Development and Optimization of Hyaluronic Acid-Poloxamer In-Situ Gel Loaded with Voriconazole Cubosomes for Enhancement of Activity against Ocular Fungal Infection
Nabil A. Alhakamy, Khaled M. Hosny, Waleed Y. Rizg, Bayan A. Eshmawi, Moutaz Y. Badr, Awaji Y. Safhi, Samar S. A. Murshid
2022
Gels
This formulation led to a minimum PS of 71 nm, an EE% of 66%, Jss value of 6.5 µg/(cm2·min), and stability index of 94 ± 2%. ...
The produced nano vesicles were evaluated for the dependent variables of particle size (PS), entrapment efficiency (EE%), and transcorneal steady-state flux (Jss) of the VZ, and, the obtained optimal VZ-Cub ...
Conflicts of Interest: The authors declare no conflict of interest. Gels 2022, 8, 241 ...
doi:10.3390/gels8040241
pmid:35448142
pmcid:PMC9032757
fatcat:67jfepkw65gxjdfo6rgzcb36ee