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Clinical bioinformatics: a new emerging science

Xiangdong Wang, Lance Liotta
2011 Journal of Clinical Bioinformatics  
Welcome to the open-access journal titled Journal of Clinical Bioinformatics (JCBi), a truly international journal devoted to clinical applications of bioinformatics, medical informatics and the development  ...  JCBi is the only journal focusing on the clinical application of bioinformatics and keeping track of the wealth of new information related to this topic.  ...  Submit your next manuscript to BioMed Central and take full advantage of:  ... 
doi:10.1186/2043-9113-1-1 pmid:21884620 pmcid:PMC3097094 fatcat:66zfijcvwren3bdldfbnexzgle

Role of clinical bioinformatics in the development of network-based Biomarkers

Xiangdong Wang
2011 Journal of Clinical Bioinformatics  
A number of methodologies and computational programs have been developed to integrate selected proteins into the knowledge-based networks via the combination of genomics, proteomics and bioinformatics.  ...  Dynamic network biomarkers should be furthermore correlated with clinical informatics, including patient complaints, history, therapies, clinical symptoms and signs, physician's examinations, biochemical  ...  Clinical bioinformatics has been suggested as a new emerging science combining clinical informatics, bioinformatics, medical informatics, information technology, mathematics and omics science together  ... 
doi:10.1186/2043-9113-1-28 pmid:22024468 pmcid:PMC3221619 fatcat:h66h2jstl5e6zlisqq76waruei

Brain cancer prognosis: independent validation of a clinical bioinformatics approach

Raffaele Fronza, Michele Tramonti, William R Atchley, Christine Nardini
2012 Journal of Clinical Bioinformatics  
The clinical information hidden in these data can be clarified with clinical bioinformatics approaches.  ...  Translational and evidence based medicine can take advantage of biotechnology advances that offer a fast growing variety of high-throughput data for screening molecular activities of genomic, transcriptional  ...  Second, it offers a useful analysis tool in the clinical bioinformatics research area.  ... 
doi:10.1186/2043-9113-2-2 pmid:22297051 pmcid:PMC3296594 fatcat:wzikpz7vhbbtneb4fqk7663ygm

Reverse translational bioinformatics: a bioinformatics assay of age, gender and clinical biomarkers

Amit Fliss, Micha Ragolsky, Eitan Rubin
2008 Summit on translational bioinformatics  
In bioinformatics, clinical data is rarely used. Here, we propose using bedsidedata in basic research, via bioinformatics methodologies.  ...  To demonstrate the potential of this so called Reverse Translational Bioinformatics approach, classical bioinformatics tools were applied to blood biomarker information attained from a large scale, open-access  ...  This work was supported by the Horowitz Center for Complexity Science, the RICH foundation and the National Institute of Biotechnology in the Negev.  ... 
pmid:21347121 pmcid:PMC3041524 fatcat:wskvhfng3rgpnopyinw7xibaha

Significance of bioinformatics in research of chronic obstructive pulmonary disease

Hong Chen, Xiangdong Wang
2011 Journal of Clinical Bioinformatics  
We also presented the requirements and challenges in implementing bioinformatics to COPD research and interpreted these results as clinical physicians.  ...  As an interdispline, bioinformatics supplied vital information on integrative understanding of COPD.  ...  Clinical bioinformatics on COPD could be achieved from the combination of clinical informatics, medical informatics, bioinformatics and informatics by collaborations among clinicians, bioinformaticians  ... 
doi:10.1186/2043-9113-1-35 pmid:22185624 pmcid:PMC3285039 fatcat:ncwr3gw2rvexpmffl6quxa6ofq

ObTiMA

Holger Stenzhorn
2015 Journal of Clinical Bioinformatics  
Display of creating a CRF to register a patient in the SIOP trial.  ...  Tool description ObTiMA is an ontology-based clinical trial data management system [1] to support clinicians in designing and conducting clinical trials.  ...  The ontology-based CRF (case report form) creation module of the Trial Builder is one of the systems core functionalities ( Figure 1 ).  ... 
doi:10.1186/2043-9113-5-s1-s3 pmcid:PMC4460786 fatcat:projkhk2qfgaphjupiujzsaesq

Decima

Anca Bucur
2015 Journal of Clinical Bioinformatics  
Status of development Users Oncologists, trial nurses, investigators, clinical researchers. Version 3 ( 3 June 2014).  ...  We address both aspects and propose a scalable, efficient and pragmatic application enabling automatic evaluation of eligibility of patients for a relevant set of clinical trials (Figure 1 ).  ... 
doi:10.1186/2043-9113-5-s1-s11 pmcid:PMC4460922 fatcat:njbawrwfkjdqnmlmudyahbqake

