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Gray matter atrophy in multiple sclerosis: A longitudinal study

Elizabeth Fisher, Jar-Chi Lee, Kunio Nakamura, Richard A. Rudick
2008 Annals of Neurology  
MRI measures of focal and diffuse tissue damage accounted for 62% of the variance in GM atrophy in RRMS, but there were no significant predictors of GM atrophy in SPMS.  ...  Objective: To determine gray matter (GM) atrophy rates in multiple sclerosis (MS) patients at all stages of disease, and to identify predictors and clinical correlates of GM atrophy.  ...  This study was supported by the NIH (National Institute of Neurological Diseases and Stroke, P01-NS38667, Project 3 to Richard A.  ... 
doi:10.1002/ana.21436 pmid:18661561 fatcat:wx7qu5jkdjfptdmb7mifubbt4m

Repeatability and reproducibility of in-vivo brain temperature measurements [article]

Ayushe Sharma, Rodolphe Nenert, Christina Mueller, Andrew Maudsley, Jarred Younger, Jerzy P Szaflarski
2020 medRxiv   pre-print
., thermometry) over a large brain volume. To date, intra-subject reproducibility of MRSI-based brain temperature (MRSI-t) has not been investigated.  ...  Brain temperature was derived using the frequency difference between water and creatine (TCRE) for 47 regions of interest (ROIs) delineated by the modified Automated Anatomical Labeling (AAL) atlas.  ...  Automated anatomical labeling of activations in SPM using a macroscopic anatomical 537 parcellation of the MNI MRI single-subject brain.  ... 
doi:10.1101/2020.10.27.20220715 fatcat:kr2ufbhwt5bonb5tyulontgxwi

Repeatability and Reproducibility of in-vivo Brain Temperature Measurements

Ayushe A. Sharma, Rodolphe Nenert, Christina Mueller, Andrew A. Maudsley, Jarred W. Younger, Jerzy P. Szaflarski
2020 Frontiers in Human Neuroscience  
Magnetic resonance spectroscopic imaging (MRSI) is a neuroimaging technique that may be useful for non-invasive mapping of brain temperature (i.e., thermometry) over a large brain volume.  ...  Brain temperature was derived using the frequency difference between water and creatine (TCRE) for 47 regions of interest (ROIs) delineated by the modified Automated Anatomical Labeling (AAL) atlas.  ...  This yielded 5.6 × 5.6 × 5 mm voxels, with a voxel volume of ∼0.1568 cm 3 .  ... 
doi:10.3389/fnhum.2020.598435 pmid:33424566 pmcid:PMC7785722 fatcat:5wsckicngfeu5bcpgifea6o6ae

High Sensitivity, Rapid Detection of Virus in High Traffic Environments

Lauren Waller, Zhilin Guo, Rui Tang, Zunming Zhang, Edward Wang, Jarred Yasuhara-Bell, Louise Laurent, Yu-Hwa Lo
2022 Frontiers in Bioengineering and Biotechnology  
The device is almost fully automated and is deployable in any community setting with a power source.  ...  A colorimetric change from red to yellow occurs in the presence of a positive sample. Positive samples are run through a LFIA to achieve specificity on a multiplex three-test line paper assay.  ...  However, RT-qPCR is not sufficient for use in many hightraffic community settings for a number of reasons.  ... 
doi:10.3389/fbioe.2022.877603 pmid:35402391 pmcid:PMC8989402 fatcat:j42xrk7tqzaxnp4xtctufbikye

Targeted Versus Continuous Delivery of Volatile Anesthetics During Cholinergic Bronchoconstriction

Jarred R. Mondoñedo, John S. McNeil, Jacob Herrmann, Brett A. Simon, David W. Kaczka
2018 Journal of Engineering and Science in Medical Diagnostics and Therapy  
This lack of response may have resulted from an insufficient dose of the anesthetic to cause bronchodilation, or from the preferential distribution of air flow with inhaled anesthetic delivery to less  ...  To test this hypothesis, we designed a delivery system for precise timing of inhaled volatile anesthetics during the course of a positive pressure breath.  ...  National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (T32 EB006359).  ... 
doi:10.1115/1.4040001 pmid:31106293 pmcid:PMC6516463 fatcat:qdcw5idoszbcdhmvi5yxswlkye

