A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is
Increasing evidences indicate that circular RNAs exert critical function in regulating bladder cancer progression. However, the expressive patterns and roles of circular RNAs in bladder cancer remain less investigated. circRIP2 was identified and evaluated by RNA-sequencing and qPCR; in vitro effects of circRIP2 were determined by CCK8, clone forming, wound healing and trans-well assays; while mice subcutaneous tumor model was designed for in vivo analysis. Western blot, RNA pulldown assay,doi:10.1186/s12943-019-1129-5 pmid:32019579 pmcid:PMC6998850 fatcat:q2xmbznnfff2xgyqj44xep6r5q
more »... A capture and dual luciferase assessment were applied for mechanistic studies. circRIP2 was identified as a conserved and dramatically repressed circular RNA in bladder cancer. Patients that displayed higher circRIP2 expression negatively associate with the grade, stage, metastasis as well as outcome of bladder cancer. In vitro and in vivo studies suggest that circRIP2 enables to promote bladder cancer progression via inducing EMT. Regarding the mechanism, we performed RNA-sequencing analysis, RNA pulldown with biotin-labeled circRIP2-specific probe, dual luciferase reporter assay. It was found that circRIP2 enables to sponge miR-1305 to elevate Tgf-β2 in bladder cancer, and inducing EMT via Tgf-β2/smad3 pathway. Blocking Tgf-β2 in bladder cancer deprives circRIP2 induced cancer progression and EMT. Taken together, our study provides the first evidence that circRIP2 expresses differentially in bladder cancer and negatively along with the cancer progression; effective circRIP2 activity accelerates bladder cancer progression via inducing EMT by activating miR-1305/Tgf-β2/smad3 pathway. The research implies that circRIP2 might be a potential biomarker and therapeutic target for bladder cancer patients.
Juanyi Shi and Kuiqing Li collected references and critically revised the manuscript. Jiamin Zhu and Zhenhong Chen collected data and helped draft the manuscript. ...doi:10.18632/aging.103947 pmid:33175697 pmcid:PMC7695412 fatcat:nvfmycnrq5grrbg2b5vffzi6vm
Shi and Luping Chen assisted in collecting results. ... , Wen Dong and Yinjie Su conceptualized the article; Yinjie Su originally designed the project and wrote this article; Zehu Du prepared the tables and figures; Guangzheng Zhong, Yiyao Ya, Junming Bi, Juanyi ...doi:10.18632/aging.102464 pmid:31808751 pmcid:PMC6932894 fatcat:eezbi5hjlbaknad62ifmcskqe4
Shi, Zehu Du and Luping Chen assisted in collecting results. , 2C), clone formation ability (Figure 2D, 2E) and percentage of cells in S phase (Figure 2F, 2G) were AGING Figure 1 . 1 ciRs-6 is downregulated ... CONTRIBUTIONS Tianxin Lin, Wen Dong and Yinjie Su conceptualized and Yinjie Su wrote this article; Weilian Feng prepared the tables and figures; Guanglei Zhong and Yiyao Ya edited the language of the manuscript; Juanyi ...doi:10.18632/aging.102525 pmid:31819015 pmcid:PMC6932879 fatcat:gu5cwmtexza3lll3un7maldn7q
This article has been corrected: The authors requested the replacement of Figure 4E and Table 1 . Figure 4E (ciRs-6+miR-nc) was quite similar to Supplementary Figure 1D (si-3 in T24 cells) and was slightly updated. Changes of Table 1 are done to correct the statistical mistakes. These corrections do not change the content of the publication and do not affect the conclusion of this research. The authors apologize for the unintentional mistakes. The corrected Figure and Table are provided below.doi:10.18632/aging.102885 pmid:32139656 fatcat:ejzucrjq4ncc7pe2453o6ntiqq
COIN-NGNCON 2006 - The Joint International Conference on Optical Internet and Next Generation Network
A supervisory scheme based on different time-delay recognition is proposed for optical cross-connects (OXCs). Besides providing actual routing information, it can detect and locate multiple faults. Additionally,doi:10.1109/coinngncon.2006.4454521 fatcat:gqtv37jozrhz5mouochylztuoy
Hypoxia plays a critical role in cancer biology. It induces genomic instability, which in turn helps cancer cells respond adaptively to meet the needs of carcinogenesis, cancer progression and relapse. Circular RNA has not been reported among the variety of downstream factors in this adaptive response. Although a few studies have demonstrated the important role of circular RNAs in driving human bladder cancer progression, their carcinogenic roles are still under investigated. Here, wedoi:10.7150/ijbs.26826 pmid:30745833 pmcid:PMC6367558 fatcat:hvm7bkfyobbvvh6vi5we2z7hly
more »... a hypoxia-elevated circular RNA, circELP3, that contributes to bladder cancer progression and cisplatin resistance. Decreasing the level of circELP3 via siRNA clearly reduced the in vitro proliferation and cisplatin resistance of bladder cancer cells and promoted apoptosis. Interfering with circELP3 suppressed tumor xenograft growth in nude mice in vivo. In addition, lower circELP3-expressing bladder cancer cells displayed poorer self-renewal capacity, as demonstrated by lower levels of sphere formation and stem cell marker expression. Furthermore, in human bladder cancer patients, strong correlations between a high circELP3 level and advanced tumor grade and lymph node metastasis were observed. In summary, we provide the first direct evidence that circular RNA participates in the adaptive response to hypoxia and may play a role in the progression and drug resistance of bladder cancer.