Bioinformatic-driven search for metabolic biomarkers in disease

Christian Baumgartner, Melanie Osl, Michael Netzer, Daniela Baumgartner
2011 Journal of Clinical Bioinformatics  
This review demonstrates that clinical bioinformatics has evolved into an essential element of biomarker discovery, translating new innovations and successes in profiling technologies and bioinformatics  ...  This survey article highlights emerging bioinformatics methods for biomarker discovery in clinical metabolomics, focusing on the problem of data preprocessing and consolidation, the data-driven search,  ...  Acknowledgements The authors gratefully acknowledge support from the Austrian Genome Research Program GEN-AU and its "Bioinformatics Integration Network (BIN III)" project.  ... 
doi:10.1186/2043-9113-1-2 pmid:21884622 pmcid:PMC3143899 fatcat:cji7s2zn3vbz5p5irjb45xykqu

Clinical Proteomics Perspective

Punit Kaur
2015 Journal of Proteomics & Bioinformatics  
Clinical Proteomics is a special peer-reviewed proteomics journal published as a special issue this year by Journal of Proteomics and Bioinformatics.  ...  Journal of Proteomics and Bioinformatics is an open access, peerreviewed, online journal considering research in proteomics.  ... 
doi:10.4172/jpb.s8-e001 fatcat:gatp3tihdfbblgoghmnves3uoe

Brachyury goes Clinical

Debalina Sarkar
2012 Journal of Proteomics & Bioinformatics  
Completion of the clinical trial will definitely tell a lot more in this field of study, but continuation of Brachyury to be studied in basic science, is still needed to answer many questions.  ...  These steps usually involve many years of basic science research, financial support, and yet no conclusion for a clinical trial.  ... 
doi:10.4172/jpb.10000e20 fatcat:2ys5zqedfnbpfervxumofvgfoy

Clinical trials information mediator (CTIM)

Benjamin Braasch, Töresin Karakoyun
2015 Journal of Clinical Bioinformatics  
Results of a query for "informed consent" is shown. Left side indicates NCT numbers; the right side offers links to ClinicalTrials.gov.  ...  Journal of Clinical Bioinformatics 2015 5(Suppl 1):S7.  ...  Braasch and Karakoyun Journal of Clinical Bioinformatics 2015, 5(Suppl 1):S7 http://www.jclinbioinformatics.com/content/5/S1/S7 Status of development this article as: Braasch and Karakoyun: Clinical  ... 
doi:10.1186/2043-9113-5-s1-s7 pmcid:PMC4460620 fatcat:n5hsjydv7rfrjjgrhxbiw6hpli

Section 7: Bioinformatics: Bioinformatics and its Impact on Clinical Research Methods

E. Lang
2006 IMIA Yearbook of Medical Informatics  
Results: Current research in the field of bioinformatics clearly shows ongoing unification of experimental findings and clinical outcomes.  ...  Examination of appropriate methods covers data and text mining, ontologies as well as machine learning and classification.The best paper selection of articles on bioinformatics shows examples of excellent  ...  Acknowledgement We greatly acknowledge the support of Martina Hutter and of the reviewers in the selection process of the IMIA Yearbook.  ... 
doi:10.1055/s-0038-1638478 fatcat:kwwamrqcffbbzaasbwpo5hq76e

EHR4CR local workbench

David Voets
2015 Journal of Clinical Bioinformatics  
Characterisation Tool, recruitment process, multi-centric clinical trials.  ...  Journal of Clinical Bioinformatics 2015 5(Suppl 1):S12.  ...  Voets Journal of Clinical Bioinformatics 2015, 5(Suppl 1):S12 http://www.jclinbioinformatics.com/content/5/S1/S12 From 1st Clinical Research Informatics (CRI) Solutions Day Duesseldorf, Germany. 26-27  ... 
doi:10.1186/2043-9113-5-s1-s12 pmcid:PMC4460753 fatcat:vmajhab6y5bjra5pxlifyhqun4

VISTA Trials

Caroline Gilotay, Stéphane Lejeune
2015 Journal of Clinical Bioinformatics  
EORTC, Avenue Emmanuel Mounier 83/11, 1200 Brussels, Belgium Gilotay and Lejeune Journal of Clinical Bioinformatics 2015, 5(Suppl 1):S4 http://www.jclinbioinformatics.com/content/5/S1/S4 JOURNAL OF  ...  Display of ClinicalData module indicating a check for correctness of data input (in red). this article as: Gilotay and Lejeune: VISTA Trials. Journal of Clinical Bioinformatics 2015 5(Suppl 1):S4.  ... 
doi:10.1186/2043-9113-5-s1-s4 pmcid:PMC4460619 fatcat:rxagtdgo2jb6xpcsni22vt2gyi

EHR4CR central workbench

David Voets
2015 Journal of Clinical Bioinformatics  
Characterisation Tool, protocol feasibility, recruitment process, electronic data capture, multi-centric clinical trials.  ...  Correspondence: david.voets@custodix.com Custodix, Kortrijkse steenweg 214, bus 3, 9830 Sint-Martens-Latem, Belgium Figure 1 User interface of the central workbench showing different eligibility criteria  ...  The study manager is automatically informed about relevant changes occurring at each of the engaged clinical sites such as changes in the number of potential candidate patients, the number of consenting  ... 
doi:10.1186/2043-9113-5-s1-s13 pmcid:PMC4460653 fatcat:2xuwqsxkgbdlzett66fbn5jfyq
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