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Gray matter atrophy in multiple sclerosis: A longitudinal study
2008
Annals of Neurology
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MRI measures of focal and diffuse tissue damage accounted for 62% of the variance in GM atrophy in RRMS, but there were no significant predictors of GM atrophy in SPMS. ...
Objective: To determine gray matter (GM) atrophy rates in multiple sclerosis (MS) patients at all stages of disease, and to identify predictors and clinical correlates of GM atrophy. ...
This study was supported by the NIH (National Institute of Neurological Diseases and Stroke, P01-NS38667, Project 3 to Richard A. ...
doi:10.1002/ana.21436
pmid:18661561
fatcat:wx7qu5jkdjfptdmb7mifubbt4m
Repeatability and reproducibility of in-vivo brain temperature measurements
[article]
2020
medRxiv
pre-print
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., thermometry) over a large brain volume. To date, intra-subject reproducibility of MRSI-based brain temperature (MRSI-t) has not been investigated. ...
Brain temperature was derived using the frequency difference between water and creatine (TCRE) for 47 regions of interest (ROIs) delineated by the modified Automated Anatomical Labeling (AAL) atlas. ...
Automated anatomical labeling of activations in SPM using a macroscopic anatomical 537 parcellation of the MNI MRI single-subject brain. ...
doi:10.1101/2020.10.27.20220715
fatcat:kr2ufbhwt5bonb5tyulontgxwi
Repeatability and Reproducibility of in-vivo Brain Temperature Measurements
2020
Frontiers in Human Neuroscience
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Magnetic resonance spectroscopic imaging (MRSI) is a neuroimaging technique that may be useful for non-invasive mapping of brain temperature (i.e., thermometry) over a large brain volume. ...
Brain temperature was derived using the frequency difference between water and creatine (TCRE) for 47 regions of interest (ROIs) delineated by the modified Automated Anatomical Labeling (AAL) atlas. ...
This yielded 5.6 × 5.6 × 5 mm voxels, with a voxel volume of ∼0.1568 cm 3 . ...
doi:10.3389/fnhum.2020.598435
pmid:33424566
pmcid:PMC7785722
fatcat:5wsckicngfeu5bcpgifea6o6ae
High Sensitivity, Rapid Detection of Virus in High Traffic Environments
2022
Frontiers in Bioengineering and Biotechnology
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The device is almost fully automated and is deployable in any community setting with a power source. ...
A colorimetric change from red to yellow occurs in the presence of a positive sample. Positive samples are run through a LFIA to achieve specificity on a multiplex three-test line paper assay. ...
However, RT-qPCR is not sufficient for use in many hightraffic community settings for a number of reasons. ...
doi:10.3389/fbioe.2022.877603
pmid:35402391
pmcid:PMC8989402
fatcat:j42xrk7tqzaxnp4xtctufbikye
Targeted Versus Continuous Delivery of Volatile Anesthetics During Cholinergic Bronchoconstriction
2018
Journal of Engineering and Science in Medical Diagnostics and Therapy
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This lack of response may have resulted from an insufficient dose of the anesthetic to cause bronchodilation, or from the preferential distribution of air flow with inhaled anesthetic delivery to less ...
To test this hypothesis, we designed a delivery system for precise timing of inhaled volatile anesthetics during the course of a positive pressure breath. ...
National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (T32 EB006359). ...
doi:10.1115/1.4040001
pmid:31106293
pmcid:PMC6516463
fatcat:qdcw5idoszbcdhmvi5yxswlkye
Multiple sclerosis normal-appearing white matter: Pathology-imaging correlations
2011
Annals of Neurology
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Four types of MRI-defined regions of interest (ROIs) were analyzed: (1) Regions that were abnormal on all images ("T2T1MTR lesions"); (2) NAWM regions with slightly-abnormal MTR located close to white ...
Objective-To determine the pathologic basis of subtle abnormalities in magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) parameters observed in normal-appearing white matter (NAWM) ...
Acknowledgments This study was supported by the National Institute of Health, National Institute of Neurological Disorders and Stroke, P50 NS 38667 (R.M.R., PI; EF Project 3 Leader). ...
doi:10.1002/ana.22521
pmid:22162059
pmcid:PMC3241216
fatcat:h32nvfr4dvcclcxmkh4yzcrcdu
Excessive Biologic Response to IFNβ Is Associated with Poor Treatment Response in Patients with Multiple Sclerosis
2011
PLoS ONE
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The findings suggest a strategy for biologically based, rational use of IFNb for individual MS patients. ...
Poor treatment response is not explained by the duration of biological effects or the specific genes induced. ...
Joerg Schlaak (University of Essen, Germany) and his colleagues for extensive and thoughtful assistance during the development of the macroarray assay. ...
doi:10.1371/journal.pone.0019262
pmid:21602934
pmcid:PMC3094352
fatcat:xgko7femdrhzbpvdemj625k5z4
Myosin Vc Interacts with Rab32 and Rab38 Proteins and Works in the Biogenesis and Secretion of Melanosomes
2014
Journal of Biological Chemistry
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The biogenesis of melanosomes and other lysosome-related organelles requires a pair of Rab GTPases, Rab32 and Rab38. Results: Myosin Vc is a novel binding partner of these Rabs. ...
Knockdown of Myosin Vc in MNT-1 cells more than doubled the abundance of pigmented melanosomes but did not change the number of unpigmented melanosomes. ...
