Filters








145 Hits in 0.94 sec

Phosphatidylethanol (PEth) as a Biomarker of Alcohol Consumption in HIV-Positive Patients in Sub-Saharan Africa

Judith A. Hahn, Loren M. Dobkin, Bernard Mayanja, Nneka I. Emenyonu, Isaac M. Kigozi, Stephen Shiboski, David R. Bangsberg, Heike Gnann, Wolfgang Weinmann, Friedrich M. Wurst
2011 Alcoholism: Clinical and Experimental Research  
PEth in whole blood was compared to prior 7-, 14-, and 21-day alcohol consumption.  ...  The sensitivity for any detectable PEth was 88.0% (95% CI: 76.0-95.6%) and the specificity was 88.5% (95% CI: 69.8-97.6%). 2) The ROC-AUC of PEth versus any 21-day alcohol consumption did not vary by age  ...  Further PEth results refer to PEth 16:0/18:1 unless otherwise specified.  ... 
doi:10.1111/j.1530-0277.2011.01669.x pmid:22150449 pmcid:PMC3310261 fatcat:efqwsticj5ay3abolykh2x2raa

Unerwünschte Effekte von Psychotherapie bei depressiven Patienten – Erste Anwendung der Positive and Negative Effects of Psychotherapy Scale (PANEPS)

Judith Peth, Lena Jelinek, Yvonne Nestoriuc, Steffen Moritz
2018 PPmP. Psychotherapie, Psychosomatik, medizinische Psychologie  
Zusammenfassung Hintergrund Die Positive and Negative Effects of Psychotherapy Scale (PANEPS), ein Selbstauskunftsfragebogen für Patienten zur Erfassung von positiven Effekten (PE) und unerwünschten Ereignissen (UE) während der letzten Psychotherapie (PT), wurde erstmalig bei einer Patientenstichprobe mit Depression eingesetzt. Der Fragebogen wurde auf seine Anwendbarkeit hin überprüft und lieferte erste empirische Ergebnisse zu PE und UE einer PT bei dieser Patientengruppe. Methode Im Rahmen
more » ... ner Onlinebefragung füllten 135 Personen mit einer aktuellen oder früheren depressiven Störung die 43 Items der PANEPS aus, welche UE in Nebenwirkungen (NW), Kunstfehler (KF) und unethisches Fehlverhalten (UF) unterteilt. Zusätzlich wurden soziodemografische Angaben (Alter, Geschlecht, Beziehungsstatus) sowie Details zu psychotherapeutischer Vorerfahrung und der zuletzt wahrgenommenen PT erfasst. Die PANEPS wurde mittels Hauptkomponentenanalyse mit Varimax-Rotation geprüft und überarbeitet. Ergebnisse Eine 4-Faktoren-Lösung wurde ermittelt, welche die zuvor definierten Skalen (PE, NW, KF, UF) abbildet und eine weitere Reduktion der PANEPS ermöglicht. Die finale Version der PANEPS, wies eine zufriedenstellende bis exzellente interne Konsistenz auf (Cronbach's α=0,72–0,92). Von den Befragten gaben 95,6% mind. einen PE (Range=0–5, MW=3,3, SD=1,4) an und 52,6% mind. ein UE (Range=0–14, MW=1,8, SD=2,9). Es gaben 38,5% mind. eine NW (Range=0–6, MW=0,7, SD=1,3), 26,7% mind. einen KF (Range=0–10, MW=0,9, SD=1,9) und 8,1% mind. ein UF (Range=0–4, MW=0,1, SD=0,5) an. PE korrelierten negativ mit KF, aber nicht mit NW und UF. Zudem bestehen Zusammenhänge zwischen Patientenmerkmalen und dem Auftreten von GE und UE. Diskussion Etwas mehr als die Hälfte der Befragten bestätigte mind. ein UE im PANEPS, wobei besonders die Zustimmung zu mind. einem KF oder UF unerwartet hoch ausfielen. Insbesondere die aktuelle Symptombelastung (PHQ-9) scheint für die Zustimmung zu PE und UE einer PT relevant zu sein. Der negative Zusammenhang zwischen PE und KF unterstreicht die Wichtigkeit leitliniengerechter Behandlung für den Erfolg von Psychotherapie. Schlussfolgerung Nebenwirkungen von PT sind auch bei Patienten mit Depressionen zu erwarten und sollten regelhaft erfasst werden.
doi:10.1055/s-0044-101952 pmid:29631298 fatcat:7ykk4b7brzfevgbloujisscrbu

