribution of data and labels. Finally, we combine our boosting framework with the multiplicative boosting framework, which further improves the learning power of generative models.
arXiv:1905.04534v1 fatcat:unxtfabktjckjfqlyfixr65c2a

Robust visual tracking algorithm based on bidirectional sparse representation

Wang Bao-Xian, Zhao Bao-Jun, Tang Lin-Bo, Wang Shui-Gen, Wu Jing-Hui
2014 Wuli xuebao  
At present the visual tracking model based on sparse representation is mainly divided into two types: one is to use the template set to reconstruct candidate samples, which is called forward model; the other is to project the template set into a candidate space, which is called reverse model. What the two models have in common is to compute the sparse correlation coefficient matrix of candidate sample and template set. Based on this, the paper establishes a bidirectional cooperative sparse
more » ... sentation tracking model. Using L2-norm constraint item, the forward and reverse sparse correlation matrix coefficients could be uniformly convergent. In comparison to conventional unidirectional sparse tracking model, bidirectional sparse tracking model could fully excavate the sparse mapping relation of the whole candidate sample and template set. And the candidate that scores highest in the sparse mapping table for the positive and negative templates is the tracking result. Based on the accelerated proximal gradient fast method, the paper derives the optimum solution (in matrix form) of bidirectional sparse tracking model. As a result, it allows the candidates and templates to be calculated in parallel, which can improve the calculation efficiency to some extent. Numerical examples show that the proposed tracking algorithm has certain priority over against the conventional unidirectional sparse tracking methods.
doi:10.7498/aps.63.234201 fatcat:luohuxlrz5ftlp42auquhsxz3y

Wettability Alteration of Sandstone by Chemical Treatments

Yan-ling Wang, Li Ma, Bao-jun Bai, Guan-cheng Jiang, Jia-feng Jin, Zeng-bao Wang
2013 Journal of Chemistry  
Liquid condensation in the reservoir near a wellbore may kill gas production in gas-condensate reservoirs when pressure drops lower than the dew point. It is clear from investigations reported in the literature that gas production could be improved by altering the rock wettability from liquid-wetness to gas-wetness. In this paper, three different fluorosurfactants FG1105, FC911, and FG40 were evaluated for altering the wettability of sandstone rocks from liquid-wetting to gas-wetting using
more » ... ct angle measurement. The results showed that FG40 provided the best wettability alteration effect with a concentration of 0.3% and FC911 at the concentration of 0.3%.
doi:10.1155/2013/845031 fatcat:kuc3prcyfral5a575omcixyzoa
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