NOVEMBER 28, 2014 • VOLUME 289 • NUMBER 48 JOURNAL OF BIOLOGICAL CHEMISTRY 33519 by guest on July 25, 2018 http://www.jbc.org/ Downloaded from
NOVEMBER 28, 2014 • VOLUME 289 • NUMBER 48 JOURNAL ...
doi:10.1074/jbc.m114.578948
pmid:25324551
pmcid:PMC4246105
fatcat:khla6rbla5hl3dnmotryn24fmu
The influence of net community production and phytoplankton community structure on CO2uptake in the Gulf of Alaska
2013
Global Biogeochemical Cycles
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While the transition zone comprises 20% of the total area covered in crossing the Gulf of Alaska, it contributed 58% of the total NCP and 67% of the total CO 2 uptake observed along the cruise track. ...
(HNLC) waters of the Alaskan Gyre and the coastal waters off the Aleutian Islands. ...
Data were analyzed using the R package flowPhyto , which uses statistical clustering methods to automate the identification of phytoplankton populations. ...
doi:10.1002/gbc.20058
fatcat:mbv65nfwarfzviqopvh2tmvxnm
BLOC-2, AP-3, and AP-1 Proteins Function in Concert with Rab38 and Rab32 Proteins to Mediate Protein Trafficking to Lysosome-related Organelles
2012
Journal of Biological Chemistry
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Examples of common components are the adaptor protein complex-3 (AP-3) and biogenesis of lysosome-related organelle complex (BLOC)-2. ...
Rab38-and Rab32-deficient MNT-1 cells displayed abnormal trafficking and steady state levels of known cargoes of the BLOC-2, AP-3, and AP-1 pathways, the melanin-synthesizing enzymes tyrosinase and tyrosinase-related ...
(24 -32) . ...
doi:10.1074/jbc.m112.351908
pmid:22511774
pmcid:PMC3365991
fatcat:5dy3al64n5hyfdgbflyamh5p2q
Automated segmentation of microtomography imaging of Egyptian mummies
2021
PLoS ONE
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In the Automated SEgmentation of Microtomography Imaging (ASEMI) project, we developed a tool to automatically segment these volumetric images, using manually segmented samples to tune and train a machine ...
For a set of four specimens of ancient Egyptian animal mummies we achieve an overall accuracy of 94–98% when compared with manually segmented slices, approaching the results of off-the-shelf commercial ...
We also want to thank the Muse ´e de Grenoble (France) in the person of Vale ´rie Huss for providing access to the sealed jar MG.2038. ...
doi:10.1371/journal.pone.0260707
pmid:34910736
pmcid:PMC8673632
fatcat:uvkrarftdncaxfdpyhumj5tpuq
A paper microfluidic cartridge for automated staining of malaria parasites with an optically transparent microscopy window
2014
Lab on a Chip
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A capillary flow driven microfluidic system for the generation and staining of thin and thick blood smears prior to microscopy is presented. ...
for design of a microscope adapter ring, LabVIEW programming, and photography, respectively. ...
Acknowledgements The authors would like to thank: Bill and Melinda Gates for their sponsorship through Global Good; David Bell of Intellectual Ventures Laboratory, for comments on the manuscript; Jen Hume ...
doi:10.1039/c4lc00293h
pmid:24781199
fatcat:6jzanqt6brbcrdsrnq2ue2mhgm
Validity of the ipsilateral acoustic reflex as a screening parameter
1997
Journal of american academy of audiology
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Further, if the IAR screening were to be carried out using an automated (programmed) immittance system with an equivalent volume change criteria for IAR detection, the equivalent volume change of > or ...
Based on our findings, an optimal IAR screening protocol would use a pulsed elicitation immittance system (multiplexing circuit) and a maximum intensity level of 105 dB HL. ...
Further, if the IAR screening were to be carried out using an automated (programmed) immittance system with an equivalent volume change criteria for I|AR detection, the equivalent volume change of >0.03 ...
pmid:9101459
fatcat:kr6hmcwprjdupdigldwuuqckay
Novel multimodality segmentation using level sets and Jensen-Rényi divergence
2013
Medical Physics (Lancaster)
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The estimated maximal diameters of the gross tumor volume (GTV) showed a high correlation with the macroscopically determined maximal diameters, with a R 2 value of 0.85 and 0.88 using the PET and PET/ ...
Results: The average concordance index (CI) of the JRD segmentation of the PET images was 0.56 with an average classification error of 65%. ...
The interpretation of visual information from multiple images is another source of variability that may be aided by computer automation. ...
doi:10.1118/1.4828836
pmid:24320519
fatcat:dvgbu2bmzfe73hu2dwb2itcsr4
Sugar Profiling of Honeys for Authentication and Detection of Adulterants Using High-Performance Thin Layer Chromatography
2020
Molecules
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Honey adulteration, where a range of sugar syrups is used to increase bulk volume, is a common problem that has significant negative impacts on the honey industry, both economically and from a consumer ...
Quantifications of sucrose and maltose can be used to identify the type of syrup adulterant, in particular when used in combination with HPTLC fingerprinting of the organic honey extracts. ...
Acknowledgments: We thank Chromatech Scientific for their technical support of this project.
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/molecules25225289
pmid:33202752
fatcat:vor455czozcrpjn5cns3ishlqi
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