Study protocol for a randomised controlled trial evaluating an evidence-based, stepped and coordinated care service model for mental disorders (RECOVER)

Martin Lambert, Anne Karow, Jürgen Gallinat, Daniel Lüdecke, Vivien Kraft, Anja Rohenkohl, Romy Schröter, Constanze Finter, Anna-Katharina Siem, Lisa Tlach, Nathalie Werkle, Susann Bargel (+29 others)
2020 BMJ Open  
IntroductionHealthcare systems around the world are looking for solutions to the growing problem of mental disorders. RECOVER is the synonym for an evidence-based, stepped and cross-sectoral coordinated care service model for mental disorders. RECOVER implements a cross-sectoral network with managed care, comprehensive psychological, somatic and social diagnostics, crisis resolution and a general structure of four severity levels, each with assigned evidence-based therapy models (eg, assertive
more » ... ommunity treatment) and therapies (eg, psychotherapy). The study rationale is the investigation of the effectiveness and efficiency of stepped and integrated care in comparison to standard care.Methods and analysisThe trial is conducted in accordance to the Standard Protocol Items: Recommendations for Interventional Trials Statement. The study aims to compare the RECOVER model with treatment as usual (TAU). The following questions are examined: Does RECOVER reduce healthcare costs compared with TAU? Does RECOVER improve patient-relevant outcomes? Is RECOVER cost-effective compared with TAU? A total sample of 890 patients with mental disorders will be assessed at baseline and individually randomised into RECOVER or TAU. Follow-up assessments are conducted after 6 and 12 months. As primary outcomes, cost reduction, improvement in symptoms, daily functioning and quality of life as well as cost-effectiveness ratios will be measured. In addition, several secondary outcomes will be assessed. Primary and secondary outcomes are evaluated according to the intention-to-treat principle. Mixed linear or logistic regression models are used with the direct maximum likelihood estimation procedure which results in unbiassed estimators under the missing-at-random assumption. Costs due to healthcare utilisation and productivity losses are evaluated using difference-in-difference regressions.Ethics and disseminationEthical approval from the ethics committee of the Hamburg Medical Association has been obtained (PV5672). The results will be disseminated to service users and their families via the media, to healthcare professionals via professional training and meetings and to researchers via conferences and publications.Trial registration number and registry nameClinicalTrials.gov (NCT03459664), RECOVERProtocol version19 March 2020 (V.3.0)
doi:10.1136/bmjopen-2019-036021 pmid:32371520 fatcat:qvwpiltlcfg7ve2wofkml6a4rq

The Formation, Elimination, Interpretation, and Future Research Needs of Phosphatidylethanol for Research Studies and Clinical Practice

Judith A. Hahn, Raymond F. Anton, Martin A. Javors
2016 Alcoholism: Clinical and Experimental Research  
PEth >2000 ng/ml) with a 4-day half-life, or someone with a lower PEth level (e.g. 250 ng/mL) and a long PEth half-life (e.g. 10 days) may still test positive for PEth after 30 days of abstinence.  ...  These examples show that one cannot be certain regarding timing of last drink from PEth levels alone. Laboratory determination of PEth and PEth homologues.  ... 
doi:10.1111/acer.13213 pmid:27716960 pmcid:PMC5117827 fatcat:wzzityruwvhufkmyd6227njnsa

Comparison of Phosphatidylethanol Results to Self-Reported Alcohol Consumption Among Young Injection Drug Users