XiaogengFigure 1 . 1 Deng and Luping Chen conceived and designed the experiments. Luping Chen, Juanyi Shi and Yaohao Wu performed the experiments. ... Xiaogeng Deng, Luping Chen and Juanyi Shi wrote and critically reviewed the manuscript. All authors discussed the results and commented on the manuscript. ...doi:10.18632/aging.103748 pmid:33052880 pmcid:PMC7732296 fatcat:nzfgefm2pvbkjck5cpbilwawea
was the first time that nomogram incorporating age, tumor size, tumor grade, LNR and T stage was applied to predict the CSS of HCCA after surgery, of which the objective was different from the study of Chen ...doi:10.21037/jgo-21-543 pmid:35557567 pmcid:PMC9086037 fatcat:2kvxtthflje5leqjiy3wl5irzu
计算机科学， ２０１６， ４３(２) ：２３５•２３８，２４４ Ｙｕａｎ Ｄｅｐｉｎｇ， Ｚｈｅｎｇ Ｊｕａｎｙｉ， Ｓｈｉ Ｈａｏｓｈａｎ， ｅｔ ａｌ． Ｔａｒｇｅｔ Ｇｒｏｕｐｉｎｇ Ａｌｇｏｒｉｔｈｍ Ｂａｓｅｄ ｏｎ Ｍｕｌｔｉｐｌｅ Ｃｏｍｂａｔ Ｆｏｒｍａｔｉｏｎｓ［ Ｊ］ ． ... 天津：中国民航大学， ２０１７ Ｘｉｎｇ Ｃｈｅｎ． Ｒｅｓｅａｒｃｈ ｏｎ ｔｈｅ Ｍｅｔｈｏｄ ｏｆ Ｏｂｊｅｃｔ Ｇｒｏｕｐｉｎｇ ｉｎ Ｆｌｉｇｈｔ Ｓｉｔｕａｔｉｏｎ Ａｗａｒｅｎｅｓｓ［ Ｄ］ ． Ｔｉａｎｊｉｎ， Ｃｉｖｉｌ Ａｖｉａｔｉｏｎ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｃｈｉｎａ， ２０１７ ［９］ 淦文燕， 刘冲． 一种改进的搜索密度峰值的聚类算法［ Ｊ］ ． ...doi:10.1051/jnwpu/20183661121 fatcat:en23lf5upzhkrhr5mbfxyffjoy
Proceedings of the 4th International Conference on Arts, Design and Contemporary Education (ICADCE 2018)
Cultural Background of Juancheng Lu Brocade Belonging to Heze City, Shandong province, Juancheng County is located in the southwest of Shandong, and gets the name due to Juanyi and Juancheng. ...doi:10.2991/icadce-18.2018.101 fatcat:c4p6sd26tvhj7b436vvsht2xfi
How did pro-government writers like Lu Mengshu, and others like Ye Lingfeng and Chen Junbao, channel their wartime experience through rain imagery and symbolism? ... (Chen 812) . ... of his pieces in Modern Fiction (128).The early works of Hong Kong writers like Lui Lun and Tse Sen-kwong (謝晨光 n.d.) 25 also imitated Ye's florid vocabulary and sentimental style (Xianggang: xiaoshuo juanyi ...doi:10.26153/tsw/3309 fatcat:xlk6lgiojfdmdnadev4huvs7ou
Chang, Chen, Waggoner and Zha (2015) use a different approach (time-variying BVAR model) to estimate the trend and cycle. ... Chang, Chen, Waggoner and Zha (2015) develops a two-sector model to study the trend and cycle in Chinese macroeconomy, but facts emphasized and the method used in their paper are different from ours. ...doi:10.2139/ssrn.2728171 fatcat:sdnnx4mpjjbq5lq5xai6wff4ni