Multiple sclerosis normal-appearing white matter: Pathology-imaging correlations

Natalia M. Moll, Anna M. Rietsch, Smitha Thomas, Amy J. Ransohoff, Jar-Chi Lee, Robert Fox, Ansi Chang, Richard M. Ransohoff, Elizabeth Fisher
2011 Annals of Neurology  
Four types of MRI-defined regions of interest (ROIs) were analyzed: (1) Regions that were abnormal on all images ("T2T1MTR lesions"); (2) NAWM regions with slightly-abnormal MTR located close to white  ...  Objective-To determine the pathologic basis of subtle abnormalities in magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) parameters observed in normal-appearing white matter (NAWM)  ...  Acknowledgments This study was supported by the National Institute of Health, National Institute of Neurological Disorders and Stroke, P50 NS 38667 (R.M.R., PI; EF Project 3 Leader).  ... 
doi:10.1002/ana.22521 pmid:22162059 pmcid:PMC3241216 fatcat:h32nvfr4dvcclcxmkh4yzcrcdu

Excessive Biologic Response to IFNβ Is Associated with Poor Treatment Response in Patients with Multiple Sclerosis

Richard A. Rudick, M. R. Sandhya Rani, Yaomin Xu, Jar-Chi Lee, Jie Na, Jennifer Shrock, Anupama Josyula, Elizabeth Fisher, Richard M. Ransohoff, Steven Jacobson
2011 PLoS ONE  
The findings suggest a strategy for biologically based, rational use of IFNb for individual MS patients.  ...  Poor treatment response is not explained by the duration of biological effects or the specific genes induced.  ...  Joerg Schlaak (University of Essen, Germany) and his colleagues for extensive and thoughtful assistance during the development of the macroarray assay.  ... 
doi:10.1371/journal.pone.0019262 pmid:21602934 pmcid:PMC3094352 fatcat:xgko7femdrhzbpvdemj625k5z4

Myosin Vc Interacts with Rab32 and Rab38 Proteins and Works in the Biogenesis and Secretion of Melanosomes

Jarred J. Bultema, Judith A. Boyle, Parker B. Malenke, Faye E. Martin, Esteban C. Dell'Angelica, Richard E. Cheney, Santiago M. Di Pietro
2014 Journal of Biological Chemistry  
The biogenesis of melanosomes and other lysosome-related organelles requires a pair of Rab GTPases, Rab32 and Rab38. Results: Myosin Vc is a novel binding partner of these Rabs.  ...  Knockdown of Myosin Vc in MNT-1 cells more than doubled the abundance of pigmented melanosomes but did not change the number of unpigmented melanosomes.  ...  NOVEMBER 28, 2014 • VOLUME 289 • NUMBER 48 JOURNAL OF BIOLOGICAL CHEMISTRY 33519 by guest on July 25, 2018 http://www.jbc.org/ Downloaded from NOVEMBER 28, 2014 • VOLUME 289 • NUMBER 48 JOURNAL  ... 
doi:10.1074/jbc.m114.578948 pmid:25324551 pmcid:PMC4246105 fatcat:khla6rbla5hl3dnmotryn24fmu

The influence of net community production and phytoplankton community structure on CO2uptake in the Gulf of Alaska

Hilary I. Palevsky, Francois Ribalet, Jarred E. Swalwell, Catherine E. Cosca, Edward D. Cokelet, Richard A. Feely, E. Virginia Armbrust, Paul D. Quay
2013 Global Biogeochemical Cycles  
While the transition zone comprises 20% of the total area covered in crossing the Gulf of Alaska, it contributed 58% of the total NCP and 67% of the total CO 2 uptake observed along the cruise track.  ...  (HNLC) waters of the Alaskan Gyre and the coastal waters off the Aleutian Islands.  ...  Data were analyzed using the R package flowPhyto , which uses statistical clustering methods to automate the identification of phytoplankton populations.  ... 
doi:10.1002/gbc.20058 fatcat:mbv65nfwarfzviqopvh2tmvxnm

BLOC-2, AP-3, and AP-1 Proteins Function in Concert with Rab38 and Rab32 Proteins to Mediate Protein Trafficking to Lysosome-related Organelles

Jarred J. Bultema, Andrea L. Ambrosio, Carolyn L. Burek, Santiago M. Di Pietro
2012 Journal of Biological Chemistry  
Examples of common components are the adaptor protein complex-3 (AP-3) and biogenesis of lysosome-related organelle complex (BLOC)-2.  ...  Rab38-and Rab32-deficient MNT-1 cells displayed abnormal trafficking and steady state levels of known cargoes of the BLOC-2, AP-3, and AP-1 pathways, the melanin-synthesizing enzymes tyrosinase and tyrosinase-related  ...  (24 -32) .  ... 
doi:10.1074/jbc.m112.351908 pmid:22511774 pmcid:PMC3365991 fatcat:5dy3al64n5hyfdgbflyamh5p2q