Jennifer Jain, Jennifer L. Evans, Alya Briceño, Kimberly Page, Judith A. Hahn
2014 Alcohol and Alcoholism  
We compared self-reported alcohol use to detectable PEth (≥8 ng/ml) in the blood spots as well as the relationships between quantitative PEth results and quantity measures of alcohol consumption.  ...  Conclusions: The positive correlation of PEth with reported alcohol consumption suggests that PEth may be a useful marker in settings where alcohol consumption is difficult to assess, or to corroborate  ...  levels of PEth.  ... 
doi:10.1093/alcalc/agu037 pmid:24939855 pmcid:PMC4128670 fatcat:2ltozr2qjrbzbkvyims47v3bjq

Page 187 of Rehabilitation Literature Vol. 32, Issue 6 [page]

1971 Rehabilitation Literature  
Peth, Peter R. A critical examination of the role and function of the nonprofessional in rehabilitation. Rehab. Counseling Bul. Mar., 1971. 14:3:141-151.  ...  —Group therapy in an elementary school, Judith Mishne, p. 18-25.—Pre- conditioned panic responses to black militancy, Gloria D. Reeves, p. 26-31.—Social-conditioning casework in a school setting, H.  ... 

Page 154 of Plant Disease Vol. , Issue SUPPLEMENT 69 [page]

1929 Plant Disease  
Wilt damaged some common flax in Judith Basin County in 1926 according to A. C.  ...  Dillman, Flax Investigator, United States Department of Agriculture, ANTHRACNOSE (Colletotrichum linicolum Peth. and Laf.).  ... 

Phosphatidylethanol confirmed alcohol use among ART-naïve HIV-infected persons who denied consumption in rural Uganda

Winnie R. Muyindike, Christine Lloyd-Travaglini, Robin Fatch, Nneka I. Emenyonu, Julian Adong, Christine Ngabirano, Debbie M. Cheng, Michael R. Winter, Jeffrey H. Samet, Judith A. Hahn
2017 AIDS Care  
A positive PEth was defined as ≥8 ng/ml.  ...  Among the 198 participants in Group 2, 13.1% were PEth-positive.  ...  : N = 30, median PEth 46.48 (IQR 14.16-397.00), Mean PEth 247.16 (SD = 379.04).  ... 
doi:10.1080/09540121.2017.1290209 pmid:28278568 fatcat:sgrgjqr3kjcozglg4ckcfvgffu

Comparison of Self-Reported Alcohol Consumption to Phosphatidylethanol Measurement among HIV-Infected Patients Initiating Antiretroviral Treatment in Southwestern Uganda

Francis Bajunirwe, Jessica E. Haberer, Yap Boum, Peter Hunt, Rain Mocello, Jeffrey N. Martin, David R. Bangsberg, Judith A. Hahn, Anil Kumar
2014 PLoS ONE  
alcohol consumption with PEth.  ...  Baseline dried blood spots (DBS) were collected and retrieved to measure PEth. Results: One hundred fifty samples were tested, and 56 (37.3%) were PEth positive (>8 ng/mL).  ...  for PEth.  ... 
doi:10.1371/journal.pone.0113152 pmid:25436894 pmcid:PMC4249861 fatcat:jvr4mvotwrdktcsjnbnq3iq5c4

High prevalence of unhealthy alcohol use and comparison of self-reported alcohol consumption to phosphatidylethanol among women engaged in sex work and their male clients in Cambodia

Marie-Claude Couture, Kimberly Page, Neth Sansothy, Ellen Stein, Mean Chhi Vun, Judith A. Hahn
2016 Drug and Alcohol Dependence  
Correlates of self-reported unhealthy alcohol use and PEth positive were determined.  ...  Self-reported unhealthy alcohol use (AUDIT-C) was compared to phosphatidylethanol (PEth) positive (≥50ng/ml), a biomarker of alcohol intake. Sociodemographics data was collected.  ...  FSW Clients PEth results PEth results Table 4 a 4 Correlates of self-reported unhealthy alcohol use and PEth biomarker among FSW in Preah Sihanouk, Cambodia b Correlates of self-reported unhealthy  ... 
doi:10.1016/j.drugalcdep.2016.05.011 pmid:27251102 pmcid:PMC5565395 fatcat:3frhvozn6jhudgd7bws3pmafvy

Page 101 of The Continent Vol. 4, Issue 76 [page]

1883 The Continent  
JUDITH.  ...  That was the peth o’ the talk, ma’am, arfter we had sont the chillen to bed ; but it sot me to argyin’ an’ thinkin’, an’ when I come into the house to fix yo’ room for the night, I couldn’t fetch up all  ... 