Automated segmentation of microtomography imaging of Egyptian mummies

Marc Tanti, Camille Berruyer, Paul Tafforeau, Adrian Muscat, Reuben Farrugia, Kenneth Scerri, Gianluca Valentino, V. Armando Solé, Johann A. Briffa, Siân E Halcrow
2021 PLoS ONE  
In the Automated SEgmentation of Microtomography Imaging (ASEMI) project, we developed a tool to automatically segment these volumetric images, using manually segmented samples to tune and train a machine  ...  For a set of four specimens of ancient Egyptian animal mummies we achieve an overall accuracy of 94–98% when compared with manually segmented slices, approaching the results of off-the-shelf commercial  ...  We also want to thank the Muse ´e de Grenoble (France) in the person of Vale ´rie Huss for providing access to the sealed jar MG.2038.  ... 
doi:10.1371/journal.pone.0260707 pmid:34910736 pmcid:PMC8673632 fatcat:uvkrarftdncaxfdpyhumj5tpuq

A paper microfluidic cartridge for automated staining of malaria parasites with an optically transparent microscopy window

Matthew P. Horning, Charles B. Delahunt, S. Ryan Singh, Spencer H. Garing, Kevin P. Nichols
2014 Lab on a Chip  
A capillary flow driven microfluidic system for the generation and staining of thin and thick blood smears prior to microscopy is presented.  ...  for design of a microscope adapter ring, LabVIEW programming, and photography, respectively.  ...  Acknowledgements The authors would like to thank: Bill and Melinda Gates for their sponsorship through Global Good; David Bell of Intellectual Ventures Laboratory, for comments on the manuscript; Jen Hume  ... 
doi:10.1039/c4lc00293h pmid:24781199 fatcat:6jzanqt6brbcrdsrnq2ue2mhgm

Validity of the ipsilateral acoustic reflex as a screening parameter

J P Sells, R M Hurley, C R Morehouse, J E Douglas
1997 Journal of american academy of audiology  
Further, if the IAR screening were to be carried out using an automated (programmed) immittance system with an equivalent volume change criteria for IAR detection, the equivalent volume change of > or  ...  Based on our findings, an optimal IAR screening protocol would use a pulsed elicitation immittance system (multiplexing circuit) and a maximum intensity level of 105 dB HL.  ...  Further, if the IAR screening were to be carried out using an automated (programmed) immittance system with an equivalent volume change criteria for I|AR detection, the equivalent volume change of >0.03  ... 
pmid:9101459 fatcat:kr6hmcwprjdupdigldwuuqckay

Novel multimodality segmentation using level sets and Jensen-Rényi divergence

Daniel Markel, Habib Zaidi, Issam El Naqa
2013 Medical Physics (Lancaster)  
The estimated maximal diameters of the gross tumor volume (GTV) showed a high correlation with the macroscopically determined maximal diameters, with a R 2 value of 0.85 and 0.88 using the PET and PET/  ...  Results: The average concordance index (CI) of the JRD segmentation of the PET images was 0.56 with an average classification error of 65%.  ...  The interpretation of visual information from multiple images is another source of variability that may be aided by computer automation.  ... 
doi:10.1118/1.4828836 pmid:24320519 fatcat:dvgbu2bmzfe73hu2dwb2itcsr4

Sugar Profiling of Honeys for Authentication and Detection of Adulterants Using High-Performance Thin Layer Chromatography

Md Khairul Islam, Tomislav Sostaric, Lee Yong Lim, Katherine Hammer, Cornelia Locher
2020 Molecules  
Honey adulteration, where a range of sugar syrups is used to increase bulk volume, is a common problem that has significant negative impacts on the honey industry, both economically and from a consumer  ...  Quantifications of sucrose and maltose can be used to identify the type of syrup adulterant, in particular when used in combination with HPTLC fingerprinting of the organic honey extracts.  ...  Acknowledgments: We thank Chromatech Scientific for their technical support of this project. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/molecules25225289 pmid:33202752 fatcat:vor455czozcrpjn5cns3ishlqi
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