Biomarker-Measured Unhealthy Alcohol Use in Relation to CD4 Count Among Individuals Starting ART in Sub-Saharan Africa

Jessica F. Magidson, Robin Fatch, Catherine Orrell, Gideon Amanyire, Jessica E. Haberer, Judith A. Hahn
2018 Aids and Behavior  
Overall, 32.2% (n = 129) had unhealthy alcohol use (PEth ≥ 50 ng/ml).  ...  We examined the association between CD4 count and biomarker results using multivariable regression modeling, and compared PEth results to self-report to assess underreporting.  ...  Biomarker (PEth) We used PEth, a biomarker of recent alcohol use, to objectively measure alcohol use.  ... 
doi:10.1007/s10461-018-2364-2 pmid:30560484 pmcid:PMC6535416 fatcat:2rcvlj2fqfb7fb5h3tqjyi2aty

Alcohol Use and HIV Disease Progression in an Antiretroviral Naive Cohort

Judith A. Hahn, Debbie M. Cheng, Nneka I. Emenyonu, Christine Lloyd-Travaglini, Robin Fatch, Starley B. Shade, Christine Ngabirano, Julian Adong, Kendall Bryant, Winnie R. Muyindike, Jeffrey H. Samet
2018 Journal of Acquired Immune Deficiency Syndromes  
Unhealthy alcohol consumption was 3-month Alcohol Use Disorders Identification Test -Consumption (AUDIT-C) positive (≥3 for women, ≥4 for men) and/or phosphatidylethanol (PEth -an alcohol biomarker) ≥50  ...  We also examined using alternative measures of alcohol consumption, such as using PEth alone, as a 3-level variable (PEth <50 ng/mL, PEth ≥50 to <210 ng/mL, PEth ≥210 ng/ml; 210 ng/mL is a suggested PEth  ...  PEth <50 ng/mL or confirmed abstainer −27.79 (−47.78, −7.81) −24.05 (−43.82, −4.28) Model using continuous PEth to represent drinking level Log PEth (per 1 unit log10 PEth change, per 12 months  ... 
doi:10.1097/qai.0000000000001624 pmid:29303844 pmcid:PMC5844835 fatcat:yx46gomctbfijgx4ge3d57ng2u

Comparison of Traditional and Novel Self-Report Measures to an Alcohol Biomarker for Quantifying Alcohol Consumption Among HIV-Infected Adults in Sub-Saharan Africa

Stephen B. Asiimwe, Robin Fatch, Nneka I. Emenyonu, Winnie R. Muyindike, Allen Kekibiina, Glenn-Milo Santos, Thomas K. Greenfield, Judith A. Hahn
2015 Alcoholism: Clinical and Experimental Research  
PEth levels were measured from dried blood spots.  ...  We compared self-reports of drinking to phosphatidylethanol (PEth), an alcohol biomarker.  ...  PEth values The median PEth concentration for the entire sample was 57 ng/ml (IQR 0 to 221).  ... 
doi:10.1111/acer.12781 pmid:26148140 pmcid:PMC4515166 fatcat:wlglqrwfenfcbi35aksiwz3zzq

Declining and rebounding unhealthy alcohol consumption during the first year of HIV care in rural Uganda, using phosphatidylethanol to augment self-report

Judith A. Hahn, Nneka I. Emenyonu, Robin Fatch, Winnie R. Muyindike, Allen Kekiibina, Adam W. Carrico, Sarah Woolf-King, Stephen Shiboski
2015 Addiction  
We chose this PEth cutoff based on previous studies.  ...  At baseline, AUDIT-C was positive in 44% of the participants, while PEth was positive (≥50 ng/ml) in 52%. Median PEth at baseline was 57.8 ng/ml (IQR: 1.0-211.0).  ... 
doi:10.1111/add.13173 pmid:26381193 pmcid:PMC4715487 fatcat:gqk6vjt5qbb5fbmxyojsmyejge
« Previous Showing results 1 — 15 out of 145 results